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Biomechanics and clinical outcomes of various conduit configurations in valve sparing aortic root replacementThe goal was to preserve the native aortic valve (AV) leaflets in patients with aortic root aneurysm with or without aortic regurgitation (AR). The ex vivo system consists of a linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) to generate a physiologic waveform in compliance with ISO 5840 standards. Similar to our previous ex vivo evaluation of the VSARR operation, we again confirmed that SG, compared with sinus containing graft, most closely recapitulated the native aortic root biomechanics.
Ultrafast Myocardial Principal Strain Ultrasound Elastography during Stress Tests: in vitro Validation and in vivo FeasibilityAssessment of myocardial contractility during a stress test is of high clinical value for the diagnosis and evaluation of cardiovascular diseases, especially coronary disease and heart failure. Both ends of this left-ventricular mimicking phantom (wall thickness of 15 mm) was then connected to polyvinyl chloride tubing by a pair of loosely attached steel clamps to a pulse duplicator (model #SD2001-1, ViVitro systems Inc., Victoria, BC, Canada). The complex, large, and rapid myocardial deformation during stress tests were also accurately imaged by the proposed strain estimator with close agreement with sonomicrometry.
A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosisAdvances in soft robotics have led to the development of high-fidelity simulators of pathophysiology for biomedical applications. An MCL was built using a pulsatile pump (SuperPump, ViVitro Labs), an anatomically accurate compliant silicone aortic vessel (E ≈ 1 MPa, United Biologics) connected to two adjustable compliance chambers (that is, ventricular, systemic), and a resistive valve. The models leverage haemodynamic mimicry and may facilitate the development of patient-specific applications. The models could also facilitate the clinical translation of treatments; in particular, a cohort of AS patients could be recapitulated in an in vivo porcine model, and new treatments could be evaluated preclinically.
Development of a Modular Tissue Phantom for Evaluating Vascular Access DevicesCentral vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics available in these resource-limited scenarios, but they must be properly designed. Unfortunately, currently available tissue phantoms are inadequate for this use, resulting in delayed product development. ...A SuperPump (ViVitro Labs, Victoria, BC, Canada) was used for generating pulsatile, cardiac mimicking arterial flow within the flow loop test platform (Figure 1D)... ...In conclusion, the tissue phantom model presented addresses a current testing gap for developing central vascular access medical devices. Troubleshooting is essential and having to rely on live, or even ex vivo, animal testing for evaluating a medical device with physiological mimicking fluid flow or pressure levels will slow device development...
Feasibility and Technical Aspects of Proximal Nellix-in-Nellix Extension for Late Caudal Endograft MigrationPurpose: To describe the feasibility and technical aspects of a proximal Nellix-in-Nellix extension to treat caudal stent-graft migration after endovascular aneurysm sealing (EVAS) in the in vitro and in vivo settings. ... Silicone anatomical models were used in conjunction with a pulsatile flow pump (SuperPump; Vivitro Labs Inc, Victoria, British Columbia, Canada). The system was tuned to a pressure of ~120/80 mm Hg, with 4.5- to 5-L/min flow at a rate of 70 beats/min. ...