Computational Modeling in TAVR Webinar – Free Recording

August 12th, 2024

View the 9.2/10 rated free recording of Computational Modeling in TAVR webinar on YouTube (https://youtu.be/Qy6QH7GPFKA) and CCI–CIC (https://cci-cic.org/computational-modeling-in-tavr/ )

The free recording of Computational Modeling in TAVR September 18 webinar is now available. Karim Mouneimne, President – ViVitro Labs, highlights his key takeaways from a non-clinician perspective below:

“ViVitro Labs is proud to support research at The Translational Lab at St Paul in Vancouver and contribute to the advancement of in-vitro testing in the cardiovascular space and heart valve therapy. Here are the highlights from a non expert (me) and some take home messages from this second webinar edition on computational modeling in the heart valve space:

Dr. Hatoum highlighted the need for having robust surgical planning tools to mitigate the risk of leaflet thrombosis after aortic valve replacement. A proposed phone app was developed to calculate the risk of leaflet thrombosis for various valve types integrating patient baseline characteristics, anatomical characteristics and hemodynamic factors obtained from routine echocardiography. A logistics regression based on 99 patients was used to return the probability of a valve fitting a patient and eliminate non contributing factors. The annulus to left coronary artery height and the annulus to right coronary height were the most significant factors. Dr. Hatoum proposes to pursue this research by expanding the database to include more patient data from more centers and different patient profiles.

Dr Ihdayhid presented a clinical perspective on how CAD are critical when choosing heart valve prosthesis and the importance of integrating computational models in during surgical planning. Even though data from trials on revascularization in TAVR patient is not clear, the ability to treat patients in the long term by understanding CAD in younger patients may have a significant impact on TAVR success rate.

Understanding the underlying coronary anatomy and patient’s physiology may have implications on the valve type and the lifetime risk that the patient may have in the future. Dr Ihdayhid supported his perspective with a preview of the results from an international multicentric registry of 327 patients, where patients undergoing routine pretest TAVR CT, were given nitrates and plus/minus beta blockers. Data from the 18-segment read on coronary arteries and the FFR CT to better risk stratify were integrated in the heart team discussion to help decide whether or not to defer invasive angiography.

In the clinical case presented, the physicians were able to skip the invasive coronary angiogram and go straight to TAVI. Dr Ihdayhid believes in the need to develop more efficient ways to manage patients from diagnosis to treatment. Removing the invasive angiogram for most patients could create an opportunity to streamlining the process, reduce cost and complications as well as reduce door to valve time. Some of those results will be presented at TCT in Washington DC in October.

Dr. Motamed presented a more global computational modeling perspective which integrates an upstream and downstream approach that quantifies the interactive coupling of native aortic and mitral valves, but also ventricles and transcatheter heart valves.

Dr Motamed presented several predictive computational models serving different purposes:

1) A doppler based predictive model to quantify the impact of THV on cardiac function and hemodynamics and left ventricular remodeling pre and post TAVI. In this model, reduction of LV workload after TAVR could be as important as reducing pressure gradient.

2) A doppler based Finite Element model was developed to quantify valve stress and strain distribution as it relates to predicting the evolution of calcification and durability. In the data set presented on 12 patients the model showed that the valve dynamics in some cases was degraded after TAVR even though the leaflets opened and closed properly. Dr Motamed highlighted the importance of quantifying the impact of TAVR on mitral valve function and inversely. Data from 30 patients shows that the doppler based model provided the ability to calculate the stress and strain on mitral valves after TAVR.

3) A CT scan calcification scoring model to show the impact of mechanical stress and strain on the progression of calcification pre intervention and post intervention.

Through this webinar series, ViVitro Labs is proud to promote scientific learning in the medical device industry. ViVitro Labs reliable test systems and validated test methods used for medical device performance evaluation during simulated use improve patient safety at the pre-clinical stage.”

Sincerely,

Karim Mouneimne
President – ViVitro Labs Inc
General Manager – Vivitro Labs SASU

Computational Modeling in TAVR Fall Webinar

ViVitro Labs and The Cardiovascular Translational Lab at St. Paul’s bring the latest in translational cardiovascular research in a free, quarterly interactive webinar format. On September 18, 2024, Abdul Ihdayhid, Hoda Hatoum, and Zahra Motamed discuss computational modeling and many of the emerging technologies and approaches to guiding personalized care.

Hoda Hatoum: “Predicting Leaflet Thrombosis”
Abdul Ihdayhid: “FFRct and TAVR”.
Zahra Motamed: “Insights to Ventricular Function in TAVR”

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The webinar and audience Q&A will be moderated by Dr. Stephanie Sellers, University of British Columbia and Dr. David Meier, CHUV Lausanne, Vaud, Switzerland. A recording of presentations will be available shortly after the webinar, but audience discussion sessions will not be recorded and will only be available to those viewing live.

Attendees rated this webinar “9.2/10” in an exit survey. View the recording here.

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Presenter Bios:

Dr. Hoda Hatoum
Assistant Professor, Biomedical Engineering | Affiliated Assistant Professor, Mechanical and Aerospace Engineering
Michigan Technological University

Dr. Hoda Hatoum obtained her BS degree in mechanical engineering from the American University of Beirut and her PhD degree from the Ohio State University (OSU). She was awarded the American Heart Association postdoctoral fellowship and right after graduation, she completed her postdoctoral training at the Ohio State University and at Georgia Institute of Technology.

Her research focuses on tackling the complexity of: (a) structural heart biomechanics (adult and congenital); (b) patient-specific cardiovascular model development and in-vitro testing; (c) prosthetic heart valve engineering (surgical and transcatheter); (d) structure-function relationships of the heart in health and disease at the pediatric and adult stages; and (e) turbulence in blood flow in relation to blood damage; and (f) impact of arrhythmias and treatment approaches on cardiovascular flows. Dr. Hatoum has published in multiple journals spanning both clinical and bioengineering sides and given oral and poster presentations at national and international conferences.

Dr Abdul Ihdayhid is an interventional and structural cardiologist at Fiona Stanley Hospital and specialist in cardiac CT. He is the Director of Cardiology Research and has an academic appointment at Curtin University.

In 2023 Dr. Ihdayhid co-founded and became the Director of Interventional & Structural Cardiologist of CORAMETIX, a startup company developing a next-generation heart valve using specialised biopolymers manufactured using advanced 3D printing.

Dr Ihdayhid completed fellowship training in interventional cardiology at MonashHeart, Melbourne and a PhD in intracoronary physiology and cardiac CT at Monash University. This was followed by a clinical fellowship at the University of British Columbia, St Paul’s Hospital, Canada in structural heart intervention and advanced cardiac imaging.

Dr. Zahra Motamed Ph.D., P.Eng.
Associate Professor | Joseph Ip Distinguished Engineering Fellow | Director of Cardiovascular Research Group
McMaster University

Dr. Motamed directs Cardiovascular Research Group and is an Associate Professor in the Department of Mechanical Engineering at McMaster University. She holds associate faculty memberships in the Department of Computing and Software, in the School of Biomedical Engineering, and in the School of Computational Science and Engineering. She is a member of the Thrombosis u0026 Atherosclerosis Research Institute (TaARI) and McMaster Institute for Research on Aging (MIRA). Moreover, Dr. Motamed is a research affiliate faculty member at the Institute for Medical Engineering u0026 Science and Harvard-MIT Biomedical Engineering Center at MIT (Cambridge, USA).

Before joining McMaster, she was a postdoctoral fellow in the Institute for Medical Engineering u0026 Science and Harvard-MIT Biomedical Engineering Center at MIT. She received her Ph.D. degree in mechanical engineering from Concordia University (Montreal, Canada) in 2012 where she was a part-time/adjunct faculty member from 2013 to 2014. She was a postdoctoral fellow at the University of Montreal/Laval University (2013–2014).

Session Moderator Bios

Stephanie L Sellers MSc PhD
Assistant Professor | Director, Fundamental Research Cardiovascular Imaging, Radiology
UBC Division of Cardiology | Providence Health Care

Stephanie Sellers is Director, Fundamental Research Cardiovascular Imaging, Radiology at Providence Health Care and Assistant Professor, UBC Division of Cardiology. Her focus is to integrate clinical and basic science research in cardiovascular imaging as it relates to structural heart disease.

Dr. David Meier
Interventional cardiologist
Lausanne University Hospital

Dr. David Meier is an interventional cardiologist at Lausanne University Hospital in Switzerland. He earned his medical degree from the University of Lausanne, followed by specialized training in internal medicine and cardiology. He then completed a fellowship in interventional cardiology in Vancouver, Canada. Alongside his clinical duties, Dr. Meier maintains an active research collaboration with the cardiovascular translational lab in Vancouver.