A Tri-Leaflet Nitinol Mesh Scaffold for Engineering Heart Valves

...The main problem with the tissue engineered heart valves is their progressive deterioration that leads to regurgitation and/or leaflet thickening a few months after implantation... ...The current work aims to study the effects of the design features on mechanical characteristics of this valve scaffold to attain proper function prior to in vivo implantation. ... The heart flow simulator system was adjusted for left ventricular pressure waveform with diastolic/systolic pressures of 80/120 mmHg produced by a hydraulic pump system (Superpump system, VSI, SPS3891, Vivitro systems Inc., Victoria, BC, Canada).10 The scaffolds were ...