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H.Sodawalla, M.Alnajrani, J.Wells, et al., Journal of Biomedical Materials Research Part B: Applied Biomaterials114, no. 2 (2026): e70030
The ViVitro SuperPump enabled a physiologically relevant benchtop platform for evaluating treatment strategies for giant intracranial aneurysms using a rupture-prone 3D-printed model. In this study, researchers implemented a custom flow loop to compare flow diverter-only treatment, flow diverter combined with synthetic thrombus, and flow diverter with liquid embolic, while continuously monitoring intra-aneurysmal pressure and time to rupture. The results demonstrate that benchtop aneurysm testing provides a practical and repeatable approach for assessing treatment performance and mechanical stability under controlled physiological conditions, while underscoring the value of realistic in-vitro models for preclinical device evaluation
Other Products Cited: Customized Circulatory Loop Peripheral devices testing Pulsatile Flow Simulation
Visit SourceTymoshenko V, Suria AJ, Dimonte G, et al. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 2026;0(0).
This study demonstrates how the ViVitro Labs SuperPump enables precise control of flow and stroke, providing the stable and clinically relevant hemodynamic conditions required to accurately quantify leakage. Automated versus manual suturing techniques in Bentall procedures were evaluated using an ex vivo passive beating heart model integrated into an advanced mock circulatory loop (MCL) platform. Twenty porcine hearts underwent Bentall surgery with either automated or manual suturing and were tested under progressively increasing aortic pressures using the ViVitro Labs SuperPump. The results revealed no significant difference in anastomotic leakage between the two techniques, even under hypertensive conditions. These findings indicate that automated suturing achieves comparable holding strength and hemostatic performance to manual methods, supporting its use in complex aortic root procedures.
Other Products Cited: Customized Circulatory Loop Peripheral devices testing Pulsatile Flow Simulation
Visit SourceMerhi, Y., Montero, K.L., Johansen, P. et al. npj Flex Electron 10, 31 (2026).
This work highlights how ViVitro systems enable realistic cardiovascular bench testing for next-generation bioelectronic devices, helping advance translational implant development. Using a ViVitro SuperPump to recreate physiologically relevant pulsatile left-heart conditions, this study evaluates a biodegradable PLLA piezoelectric sensor for real-time monitoring during aortic annuloplasty. The authors enhanced PLLA film performance through uniaxial stretching and thermal annealing, significantly increasing voltage output and enabling stable, pressure-correlated sensing in a ring-like prototype. Within the in-vitro setup, the sensor produced repeatable signals across clinically relevant pressure ranges, supporting its potential as a temporary smart implant.
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Peripheral devices testing Pulsatile Flow Simulation
Visit SourceMichael A. Bielecki, Julianne H. Spencer, Paul A. Iaizzo
Pumping New Life into Heart Research: How ViVitro's Superpump is Changing TAVR Studies In this study, researchers took a unique approach by reanimating swine and human hearts with a ViVitro Superpump to investigate how TAVR implantation affects coronary pressure. Using the Superpump and detailed CT scans, they measured what they call the Estimated Leaflet to Ostium Distance, or ELOD, and found a clear correlation: the shorter that distance, the more coronary pressure could drop. In other words, by getting these hearts beating again in a lab setting, they demonstrated that ELOD might be a better predictor of coronary obstruction risk than some traditional measurements. It’s a solid example of how ViVitro’s technology is helping refine our understanding of heart valve procedures, all without the need for animal or patient trials.
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Visit SourceDelanoë, K., Erwan, S., Rieu, R., Côté, N., Pibarot, P., & Stanová, V. Bioengineering, 2025, 12, 397.
The goal of this study is to enhance the understanding of both healthy and pathological mitral valves by reproducing precisely their anatomical properties and testing them under controlled conditions. Both cavities are surrounded by liquid and are activated by piston-pumps (Vivitro Inc., Victoria, Canada) controlled using LabVIEW8.2. The main finding of this study is that silicon combination EF50DS10 (=V7) was able to replicate the anatomical features of a healthy mitral valve while inducing a normal physiological hemodynamic behavior.
Other Products Cited: Heart Valve Testing Pulsatile Flow Simulation
Visit SourceJosien Snoeijink, T., Lucas van der Hoek, J., Mirgolbabaee, H., Gerard Vlogman, T., Roosen, J., Frank Wilhelmus Nijsen, J., & Groot Jebbink, E. Journal of Endovascular Therapy. 2025.
A symmetrical phantom with circular successively bifurcating vessels was developed to study the behavior of the clinical catheter during microsphere injection. The outlets led to an open fluid collection reservoir, which was connected to a continuous pump and a pulsatile pump (SuperPump, ViVitro labs, Victoria, Canada). The most interesting finding from this study was the observed motion of the clinical catheter and its influence on the microsphere distribution.
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Visit SourceSibut-Pinote, Vincent; Reymon, Philippe; Cikirikcioglu, Mustafa; Bendjelid, Karim; Huber, Christoph. ASAIO Journal ():10.1097/MAT.0000000000002454, May 13, 2025.
Use of the ViVitro Labs Super Pump to build a complex mock circulatory loop to study the effect of VA-ECMO/IABP combination on the with systemic, coronary, cerebral, and renal circulation. In this study the ViVitro Labs system is used to improve the outcome of clinical procedures. "We used the same silicone circuit as in our previous publication (model ref T-S-N-009+; Elastrat, Geneva, Switzerland). To prevent the formation of air bubbles when testing at a heart rate of 100 bpm, and to improve the quality of aortic flow measurements, a rigid plastic grid was placed in the compliance reservoir tank. We used a pulsatile pump (Superpump; ViVitro Labs, Inc., Victoria, BC, Canada) to simulate cardiac function at the circuit inlet. Positioning the pump in line with the aortic root was the configuration with the fewest disturbances flow and pressure measurements (Figure 1)"
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Visit SourceJelle Plomp, Ashkan Ghanbarzadeh-Dagheyan, Michel Versluis, Guillaume Lajoinie, Erik Groot Jebbink, Imaging Behind the Plaque: Improved Blood Flow Quantification Using an Iterative Scheme for Active Attenuation Correction, Ultrasound in Medicine & Biology, Volume 51, Issue 6, 2025, Pages 984-998
This publication demonstrates how the ViVitro Labs Pulsatile Flow Pump can be used to create a mock circulatory flow loop (MCL) in the context of particle image velocimetry (PIV) "To confirm ISAAC's applicability, measurements were also performed using a pulsatile flow with a frequency of 70 beats per minute, produced using the ViVitro SuperPump (ViVitro Labs Inc, Victoria, CA, USA). The setup in Figure 1a was adjusted such that the pulsatile flow would be added to the constant output of the other pump. Approximately two cycles were imaged at 1667 fps, resulting in 3000 frames. Singular value decomposition filtering was performed over all 3000 frames"
Other Products Cited: Flow Visualization Pulsatile Flow Simulation
Visit SourceLuca Bontempi, Marta Zattoni, Anna Ramella, Francesco Migliavacca, Steffen Ringgaard, Won Yong Kim, Peter Johansen, Monika Colombo bioRxiv 2025.03.05.641637
This publication demonstrates the modularity of the ViVitro Labs Pulsatile flow pump and how it can be used to construct an advanced mock circulatory flow-loop (MCL) and obtain boundary flow conditions for an FSI model. "A pulsatile in-vitro MCL was employed to replicate a left heart flow cycle, as previously described [9,10]. . An electromechanical piston pump (VSI Superpump, ViVitro Labs, Victoria, Canada) was connected to the ventricular chamber to generate pulsatile flow and pressure waveforms. The atrial reservoir and ventricular chamber were linked via a mechanical heart valve mimicking the mitral valve, while the ventricular chamber and the compliance chamber were connected through the AR model with the integrated AV"
Other Products Cited: Customized circulatory systems Flow Visualization Heart Valve Repair Pulsatile Flow Simulation
Visit SourceSmid CC, Haselmann C, Irani SK, Cesnjevar R, Schweiger M, Pappas GA
This study demonstrates how the ViVitro Labs Pulsatile flow pump was used to design a customized pulse duplicator system to assess the hydrodynamic performance of a pediatric “biological valve model (BVM)”. The flow loop integrates a unique system to simulate aortic annulus expansion. The performance of the patient-tailored valve was benchmarked against a commercially available pulmonary conduit along with an in-house built polyurethane valve. This research provides valuable insight on valve design potential improvements and demonstrates how ViVitro systems can play a critical role in valve performance assessment.
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Visit SourceKedwai, Baqir et al. JVS-Vascular Science, Volume 6, 100287
AAA sac management with persistent growth or endoleak in patient continue to be a challenge. This publication demonstrates the modularity of the ViVitro Labs Pulsatile Flow Pump in building advanced mock circulatory loops, and how the ViVitro Labs systems can be used to assess the impact of an embolization technique on the reduction of AAA sac volume and improve a procedure clinical outcome. "A Vivitro SuperPump (Victoria, BC, Canada) cardiac simulator was connected to both ends of a 30-gallon plastic basin using plastic tubing. The graft model construct was placed into the basin and securely attached proximally and distally to the plastic tubing with circumferential clamps. The basin was filled with water and gel beads for optimal acoustic conditions. Once the model was connected to the flow circuit, water was pumped through the system at 70 beats per minute with an average flow rate of 3.5 L/min."
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Endovascular Simulator Peripheral devices testing Stent and Stent/Graft
Visit SourceHernandez Torres, S. I., Caldwell, N. W., & Snider, E. J. Bioengineering, 11(12), 1271.
Here, we conduct independent evaluation testing of the Vu-Path™ Ultrasound Guidance system, or Vu-Path™. The device was evaluated using a custom, modular tissue-mimicking phantom that can easily be adjusted to multiple different vessel diameters. The phantom was connected to a flow loop with a pulsatile, heart-mimicking pump (ViVitro Labs, Victoria, BC, Canada) circulating water, and pressure was quantified by sensors connected to a patient monitor. Overall, the Vu-Path™ device performed well for this vascular access task across the standardized test pipeline we presented.
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Visit SourceLevent Beker, Alp Toymus, Süleyman Peker, Abdülkadir Atik, Umut Yener, Maide Albay, Emel Yılgör, İskender Yılgör. Research Square. 08 January 2025.
Despite the rapid emergence of wearable ultrasound technologies in the research community, the common practice still requires wired connections to benchtop instruments. For the in vitro characterization of the heart rate and blood pressure monitoring US tag, a pulsatile pump (SuperPump, ViVitro Labs) with a silicone rubber vessel was used. Thanks to the advances in soft materials, fabrication techniques and sensing strategies, wearable medical devices are revolutionizing the healthcare system by enabling continuous and quantitative assessment of various biomarkers.
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Visit SourceGhanbarzadeh-Dagheyan A, van Helvert M, van de Velde L, Reijnen MMPJ, Versluis M, Groot Jebbink E. Journal of Endovascular Therapy. 2024;0(0).
Helical stents have been developed to treat peripheral arterial disease (PAD) in the superficial femoral artery (SFA), with the premise that their particular geometry could promote swirling flow in the blood. The aim of this work is to provide evidence on the existence of this swirling flow by quantifying its signatures. The flow setup consisted of a programmable piston pump (Super Pump, Vivitro, Victoria, Canada), to create pulsating flow. The in vitro results show that skewedness is increased due to the helical geometry of the stents.
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Visit SourceMerhi Y, Montero KL, Johansen P, Mäntysalo M, Agarwala S, ChemRxiv, 2025
We assessed the piezoelectric performance of poly-L-lactic acid (PLLA) films, fabricated using solvent casting and processed using uniaxial stretching and thermal annealing, through tapping, straining, and force- and vibration-sweep tests. The ventricular chamber was connected to a digitally controlled piston pump (Super Pump, ViVitro, Victoria, BC, Canada), which provided pulsatile flow to simulate left ventricular ejection into the aortic root. These results establish the feasibility of PLLA-based sensors for real-time biomechanical feedback during and after cardiovascular surgeries, paving the way for next-generation monitoring technologies that enhance patient outcomes.
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Visit SourceRafiei D, Pahlevan NM, PLoS ONE 19(12): e0310793
Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. To create a systolic contraction, the compliant LV sac is squeezed inside a fluid-filled plexiglass container using a programmable piston pump (ViVitro Labs Inc, SuperPump, AR SERIES). Our principal finding is that CoA increases cerebral blood flow and harmful pulsatile energy transmission to the brain.
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Visit SourceCaroline C. Smid, Georgios A. Pappas, Nikola Cesarovic, Volkmar Falk & Paolo Ermanni
This study discussed novel flexible leaflet designs, focusing on polymeric materials with proven hemocompatibility, such as polyether ether ketone, of much higher stiffness than native tissue, aiming at optimal valve implants
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Visit SourceSébastien Hecht MSc, Mohamed-Salah Annabi MD, MSc, Viktória Stanová PhD, Abdellaziz Dahou MD, PhD, Ian G. Burwash MD, Matthias Koschutnik MD, Philipp E. Bartko MD, Jutta Bergler-Klein MD, Julia Mascherbauer MD, Carolina Donà MD, Stefan Orwat MD, Helmut Baumgartner MD, Joao L. Cavalcante MD, Henrique B. Ribeiro MD, PhD, Alexis Théron MD, PhD, Josep Rodes-Cabau MD, Marie-Annick Clavel DVM, PhD, Philippe Pibarot DVM, PhD, JACC: Advances, Volume 3, Issue 10, 2024
The purpose of this study was to evaluate the diagnostic and prognostic value of MG/EOA ratio. Contraction of the left ventricle is achieved by a piston pump (Vivitro Inc). MG/EOA ratio can be useful in low-flow, LG-AS to confirm AS severity and may complement DSE or aortic valve calcium scoring.
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Visit SourceLaengle S, Suria A, Poschner T, Tasdelen S, Pitsis A, Kocher A, Andreas M. Bioengineering. 2024; 11(7):666.
Clover repair offers a surgical solution that can be applied for the treatment of primary and secondary Tricuspid regurgitation (TR). Flow was provided by a pulsatile pump system (ViVitro Labs Inc., Victoria, BC, Canada), which was coupled to the right ventricle through a third connector. This new clover technique was demonstrated to successfully reduce TR in an ex vivo porcine heart model.
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Visit SourceMohl, L., Karl, R., Hagedorn, M.N. et al. Int J CARS (2024)
Complicated type B Aortic dissection is a severe aortic pathology that requires treatment through thoracic endovascular aortic repair (TEVAR). A realistic pulsatile flow through the aortic phantom is provided by a cardiac piston pump (Superpump, Vivitro Labs Inc., Victoria, Canada). The flexible aortic dissection phantom was successfully incorporated in the hemodynamic flow loop, a systolic pressure of 112 mmHg and physiological flow of 4.05 L per minute was reached.
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