Impact of Bioprosthetic Valve Leaflet Stiffness and Anisotropy on TAVR Stent Fatigue Life

Towards developing a simulation methodology for the design of next-generation Transcatheter Aortic Valve Replacement (TAVR) devices, this numerical study investigates the impact of bioprosthetic valve stiffness and anisotropic behaviour on the fatigue of the nitinol stent frame during a single cardiac cycle. The simulation results were compared to in vitro testing of the device in a ViVitro pulse duplicator. The leaflet anisotropy can have a significant impact on how well the valve closes during the diastole phase, as well as whether the stent frame is symmetrically loaded, which may impact the overall fatigue life of the nitinol stent.

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