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Flow Visualization

The most advanced flow diagnostics capability: a high-speed Particle Image Velocimetry (PIV) system.  PIV is a non-invasive velocimetry technique that delivers high spatial and temporal resolution of the flow field.  In PIV, neutrally buoyant tracer particles are introduced into the flow, which are imaged using a high speed camera. These images are cross-correlated in order to obtain velocity fields.

Flow Visualization AnimationParticle Streak Animation

ViVitro Labs offers PIV flow visualization studies in accordance with ISO 5840 requirements.

Using PIV, ViVitro’s laboratory testing services can diagnose pulsatile flow and determine the viability of cardiovascular devices meeting regulatory standards. Triggers for disease (such as shear stresses and regions of stagnation) can be quantified with a high degree of accuracy. Advanced methods, including proper orthogonal decomposition, also capture the implicit fluid mechanical phenomenon of interest.

ViVitro Labs testing provides 2D high-speed information regarding the Quantitative and Qualitative nature of the flow surrounding a device. Qualitative outputs include flow assessment based on particle streaks with assessment and description of any occurrences of flow separation, flow stasis, vortex formation, jet nature, regurgitant and other fluid mechanical phenomenon. Quantitative outputs include velocity, shear stresses, and particle residence times during various phases of the cardiac cycle. Stagnant flow may induce potential blood clot formation during heart valve operation.

High flow velocities in the vicinity of the valve may induce potential haemolysis and platelet activation.


Valves (Transcatheter, Biological, Mechanical, Venous, Conduits)


Flow Visualization AnimationVector field and shear stress animation

ISO 5840-3:2013 N.4.3.5 and N.4.3.6 requires that flow fields in the immediate vicinity of the valve be assessed qualitatively for flow regime identification and quantitatively for haemolytic and thrombogenic potential. CFD is a popular choice for designers, but ISO 5840 requires CFD results to be validated by comparison with experimental results. ViVitro has helped numerous clients achieve this validation.



Cardiovascular Devices

Most steady or pulsatile flow applications can be visualized using the ViVitro Labs PIV system. Although new device classes like repair devices do not have accepted guidance documents and standards for testing as more established technologies, all approval bodies are interested in regions of stagnation, high shear and turbulent flow regions.

Contact us today to discuss your cardiovascular testing requirements including:

  • Ventricular Assist devices (VAD, LVAD, RVAD) (ISO 14708-5:2010 Annex DD)
  • Total artificial hearts (TAH) (ISO 14708-5:2010 Annex DD)
  • Occluders or Closure Devices (ASD – Atrial Septal Defect, PFO – Patent Foramen Ovale, ASO – Atrial Septal Occluder, VSD- Ventricular Septal Defect, PDA Patent Ductus Arteriosus, PLD- Paravalvular Leakage Device)
  • Valvular repair or reconstruction devices
  • Shunts
  • Stents
  • Delivery systems
  • Intra-aortic balloon pumps
  • Venous Filters
  • Left atrial appendage (LAA) devices




PIV Website Concept


ViVitro Labs Advantages

Many companies look to academia to handle their flow visualization experiments due to their low cost.  With ViVitro Laboratory Services you gain the following advantages:

Time to Market
We  understand how critical your timelines are. We work to your schedule and deliver to our commitments.

Free Set-Up Consultations
All of our pulsatile studies are developed via no-cost, no obligation, collaborative consultation.  We design unique tests to meet specific developmental or regulatory needs.

Guaranteed Confidentiality
We happily provide Non-Disclosure Agreements for all services, including initial consultation.

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