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Ex vivo biomechanical analysis of flexible versus rigid annuloplasty rings in mitral valves using a novel annular dilation system

Y. Zhu, A. M. Imbrie-Moore, R. J. Wilkerson, M. J. Paulsen, M. H. Park & Y. Joseph Woo, BMC Cardiovascular Disorders volume 22, Article number: 73 (2022)

...The left heart simulator, which has been previously described, features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, British Columbia, Canada) to generate physiologic parameters using the pump controller and software (ViVitest Software, ViVitro Labs) programmed in accordance with ISO 5840 standards for in vitro valve testing...The mitral annular dilation system successfully generated an ex vivo mitral annular dilation model with MR...

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Biomechanical Engineering Analysis of an Acute Papillary Muscle Rupture Disease Model Using an Innovative 3D-Printed Left Heart Simulator

M. Marin-Cuartas, Y. Zhu, A. M. Imbrie-Moore, M. H. Park, R. J. Wilkerson, M. Leipzig, P. K. Pandya, M. J. Paulsen, M. A. Borger, Y. J. Woo, Interactive CardioVascular and Thoracic Surgery (2021) 1–9

...The severity of acute papillary muscle (PM) rupture varies according to the extent and site of the rupture. However, the haemodynamic effects of different rupture variations are still poorly understood...A 3D printer (Carbon 3D, Redwood City, CA, USA) was used to prototype a modular left heart (left atrium and ventricle) and was mounted to a pulsatile linear piston pump (ViVitro Superpump; ViVitro Labs, Victoria, BC, Canada)...

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Ex Vivo Model of Ischemic Mitral Regurgitation and Analysis of Adjunctive Papillary Muscle Repair

A. Imbrie-Moore, Y. Zhu, T. Bandy-Vizcaino, M. Park, R. Wilkerson, Y. Woo, Annals of Biomedical Engineering, 49

Driven by a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) which generates physiologic hemodynamics in accordance with ISO 5840 in vitro cardiac valve testing standards.

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Impact of simulated MitraClip on forward flow obstruction in the setting of mitral leaflet tethering: An in vitro investigatio

Charles H. Bloodworth MS IV Eric L. Pierce PhD Keshav Kohli MS Nancy J. Deaton BS Kaitlin J. Jones BS Radhika Duvvuri BS Norihiko Kamioka MD Vasilis - C. Babaliaros MD Ajit P. Yoganathan PhD - Catheterization and Cardiovascular Interventions 09 August 2018

...Leaflet tethering commonly seen in functional mitral regurgitation may be a significant factor affecting the severity of MS after MitraClip implantation... … conditions. A piston pump (Vivitro Labs Inc. Victoria, Canada) drove physiological left heart flow within the simulator, while an electromagnetic flow probe (Carolina Medical Electronics, East Bend, NC) measured cardiac output (CO) …

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In Vitro Evaluation of Hemodynamic Performance for Right Ventricular Outflow Tract RVOT Reconstruction with Trileaflet ePTFE Valved Conduit

Wei-Ling ChenChiu-Chin WuChung-Dann Kan - World Congress on Medical Physics and Biomedical Engineering 2018 pp 519-524

...Percutaneous pulmonary valve implantation (PPVI) has evolved as most exciting development surgical strategy with dysfunctional right ventricle-pulmonary artery conduits. ... ...The purpose of this study is to investigate the hemodynamic and functional consequences of the new design using a mock circulation system... … vasculature. Blood pressures and flows are driven by a digitally controlled hydraulic piston pump (ViViTro Labs Inc., Super Pump System, Victor, BC) to produce pulsatile waves with heart rates of 60 and 80 beats/min from ARV to ARA …

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Assistive technology using regurgitation fraction and fractional-order integration to assess pulmonary valve insufficiency for pre-surgery decision making and post-surgery outcome evaluation

Wei-Ling Chena, Chia-Hung Linb, Jieh-Neng Wangc, Pong-Jeu Lud, Ming-Yao Chand, Jui-Te Wue, Chung-Dann Kanf

...This study proposes an assistive technology to quantify regurgitation using the regurgitation fraction (RF) and heart pump efficiency (HPE). … pulmonary valves. The blood pressure and flow were driven by a digitally controlled hydraulic piston pump (ViViTro Labs Inc., Super Pump System, Victor, BC) to produce pulsatile waves with heart rates of 60 and 80 beats/min. The …

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Experimental Investigation of Left Ventricular Flow Patterns After Percutaneous Edge‐to‐Edge Mitral Valve Repair

M Jeyhani, S Shahriari, M Labrosse - Artificial Organs, 2017 First published: 23 November 2017

This in vitro study aims to evaluate the hemodynamic modifications following a simulated PEtER. A custom-made mitral valve was developed, and two configurations were tested: (i) a single-orifice valve with mitral regurgitation and (ii) a double-orifice mitral valve configuration following PEtER. … MATERIALS AND METHODS In vitro model For the purpose of this study, a ViVitro pulse duplicator (ViVitro Labs, Victoria, BC, Canada) was used (Fig. 1). This system is capable of reproducing physiological flow and pressure waveforms in left heart cavity models …

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