Articles Related to Applications

Lawrence N. Scotten, Rolland Siegel, David J. Blundon, Marcus-André Deutsch, Terence R. P. Martin, James W. Dutton, Ebrahim M. Kolahdouz, Boyce E. Griffith

To demonstrate a clear link between predicted blood shear forces during valve closure and thrombogenicity that explains the thrombogenic difference between tissue and mechanical valves and provides a practical metric to develop and refine prosthetic valve designs for reduced thrombogenicity. Incorporated as Vivitro Systems Inc (VSI), our primary focus was research, design and development of cardiac valve implant devices and on the laboratory test systems required. In 2009, work transitioned into a separate independent research and development enterprise, ViVitro Laboratories Inc. (VLI). The application of unique technology, rapid prototyping and ranking of flow velocity patterns near valve closure optimized experimental valve geometry for reduced thrombus potential compared with control valves.

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David Meier, MD; Geoffrey W. Payne, MSc, PhD; Leila B. Mostaço-Guidolin, PhD; Rihab Bouchareb, MSc, PhD; Courtney Rich, BASc; Althea Lai, BSc; Andrew G. Chatfield, MB ChB; Mariama Akodad; Hannah Salcudean, MSc; Georg Lutter, MD; Thomas Puehler, MD; Philippe Pibarot, DVM, PhD; Keith B. Allen, MD; Adnan K. Chhatriwalla, MD; Lars Sondergaard, MD; David A. Wood, MD; John G. Webb, MD; Jonathon A. Leipsic, MD; Janarthanan Sathananthan, MPH, MBChB; Stephanie L. Sellers, MSc, PhD, EuroIntervention 2022;17:1-1

To assess the impact of bioprosthetic valve fracture (BVF) timing on long-term transcatheter heart valve (THV) durability. Valve testing was performed in the ViVitro Labs testing facilities (ViVitro Labs Inc, Victoria, Canada). Hydrodynamic testing was performed using a commercially available pulse duplicator (ViVitro Labs Inc, Victoria, Canada), meeting the equipment requirements defined in ISO 5840-3 for pulsatile flow testing (16) (Figure 1A). In this bench study, the ACn and the S3 showed acceptable hydrodynamic performances after AWT to 200M cycles, equivalent to 5 years, irrespective of BVF timing compared to no fracture.

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Lisa Carlson Hanse, Marcell J Tjørnild, Simon G Sørensen, Peter Johansen, Ignacio Lugones, Vibeke E Hjortdal, Interactive CardioVascular and Thoracic Surgery, Volume 35, Issue 4, October 2022, ivac227

We investigated a new surgical technique of trileaflet semilunar valve reconstruction possessing the potential of remaining sufficient and allowing for some growth with the child. Pulsatile flow was produced by a Series piston pump (SuperPump AR; ViVitro Labs, Victoria, Canada), connected to the ventricular chamber. TSVR was achievable in vitro. Hydrodynamic pressure and echocardiographic evaluations demonstrated a sufficient and non-stenotic neo-valve.

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David Meier, Mariama Akodad, Andrew G. Chatfield, Georg Lutter, Thomas Puehler, Lars Søndergaard, David A. Wood, John G. Webb, Stephanie L. Sellers, and Janarthanan Sathananthan, J Am Coll Cardiol Intv. 2022 Aug, 15 (15) 1532–1539

The aim of this study was to assess the impact of commissural misalignment (CMA) on hydrodynamic function following VIV intervention with the ACURATE neo THV using a bench model. In VIV using the ACURATE neo THV at deep implantation, increasing degree of CMA was associated with THV leaflet interaction with those of the surgical valve and worsening regurgitant fraction. THV leaflet interaction was prevented when there was CA.

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K.Yu. Klyshnikov, E.A. Ovcharenko, Yu.A. Kudryavtseva, L.S. Barbarash, RUSSIAN JOURNAL OF TRANSPLANTOLOGY AND ARTIFICIAL ORGANS, Vol. XXII, No 2–2020

The aim of the study was an in vitro hydrodynamic study of the developed prosthetic heart valve of the second generation, designed to carry out an implantation using “valve-in-valve” method. ...Prototypes of the developed prosthesis were studied under simulated physiological conditions of the heart using a Vivitro Labs pulse duplicator (Canada) in a comparative aspect with “UniLine” clinical commercial aortic valve bioprosthesis (Russia)... ...The design of the prosthesis under development has shown its consistency in terms of functional characteristics, both in comparison with the original UniLine prosthesis and with literature data....

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Lawrence N. Scotten, Rolland Siegel, David J. Blundon, Marcus-André Deutsch, Terence R. P. Martin, James W. Dutton, Ebrahim M. Kolahdouz, Boyce E. Griffith, bioRxiv submission manuscript, TIFF, 23 June 2022

A derived laboratory metric for valve closing flow velocity offers a way to rank valve models for potential blood damage. These results provide new insight and a mechanistic explanation for prior clinical observations where aortic and mitral valve replacements differ in thrombogenic potential and anticoagulation requirement. The study suggests a path forward to design and evaluate novel mechanical valve models for future development. ...In 2009, work transitioned into a separate independent research and development enterprise, ViVitro Laboratories Inc. (VLI) also based in Victoria, BC, Canada... ...This work exposes the central relationship between thrombogenicity and predicted high velocity flows and shear forces at valve closure. As practical application of our findings, specific valve geometric features were identified that led to prototype designs with potential for further development...

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Emily N. Boice, David Berard, Jose M. Gonzalez, Sofia I. Hernandez Torres, Zechariah J. Knowlton, Guy Avital, Eric J. Snider, Bioengineering 2022, 9(7), 319

Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics available in these resource-limited scenarios, but they must be properly designed. Unfortunately, currently available tissue phantoms are inadequate for this use, resulting in delayed product development. ...A SuperPump (ViVitro Labs, Victoria, BC, Canada) was used for generating pulsatile, cardiac mimicking arterial flow within the flow loop test platform (Figure 1D)... ...In conclusion, the tissue phantom model presented addresses a current testing gap for developing central vascular access medical devices. Troubleshooting is essential and having to rely on live, or even ex vivo, animal testing for evaluating a medical device with physiological mimicking fluid flow or pressure levels will slow device development...

Other Products Cited:  Endovascular Simulator  Pulsatile Flow Simulation

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Paulo Yu, Vibhav Durgesh, Experimental Thermal and Fluid Science, Vol 138, October 1 2022

Aneurysms are abnormal expansion of weakened blood vessels which can be debilitating or fatal upon rupture. Previous studies have shown that hemodynamics play a role in aneurysm formation, growth and rupture. Therefore, the objective of this work is to investigate the impact of flow structures on vortex strength, impinging location, and wall shear stress for two aneurysm models. ...The inflow parameters used in this study, and , were controlled using a ViVitro Labs Inc. SuperPump system... ...The flow evolution results showed that impacted the vortex formation, growth, and dissipation processes for the studied aneurysm model...

Other Products Cited:  Analysis and Computational Modeling  Flow Visualization  Pulsatile Flow Simulation  Stent Testing  SuperPump

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Libby H. Welborn, Anna K. Himes, Ida E. Greenlee, Nyna J. DeWitt, Ava T. Burgess, Brandon K. Eberl, Olga Pierrakos, 2022 Systems and Information Engineering Design Symposium (SIEDS)

The aim of this paper is to: 1) showcase the design process of a quadleaflet ePTFE valved conduit with a diameter of 16mm or less and 2) offer a hemodynamic performance comparison. ...The proposed valve was tested using the ViVitro Pulse Duplicator under physiologic cardiac conditions... ...A comparison between the two ePTFE handmade valves (trileaflet and quadleaflet) demonstrated hemodynamic differences in regurgitation due to leaflet number. The handmade valves both showed increased regurgitation compared to a Carbomedics valve (commercially available design). Regurgitation had varying effects on pressure gradients and cardiac output...

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K.Yu. Klyshnikov, P.S. Onischenko, Е.А. Ovcharenko, СТМ, 2022, vol. 14, No.2

The aim of the study was to study the complex biomechanics of the aortic valve prosthesis and to analyze the effect of frame mobility on the stress-strain state and geometry of the valve leaflet apparatus using a numerical simulation method, which reproduces the qualitative and quantitative results of its bench tests. ...The simulation was validated by comparing the results of numerical and bench simulation on the ViVitro Labs hydrodynamic system (ViVitro Labs Inc., Canada)... ...The results of the UniLine prosthesis biomechanics modeling have demonstrated that mobility of the frame struts of the heart valve prosthesis is a crucial aspect in assessing the effectiveness of the leaflet apparatus geometry and may be a negative factor in case of a highly elastic leaflet material...

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Paulo Yu, Vibhav Durgesh, Fluids, 2022, 7, 165.

Aneurysms are localized expansions of blood vessels which can be fatal upon rupture. Studies have shown that aneurysm flows exhibit complex flow phenomena which consist of single or multiple vortical structures that move within the flow cycle. ...Rep and α were the inflow parameters used to match and simulate the conditions in the human circulatory system. These inflow parameters were precisely controlled with a ViVitro Labs Inc. SuperPump system... ...Both POD and DMD are capable analysis tools to investigate the spatial and temporal behavior of large-scale structures of a given flow field. POD and DMD can be used to create mathematical models to look into the flow evolution in sufficiently high detail and at any time step...

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Salwa B. Anam, Brandon J. Kovarovic, Ram P. Ghosh, Matteo Bianchi, Ashraf Hamdan, Rami Haj-Ali & Danny Bluestein - Cardiovascular Engineering and Technology (2022)

Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which had been treated off-label by transcatheter aortic valve replacement (TAVR) procedure for several years, until its recent approval by the Food and Drug Administration (FDA) and Conformité Européenne (CE) to treat BAVs. ...Materials and Methods Patient-specific in silico models and 3D printed replicas of 3 BAV patients with different degrees of post-TAVR paravalvular leakage (PVL) were created. Patient-specific TAVR device deployment was modeled in silico and in vitro—following … ...PVL degree and locations were consistent with the clinical data. Cross-validation comparing the stent deformation and the flow parameters between the in silico and the in vitro models demonstrated good agreement....

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L. van de Velde, E. Groot Jebbink, B. A. Zambrano, M. Versluis, J. Tessarek & M. M. P. J. Reijnen: CardioVascular and Interventional Radiology (2022)

...To assess this flow diverting strategy for popliteal aneurysms, flow profiles and thrombus formation likelihood were investigated in popliteal aneurysm models... ...The model was placed in a circulating flow set-up with a blood-mimicking fluid (Fig. 3). At the inlet, a hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to enforce time-varying forward flow...

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Paulo Yu, Vibhav Durgesh, Fluids, 2022

...Rep and α were two inflow parameters used in this study, and these were controlled using a ViVitro Labs Inc. (Victoria, BC, Canada) SuperPump system...POD provides a method for analyzing complex flow phenomena in great detail. It can be used to study a variety of unsteady, physiological flows to understand the behavior of energetic flow structures..

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H. Appa, K. Park, D. Bezuidenhout, B. van Breda, B. de Jongh, J. de Villiers, R. Chacko, J. Scherman, C. Ofoegbu, J. Swanevelder, M. Cousins, P. Human, R. Smith, F. Vogt, B, K. Podesser, C. Schmitz, L. Conradi, H. Treede, H. Schröfel, T. Fischlein, M. Grabenwöger, X. Luo, H. Coombes, S. Matskeplishvili, D. F. Williams, P. Zilla, Front. Cardiovasc. Med., 03 March 2022

...Hydrodynamic testing to determine gradients (ΔP), effective orifice areas (EOA) and regurgitant fractions was performed in a pulse duplicator (Cardiac Output: 5 L/min; 37°C; 70 bpm; Stroke Volume: 32 ± 5 ml; Systolic Phase Duration of 35 ± 5%) (ViVitro Labs Inc; Victoria, BC, Canada)...The BE TAVR system met all requirements for which it was developed...

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Y. Zhu, A. M. Imbrie-Moore, R. J. Wilkerson, M. J. Paulsen, M. H. Park & Y. Joseph Woo, BMC Cardiovascular Disorders volume 22, Article number: 73 (2022)

...The left heart simulator, which has been previously described, features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, British Columbia, Canada) to generate physiologic parameters using the pump controller and software (ViVitest Software, ViVitro Labs) programmed in accordance with ISO 5840 standards for in vitro valve testing...The mitral annular dilation system successfully generated an ex vivo mitral annular dilation model with MR...

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N Norris, K Lewis, C Settanni, T Becker, A Ducruet, Journal of NeuroInterventional Surgery 2021, 13 (Suppl 1)

...Physiologically-relevant patient flow parameters were tuned within the system using a Super Pump AR (ViVitro Labs)...This in-vitro aneurysm flow model utilized the latest in UV-cured 3D-printing techniques to provide a realistic simulation of neurovascular tortuosity and aneurysm device delivery...

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M. Alizadeh, M. Cote, A. Branzan Albu, Proceedings of the IEEE/CVF Winter Conference on Applications of Computer Vision 2022

...Our experimental setup to collect high-quality videos and pressure and velocity data involves tricupsid BHVs mounted in the Pulse Duplicator device from ViVitro Labs...Experiments on four cases that include three different tricuspid BHVs yielded promising results, with the DTW scores showing a good coherence with respect to the simulations...

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M. Marin-Cuartas, Y. Zhu, A. M. Imbrie-Moore, M. H. Park, R. J. Wilkerson, M. Leipzig, P. K. Pandya, M. J. Paulsen, M. A. Borger, Y. J. Woo, Interactive CardioVascular and Thoracic Surgery (2021) 1–9

...The severity of acute papillary muscle (PM) rupture varies according to the extent and site of the rupture. However, the haemodynamic effects of different rupture variations are still poorly understood...A 3D printer (Carbon 3D, Redwood City, CA, USA) was used to prototype a modular left heart (left atrium and ventricle) and was mounted to a pulsatile linear piston pump (ViVitro Superpump; ViVitro Labs, Victoria, BC, Canada)...

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A. Imbrie-Moore, Y. Zhu, T. Bandy-Vizcaino, M. Park, R. Wilkerson, Y. Woo, Annals of Biomedical Engineering, 49

Driven by a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) which generates physiologic hemodynamics in accordance with ISO 5840 in vitro cardiac valve testing standards.

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