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H.Sodawalla, M.Alnajrani, J.Wells, et al., Journal of Biomedical Materials Research Part B: Applied Biomaterials114, no. 2 (2026): e70030
The ViVitro SuperPump enabled a physiologically relevant benchtop platform for evaluating treatment strategies for giant intracranial aneurysms using a rupture-prone 3D-printed model. In this study, researchers implemented a custom flow loop to compare flow diverter-only treatment, flow diverter combined with synthetic thrombus, and flow diverter with liquid embolic, while continuously monitoring intra-aneurysmal pressure and time to rupture. The results demonstrate that benchtop aneurysm testing provides a practical and repeatable approach for assessing treatment performance and mechanical stability under controlled physiological conditions, while underscoring the value of realistic in-vitro models for preclinical device evaluation
Other Products Cited: Peripheral devices testing Pulsatile Flow Simulation SuperPump
Visit SourceTymoshenko V, Suria AJ, Dimonte G, et al. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 2026;0(0).
This study demonstrates how the ViVitro Labs SuperPump enables precise control of flow and stroke, providing the stable and clinically relevant hemodynamic conditions required to accurately quantify leakage. Automated versus manual suturing techniques in Bentall procedures were evaluated using an ex vivo passive beating heart model integrated into an advanced mock circulatory loop (MCL) platform. Twenty porcine hearts underwent Bentall surgery with either automated or manual suturing and were tested under progressively increasing aortic pressures using the ViVitro Labs SuperPump. The results revealed no significant difference in anastomotic leakage between the two techniques, even under hypertensive conditions. These findings indicate that automated suturing achieves comparable holding strength and hemostatic performance to manual methods, supporting its use in complex aortic root procedures.
Other Products Cited: Peripheral devices testing Pulsatile Flow Simulation SuperPump
Visit SourceMerhi, Y., Montero, K.L., Johansen, P. et al. npj Flex Electron 10, 31 (2026).
This work highlights how ViVitro systems enable realistic cardiovascular bench testing for next-generation bioelectronic devices, helping advance translational implant development. Using a ViVitro SuperPump to recreate physiologically relevant pulsatile left-heart conditions, this study evaluates a biodegradable PLLA piezoelectric sensor for real-time monitoring during aortic annuloplasty. The authors enhanced PLLA film performance through uniaxial stretching and thermal annealing, significantly increasing voltage output and enabling stable, pressure-correlated sensing in a ring-like prototype. Within the in-vitro setup, the sensor produced repeatable signals across clinically relevant pressure ranges, supporting its potential as a temporary smart implant.
Other Products Cited: Customized circulatory systems Peripheral devices testing Pulsatile Flow Simulation SuperPump
Visit SourceMichael A. Bielecki, Julianne H. Spencer, Paul A. Iaizzo
Pumping New Life into Heart Research: How ViVitro's Superpump is Changing TAVR Studies In this study, researchers took a unique approach by reanimating swine and human hearts with a ViVitro Superpump to investigate how TAVR implantation affects coronary pressure. Using the Superpump and detailed CT scans, they measured what they call the Estimated Leaflet to Ostium Distance, or ELOD, and found a clear correlation: the shorter that distance, the more coronary pressure could drop. In other words, by getting these hearts beating again in a lab setting, they demonstrated that ELOD might be a better predictor of coronary obstruction risk than some traditional measurements. It’s a solid example of how ViVitro’s technology is helping refine our understanding of heart valve procedures, all without the need for animal or patient trials.
Other Products Cited: Customized circulatory systems Ex ViVo Simulation Pressure Measurement System SuperPump
Visit SourceCamilo E Pérez-Cualtán et al 2025 Prog. Biomed. Eng. 7 042007
Using a modified ViVitro Pulse Duplicator system, researchers achieved one of the most advanced preclinical test benches to date for Transcatheter Pulmonary Valve Replacement (TPVR). This platform allowed integration of patient-specific 3D-printed pulmonary artery models to evaluate valve hemodynamics under physiologic conditions. The ViVitro system enabled precise measurement of pressure gradients and regurgitation, which were then compared with in vivo catheterization data—demonstrating excellent correlation and validating the use of 3D-printed geometries for personalized testing. This work highlights how ViVitro technology facilitates translational research by linking computational design, in-vitro modeling, and clinical validation to optimize device sizing and placement for complex congenital heart conditions.
Other Products Cited: Analysis and Computational Modeling Heart Valve Testing Pulse Duplicator
Visit SourceJosien Snoeijink, T., Lucas van der Hoek, J., Mirgolbabaee, H., Gerard Vlogman, T., Roosen, J., Frank Wilhelmus Nijsen, J., & Groot Jebbink, E. Journal of Endovascular Therapy. 2025.
A symmetrical phantom with circular successively bifurcating vessels was developed to study the behavior of the clinical catheter during microsphere injection. The outlets led to an open fluid collection reservoir, which was connected to a continuous pump and a pulsatile pump (SuperPump, ViVitro labs, Victoria, Canada). The most interesting finding from this study was the observed motion of the clinical catheter and its influence on the microsphere distribution.
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Visit SourceOdemis, E., Başar Aka, I., & Han Kızılkaya, M. Pediatric Cardiology. 2025.
This study assesses the Pulsta THV® valve’s in vitro hemodynamic performance across these RVOT morphologies using 3D-printed models. For this study, valves were tested using the ViVitro Pulse Duplicator System (ViVitro Labs Inc., Victoria, BC), a system designed to simulate physiological conditions as used in previous studies. Our experiments demonstrated that the larger valve size consistently had lower regurgitation rates across all cardiac outputs.
Other Products Cited: Heart Valve Testing Pulsatile Flow Simulation Pulse Duplicator
Visit SourceSibut-Pinote, Vincent; Reymon, Philippe; Cikirikcioglu, Mustafa; Bendjelid, Karim; Huber, Christoph. ASAIO Journal ():10.1097/MAT.0000000000002454, May 13, 2025.
Use of the ViVitro Labs Super Pump to build a complex mock circulatory loop to study the effect of VA-ECMO/IABP combination on the with systemic, coronary, cerebral, and renal circulation. In this study the ViVitro Labs system is used to improve the outcome of clinical procedures. "We used the same silicone circuit as in our previous publication (model ref T-S-N-009+; Elastrat, Geneva, Switzerland). To prevent the formation of air bubbles when testing at a heart rate of 100 bpm, and to improve the quality of aortic flow measurements, a rigid plastic grid was placed in the compliance reservoir tank. We used a pulsatile pump (Superpump; ViVitro Labs, Inc., Victoria, BC, Canada) to simulate cardiac function at the circuit inlet. Positioning the pump in line with the aortic root was the configuration with the fewest disturbances flow and pressure measurements (Figure 1)"
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Visit SourceSmid CC, Haselmann C, Irani SK, Cesnjevar R, Schweiger M, Pappas GA
This study demonstrates how the ViVitro Labs Pulsatile flow pump was used to design a customized pulse duplicator system to assess the hydrodynamic performance of a pediatric “biological valve model (BVM)”. The flow loop integrates a unique system to simulate aortic annulus expansion. The performance of the patient-tailored valve was benchmarked against a commercially available pulmonary conduit along with an in-house built polyurethane valve. This research provides valuable insight on valve design potential improvements and demonstrates how ViVitro systems can play a critical role in valve performance assessment.
Other Products Cited: Customized circulatory systems Heart Valve Testing SuperPump
Visit SourceKedwai, Baqir et al. JVS-Vascular Science, Volume 6, 100287
AAA sac management with persistent growth or endoleak in patient continue to be a challenge. This publication demonstrates the modularity of the ViVitro Labs Pulsatile Flow Pump in building advanced mock circulatory loops, and how the ViVitro Labs systems can be used to assess the impact of an embolization technique on the reduction of AAA sac volume and improve a procedure clinical outcome. "A Vivitro SuperPump (Victoria, BC, Canada) cardiac simulator was connected to both ends of a 30-gallon plastic basin using plastic tubing. The graft model construct was placed into the basin and securely attached proximally and distally to the plastic tubing with circumferential clamps. The basin was filled with water and gel beads for optimal acoustic conditions. Once the model was connected to the flow circuit, water was pumped through the system at 70 beats per minute with an average flow rate of 3.5 L/min."
Other Products Cited: Customized circulatory systems Endovascular Simulator Peripheral devices testing Stent and Stent/Graft SuperPump
Visit SourceMao, P.; Jin, M.; Li, W.; Zhang, H.; Li, H.; Li, S.; Yang, Y.; Zhu, M.; Shi, Y.; Zhang, X.; et al. Biomedicines 2025, 13, 1135.
This research the left ventricular chamber of a ViVitro Labs Pulse was customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. The ViVitro Labs Pulse chamber design and structure provides maximum modularity to create unique support without compromising system performance. "The TaurusOne was tested in vitro in a pulse duplicator system (ViVitro Labs Inc., Victoria, BC, Canada) (Figure 1b), operating at a rate of 70 beats per minute (bpm). The test chamber was filled with 37 °C distilled water to simulate the testing environment recommended by ISO 5840-3 [20]. A linear motor-driven plunger pump was used to precisely control the pressure values on both sides of the fluid according to the aortic valve pressure gradient curve of the clinical patient"
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Visit SourceHernandez Torres, S. I., Caldwell, N. W., & Snider, E. J. Bioengineering, 11(12), 1271.
Here, we conduct independent evaluation testing of the Vu-Path™ Ultrasound Guidance system, or Vu-Path™. The device was evaluated using a custom, modular tissue-mimicking phantom that can easily be adjusted to multiple different vessel diameters. The phantom was connected to a flow loop with a pulsatile, heart-mimicking pump (ViVitro Labs, Victoria, BC, Canada) circulating water, and pressure was quantified by sensors connected to a patient monitor. Overall, the Vu-Path™ device performed well for this vascular access task across the standardized test pipeline we presented.
Other Products Cited: SuperPump Ultrasound Measurements
Visit SourceZhu, Y., Imbrie-Moore, A.M., Park, M.H. et al. Commun Med 5, 40 (2025). https://doi.org/10.1038/s43856-025-00753-6
This research demonstrates how the left ventricular chamber of a ViVitro Labs Pulse can be customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. "The ex vivo left heart simulator, which has been previously described17,18,19,20,21, features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) which generates physiologic hemodynamics in accordance with ISO 5840 in vitro cardiac valve testing standards using the pump controller and software (ViVitest Software, ViVitro Labs, Fig. 3d)."
Other Products Cited: Heart Valve Repair Pulse Duplicator
Visit SourceLevent Beker, Alp Toymus, Süleyman Peker, Abdülkadir Atik, Umut Yener, Maide Albay, Emel Yılgör, İskender Yılgör. Research Square. 08 January 2025.
Despite the rapid emergence of wearable ultrasound technologies in the research community, the common practice still requires wired connections to benchtop instruments. For the in vitro characterization of the heart rate and blood pressure monitoring US tag, a pulsatile pump (SuperPump, ViVitro Labs) with a silicone rubber vessel was used. Thanks to the advances in soft materials, fabrication techniques and sensing strategies, wearable medical devices are revolutionizing the healthcare system by enabling continuous and quantitative assessment of various biomarkers.
Other Products Cited: Customized circulatory systems Pulsatile Flow Simulation SuperPump Ultrasound Measurements
Visit SourceGhanbarzadeh-Dagheyan A, van Helvert M, van de Velde L, Reijnen MMPJ, Versluis M, Groot Jebbink E. Journal of Endovascular Therapy. 2024;0(0).
Helical stents have been developed to treat peripheral arterial disease (PAD) in the superficial femoral artery (SFA), with the premise that their particular geometry could promote swirling flow in the blood. The aim of this work is to provide evidence on the existence of this swirling flow by quantifying its signatures. The flow setup consisted of a programmable piston pump (Super Pump, Vivitro, Victoria, Canada), to create pulsating flow. The in vitro results show that skewedness is increased due to the helical geometry of the stents.
Other Products Cited: Customized circulatory systems Flow Visualization Stent and Stent/Graft SuperPump
Visit SourceRafiei D, Pahlevan NM, PLoS ONE 19(12): e0310793
Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. To create a systolic contraction, the compliant LV sac is squeezed inside a fluid-filled plexiglass container using a programmable piston pump (ViVitro Labs Inc, SuperPump, AR SERIES). Our principal finding is that CoA increases cerebral blood flow and harmful pulsatile energy transmission to the brain.
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Visit SourceCaroline C. Smid, Georgios A. Pappas, Nikola Cesarovic, Volkmar Falk & Paolo Ermanni
This study discussed novel flexible leaflet designs, focusing on polymeric materials with proven hemocompatibility, such as polyether ether ketone, of much higher stiffness than native tissue, aiming at optimal valve implants
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Visit SourceSébastien Hecht MSc, Mohamed-Salah Annabi MD, MSc, Viktória Stanová PhD, Abdellaziz Dahou MD, PhD, Ian G. Burwash MD, Matthias Koschutnik MD, Philipp E. Bartko MD, Jutta Bergler-Klein MD, Julia Mascherbauer MD, Carolina Donà MD, Stefan Orwat MD, Helmut Baumgartner MD, Joao L. Cavalcante MD, Henrique B. Ribeiro MD, PhD, Alexis Théron MD, PhD, Josep Rodes-Cabau MD, Marie-Annick Clavel DVM, PhD, Philippe Pibarot DVM, PhD, JACC: Advances, Volume 3, Issue 10, 2024
The purpose of this study was to evaluate the diagnostic and prognostic value of MG/EOA ratio. Contraction of the left ventricle is achieved by a piston pump (Vivitro Inc). MG/EOA ratio can be useful in low-flow, LG-AS to confirm AS severity and may complement DSE or aortic valve calcium scoring.
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Visit SourceMichele Mastrogiacomo. Rel. Stefania Scarsoglio, Vrishank Raghav. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Aerospaziale, 2024
Given the prevalence and impact of Paravalvular Leakage, there is a critical need to study and mitigate this issue to improve patient outcomes. The experimental setup replicates the human left heart, featuring a Pulsatile Pump ViVitro, an em-tec flow meter, pressure taps, and a transparent acrylic test chamber housing a heart valve. The results of the experiments indicate that a wall jet forms during diastole, flowing back from the aortic side into the ventricular side.
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Visit SourceHoving, A.M., Mikhal, J., Kuipers, H. et al. Med Biol Eng Comput 62, 1165–1176 (2024).
To investigate flow conditions in a double-layered carotid artery stent, a bench-top in vitro flow setup including a bifurcation phantom was designed and fabricated. For the introduction of pulsatile flow, a linear piston pump (Superpump AR, ViVitro Labs, Victoria, BC, Canada) and two compliances were added to the stationary circuit. We illustrated, with 3D printing and molding, how it is possible to transfer geometry from literature to a model and thereafter to a flexible phantom.
Other Products Cited: Customized circulatory systems Flow Visualization Pulsatile Flow Simulation
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