Using a Mock Circulatory Loop as a Regulatory Science Tool to Simulate Different Heart Failure Conditions

Mechanical circulatory support (MCS) device therapy is one of the primary treatment options for end-stage heart failure (HF), whereby a mechanical pump is integrated with the failing heart to maintain adequate tissue perfusion. In this study, the BAF solution is circulated through the MCL using a piston pump (SuperPump (AR Series), ViVitro Labs, Inc., Victoria, BC, Canada), which is fluid-coupled to a suspended silicone mock LV sac. An MCL can be an effective regulatory tool for simulating different patient disease states and evaluating the flow performance of MCS devices over their entire operating ranges in a well-controlled environment.

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