Canary in the cardiac-valve coal mine: Flow velocity and inferred shear during prosthetic valve closure –predictors of blood damage and clotting

A derived laboratory metric for valve closing flow velocity offers a way to rank valve models for potential blood damage. These results provide new insight and a mechanistic explanation for prior clinical observations where aortic and mitral valve replacements differ in thrombogenic potential and anticoagulation requirement. The study suggests a path forward to design and evaluate novel mechanical valve models for future development. ...In 2009, work transitioned into a separate independent research and development enterprise, ViVitro Laboratories Inc. (VLI) also based in Victoria, BC, Canada... ...This work exposes the central relationship between thrombogenicity and predicted high velocity flows and shear forces at valve closure. As practical application of our findings, specific valve geometric features were identified that led to prototype designs with potential for further development...

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