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Najla Sadat , Antonia Osterloh , Michael Scharfschwerdt , Matthias Klinger , Buntaro Fujita , Stephan Ensminger
Structural Valve Deterioration Under the Lens: Insight into Heart Valve Durability and Calcification This study showcases some truly remarkable transformations in both surgical and transcatheter heart valves, all achieved in a controlled lab environment using our ViVitro AWT systems and a Pulse Duplicator. Over a 157 million cycle durability test, these valves were exposed to conditions that mimic years of loading while calcification occurs, allowing us to observe how calcium deposits impact structural valve deterioration. The findings are truly eye-opening. The study not only demonstrated how different valve designs and tissue types respond to calcification but also highlighted that our 1st gen HiCycle system, while solid and reliable, has paved the way for the even more advanced features of our current 3rd gen AWT systems. Imagine how much more we could uncover now with independent valve environments and continuous monitoring! We were especially impressed by the visual content—like Video 8 in the paper, which offers a side-by-side view of control versus calcified valves, a feature reminiscent of our latest Valve Comparison Tool. Ultimately, this research is a great testament to how ViVitro’s products are helping advance medical device testing in a way that reduces the need for animal and patient trials.
Other Products Cited: AWT with DCT Heart Valve Testing HiCycle Durability Tester Pulse Duplicator
Visit SourceJunke Yao, Xinyi Pi, Giorgia Maria Bosi, Gaetano Burriesci, & Helge Wurdemann. IEEE Robotics and Automation Letters, vol. 10, no. 2, pp. 1114-1121, Feb 2025.
The main goal of this study is to analyze the phase synchrony of balloon inflation with cardiac frequency using a robotic device and assess its dilatation performance compared to the standard. A pressure sensor was hydraulically connected to the ventricular chamber of a ViVitro Pulse Duplicator (ViVitro Labs, Inc. Victoria, BC, Canada). The ViVitest software enables the analysis of the flow rate and pressures of the aortic and ventricular chambers and the estimation of the effective orifice area. Our method shows better dilatation performance, as evidenced by notable improvements in pressure gradient and aortic valve opening area.
Other Products Cited: Pulse Duplicator
Visit SourceJanarthanan Sathananthan MBChB, MPH Mark Hensey MB BCh BAO Rob Fraser MSc Uri Landes MD Philipp Blanke MD Hoda Hatoum PhD Lakshmi Prasad Dasi PhD Alexander Sedaghat MD Vinayak N Bapat MD Jonathon Leipsic MD Lars Søndergaard MD, DMSc David A. Wood MD John G. Webb MD - Catheterization and Cardiovascular Interventions October 2019
...Bench study assessed the hydrodynamic performance of different sizes of self‐expanding supra‐annular THVs in three different surgical aortic bioprostheses at different implantation depths.... ...A small versus medium ACURATE neo (ACn), and a 26 mm versus 29 mm Evolut R were assessed after VIV implantation in 25 mm Mitroflow, Mosaic, and Magna Ease aortic surgical bioprostheses, at three implantation depths (+2 mm, ‐2 mm, and ‐6 mm).... ...Use of a larger self‐expanding THV was associated with superior hydrodynamic performance if the THV was implanted high....
Other Products Cited: Pulse Duplicator
Visit SourceJanarthanan Sathananthan, Stephanie Sellers, Aaron Barlow, Rob Fraser, Viktória Stanová, Anson Cheung, Jian Ye, Abdullah Alenezi, Dale J. Murdoch, Mark Hensey, Danny Dvir, Philipp Blanke, Régis Rieu, David Wood, Phillippe Pibarot, Jonathan Leipsic and John Webb - JACC: Cardiovascular Interventions Volume 11, Issue 17, September 2018
Objectives This study assessed the effect of overexpansion beyond labeled size (diameter) of transcatheter heart valves through an ex vivo bench study... Background Transcatheter heart valves function optimally when expanded to specific dimensions. However, clinicians may sometimes wish to overexpand balloon-expandable valves to address specific clinical challenges. The implications of overexpansion have assumed considerable importance, and objective information to guide practice is limited...
Other Products Cited: Pulse Duplicator
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