中国地区询价
1 (250) 388-3531
+33 4 86 68 68 10
Cited Publications
ViVitro Labs products are cited in hundreds of peer reviewed publications. Please contact us if you would like to add your publication to our list.
ViVitro Labs systems are the systems most cited in the literature for building simple and complex mock circulatory loops or circulatory flow loops. Currently there are over 1,130 search results on Google Scholar. Use Google Scholar to discover our full range of Cited Peer Reviewed Publications.
-
A 3D-Printed Rupture-Prone Aneurysm Model for Assessing the Safety and Efficacy of Endovascular Devices
The ViVitro SuperPump enabled a physiologically relevant benchtop platform for evaluating treatment strategies for giant intracranial aneurysms using a rupture-prone 3D-printed model. In this study, researchers implemented a custom flow loop to compare flow diverter-only treatment, flow diverter combined with synthetic thrombus, and flow diverter with liquid embolic, while continuously monitoring intra-aneurysmal pressure and time to rupture. The results demonstrate that benchtop aneurysm testing provides a practical and repeatable approach for assessing treatment performance and mechanical stability under controlled physiological conditions, while underscoring the value of realistic in-vitro models for preclinical device evaluation -
Evaluating the Efficacy of Automated Suturing Technology for Bentall Procedures in a Passive Beating Heart Model
This study demonstrates how the ViVitro Labs SuperPump enables precise control of flow and stroke, providing the stable and clinically relevant hemodynamic conditions required to accurately quantify leakage. Automated versus manual suturing techniques in Bentall procedures were evaluated using an ex vivo passive beating heart model integrated into an advanced mock circulatory loop (MCL) platform. Twenty porcine hearts underwent Bentall surgery with either automated or manual suturing and were tested under progressively increasing aortic pressures using the ViVitro Labs SuperPump. The results revealed no significant difference in anastomotic leakage between the two techniques, even under hypertensive conditions. These findings indicate that automated suturing achieves comparable holding strength and hemostatic performance to manual methods, supporting its use in complex aortic root procedures. -
Harnessing piezoelectric poly L lactic acid for enhanced sensing in aortic annuloplasty
This work highlights how ViVitro systems enable realistic cardiovascular bench testing for next-generation bioelectronic devices, helping advance translational implant development. Using a ViVitro SuperPump to recreate physiologically relevant pulsatile left-heart conditions, this study evaluates a biodegradable PLLA piezoelectric sensor for real-time monitoring during aortic annuloplasty. The authors enhanced PLLA film performance through uniaxial stretching and thermal annealing, significantly increasing voltage output and enabling stable, pressure-correlated sensing in a ring-like prototype. Within the in-vitro setup, the sensor produced repeatable signals across clinically relevant pressure ranges, supporting its potential as a temporary smart implant. -
Coronary Perfusion Following a Transcatheter Aortic Valve Replacement in Either Reanimated Swine or Preserved Human Hearts
Pumping New Life into Heart Research: How ViVitro's Superpump is Changing TAVR Studies In this study, researchers took a unique approach by reanimating swine and human hearts with a ViVitro Superpump to investigate how TAVR implantation affects coronary pressure. Using the Superpump and detailed CT scans, they measured what they call the Estimated Leaflet to Ostium Distance, or ELOD, and found a clear correlation: the shorter that distance, the more coronary pressure could drop. In other words, by getting these hearts beating again in a lab setting, they demonstrated that ELOD might be a better predictor of coronary obstruction risk than some traditional measurements. It’s a solid example of how ViVitro’s technology is helping refine our understanding of heart valve procedures, all without the need for animal or patient trials. -
The role of 3D printing and finite element-based computational simulations in transcatheter pulmonary valve replacement
Using a modified ViVitro Pulse Duplicator system, researchers achieved one of the most advanced preclinical test benches to date for Transcatheter Pulmonary Valve Replacement (TPVR). This platform allowed integration of patient-specific 3D-printed pulmonary artery models to evaluate valve hemodynamics under physiologic conditions. The ViVitro system enabled precise measurement of pressure gradients and regurgitation, which were then compared with in vivo catheterization data—demonstrating excellent correlation and validating the use of 3D-printed geometries for personalized testing. This work highlights how ViVitro technology facilitates translational research by linking computational design, in-vitro modeling, and clinical validation to optimize device sizing and placement for complex congenital heart conditions. -
In Vitro Investigation of Microcatheter Behavior During Microsphere Injection in Transarterial Radioembolization
A symmetrical phantom with circular successively bifurcating vessels was developed to study the behavior of the clinical catheter during microsphere injection. The outlets led to an open fluid collection reservoir, which was connected to a continuous pump and a pulsatile pump (SuperPump, ViVitro labs, Victoria, Canada). The most interesting finding from this study was the observed motion of the clinical catheter and its influence on the microsphere distribution. -
3D Modeling of Self-Expandable Valves for PPVI in Distinct RVOT Morphologies
This study assesses the Pulsta THV® valve’s in vitro hemodynamic performance across these RVOT morphologies using 3D-printed models. For this study, valves were tested using the ViVitro Pulse Duplicator System (ViVitro Labs Inc., Victoria, BC), a system designed to simulate physiological conditions as used in previous studies. Our experiments demonstrated that the larger valve size consistently had lower regurgitation rates across all cardiac outputs. -
Extracorporeal Membrane Oxygenation Cannulation Site Affects Coronary and Cerebral Perfusion When Combined With Intra-Aortic Balloon Pump
Use of the ViVitro Labs Super Pump to build a complex mock circulatory loop to study the effect of VA-ECMO/IABP combination on the with systemic, coronary, cerebral, and renal circulation. In this study the ViVitro Labs system is used to improve the outcome of clinical procedures. "We used the same silicone circuit as in our previous publication (model ref T-S-N-009+; Elastrat, Geneva, Switzerland). To prevent the formation of air bubbles when testing at a heart rate of 100 bpm, and to improve the quality of aortic flow measurements, a rigid plastic grid was placed in the compliance reservoir tank. We used a pulsatile pump (Superpump; ViVitro Labs, Inc., Victoria, BC, Canada) to simulate cardiac function at the circuit inlet. Positioning the pump in line with the aortic root was the configuration with the fewest disturbances flow and pressure measurements (Figure 1)" -
In Vitro Performance Assessment of a Bioprosthetic Individualized Aortic Valve Prosthesis for Infants and Toddlers
This study demonstrates how the ViVitro Labs Pulsatile flow pump was used to design a customized pulse duplicator system to assess the hydrodynamic performance of a pediatric “biological valve model (BVM)”. The flow loop integrates a unique system to simulate aortic annulus expansion. The performance of the patient-tailored valve was benchmarked against a commercially available pulmonary conduit along with an in-house built polyurethane valve. This research provides valuable insight on valve design potential improvements and demonstrates how ViVitro systems can play a critical role in valve performance assessment. -
Quantifying the effect of IMPEDE-FX packing rate and volume on pressure-normalized principal wall strain in an idealized 3D-printed aneurysm model
AAA sac management with persistent growth or endoleak in patient continue to be a challenge. This publication demonstrates the modularity of the ViVitro Labs Pulsatile Flow Pump in building advanced mock circulatory loops, and how the ViVitro Labs systems can be used to assess the impact of an embolization technique on the reduction of AAA sac volume and improve a procedure clinical outcome. "A Vivitro SuperPump (Victoria, BC, Canada) cardiac simulator was connected to both ends of a 30-gallon plastic basin using plastic tubing. The graft model construct was placed into the basin and securely attached proximally and distally to the plastic tubing with circumferential clamps. The basin was filled with water and gel beads for optimal acoustic conditions. Once the model was connected to the flow circuit, water was pumped through the system at 70 beats per minute with an average flow rate of 3.5 L/min." -
In Silico Trials of Prosthetic Valves Replicate Methodologies for Evaluating the Fatigue Life of Artificial Leaflets to Expand Beyond In Vitro Tests and Conventional Clinical Trials
This research the left ventricular chamber of a ViVitro Labs Pulse was customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. The ViVitro Labs Pulse chamber design and structure provides maximum modularity to create unique support without compromising system performance. "The TaurusOne was tested in vitro in a pulse duplicator system (ViVitro Labs Inc., Victoria, BC, Canada) (Figure 1b), operating at a rate of 70 beats per minute (bpm). The test chamber was filled with 37 °C distilled water to simulate the testing environment recommended by ISO 5840-3 [20]. A linear motor-driven plunger pump was used to precisely control the pressure values on both sides of the fluid according to the aortic valve pressure gradient curve of the clinical patient" -
Evaluation of a Semi-Automated Ultrasound Guidance System for Central Vascular Access
Here, we conduct independent evaluation testing of the Vu-Path™ Ultrasound Guidance system, or Vu-Path™. The device was evaluated using a custom, modular tissue-mimicking phantom that can easily be adjusted to multiple different vessel diameters. The phantom was connected to a flow loop with a pulsatile, heart-mimicking pump (ViVitro Labs, Victoria, BC, Canada) circulating water, and pressure was quantified by sensors connected to a patient monitor. Overall, the Vu-Path™ device performed well for this vascular access task across the standardized test pipeline we presented. -
An axis-specific mitral annuloplasty ring eliminates mitral regurgitation allowing mitral annular motion in an ovine model
This research demonstrates how the left ventricular chamber of a ViVitro Labs Pulse can be customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. "The ex vivo left heart simulator, which has been previously described17,18,19,20,21, features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) which generates physiologic hemodynamics in accordance with ISO 5840 in vitro cardiac valve testing standards using the pump controller and software (ViVitest Software, ViVitro Labs, Fig. 3d)." -
Wirelessly-powered, Electronics-free Ultrasonic Tags for Continuous Wearable Health Monitoring in Epidermal and Ocular Applications
Despite the rapid emergence of wearable ultrasound technologies in the research community, the common practice still requires wired connections to benchtop instruments. For the in vitro characterization of the heart rate and blood pressure monitoring US tag, a pulsatile pump (SuperPump, ViVitro Labs) with a silicone rubber vessel was used. Thanks to the advances in soft materials, fabrication techniques and sensing strategies, wearable medical devices are revolutionizing the healthcare system by enabling continuous and quantitative assessment of various biomarkers. -
Swirling Flow Quantification in Helical Stents Using Ultrasound Velocimetry
Helical stents have been developed to treat peripheral arterial disease (PAD) in the superficial femoral artery (SFA), with the premise that their particular geometry could promote swirling flow in the blood. The aim of this work is to provide evidence on the existence of this swirling flow by quantifying its signatures. The flow setup consisted of a programmable piston pump (Super Pump, Vivitro, Victoria, Canada), to create pulsating flow. The in vitro results show that skewedness is increased due to the helical geometry of the stents. -
The global effect of aortic coarctation on carotid and renal pulsatile hemodynamics
Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. To create a systolic contraction, the compliant LV sac is squeezed inside a fluid-filled plexiglass container using a programmable piston pump (ViVitro Labs Inc, SuperPump, AR SERIES). Our principal finding is that CoA increases cerebral blood flow and harmful pulsatile energy transmission to the brain. -
Novel heart valve leaflet designs with stiff polymeric materials and biomimetic kinematics
This study discussed novel flexible leaflet designs, focusing on polymeric materials with proven hemocompatibility, such as polyether ether ketone, of much higher stiffness than native tissue, aiming at optimal valve implants -
A Novel Echocardiographic Parameter to Confirm Low-Gradient Aortic Stenosis Severity
The purpose of this study was to evaluate the diagnostic and prognostic value of MG/EOA ratio. Contraction of the left ventricle is achieved by a piston pump (Vivitro Inc). MG/EOA ratio can be useful in low-flow, LG-AS to confirm AS severity and may complement DSE or aortic valve calcium scoring. -
Quantifying paravalvular leakage after transcatheter aortic valve replacement using particle image velocimetry
Given the prevalence and impact of Paravalvular Leakage, there is a critical need to study and mitigate this issue to improve patient outcomes. The experimental setup replicates the human left heart, featuring a Pulsatile Pump ViVitro, an em-tec flow meter, pressure taps, and a transparent acrylic test chamber housing a heart valve. The results of the experiments indicate that a wall jet forms during diastole, flowing back from the aortic side into the ventricular side. -
Development of an in vitro setup for flow studies in a stented carotid artery bifurcation
To investigate flow conditions in a double-layered carotid artery stent, a bench-top in vitro flow setup including a bifurcation phantom was designed and fabricated. For the introduction of pulsatile flow, a linear piston pump (Superpump AR, ViVitro Labs, Victoria, BC, Canada) and two compliances were added to the stationary circuit. We illustrated, with 3D printing and molding, how it is possible to transfer geometry from literature to a model and thereafter to a flexible phantom. -
Modified Clover Technique Using Automated Suture Placement and Securing Technology in a Passive Beating Heart Model
Clover repair offers a surgical solution that can be applied for the treatment of primary and secondary Tricuspid regurgitation (TR). Flow was provided by a pulsatile pump system (ViVitro Labs Inc., Victoria, BC, Canada), which was coupled to the right ventricle through a third connector. This new clover technique was demonstrated to successfully reduce TR in an ex vivo porcine heart model. -
Simulation of thoracic endovascular aortic repair in a perfused patient-specific model of type B aortic dissection
Complicated type B Aortic dissection is a severe aortic pathology that requires treatment through thoracic endovascular aortic repair (TEVAR). A realistic pulsatile flow through the aortic phantom is provided by a cardiac piston pump (Superpump, Vivitro Labs Inc., Victoria, Canada). The flexible aortic dissection phantom was successfully incorporated in the hemodynamic flow loop, a systolic pressure of 112 mmHg and physiological flow of 4.05 L per minute was reached. -
Validation of ultrasound velocimetry and computational fluid dynamics for flow assessment in femoral artery stenotic disease
To investigate the accuracy of high-framerate echo particle image velocimetry (ePIV) and computational fluid dynamics (CFD) for determining velocity vectors in femoral bifurcation models through comparison with optical particle image velocimetry (oPIV). A hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to enforce time-varying forward flow. The accuracy of blood flow assessment was investigated in models of the femoral bifurcation by clinically applicable ePIV measurements and CFD simulations. -
Ultrasound Particle Image Velocimetry to Investigate Potential Hemodynamic Causes of Limb Thrombosis After Endovascular Aneurysm Repair With the Anaconda Device
To identify potential hemodynamic predictors for limb thrombosis (LT) following endovascular aneurysm repair with the Anaconda endograft in a patient-specific phantom. A hydraulic piston-driven pump (SuperPump, ViVitro labs, Victoria) was used to set a suprarenal flow profile as inlet boundary condition. In conclusion, these in vitro data show that unfavorable hemodynamics are present in the limb that presented with LT, compared to the non-thrombosed side, with higher VC and longer RT. -
Framework Development for Patient-specific Compliant Aortic Dissection Phantom Model Fabrication
Type B aortic dissection is a life-threatening medical emergency that can result in rupture of the aorta. The aortic simulator is a hydraulic model that has physical and dynamical properties similar to the human circulatory system. This hydraulic model consists of a piston-in-cylinder pump (ViVitro Labs Inc.) that generates a physiologically accurate pulsatile flow (using a programmable waveform generator ViVigen) and a pump head, including a silicone ventricle membrane, mitral valve, and aortic valve. Results demonstrate that the deep-learning model can accurately capture the dissection geometry from patients’ medical images. -
Comparison of aortic valve repair techniques with single and double ring annuloplasties
For patients with isolated aortic regurgitation, a double sub- and supravalvular annuloplasty has been shown to reduce recurrent aortic regurgitation after aortic valve repair compared with a single subvalvular annuloplasty. The ventricular chamber was connected to an electromechanical piston pump system (Superpump AR series, ViVitro labs, Victoria, Canada). These two findings support the concept of a functional aortic annulus, where the two levels interact and affect the function and competence of the aortic valve. -
Biomechanical Engineering Analysis of an Acute Papillary Muscle Rupture Disease Model Using an Innovative 3D-Printed Left Heart Simulator
...The severity of acute papillary muscle (PM) rupture varies according to the extent and site of the rupture. However, the haemodynamic effects of different rupture variations are still poorly understood...A 3D printer (Carbon 3D, Redwood City, CA, USA) was used to prototype a modular left heart (left atrium and ventricle) and was mounted to a pulsatile linear piston pump (ViVitro Superpump; ViVitro Labs, Victoria, BC, Canada)... -
2D PIV experiments of oscillatory flow in a stenosis: A study into the physics of flow of cerebrospinal fluid
...the Vivitro pump, labeled F, (SuperPump, ViVitro labs,Victoria, Canada) was used to create the oscillatory waveform... -
Mitral chordae tendineae force profile characterization using a posterior ventricular anchoring neochordal repair model for mitral regurgitation in a three-dimensional-printed ex vivo left heart simulator
Posterior ventricular anchoring neochordal (PVAN) repair is a non-resectional technique for correcting mitral regurgitation (MR) due to posterior leaflet prolapse, utilizing a single suture anchored in the myocardium behind the leaflet... ...Porcine mitral valves were mounted in a 3-dimensional-printed heart simulator and chordal forces, haemodynamics and echocardiography were collected at baseline, after inducing MR by severing chordae, and after PVAN repair.... ...PVAN repair eliminates MR by positioning the posterior leaflet for coaptation, distributing forces throughout the valve.... -
In Vitro Pulsatile Performance Evaluation of the HeartMate PHP TM (Percutaneous Heart Pump)
The HeartMate PHP is a 13F catheter-based trans-aortic heart pump with a collapsible distal portion that expands to 24F to provide minimally invasive acute hemodynamic stabilization and left ventricular unloading in both prophylactic and emergent clinical settings... Objective: To evaluate the interaction of the HeartMate PHP with native cardiovascular system via in vitro pulsatile mock flow loop testing. A custom-built pulsatile heart simulator adapted from Vivitro Pulse Duplicator (Vivitro Labs Inc., Canada) was tuned to generate physiological flow pressure waveforms while mimicking the preload sensitivity of the native heart.