In Silico Trials of Prosthetic Valves Replicate Methodologies for Evaluating the Fatigue Life of Artificial Leaflets to Expand Beyond In Vitro Tests and Conventional Clinical Trials

This research the left ventricular chamber of a ViVitro Labs Pulse was customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. The ViVitro Labs Pulse chamber design and structure provides maximum modularity to create unique support without compromising system performance. "The TaurusOne was tested in vitro in a pulse duplicator system (ViVitro Labs Inc., Victoria, BC, Canada) (Figure 1b), operating at a rate of 70 beats per minute (bpm). The test chamber was filled with 37 °C distilled water to simulate the testing environment recommended by ISO 5840-3 [20]. A linear motor-driven plunger pump was used to precisely control the pressure values on both sides of the fluid according to the aortic valve pressure gradient curve of the clinical patient"