Articles Related to Applications

C Settanni, T Becker, A Ducruet, W Merritt, A Huckleberry - Journal of NeuroInterventional Surgery (JNIS) Volume 11, Issue Suppl 1

Although current microcatheter technologies have advanced in recent years, corresponding endovascular devices still lag behind... ...This research project includes development of innovative in vitro aneurysm vessel model with complex side branching.... … communicating (ACA) bifurcation. Flow is regulated through the use of a Super Pump AR (ViVitro Labs). This 3D printed model will be implemented in an in vitro flow model that enables systemic data collection. A data acquisition … ...The in vitro model is used to simulate and quantify short-and long-term viability of new biomaterials for brain aneurysm embolization...

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Immanuel David Madukauwa-DavidVahid SadriPrem A MidhaVasilis BabaliarosCyrus AidunAjit P. Yoganathan - Annals of Biomedical Engineering First Online: 16 July 2019

Transcatheter heart valve (THV) leaflet thrombosis in the neo-sinus and associated reduced leaflet motion is of clinical concern due to risks of embolism and worsened valve hemodynamics... ...We tested two replicas of FDA approved commercial THVs—intra-annular and supra-annular (similar to the SAPIEN 3 and CoreValve families)—in a left heart simulator with coronary flow... … The Georgia Tech left heart simulator is shown in Fig. 2a. The main flow rate was driven by the primary piston pump (Vivitro Labs Inc. Victoria, Canada); wall-tapped pressure transducers (Deltran DPT-200, Utah Medical Products Inc

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Fergal B. Coulter, Manuel Schaffner, Jakob A. Faber, Ahmad Rafsanjani, Robin Smith, Harish Appa, Peter Zilla, Deon Bezuidenhout, and Andre´ R. Studart - Matter, 2019

Synthetic implants made by traditional fabrication routes are not patient specific and rarely match the performance of their biological counterparts. We present an additive manufacturing approach for the digital fabrication of tissue-like aortic heart valves featuring customizable geometry and leaflet architectures that resemble those of native valve tissue... ...Flow was driven by a forward pressure of 100 mmHg imposed across the valve using a pulsatile testing machine (PD2010; ViVitro, Victoria, BC, Canada)... ...The ability to fabricate synthetic implants with tailored designs at multiple length scales is a key contribution toward the digital fabrication of functional implants that perform on par with native body parts...

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Changfu Wu, Neelakantan Saikrishnan, Aaron J. Chalekian, Rob Fraser, Ornella Ieropoli, Stephen M. Retta, Russell Joseph, Shouyan Lee, Salvador Marquez, David Mester, Ning Pan, Sepehr Vatanpour, Craig Weinberg, Ulrich Steinseifer - Cardiovascular Engineering and Technology 2019

...A round-robin study carried out in 2005 in accordance with ISO 5840:2005 revealed significant variabilities in prosthetic heart valve hydrodynamic performance measurements among the participating laboratories. In order to re-examine the inter-laboratory variability based on the “state-of-the-art” under ISO 5840-1 and 5840-2:2015, the ISO Cardiac Valve Working Groups decided in 2016 to repeat the round-robin study.... … took part in the round-robin study, including one academic laboratory (Helmholtz Institute of the RWTH University, Aachen, Germany), three testing service providers (BDC Laboratories, Wheat Ridge, CO; Medical Implant …

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MJ Paulsen, JH Bae, A Imbrie-Moore, H Wang, CE Hironaka, JM. Farry, H Lucian, AD Thakore, MR Cutkosky, WJ Woo … - Journal of Biomechanical Engineering Accepted manuscript posted July 1, 2019 2019

Few technologies exist that can provide quantitative data on forces within the mitral valve apparatus... Using FBG sensors, we created a force-sensing neochord that mimics the natural shape and movement of native chordae.... … Redwood City, CA, USA) was mounted to a programmable pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) with the ability to generate physiologic conditions using the pump controller and …

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Utku Gülan Harish Appa Pascal Corso Christian Templin Deon Bezuidenhout Peter Zilla Firat Duru Markus Holzner - Artificial organs, 2019

...In this study, we aimed at investigating the impact of transcatheter aortic valve implantation (TAVI) devices on blood flow patterns that develop in the ascending aorta under physiological flow conditions in vitro... … Graphics, Heidelberg, Germany). Valve hydrodynamics A Pulse Duplicator System (ViVitro Labs Inc) was used for the assessment of heart valve performance and function under simulated cardiac conditions. The system is a … ...We conclude that the characteristics and material designs of TAVI devices have strong influences on the hemodynamics in the ascending aorta...

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Han HungYeh, Oleksandr Barannyk, Dana Grecov, Peter Oshkaid - Computers in Biology and Medicine Volume 110, July 2019, Pages 79-92

...the objective of this study is to analyze the hemodynamics and valve mechanics of a bileaflet mechanical heart valve and investigate the hemorheological characteristics under the change of hematocrit.... … Fig. 2. Schematic illustrating DPIV test set-up used in the current experiment (Image courtesy of ViVitro Labs Inc.). To simulate the physiological flow conditions, an acrylic test chamber, that represented a simplified model of … ...The current numerical analysis revealed the hematocrit influenced the shear stress distributions over a cardiac cycle...

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Paolo Peruzzo, Francesca Maria Susin, Andrea Colli and Gaetano Burriesc - Open Heart 2019, official journal of the British Cardiovascular Society.

Clinical evaluation of pacing therapy in mitigating the aortic insufficiency after transchateter aortic valve implantation often gives contradictory outcomes... ...A series of in vitro tests reproducing the heart operating changes clinically obtained by pacing was carried out in a 26 mm Edwards Sapien XT prosthesis with mild paravalvular leakage. The effect of pacing on the regurgitant volumes per cycle and per minute was quantified, and the energy and power consumed by the left ventricle were calculated... … Following well-developed methodologies for evaluation of cardiovascular devices and in vitro haemodynamics features,14 15 physiological pulsatile flow conditions were replicated in a hydromechanical pulse duplicator …

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Ramin Zareian Jen-Chieh Tseng Robert Fraser Jeffrey Meganck Marshall Kilduff Mohammad Sarraf Danny Dvir Arash Kheradvar - Interactive CardioVascular and Thoracic Surgery, ivz024, Published: 21 February 2019

...The goal of this study was to test whether stent crimping increases the risk for early calcification.... … MA, USA). The durability experiment was performed using a standard accelerated wear test (AWT) system (HiCycle Durability Tester, ViVitro Inc., Victoria, BC, Canada) that can ac- commodate up to 6 heart valves. Among the …

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M. Kondruweit, N. Ebel, S. Kniesburges, M. Döllinger, M. Weyand - Thorac cardiovasc Surg 2019

...the debate about the clinical evidence of the so-called patient-prosthesis mismatch (PPM) arose again. In this context it was discussed which valve specific parameter has the biggest evidence for the PPM and therefore the geometric orifice area (GOA) was pointed out as an important factor... …Methods: Commercially available surgical aortic bioprosthetic heart valves from different manufacturers were tested in a FDA / DIN conform Pulse Duplicator System (ViVitro Labs Inc., Victoria, Canada). The system … ...it was clearly demonstrated, that this GOA is a dynamic process over the whole ejection period, which significantly differed from the maximum reached GOA...

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Chi Wei Ong, Fei Xiong, Foad Kabinejadian, Gideon Praveen Kumar, Fang Sen Cui. Gongfa Chen, Pei Hoe, HwaLiang Leo - Journal of Biomechanics Available online 19 January 2019

Thoracic endovascular aortic repair (TEVAR) has been introduced as a less invasive approach to the treatment of thoracic aortic aneurysm (TAA). However, the effectiveness of TEVAR in the treatment of TAA is often limited due to the complex anatomy of aortic arch... ...This study proposes a novel stent graft design with slit perforations that can positively alter the hemodynamics at the aortic arch while maintaining blood flow to supra-aortic branches... … flow preservation at side branches. The system was driven by a pulse generator (SuperPump AR series, ViVitro Labs Inc., Victoria, BC, Canada) at a flow rate of 5 L/min and a pulse rate of 1 Hz. The reservoir level and mechanical …

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Jonas Rasmussen, Søren Nielsen Skov, Ditte Bruus Nielsen, Ida Lindhardt Jensen, Marcell Juan Tjørnild, Peter Johansen, Vibeke E. Hjortdal - Journal of Cardiothoracic Surgery December 2019, 14:6

Management of congenital malformations of the pulmonary artery and valve can be challenging. The severity often demands early intervention, which is rarely definitive due to the natural growth and multiple surgeries may be required... ...In this study, a simple valve design supported by an absorbable proximal stabilization ring is evaluated both in-vitro and in-vivo... … In-vitro model and testing. All in-vitro testing was carried out in a pulsatile flow model using water as the test fluid (Fig. 2). Pulsatile flow and pressure were generated with an electromechanical piston pump (VSI Superpump, Vivitro Labs, Victoria, Canada) …

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Janarthanan Sathananthan, Stephanie Sellers, Aaron M. Barlow, Viktória Stanová, Rob Fraser, Stefan Toggweiler, Keith B. Allen, Adnan Chhatriwalla, Dale J. Murdoch, Mark Hensey, Karen Lau, Abdullah Alkhodair, Danny Dvir, Anita W. Asgar, Anson Cheung, Philipp Blanke, Jian Ye, Régis Rieu, Phillippe Pibarot, David Wood, Jonathan Leipsic and John G. Webb - JACC: Cardiovascular Interventions Volume 12, Issue 1, January 2019

The authors assessed the effect of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) followed by bioprosthetic valve fracture (BVF), testing different transcatheter heart valve (THV) designs in an ex vivo bench study... ...The authors assessed the effect of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) followed by bioprosthetic valve fracture (BVF), testing different transcatheter heart valve (THV) designs in an ex vivo bench study....

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Diya Wang; Boris Chayer ; François Destrempes ; François Toumoux ; Guy Cloutier - 2018 IEEE International Ultrasonics Symposium (IUS) 20 December 2018

Aortic stiffness is altered by cardiovascular diseases and exacerbated in innate or pathological conditions, which might be detected by noninvasive vascular elastography.... ...results suggest that the proposed model could detect and evaluate aortic aneurysm stiffness and may be useful clinically for the early and timely detection of degraded mechanical properties to impact patient outcomes.... … Hz. Normal and aneurysm aortic deformations were compared by pulsing mimicing vessels at 60 bpm, using a hydraulic pulse duplicator within a left ventricular model (Superpump system, Vivitro Inc., Victoria, BC, Canada) …

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Keyvan Amini Khoiy, Kourosh T. Asgarian, Francis Loth, Rouzbeh Amini - PLOS ONE Published: November 8, 2018

Chordae rupture is one of the main lesions observed in traumatic heart events that might lead to severe tricuspid valve (TV) regurgitation... ...we investigated the changes on TV geometry, mechanics, and function of ex-vivo porcine hearts following chordae rupture... … The schematic of this apparatus is shown in Fig 1. In short, a positive displacement pump (SuperPump AR Series, Vivitro Labs, Inc., Victoria, BC, Canada) was utilized to induce passive beating in porcine hearts …

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Sean Guo-Dong Tan, Sangho Kim Hwa, Liang Leo - European Journal of Mechanics - B/Fluids Available online 2 November 2018

Studies have suggested that the anterior leaflet of the native mitral valve aid in the formation of an asymmetric vortex ring similar to that seen in healthy left ventricles... ...we seek to investigate if this physiological left ventricular vortex can be replicated solely by the inclusion of an “anterior leaflet-like” feature within a mechanical valve design and its subsequent effects on downstream turbulence.... ...Situated within the working chamber was the left ventricular silicon phantom actuated by a pulsatile pump (ViVitro Labs Inc., Victoria, BC), the resulting ventricular pumping motion circulated a mixture of glycerin and water (40 …

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Brandon J. Tefft, Joshua A. Choe, Melissa D. Young, Ryan S. Hennessy, David W. Morse, Jeffery A. Bouchard, Herbert J. Hedberg, Joseph F. Consiglio, Dan Dragomir-Daescu, Robert D. Simari, Amir Lerman

Tissue engineered heart valves (TEHV) are being investigated to address the limitations of currently available valve prostheses... ...A bioreactor system was designed based on the Windkessel approach. Novel features including a purpose-built valve chamber and pressure feedback control were incorporated to maintain asepsis while achieving a range of hydrodynamic conditions.... … The bioreactor was used to assess the hydrodynamic performance of a bioprosthesis and the results were compared to those obtained with a ViVitro Pulse Duplicator system (ViVitro Labs, Victoria, BC, Canada)... ...The bioreactor system was able to produce a range of pressure and flow conditions from static to resting adult left ventricular outflow tract to pathological including hypertension...

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F Guo, K Jiao, Y Bai, J Guo, Q Chen, R Yang, X Zhang - Journal of Materials Science Available online 20 September 2018

Transcatheter aortic heart valves (TAHVs) have been widely used for aortic valve replacements, with less trauma and lower clinical risk compared with traditional surgical heart valve replacements. In the present study, composites of poly(ethylene glycol) diacrylate (PEGDA) hydrogels and anisotropic high-shrinkage polyethylene terephthalate/polyamide6 (PET-PA6) fabric (PEGDA/PET-PA6) were fabricated as artificial heart valve leaflets... … 2.6. Pulse duplicator test. Hemodynamic performance of the TAHVs was assessed using a pulse duplicator system (ViVitro Labs, British Columbia, Canada) under physiological conditions according to ISO 5840-3 standards [21] …

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Yuriy TASINKEVYCH, Marcin LEWANDOWSKI, Ziemowit KLIMONDA, Mateusz WALCZAK - Polish Academy of Sciences ARCHIVES OF ACOUSTICS Vol. 43, No. 3, pp. 437–446 (2018)

Commercially available cardiac scanners use 64–128 elements phased-array (PA) probes and classical delay-and-sum beamforming to reconstruct a sector B-mode image... ...The goal of this study was to show the feasibility of reducing the channel count in the diverging wave synthetic aperture image reconstruction method for phased-arrays.... … a water tank with dedicated absorbers at- tenuating the reflected waves (Aptflex F28 and Aptflex F28P, Precision Acoustics, UK), tubing system, wind- kessel (to reduce/eliminate phantom vibrations), Viv- itro Superpump …

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Oren M. RotmanBrandon KovarovicWei-Che ChiuMatteo BianchiGil MaromMarvin J. SlepianDanny Bluestei -Annals of Biomedical Engineering 07 September 2018

Transcatheter aortic valve replacement (TAVR) is a minimally-invasive approach for treating severe aortic stenosis. All clinically-used TAVR valves to date utilize chemically-fixed xenograft as the leaflet material... ... this study, we experimentally evaluated the hemodynamic performance of the valve and compared its performance to clinically-used valves: a gold standard surgical tissue valve, and a TAVR valve.... … Testing was performed in a Vivitro Pulse Duplicator (Vivitro Labs, Victoria, BC) at average Cardiac Out- puts (CO) of 4, 5, 6, and 7 L/min, Heart Rate (HR) of 70bpm, systole-diastole ratio of 0.35–0.65, aortic pressure of …

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