Articles Related to Applications
- Endovascular Simulator
- Ex ViVo Simulation
- Flow Visualization
- Heart Valve Repair
- Heart Valve Testing
- HiCycle Durability Tester
- MRI compatibility
- Pressure Measurement System
- Pulsatile Flow Simulation
- Pulse Duplicator
- Stent Testing
- Tissue Engineering
- Ultrasound Measurements
- VAD Testing
Papillary Muscle Approximation Reduces Systolic Tethering Forces and Improves Mitral Valve Closure in the Repair of Functional Mitral Regurgitation
S. Zhan-Moodie, D. Xu, K. S. Suresh, Q. He, D. Onohara, K. Kalra, R. A. Guyton, E. L. Sarin, M. Padala. JTCVS Open.
...actuating pump with a viscoelastic impedance (Superpump, Vivitro Labs, London, ON) was connected to the LV, and programmed to generate physiological left ventricular pressures. 0.9% saline was used as the working medium in this flow loop...Visit Source
C. D. Hsu, A. Mirza, R. Matheny, S. Ramaswamy. Structural Heart. Vol. 5.
...hydrodynamic testing of the valves mounted in mitral and tricuspid positions were performed using a pulse duplicator system (ViVitro Labs) using 0.9% saline solution...Visit Source
F. Stieglmeier, M. Grab, F. König, J. Büch, C. Hagl, N. Thierfelder. Journal of the Mechanical Behavior of Biomedical Materials. Vol. 118.
… was applied, was documented. 2.9. Durability testing. To investigate the long-term durability, patches were tested in a modified high-cycle (HC) system (HiCycle Durability Tester; ViVitro Labs Inc., Victoria, CAN). A 3D printed …Visit Source
Application of Proper Orthogonal Decomposition to Study Coherent Flow Structures in a Saccular Aneurysm
P. Yu, V. Durgesh, T. Xing, R. Budwig. Journal of Biomedical Engineering. Vol. 143.
… vectors in the sac region. 3.3 Pump System. To generate controlled inflow conditions for this study, a piston pump (ViVitro Labs Inc. SuperPump Sys- tem AR Series, Victoria, BC, Canada) was used. The piston pump system …Visit Source
2D PIV experiments of oscillatory flow in a stenosis: A study into the physics of flow of cerebrospinal fluid
Computational modelling of flow in the liver vasculature using the Lattice Boltzmann method to study microsphere distribution
Simulating Radial Pressure Waveforms with a Mock Circulatory Flow Loop to Characterize Hemodynamic Monitoring Systems
A. Packy, G. A. D'Souza, M. Farahmand, L. Herbertson, C. G. Scully. Cardiovascular Engineering and Technology.
… Pressure measurement location. ºFlow measurement location. Full size image. Deionized water is circulated through the MCL using a piston pump [ViVitro Labs, Victoria, BC, Canada] that is fluid-coupled to a suspended silicone-based mock ventricular sac …Visit Source
N Norris, K Lewis, C Settanni, T Becker, A Ducruet. Journal of Neurointerventional Surgery. Volume 13 Issue Suppl 1.
...physiologically-relevant patient flow parameters were tuned within the system using a Super Pump AR (ViVitro Labs). A data acquisition system (DAQ) with LabVIEW® software recorded real time pressure and flow waveforms, mean arterial pressures (MAP) and flows through each inlet and outlet branch of the 3D-printed CW model. The flow model included an introducer for microcatheter and device delivery access...Visit Source
Omid Bafkar, Gary Rosengarten, Milan.J. Patel, Daniel Lester, Hadrien Calmet, Vu Nguyen, Stefan Gulizia, Ivan.S. Cole, Effect of inhalation on oropharynx collapse via flow visualisation, Journal of Biomechanics, Volume 118, 2021, 110200, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2020.110200.
… Fluorescent spherical particles (500-600 µm diameter, Cospheric LLC, Santa Barbara, USA) were injected into the head of a piston-driven SuperPump (Vivitro Labs, Victoria, Canada) that was connected to an …Visit Source
A novel 3D-Printed preferential posterior mitral annular dilation device delineates regurgitation onset threshold in an ex vivo heart simulator
Annabel M. Imbrie-Moore, Cole C. Paullin, Michael J. Paulsen, Frederick Grady, Hanjay Wang, Camille E. Hironaka, Justin M. Farry, Haley J. Lucian. Y. Joseph Woo - Medical Engineering & Physics Available online 31 January 2020
...This work shows the design and implementation of a 3D-printed valve dilation device to preferentially dilate the posterior mitral valve annulus... ...In brief, a custom 3D-printed left heart chamber (Fig. 2A) was mounted to a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) with the ability to generate physiologic conditions … ...this annular dilation device provides the means to investigate the design and optimization of novel annuloplasty rings....Visit Source
Jason Voorneveld, Hicham Saaid, Christiaan Schinkel, Nikola Radeljic, Boris Lippe, Frank J.H. Gijsen, Antonius F.W.van der Steen, Nico de Jong, Tom Claessens, Hendrik J. Vos, Sasa Kenjeres, Johan G. Bosch - Elsevier Ultrasound in Medicine & Biology - Available online 8 January 2020
Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for testing the accuracy of echo-PIV in the presence of complex flow patterns.... … 1a). The mitral and aortic tracts of the LV were connected to atrial and compliance chambers (transparent acrylic, built in-house), which were connected via a tube with an adjustable resistance valve (ViVitro Labs … ... We demonstrate that 4-D echo-PIV could be performed in just four heart cycles, which would require only a short breath-hold, providing promising results. However, methods for resolving high velocity gradients in regions of poor spatial resolution are required before clinical translation....Visit Source
Fluid-Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator
Jae H. Lee, Alex D. Rygg, Ebrahim M. Kolahdouz, Simone Rossi, Stephen M. Retta, Nandini Duraiswamy, Lawrence N. Scotten, Brent A. Craven, and Boyce E. Grith -
Computer modeling and simulation (CM&S) is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) and promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance... ...This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.... … In vitro experiments are performed using two different experimental platforms, including a ViVitro Pulse Duplicator (ViVitro Labs, Inc., Victoria, BC, Canada) available through the FDA Cardiac Device Flow Lab and a customized …Visit Source
Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior
Feng Guo (郭峰)Chang Liu (刘唱)Rizheng Han (韩日峥)Qiang Lu (吕强)Yun Bai (白芸)Rui Yang (杨锐)Dun Niu (牛盾)Email authorXing Zhang (张兴) -Science China Materials
Herein, two types of silk fibroin (SF) fiber membranes with anisotropic (ASF) and isotropic (ISF) properties were prepared by electrospinning, and were further combined with poly(ethylene glycol) diacrylate (PEGDA) hydrogels to serve as polymeric heart valve (PHV) substitutes (PEGDA-ASF and PEGDA-ISF)... ...The PHVs from both PEGDA-ASF and PEGDA-ISF presented appropriate hydrodynamic properties from pulse duplicator tests according to the ISO 5840-3 standard.... ...The Gauss curvature analysis also indicated that the anisotropic PEGDA-ASF valve can produce appropriate surface morphology by dynamically adjusting the movement of bending area during the opening process... … 1c, d). Pulse duplicator tests In vitro hemodynamic properties of PHVs were tested in a 0.9% saline solution using a pulse duplicator system (Vivitro Labs, Inc., British Columbia, Canada) according to the ISO 5840-3 standard  …Visit Source
Miss Brittany A. Gonzalez, Miss Elnaz Pour Issa, Mr. Omkar V. Mankame, Miss Jenniffer Bustillos, Mr. Antonio Cuellar, Mr. Andres J. Rodriguez, Dr. Frank Scholl, Dr. Steven Bibevski, Dr. Lazaro Hernandez, Mr. Vincent Brehier, Mr. Mike Casares, Dr. Krishna Rivas, Dr. Pablo Morales, Mr. Jesus Lopez, Dr. Joseph Wagner, Dr. Jennifer Bibevski, Dr. Arvind Agarwal, Dr. Florence George, and Dr. Sharan Ramaswamy - Tissue Engineering Part A. December 5, 2019
Conceptually, a tissue engineered heart valve (TEHV) would be especially appealing in the pediatric setting since small size and somatic growth constraints would be alleviated. Here, we utilized porcine small intestinal submucosa (PSIS) for valve replacement... … the Dacron tubes housing the PSIS valves were measured in order to secure the valve‐in‐ conduit (Figure 1) in the mitral position within a pulse duplicator system (ViVitro Labs, Victoria, BC) … A pulse duplicator system… ... Our findings suggest that the altered structural responses of PSIS, post-fatigue, rather than de novo tissue formation, are primarily responsible for the valve’s ability to accommodate somatic growth during the acute phase (90 days) following mitral valve replacement...Visit Source
Mitral chordae tendineae force profile characterization using a posterior ventricular anchoring neochordal repair model for mitral regurgitation in a three-dimensional-printed ex vivo left heart simulator
Michael J Paulsen, Annabel M Imbrie-Moore, Hanjay Wang, Jung Hwa Bae, Camille E Hironaka, Justin M Farry, Haley J Lucian, Akshara D Thakore, John W MacArthur, Jr, Mark R Cutkosky, Y Joseph Woo - European Journal of Cardio-Thoracic Surgery, ezz258
Posterior ventricular anchoring neochordal (PVAN) repair is a non-resectional technique for correcting mitral regurgitation (MR) due to posterior leaflet prolapse, utilizing a single suture anchored in the myocardium behind the leaflet... ...Porcine mitral valves were mounted in a 3-dimensional-printed heart simulator and chordal forces, haemodynamics and echocardiography were collected at baseline, after inducing MR by severing chordae, and after PVAN repair.... ...PVAN repair eliminates MR by positioning the posterior leaflet for coaptation, distributing forces throughout the valve....Visit Source
Implications of hydrodynamic testing to guide sizing of self‐expanding transcatheter heart valves for valve‐in‐valve procedures
Janarthanan Sathananthan MBChB, MPH Mark Hensey MB BCh BAO Rob Fraser MSc Uri Landes MD Philipp Blanke MD Hoda Hatoum PhD Lakshmi Prasad Dasi PhD Alexander Sedaghat MD Vinayak N Bapat MD Jonathon Leipsic MD Lars Søndergaard MD, DMSc David A. Wood MD John G. Webb MD - Catheterization and Cardiovascular Interventions October 2019
...Bench study assessed the hydrodynamic performance of different sizes of self‐expanding supra‐annular THVs in three different surgical aortic bioprostheses at different implantation depths.... ...A small versus medium ACURATE neo (ACn), and a 26 mm versus 29 mm Evolut R were assessed after VIV implantation in 25 mm Mitroflow, Mosaic, and Magna Ease aortic surgical bioprostheses, at three implantation depths (+2 mm, ‐2 mm, and ‐6 mm).... ...Use of a larger self‐expanding THV was associated with superior hydrodynamic performance if the THV was implanted high....Visit Source
Fluid-Structure Interaction Models of an Experimental Pulse Duplicator for Simulating Bioprosthetic Heart Valve Dynamics
Jae H. Lee, Alex D. Rygg, Ebrahim M. Kolahdouz, Simone Rossi, Stephen M. Retta, Nandini Duraiswamy, Lawrence N. Scotten, Brent A. Craven, and Boyce E. Grith - ResearchGate 2019
This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform... ...We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator.... ...This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs....Visit Source
Biomechanical modeling and hemorheological assessment of ascending thoracic aortic aneurysm, aortic heart valve, and blood clot
HH Yeh - 2019 UBC Theses and Dissertations
... thesis firstly evaluated the biomechanical contributions to ATAA progression under the influence of anatomy, hypertension, and hematocrit using fully coupled fluid-structure interaction (FSI) with arterial wall anisotropy to provide additional information in patient evaluations... ...The three different ATAA models identified different aortic expansions that were not uniform under pulsatile pressure and a geometry depended on elevated wall stress under hypertension.... ... A commercially available, 23 mm BMHV with a tissue annulus diameter / internal diameter (TAD/ID) of 18.5 mm (Figure 3.2), was used as the test model. ViVitro pulse duplicator was used to assess the performance and function of prosthetic heart valves under simulated cardiac conditions. ...Visit Source
Yen Ngoc Nguyen, Edgar Lik Wui Tay, Foad Kabinejadian, Chi Wei Ong, Munirah Ismail, and Hwa Liang Leo -American Journal of Physiology-Heart and Circulatory Physiology 11 OCT 2019
The deteriorating nature of severe functional tricuspid regurgitation (FTR) has led to the heightened interest in this pathology... ...In this study, the hemodynamics of the right ventricle (RV) after (i) clover edge-to-edge tricuspid repair and (ii) double orifice tricuspid repair was evaluated in three right heart models using an ex vivo pulsatile platform emulating severe FTR with the aid of stereoscopic particle image velocimetry... … circulation (35). A closed ventricular chamber housing the silicon RV model was directly 184 connected to the pulsatile wave-generating piston pump (SuperPump AR series, ViVitro Labs 185 Inc., Victoria, BC, Canada) to …Visit Source
Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis.
Ong, C. W.; Kabinejadian, F.; Xiong, F.; Wong, Y. R.; Toma, M.; Nguyen, Y. N.; Chua, K. J.; Cui, F. S.; Ho, P.; Leo, H. - Journal of Applied Fluid Mechanics . Nov2019, Vol. 12 Issue 6, p1855-1872. 18p.
Thoracic aortic aneurysm (TAA) is a severe cardiovascular disease with a high mortality rate, if left untreated... ...In order to gain more insight on TAA formation, we developed a computational framework in vitro to investigate and compare the flow patterns between pre-aneurismal and post-aneurismal aorta using a deformable wall model... ...The pulsatile flow was created using a piston pump (SuperPump AR series, ViVitro Labs Inc., Victoria, BC, Canada) generating the inlet velocity profile with the How rate of 4 L/min at the frequency of 1 Hz, extracted from the literature …Visit Source