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Joseph Calderan, Wenbin Mao, Eric Sirois and Wei Sun-- Artificial Organs article first published online: 29 OCT 2015 DOI: 10.1111/aor.12589
Impairment of coronary artery flow, in either acute or chronic conditions, is a severe complication of transcatheter aortic valve (TAV) implantation, which can arise due to improper TAV positioning. ... LHS. An LHS was designed with the intention of providing physiological flow and pressure waveforms in the left atrium, left ventricle (LV), and ascending aorta, similar to commercially available devices such as the ViVitro LHS (ViVitro Labs, Victoria, Canada) but with additional ...
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceIkechukwu Okafor, Arvind Santhanakrishnan, Vrishank Raghav, Ajit Yoganathan- Journal of Biomechanical Engineering 10/2015;
...The results support the hypothesis that a D-shaped mitral annulus reduces dissipative energy losses in ventricular filling during diastole, and in turn suggests that a symmetric stent design does not provide lower filling efficiency than an equivalent asymmetric design. ...fluctuations were imposed in a fluid-filled chamber housing the LV physical model using a programmable piston pump (Superpump, Vivitro Systems; British Columbia, Canada). The pressure fluctuations resulted in the deformation of the LV model, driving flow through ...
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Visit SourceZeeshan Syedaina, Jay Reimera, Jillian Schmidta, Matthew Lahtic, James Berryc, Richard Biancoc, Robert T. Tranquillo - doi:10.1016/j.biomaterials.2015.09.016
Diseased aortic valves often require replacement, with over 30% of the current aortic valve surgeries performed in patients who will outlive a bioprosthetic valve. While many promising tissue-engineered valves have been created in the lab using the cell-seeded polymeric scaffold paradigm, none have been successfully tested long-term in the aortic position of pre-clinical model. ... A customized pulse duplicator system was designed based on a commercial wave generator and pump (ViVitro Systems). ...
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Visit SourceAndrea Salicaa, Giuseppe Pisanib, Umberto Morbiduccib, Raffaele Scaffaa, Diana Massaib, Alberto Audeninob, Luca Welterta, Lorenzo Guerrieri Wolfa and Ruggero De Paulisa - - European Journal of Cardio- Thoracic Surgery (2015), First published online: September 10, 2015
Normal aortic valve opening and closing movement is a complex mechanism mainly regulated by the blood flow characteristics and the cyclic modifications of the aortic root. Our previous in vitro observations demonstrated that the presence of the Valsalva sinuses, independently from root compliance, is important in reducing systolic pressure drop across the aortic valve. ... The hydrodynamic performances under pulsatile flow regimen were investigated, using a Vivitro System, Inc. ... Direct visualization of valve operating condition was performed, using an ultrafast speed camera (Casio Exlim Ex F1), mounted on top of the Vivitro system [19, 20]. ...
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Visit SourceFilippo Piatti, Francesco Sturla, Gil Marom, Jawaad Sheriff, Thomas E. Claiborne, Marvin J. Slepian, Alberto Redaelli, Danny Bluestein - Journal of Biomechanics, 2015 Published Online: August 21, 2015
... The aim of this study was to characterize the hemodynamics and thrombogenic potential of the Polynova polymeric trileaflet valve prototype using a fluid-structure interaction (FSI) approach. The FSI model replicated experimental conditions of the valve as tested in a ViVitro Left Heart Simulator (ViVitro Labs Inc., Victoria, BC, Canada). ... FSI data, ViVitro data. Cardiac output (L/min), 5.62, 5.50. ...
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Visit SourceJahren, Silje Ekroll; Heinisch, Paul Philipp; Wirz, Jessica; Winkler, Bernhard; Carrel, Thierry; Obrist, Dominik (31 March 2015). Hemodynamic Performance of Edwards Intuity Valve in a Compliant Aortic Root Model (In Press). In: IEEE EMBC 2015. Milano. 25.08.-29.08.2015.
...It was the aim of this study to perform hemodynamic and kinematic measurements for this type of valves to serve as a baseline for following studies which investigate the effect of the aortic root on the valve performance. To this end, the Edwards Intuity aortic valve was investigated in a new in vitro flow loop mimicking the left heart...
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Visit SourceBernhard Vennemann, David Hasler, Silje E. Jahren, Thomas Rösgen, Thierry P. Carrel, Dominik Obrist - Heart Valve Society 1st Annual Meeting MAY 6-9, MONTE CARLO, MONACO, GRIMALDI FORUM
...so called hot spots, where activated platelets might aggregate and form a thrombus that can ultimately lead to leaflet blockage. It is the aim of this study to assess the hemodynamics in the pivoting area of the Triflo valve.
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Visit SourceJohn C. Westerdale, Ronald Adrian, Kyle Squires, Hari Chaliki and Marek Belohlavek --The Open Cardiovascular Medicine Journal, 2015, 9, 62-68
We studied left ventricular flow patterns for a range of rotational orientations of a bileaflet mechanical heart valve (MHV) implanted in the mitral position of an elastic model of a beating left ventricle (LV). The valve was rotated through 3 angular positions (0, 45, and 90 degrees) about the LV long axis. ... MHV angular positions. Heart rate and stroke volume were kept constant. MATERIALS AND METHODOLOGY We utilized a mechanical left heart model (ViVitro Labs, Inc., Victoria, Canada) (Fig. 1A). The model was comprised ...
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Visit SourceF Shu, S Vandenberghe, J Brackett, JF Antaki - Cardiovascular Engineering and Technology July 2015
Rotodynamic blood pumps (also known as rotary or continuous flow blood pumps) are commonly evaluated in vitro under steady flow conditions. However, when these devices are used clinically as ventricular assist devices (VADs), the flow is pulsatile due to the contribution of the native heart. ... Flow Loop The pump prototype was dynamically tested using a cardiovascular simulator circuit (modified from Vivitro Systems Inc., Victoria, British Columbia) built around a silicone mock left ventricle (LV) encased in a rigid acrylic chamber ...
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Visit SourceIkechukwu U. Okafor, Arvind Santhanakrishnan, Brandon D. Chaffins, Lucia Mirabella, John N. Oshinski and Ajit P. Yoganathan - Journal of Cardiovascular Magnetic Resonance 2015, 17:51 doi:10.1186/s12968-015-0154-9
... A programmable piston pump (PPP; Vivitro Systems Inc., Victoria, Canada) was used to induce the LV wall motion by altering the pressure of the fluid in the space between the interior of acrylic chamber housing the LV model and the exterior of the LV model. ...
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Visit SourceGC D'Antonio, BV Weidner, S Rowe, O Pierrakos - Systems and Information Engineering Design Symposium (SIEDS), 2015
A prominent performance metric used by the FDA to evaluate prosthetic heart valves is transvalvular pressure drop. ... METHODS To investigate vortex ring formation as a function of time relative to changing operating conditions, a piston driven heart simulator (Vivitro Heart system SD2001-1) was used. ... (3) The data collected from the Vivitro Heart system was used to find . ...
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Visit SourceClara Seaman, Andrew McNally, Stephen Biddle, Lauren Jankowski, Philippe Sucosky Presented in part at the 2013 Biomedical Engineering Society Conference, September 2013, Seattle, WA, and at the 2013 ASME Summer Bioengineering Conference, June 2013, Sunriver, OR, USA
The study aim was to develop a laboratory protocol for the fabrication of tissue valve models mimicking mild and moderate calcific stenosis, for future use in flow studies. ... near-physiologic hemodynamics. The flow loop was driven by a programmable piston pump (Vivitro), and included resistance and compliance units to mimic the characteristics of the systemic vascular tree (Fig. 3A). The system ...
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Visit SourceM Ismail, F Kabinejadian, YN Nguyen, E Tay, S Kim… - Artificial Organs, 2015 Article first published online: 29 APR 2015 DOI: 10.1111/aor.12457
Severe tricuspid regurgitation (TR) is life-threatening but is often undertreated. Many patients with severe TR are denied heart valve replacement surgery because their old age or comorbidities predispose them to a higher risk of surgical complications associated with open-heart surgery. ... by 19% as an initial study. The silicone atrium was incorporated into a pulsatile flow loop that was driven by a wave-generating piston pump (SuperPump AR series, ViVitro Labs Inc., Victoria, BC, Canada). The flow rate in the ...
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Visit SourceZbigniew Trawińskia, Janusz Wójcika, Andrzej Nowickia, Robert Olszewskib, Andrzej Balcerzaka, Emilia Frankowskac, Arkadiusz Zegadłoc, Paweł Rydzyńskic -Biocybernetics and Biomedical Engineering 27 March 2015
The main aim of this study was to verify the suitability of the hydrogel sonographic model of the left ventricle (LV) in the computed tomography (CT) environment and echocardiography and compare the radial strain calculations obtained by two different techniques: the speckle tracking ultrasonography and the multislices computed tomography (MSCT). ... equal to 0.28 dB/cm (at 2.95 MHz). Our model of the LV was driven by a computer-controlled hydraulic piston Super-Pump (Vivitro Inc., Canada) with adjustable fluid volumes and various loads. During a cycle of the pump, the ...
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Visit SourceHoda Maleki, MASc, Shahrokh Shahriari, PhD, Michel Labrosse, PhD, Josep Rodés-Cabau, MD, Philippe Pibarot, PhD, FACC, FAHA, FESC, Lyes Kadem, PhD, Eng. -Canadian Journal of Cardiology 28 March 2015
There is few data about the patient- and prosthesis- related factors influencing the hemodynamics of transcatheter heart valves (THVs). The objective of this in vitro study was to assess the effect of aortic annulus size and prosthesis oversizing on the valve hemodynamics and estimated leaflet bending stress of the SAPIEN balloon-expandable THV. ... THV). Methods. In Vitro Model. For the purpose of this study, a left heart duplicator system was used (ViVitro Labs. Inc, BC, Canada). This simulator is capable of reproducing physiological pressure and flow waveforms. Briefly ...
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Visit SourceBarannyk O, Oshkai P. - J Biomech Eng. 2015 May; Epub 2015 Mar 5.
...he objective of this investigation is to establish a set of parameters, which are associated with abnormal flow patterns due to the flow through a prosthetic heart valve implanted in the patients that had certain types of valve diseases prior to the valve replacement.... ...By varying the aortic root geometry, while keeping the diameter of the orifice constant, it was possible to investigate corresponding changes in the levels of Reynolds shear stress and establish the possibility of platelet activation and, as a result of that, the formation of blood clots....
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Visit SourceKonduri S, Xing Y, Warnock JN, He Z, Yoganathan AP. - Ann Biomed Eng. 2005 Sep;33(9):1158-66.
The aortic valve functions in a complex mechanical environment which leads to force-dependent cellular and tissue responses. Characterization of these responses provides a fundamental understanding of valve pathogenesis. The aim of this work was to study the biological characteristics of native porcine aortic valves cultured in an ex vivo pulsatile organ culture system capable of maintaining physiological pressures (120/80 mmHg) and cardiac output (4.2 l/min).
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Visit SourceBurriesci G, Marincola FC, Zervides C. J Med Eng Technol. 2010 Jan;34(1):7-22. doi: 10.3109/03091900903261241
Polymeric heart valves could offer an optimum alternative to current prostheses, by joining the advantages of mechanical and bioprosthetic valves. Though a number of materials suitable for this application have recently become available, significant improvements in the valve design are still needed. In this paper, a novel polymeric heart valve design is proposed and its optimization procedure, based on the use of finite elements, is described...
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Visit SourceNicolas Brugger, MD, , Kerstin Wustmann, MD, Michael Hürzeler, BS, Andreas Wahl, MD, Stefano F. de Marchi, MD, Hélène Steck, RN, Fabian Zürcher, MD, Christian Seiler, MD, The American Journal of Cardiology Available online 3 February 2015
The aim of our study was, to evaluate 3-D color Doppler proximal isovelocity surface area (PISA) as a tool for quantitative assessment of mitral regurgitation (MR) against in vitro and in vivo reference methods. A customized 3-D PISA software was validated in vitro against a flowmeter MR phantom. Sixty consecutive patients, with ≥mild MR of any etiology, were recruited and the regurgitant volume (RVol) was measured by 2-D PISA, 3-D peak PISA, 3-D integrated PISA, using transthoracic (TTE) and transesophageal echocardiography (TEE).
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Visit SourceFilippo Piatti1 , Francesco Sturla 1,2 , Thomas E. Claiborne3 , Danny Bluestein3 , Alberto Redaelli 1
Experimental procedures are commonly used to obtain an overall quantification of the fluid dynamic and thrombogenic performances of cardiovascular devices [1]... (B) ViVitro gold standard testing benchmark (ViVitro Labs, BC, Canada) Boundary conditions ... obtaining comparable working conditions between the computational model and the ViVitro benchmark. Figure 2 – Schematic visualization of the ideal ...
Other Products Cited: Heart Valve Testing Pulse Duplicator
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