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H.Sodawalla, M.Alnajrani, J.Wells, et al., Journal of Biomedical Materials Research Part B: Applied Biomaterials114, no. 2 (2026): e70030
The ViVitro SuperPump enabled a physiologically relevant benchtop platform for evaluating treatment strategies for giant intracranial aneurysms using a rupture-prone 3D-printed model. In this study, researchers implemented a custom flow loop to compare flow diverter-only treatment, flow diverter combined with synthetic thrombus, and flow diverter with liquid embolic, while continuously monitoring intra-aneurysmal pressure and time to rupture. The results demonstrate that benchtop aneurysm testing provides a practical and repeatable approach for assessing treatment performance and mechanical stability under controlled physiological conditions, while underscoring the value of realistic in-vitro models for preclinical device evaluation
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Visit SourceAmico et al. Physics of Fluids 38, 021916 (2026)
The ViVitro Pulse Duplicator enabled a physiologically relevant, ISO 5840-aligned test environment for direct comparison of event-based imaging velocimetry (EBIV) and conventional PIV in a left-heart simulator with a transcatheter mitral valve. The study examined whether EBIV could quantify intraventricular flow with accuracy comparable to PIV under two cardiac-output conditions. Using synchronized, phase-locked acquisitions, the authors showed that EBIV reproduced the main hemodynamic features measured by PIV, including velocity fields, diastolic vortex structures, circulation, Lagrangian trajectories, pulsatile kinetic energy, and dominant POD modes. The work positions EBIV as a data-efficient, high-dynamic-range alternative for cardiac flow analysis, while underscoring the value of the ViVitro platform in delivering realistic, reproducible bench testing for device assessment and translational cardiovascular research.
Other Products Cited: Analysis and Computational Modeling Flow Visualization Heart Valve Testing Pulsatile Flow Simulation Pulse Duplicator TMVR
Visit SourceTymoshenko V, Suria AJ, Dimonte G, et al. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 2026;0(0).
This study demonstrates how the ViVitro Labs SuperPump enables precise control of flow and stroke, providing the stable and clinically relevant hemodynamic conditions required to accurately quantify leakage. Automated versus manual suturing techniques in Bentall procedures were evaluated using an ex vivo passive beating heart model integrated into an advanced mock circulatory loop (MCL) platform. Twenty porcine hearts underwent Bentall surgery with either automated or manual suturing and were tested under progressively increasing aortic pressures using the ViVitro Labs SuperPump. The results revealed no significant difference in anastomotic leakage between the two techniques, even under hypertensive conditions. These findings indicate that automated suturing achieves comparable holding strength and hemostatic performance to manual methods, supporting its use in complex aortic root procedures.
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Visit SourceMerhi, Y., Montero, K.L., Johansen, P. et al. npj Flex Electron 10, 31 (2026).
This work highlights how ViVitro systems enable realistic cardiovascular bench testing for next-generation bioelectronic devices, helping advance translational implant development. Using a ViVitro SuperPump to recreate physiologically relevant pulsatile left-heart conditions, this study evaluates a biodegradable PLLA piezoelectric sensor for real-time monitoring during aortic annuloplasty. The authors enhanced PLLA film performance through uniaxial stretching and thermal annealing, significantly increasing voltage output and enabling stable, pressure-correlated sensing in a ring-like prototype. Within the in-vitro setup, the sensor produced repeatable signals across clinically relevant pressure ranges, supporting its potential as a temporary smart implant.
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Visit SourceMichael A. Bielecki, Julianne H. Spencer, Paul A. Iaizzo
Pumping New Life into Heart Research: How ViVitro's Superpump is Changing TAVR Studies In this study, researchers took a unique approach by reanimating swine and human hearts with a ViVitro Superpump to investigate how TAVR implantation affects coronary pressure. Using the Superpump and detailed CT scans, they measured what they call the Estimated Leaflet to Ostium Distance, or ELOD, and found a clear correlation: the shorter that distance, the more coronary pressure could drop. In other words, by getting these hearts beating again in a lab setting, they demonstrated that ELOD might be a better predictor of coronary obstruction risk than some traditional measurements. It’s a solid example of how ViVitro’s technology is helping refine our understanding of heart valve procedures, all without the need for animal or patient trials.
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Ex ViVo Simulation Pressure Measurement System SuperPump
Visit SourceNajla Sadat , Antonia Osterloh , Michael Scharfschwerdt , Matthias Klinger , Buntaro Fujita , Stephan Ensminger
Structural Valve Deterioration Under the Lens: Insight into Heart Valve Durability and Calcification This study showcases some truly remarkable transformations in both surgical and transcatheter heart valves, all achieved in a controlled lab environment using our ViVitro AWT systems and a Pulse Duplicator. Over a 157 million cycle durability test, these valves were exposed to conditions that mimic years of loading while calcification occurs, allowing us to observe how calcium deposits impact structural valve deterioration. The findings are truly eye-opening. The study not only demonstrated how different valve designs and tissue types respond to calcification but also highlighted that our 1st gen HiCycle system, while solid and reliable, has paved the way for the even more advanced features of our current 3rd gen AWT systems. Imagine how much more we could uncover now with independent valve environments and continuous monitoring! We were especially impressed by the visual content—like Video 8 in the paper, which offers a side-by-side view of control versus calcified valves, a feature reminiscent of our latest Valve Comparison Tool. Ultimately, this research is a great testament to how ViVitro’s products are helping advance medical device testing in a way that reduces the need for animal and patient trials.
Other Products Cited: AWT with DCT Heart Valve Testing HiCycle Durability Tester Pulse Duplicator TAVI
Visit SourceKatell Delanoë, Marie-Annick Clavel, Philippe Pibarot, and Viktória Stanová, Journal of Heart Valve Society, Volume 2, Issue 3-4, September-December 2025.
In a rare head-to-head comparison study between two surgical mitral valve prostheses (EDWARDS MITRIS RESILIA 27mm vs ABBOTT EPIC Plus 29mm, 3 samples each), the author addressed the lack of hemodynamic performance data comparing bovine and porcine tissue valves when placed in the mitral position. A unique customized Pulse Duplicator system fitted with two ViVitro Labs pulsatile flow pumps was used to simultaneously activate left atrial and left ventricular chambers with molded transparent soft silicone models. The study showed that both valves met ISO 5840 requirements, but MITRIS performed noticeably better, with a 25% lower pressure gradient, 12% larger GOA, and 15% larger EOA. More work is needed to translate those results into clinical benefits for patients. This original research demonstrates how the modularity and versatility of the ViVitro Labs pulsatile flow pump empower researchers to build advanced mock flow loop systems and generate high-quality comparative performance data that support device optimization and innovation.
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Visit SourceCamilo E Pérez-Cualtán et al 2025 Prog. Biomed. Eng. 7 042007
Using a modified ViVitro Pulse Duplicator system, researchers achieved one of the most advanced preclinical test benches to date for Transcatheter Pulmonary Valve Replacement (TPVR). This platform allowed integration of patient-specific 3D-printed pulmonary artery models to evaluate valve hemodynamics under physiologic conditions. The ViVitro system enabled precise measurement of pressure gradients and regurgitation, which were then compared with in vivo catheterization data—demonstrating excellent correlation and validating the use of 3D-printed geometries for personalized testing. This work highlights how ViVitro technology facilitates translational research by linking computational design, in-vitro modeling, and clinical validation to optimize device sizing and placement for complex congenital heart conditions.
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Visit SourceJingdi Wan, Hongping Wang, Bo Liu, Xiaolei Yang, Xiaodong Hu, Shengze Cai, Guowei He, Yang Liu? arXiv:2507.09621 [physics.flu-dyn]
Physics-Based AI Enhances Prediction of Post-TAVR Flow Dynamics Using the ViVitro Pulse Duplicator, researchers generated high-fidelity in-vitro flow data to validate TrajectoryFlowNet—a physics-informed machine learning framework for predicting complex cardiovascular fluid dynamics. The ViVitro system recreated physiological pulsatile conditions within a silicone aortic root and 3D-printed arteries, enabling accurate 3D particle image velocimetry (PIV) following transcatheter aortic valve replacement (TAVR). The resulting experimental dataset trained and tested TrajectoryFlowNet without explicit boundary constraints, yet achieved high correlation (≈0.9) between predicted and measured particle velocities. This study highlights how the ViVitro Labs System’s precise flow replication enables the development of robust AI models bridging physical realism and data-driven prediction for next-generation cardiovascular diagnostics.
Other Products Cited: Flow Visualization Heart Valve Testing Pulse Duplicator
Visit SourceAlbrahimi, E., Aka, I. B., Alhaj Ali, M. H., Korun, O., Odemis, E., Ipek, G. doi:10.3791/68173 (2025).
In this study, researchers leveraged the ViVitro Pulse Duplicator System to replicate physiological cardiac function and evaluate mitral valve performance under controlled, reproducible conditions. The system enabled precise control of key hemodynamic parameters—such as heart rate, systolic-to-diastolic ratio, and stroke volume—providing a realistic simulation of cardiac cycles. Through its automated computation of critical values including regurgitant volume and pressure gradients, the Pulse Duplicator simplified complex analyses and enhanced data accuracy. By enabling real-time, quantitative hemodynamic assessment, the ViVitro system served as an essential bridge between computational models and in vivo testing. It allowed researchers to validate surgical repair strategies for congenital and pediatric mitral valve anomalies in a biologically relevant, ex vivo environment. This standardized testing framework accelerates translational research and ensures that novel repair techniques are optimized for patient safety and clinical efficacy before entering human trials. Through its unmatched precision and reproducibility, the ViVitro Pulse Duplicator System continues to empower innovation in cardiovascular device development and surgical training—driving forward the future of mitral valve repair research.
Other Products Cited: Ex ViVo Simulation Heart Valve Testing Pulse Duplicator
Visit SourceZeping Zhang, Rizheng Han, Yueen Liu, Xinqi Yu, Guixue Wang, Yun Bai, Rui Yang, Tao Jin, Xing Zhang,Chemical Engineering Journal,Volume 518, 2025,
In this study the ViVitro Labs Pulse Duplicator system played an essential role in simulating physiological aortic and pulmonary flow conditions to assess the hydrodynamic performance of a bioinspired trilayer poly(ε-caprolactone) (PCL) scaffolds designed for tissue-engineered heart valves (TEHVs). By replicating the fibrosa-spongiosa-ventricularis architecture using electrospinning on custom collectors, the authors developed a scaffold (BTS) that successfully mimics the anisotropic and nonlinear ('J-curve') mechanical behavior of native valve leaflets. The BTS exhibited favorable biomechanical performance, excellent biocompatibility, and compliance with ISO 5840-2 criteria. These results highlight the scaffold’s translational promise in pediatric and young adult valve replacements. The successful demonstration of effective orifice area and regurgitation rate compliance underscores the Pulse Duplicator’s value in de-risking translation to clinical applications.
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Visit SourceDi Leonardo S, Vella D, Pisano C, Argano V, Burriesci G IRBM, Volume 46, Issue 4, 2025, 100897
Utilizing the ViVitro Pulse Duplicator, this study simulated a wide range of clinically relevant subaortic membrane (SAM) scenarios to quantify their impact on aortic valve hydrodynamics. By varying membrane stiffness, size, and alignment, the research team demonstrated that hemodynamic compromise becomes significant below a membrane orifice area (MOA) of 75%, with stiff membranes triggering higher pressure gradients and leaflet fluttering. Concentric flexible membranes yielded better outcomes under increasing cardiac output. Notably, the ViVitro platform enabled precise measurement of dynamic variables like regurgitation and fluttering amplitude, underscoring its value in preclinical modeling of disease states and guiding surgical thresholds for intervention
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Visit SourceDelanoë, K., Erwan, S., Rieu, R., Côté, N., Pibarot, P., & Stanová, V. Bioengineering, 2025, 12, 397.
The goal of this study is to enhance the understanding of both healthy and pathological mitral valves by reproducing precisely their anatomical properties and testing them under controlled conditions. Both cavities are surrounded by liquid and are activated by piston-pumps (Vivitro Inc., Victoria, Canada) controlled using LabVIEW8.2. The main finding of this study is that silicon combination EF50DS10 (=V7) was able to replicate the anatomical features of a healthy mitral valve while inducing a normal physiological hemodynamic behavior.
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Visit SourceJosien Snoeijink, T., Lucas van der Hoek, J., Mirgolbabaee, H., Gerard Vlogman, T., Roosen, J., Frank Wilhelmus Nijsen, J., & Groot Jebbink, E. Journal of Endovascular Therapy. 2025.
A symmetrical phantom with circular successively bifurcating vessels was developed to study the behavior of the clinical catheter during microsphere injection. The outlets led to an open fluid collection reservoir, which was connected to a continuous pump and a pulsatile pump (SuperPump, ViVitro labs, Victoria, Canada). The most interesting finding from this study was the observed motion of the clinical catheter and its influence on the microsphere distribution.
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Visit SourceOdemis, E., Başar Aka, I., & Han Kızılkaya, M. Pediatric Cardiology. 2025.
This study assesses the Pulsta THV® valve’s in vitro hemodynamic performance across these RVOT morphologies using 3D-printed models. For this study, valves were tested using the ViVitro Pulse Duplicator System (ViVitro Labs Inc., Victoria, BC), a system designed to simulate physiological conditions as used in previous studies. Our experiments demonstrated that the larger valve size consistently had lower regurgitation rates across all cardiac outputs.
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Visit SourceAmponsah, J., Archibong-Eso, A., Aliyu, A. M., & Wilberforce Awotwe, T.
This work models and numerically simulate the influence of blood viscosity on cavitation within tMHVs, using FSI principles. The experiments used a hydro-mechanical pulse duplicator system (ViVitro Superpump System SP3891, ViVitro Labs Inc., Canada) designed to replicate physiological conditions. Our simulations reveal that cavitation is primarily driven by sharp pressure drops during valve closure, with cavitation inception occurring at pressures as low as 4.5 Pa, a level significantly lower than previously reported ranges of 15–20 Pa.
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Visit SourceSibut-Pinote, Vincent; Reymon, Philippe; Cikirikcioglu, Mustafa; Bendjelid, Karim; Huber, Christoph. ASAIO Journal ():10.1097/MAT.0000000000002454, May 13, 2025.
Use of the ViVitro Labs Super Pump to build a complex mock circulatory loop to study the effect of VA-ECMO/IABP combination on the with systemic, coronary, cerebral, and renal circulation. In this study the ViVitro Labs system is used to improve the outcome of clinical procedures. "We used the same silicone circuit as in our previous publication (model ref T-S-N-009+; Elastrat, Geneva, Switzerland). To prevent the formation of air bubbles when testing at a heart rate of 100 bpm, and to improve the quality of aortic flow measurements, a rigid plastic grid was placed in the compliance reservoir tank. We used a pulsatile pump (Superpump; ViVitro Labs, Inc., Victoria, BC, Canada) to simulate cardiac function at the circuit inlet. Positioning the pump in line with the aortic root was the configuration with the fewest disturbances flow and pressure measurements (Figure 1)"
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Visit SourceJelle Plomp, Ashkan Ghanbarzadeh-Dagheyan, Michel Versluis, Guillaume Lajoinie, Erik Groot Jebbink, Imaging Behind the Plaque: Improved Blood Flow Quantification Using an Iterative Scheme for Active Attenuation Correction, Ultrasound in Medicine & Biology, Volume 51, Issue 6, 2025, Pages 984-998
This publication demonstrates how the ViVitro Labs Pulsatile Flow Pump can be used to create a mock circulatory flow loop (MCL) in the context of particle image velocimetry (PIV) "To confirm ISAAC's applicability, measurements were also performed using a pulsatile flow with a frequency of 70 beats per minute, produced using the ViVitro SuperPump (ViVitro Labs Inc, Victoria, CA, USA). The setup in Figure 1a was adjusted such that the pulsatile flow would be added to the constant output of the other pump. Approximately two cycles were imaged at 1667 fps, resulting in 3000 frames. Singular value decomposition filtering was performed over all 3000 frames"
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Visit SourceLuca Bontempi, Marta Zattoni, Anna Ramella, Francesco Migliavacca, Steffen Ringgaard, Won Yong Kim, Peter Johansen, Monika Colombo bioRxiv 2025.03.05.641637
This publication demonstrates the modularity of the ViVitro Labs Pulsatile flow pump and how it can be used to construct an advanced mock circulatory flow-loop (MCL) and obtain boundary flow conditions for an FSI model. "A pulsatile in-vitro MCL was employed to replicate a left heart flow cycle, as previously described [9,10]. . An electromechanical piston pump (VSI Superpump, ViVitro Labs, Victoria, Canada) was connected to the ventricular chamber to generate pulsatile flow and pressure waveforms. The atrial reservoir and ventricular chamber were linked via a mechanical heart valve mimicking the mitral valve, while the ventricular chamber and the compliance chamber were connected through the AR model with the integrated AV"
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Visit SourceSmid CC, Haselmann C, Irani SK, Cesnjevar R, Schweiger M, Pappas GA
This study demonstrates how the ViVitro Labs Pulsatile flow pump was used to design a customized pulse duplicator system to assess the hydrodynamic performance of a pediatric “biological valve model (BVM)”. The flow loop integrates a unique system to simulate aortic annulus expansion. The performance of the patient-tailored valve was benchmarked against a commercially available pulmonary conduit along with an in-house built polyurethane valve. This research provides valuable insight on valve design potential improvements and demonstrates how ViVitro systems can play a critical role in valve performance assessment.
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