Articles Related to Ex ViVo Simulation

Meskin, M., Starkey, P.A., Kaspersen, A.E. et al. Sci Rep 14, 1864 (2024).

To understand the mechanisms and to assess the performance of cardiac devices and interventions, in vitro models can be used to replicate the complex physiological interplay between the pulmonary veins, left atrium, and left ventricle. It includes a pulsatile electromechanical pump (SuperPump AR Series, ViVitro Labs, Victoria, British Columbia, Canada) that provides the volume changes in the rigid LV chamber during the cardiac cycle. This study presents a new versatile left heart MCL that accurately captures the complex and interrelated sequences of left heart events and provides supplementary understanding of left heart fluid dynamics.

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Zhu Y, Park MH, Pandya PK, Stark CJ, Mullis DM, Walsh SK, Kim JY, Wu CA, Baccouche BM, Lee SH, Baraka AS, Joo H, Yajima S, Elde S, Woo YJ. Ann Cardiothorac Surg 2023;12(4):326-337

The goal was to preserve the native aortic valve (AV) leaflets in patients with aortic root aneurysm with or without aortic regurgitation (AR). The ex vivo system consists of a linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) to generate a physiologic waveform in compliance with ISO 5840 standards. Similar to our previous ex vivo evaluation of the VSARR operation, we again confirmed that SG, compared with sinus containing graft, most closely recapitulated the native aortic root biomechanics.

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Shin Yajima, Yuanjia Zhu, Charles J. Stark, Robert J. Wilkerson, Matthew H. Park, Elde Stefan, Y. Joseph Woo, The American Association for Thoracic Surgery

This study aimed to biomechanically evaluate the force profiles on the anterior primary and secondary chordae after neochord repair for anterior valve prolapse with varied degrees of residual mitral regurgitation using an ex vivo heart simulator. Briefly, a 3D printer was used to rapidly develop a prototype of a modular left heart coupled to a pulsatile linear actuator (ViVitro Superpump; ViVitro Labs). In our ex vivo AVP model, moderate residual MR following neochord repair was significantly associated with increased forces for both anterior primary and secondary chordae compared with those of less-than-moderate residual MR.

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Leila Louise Benhassen, Jacob Hesselby Hedensted, Mona Sharghbin, Tommy Bechsgaard, Sten Lyager Nielsen, John Michael Hasenkam, Peter Johansen, European Journal of Cardio-Thoracic Surgery, Volume 63, Issue 5, May 2023

For patients with isolated aortic regurgitation, a double sub- and supravalvular annuloplasty has been shown to reduce recurrent aortic regurgitation after aortic valve repair compared with a single subvalvular annuloplasty. The ventricular chamber was connected to an electromechanical piston pump system (Superpump AR series, ViVitro labs, Victoria, Canada). These two findings support the concept of a functional aortic annulus, where the two levels interact and affect the function and competence of the aortic valve.

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Luca Rosalia, Caglar Ozturk, Jaume Coll-Font, Yiling Fan, Yasufumi Nagata, Manisha Singh, Debkalpa Goswami, Adam Mauskapf, Shi Chen, Robert A. Eder, Efrat M. Goffer, Jo H. Kim, Salva Yurista, Benjamin P. Bonner, Anna N. Foster, Robert A. Levine, Elazer R. Edelman, Marcello Panagia, Jose L. Guerrero, Ellen T. Roche & Christopher T. Nguyen, Nature Biomedical Engineering volume 6, pages 1134–1147 (2022)

Advances in soft robotics have led to the development of high-fidelity simulators of pathophysiology for biomedical applications. An MCL was built using a pulsatile pump (SuperPump, ViVitro Labs), an anatomically accurate compliant silicone aortic vessel (E ≈ 1 MPa, United Biologics) connected to two adjustable compliance chambers (that is, ventricular, systemic), and a resistive valve. The models leverage haemodynamic mimicry and may facilitate the development of patient-specific applications. The models could also facilitate the clinical translation of treatments; in particular, a cohort of AS patients could be recapitulated in an in vivo porcine model, and new treatments could be evaluated preclinically.

Other Products Cited:  Endovascular Simulator  Flow Visualization  Pulsatile Flow Simulation  SuperPump  Tissue Engineering

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Y. Zhu, A. M. Imbrie-Moore, R. J. Wilkerson, M. J. Paulsen, M. H. Park & Y. Joseph Woo, BMC Cardiovascular Disorders volume 22, Article number: 73 (2022)

...The left heart simulator, which has been previously described, features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, British Columbia, Canada) to generate physiologic parameters using the pump controller and software (ViVitest Software, ViVitro Labs) programmed in accordance with ISO 5840 standards for in vitro valve testing...The mitral annular dilation system successfully generated an ex vivo mitral annular dilation model with MR...

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S. Zhan-Moodie, D. Xu, K. S. Suresh, Q. He, D. Onohara, K. Kalra, R. A. Guyton, E. L. Sarin, M. Padala. JTCVS Open.

...actuating pump with a viscoelastic impedance (Superpump, Vivitro Labs, London, ON) was connected to the LV, and programmed to generate physiological left ventricular pressures. 0.9% saline was used as the working medium in this flow loop...

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Annabel M. Imbrie-Moore, Cole C. Paullin, Michael J. Paulsen, Frederick Grady, Hanjay Wang, Camille E. Hironaka, Justin M. Farry, Haley J. Lucian. Y. Joseph Woo - Medical Engineering & Physics Available online 31 January 2020

...This work shows the design and implementation of a 3D-printed valve dilation device to preferentially dilate the posterior mitral valve annulus... ...In brief, a custom 3D-printed left heart chamber (Fig. 2A) was mounted to a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) with the ability to generate physiologic conditions … ...this annular dilation device provides the means to investigate the design and optimization of novel annuloplasty rings....

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Michael J Paulsen, Annabel M Imbrie-Moore, Hanjay Wang, Jung Hwa Bae, Camille E Hironaka, Justin M Farry, Haley J Lucian, Akshara D Thakore, John W MacArthur, Jr, Mark R Cutkosky, Y Joseph Woo - European Journal of Cardio-Thoracic Surgery, ezz258

Posterior ventricular anchoring neochordal (PVAN) repair is a non-resectional technique for correcting mitral regurgitation (MR) due to posterior leaflet prolapse, utilizing a single suture anchored in the myocardium behind the leaflet... ...Porcine mitral valves were mounted in a 3-dimensional-printed heart simulator and chordal forces, haemodynamics and echocardiography were collected at baseline, after inducing MR by severing chordae, and after PVAN repair.... ...PVAN repair eliminates MR by positioning the posterior leaflet for coaptation, distributing forces throughout the valve....

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Yen Ngoc Nguyen, Edgar Lik Wui Tay, Foad Kabinejadian, Chi Wei Ong, Munirah Ismail, and Hwa Liang Leo -American Journal of Physiology-Heart and Circulatory Physiology 11 OCT 2019

The deteriorating nature of severe functional tricuspid regurgitation (FTR) has led to the heightened interest in this pathology... ...In this study, the hemodynamics of the right ventricle (RV) after (i) clover edge-to-edge tricuspid repair and (ii) double orifice tricuspid repair was evaluated in three right heart models using an ex vivo pulsatile platform emulating severe FTR with the aid of stereoscopic particle image velocimetry... … circulation (35). A closed ventricular chamber housing the silicon RV model was directly 184 connected to the pulsatile wave-generating piston pump (SuperPump AR series, ViVitro Labs 185 Inc., Victoria, BC, Canada) to …

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MJ Paulsen, JH Bae, A Imbrie-Moore, H Wang, CE Hironaka, JM. Farry, H Lucian, AD Thakore, MR Cutkosky, WJ Woo … - Journal of Biomechanical Engineering Accepted manuscript posted July 1, 2019 2019

Few technologies exist that can provide quantitative data on forces within the mitral valve apparatus... Using FBG sensors, we created a force-sensing neochord that mimics the natural shape and movement of native chordae.... … Redwood City, CA, USA) was mounted to a programmable pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) with the ability to generate physiologic conditions using the pump controller and …

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Keyvan Amini Khoiy, Kourosh T. Asgarian, Francis Loth, Rouzbeh Amini - PLOS ONE Published: November 8, 2018

Chordae rupture is one of the main lesions observed in traumatic heart events that might lead to severe tricuspid valve (TV) regurgitation... ...we investigated the changes on TV geometry, mechanics, and function of ex-vivo porcine hearts following chordae rupture... … The schematic of this apparatus is shown in Fig 1. In short, a positive displacement pump (SuperPump AR Series, Vivitro Labs, Inc., Victoria, BC, Canada) was utilized to induce passive beating in porcine hearts …

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Charles H. Bloodworth MS IV Eric L. Pierce PhD Keshav Kohli MS Nancy J. Deaton BS Kaitlin J. Jones BS Radhika Duvvuri BS Norihiko Kamioka MD Vasilis - C. Babaliaros MD Ajit P. Yoganathan PhD - Catheterization and Cardiovascular Interventions 09 August 2018

...Leaflet tethering commonly seen in functional mitral regurgitation may be a significant factor affecting the severity of MS after MitraClip implantation... … conditions. A piston pump (Vivitro Labs Inc. Victoria, Canada) drove physiological left heart flow within the simulator, while an electromagnetic flow probe (Carolina Medical Electronics, East Bend, NC) measured cardiac output (CO) …

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Keyvan Amini Khoiy, Dipankar Biswas, Thomas N Decker, Kourosh T Asgarian, Francis Loth and Rouzbeh Amini Circulation November 11, 2016, Volume 134, Issue Suppl 1

...study to establish a framework for the measurement of the deformation of TV leaflets in a passive ex-vivo beating heart that mimicked the right ventricular dynamic pressure of the normal hearts. ...apexes of fresh porcine hearts (n= 8) were connected to a positive displacement pump (SuperPump AR Series, Vivitro Labs Inc., BC) to generate pulsatile flow in the right side of the hearts. The superior vena cava was connected to a reservoir as the inflow pathway and the pulmonary artery was used for the outflow pathway...

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Keyvan Amini Khoiy, Dipankar Biswas, Thomas N. Decker, Kourosh T. Asgarian, Francis Loth and Rouzbeh Amini; Journal of Biomechanical Engineering revised August 23, 2016

...For the first time, the porcine valve leaflets deformation was measured in a passive ex-vivo beating heart without isolating and remounting the valve annuli. In particular, the right ventricular apexes of porcine hearts (n = 8) were connected to a pulse-duplicator pump that maintained a pulsatile flow from and to a reservoir connected to the right atrium and the pulmonary arteries... A positive displacement pump 116 (SuperPump AR Series, Vivitro Labs Inc., BC, Canada) was connected to the apex of the right 117 ventricle after an incision was carefully made at this location (as described in more detail below)...

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Konduri S, Xing Y, Warnock JN, He Z, Yoganathan AP. - Ann Biomed Eng. 2005 Sep;33(9):1158-66.

The aortic valve functions in a complex mechanical environment which leads to force-dependent cellular and tissue responses. Characterization of these responses provides a fundamental understanding of valve pathogenesis. The aim of this work was to study the biological characteristics of native porcine aortic valves cultured in an ex vivo pulsatile organ culture system capable of maintaining physiological pressures (120/80 mmHg) and cardiac output (4.2 l/min).

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Hadi Daood Toeg, Ovais Abessi , Talal Al-Atassi, Laurent de Kerchove, Gebrine El-Khoury, Michel Labrosse, Munir Boodhwani, - Cardiovasc Surg, 2014

ABSTRACT Aortic valve (AV) repair (AVr) has become an attractive alternative to AV replacement for the correction of aortic insufficiency; however, little clinical evidence exists in determining which biomaterial at AVr would be optimal. Cusp replacement in AVr has... All aortic roots were connected to the ViVitro Left Heart Simulator (LHS; ViVitro Systems, Inc, Victoria, British Columbia, Canada) for baseline valve measurements acting as paired controls...

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James N. Warnock, Suchitra Konduri; Journal of Biomechanical Engineering: 127, Issue 5; 857.

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Osamu Kawaguchi, MD, Yoichi Goto, MD, Shiho Futaki, MD, Yuichi Ohgoshi, MD, Hitoshi Yaku, MD, Hiroyuki Suga, MDa; The Journal of Thoracic and Cardiovascular Surgery: 107; 850-859; 1994.

The purpose of this study was to determine the role of ventricular size or contractility in the effectiveness of dynamic cardiac compression in terms of the pressure-volume relationship and myocardial oxygen consumption. In 10 isolated cross-circulated dog hearts, the ventricle was directly compressed during systole.

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Osamu Kawaguchi, MDa, Yoichi Goto, MDb, Yuichi Ohgoshi, MDb, Hitoshi Yaku, MDb, Mitsuya Murase, MDa, Hiroyuki Suga, MDc; The Journal of Thoracic and Cardiovascular Surgery: 113; 923-931; 1997.

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