How to adjust systolic and diastolic (max and min) pressures in Pulse Duplicator system?
The peripheral resistance is used to set the mean pressure in the system. The compliance is used to adjust the systolic and diastolic (max/min). The more compliance in the system, the closer the min/max pressure will be to the mean value. The less compliance, the further the min/max will be from the mean.
ViVitro Pulse Duplicator compliance has been set to 70 BPM, CO =5LPM, Systolic duration of 35%, and Mean pressure of 100 mmHg. The systolic and diastolic pressure should be close to 120/80. For example, adding more compliance could change systolic and diastolic pressure to be closer to 105/95.
ViVitro offers a range of different compliance tanks which can be connected in parallel to obtain different compliance volumes. For example, removing compliance (by flooding a chamber with water or clamping one off) will give pressures around (150/50).
Please refer to the Pulse duplicator manual 17463 for more information. Reduction of the Compliance Chamber pressure will increase the ratio of maximum to minimum Aortic Pressure. As with the left heart, for some conditions it may be necessary to adjust compliance volumes to reach the desired pressure waveforms. This can be archived by using bigger tanks, or filling the tanks with water.