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Wu, X., Saaid, H., Voorneveld, J., et al. Cardiovasc Eng Tech (2023).
The development of reliable techniques and analysis tools is essential for the application of hemodynamic biomarkers in clinical practice. A commercial piston pump (Vivitro Labs Inc., BC, Canada) was used to impose a sinusoidal-like volume change of the external pressure chamber with a cardiac cycle period of 857 ms (70 bpm, systolic duration of 300 ms, stroke volume 50 ml). The results show that the pressure distribution along the (longitudinal) base-apex axis reverses at the onset and the termination of the LV filling and ejecting, respectively.
Other Products Cited: Flow Visualization Pulsatile Flow Simulation
Visit SourceZhu Y, Park MH, Pandya PK, Stark CJ, Mullis DM, Walsh SK, Kim JY, Wu CA, Baccouche BM, Lee SH, Baraka AS, Joo H, Yajima S, Elde S, Woo YJ. Ann Cardiothorac Surg 2023;12(4):326-337
The goal was to preserve the native aortic valve (AV) leaflets in patients with aortic root aneurysm with or without aortic regurgitation (AR). The ex vivo system consists of a linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) to generate a physiologic waveform in compliance with ISO 5840 standards. Similar to our previous ex vivo evaluation of the VSARR operation, we again confirmed that SG, compared with sinus containing graft, most closely recapitulated the native aortic root biomechanics.
Other Products Cited: Endovascular Simulator Ex ViVo Simulation
Visit SourceMariam Abdi Noor, Leila Louise Benhassen, Alexander Emil Kaspersen, Marc Gjern Weiss, John Michael Hasenkam, Peter Johansen, J. of Cardiovasc. Trans. Res.
The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. The ventricular chamber was coupled to a digitally controlled piston pump (SuperPump AR Series, ViVitro Labs, Victoria, Canada), delivering a pulsatile flow to simulate left ventricular ejection into the aortic root. Overall, the echographic data revealed that both interventions had a downsizing effect on the aortic root, while still maintaining the distensibility comparable to the native condition.
Other Products Cited: Heart Valve Repair Pulsatile Flow Simulation Pulse Duplicator
Visit SourceArian Aghilinejad, Heng Wei, Coskun Bilgi, Alberto Paredes, Alexander DiBartolomeo, Gregory Magee, Niema Pahlevan, J Biomech Eng. 1-31
Type B aortic dissection is a life-threatening medical emergency that can result in rupture of the aorta. The aortic simulator is a hydraulic model that has physical and dynamical properties similar to the human circulatory system. This hydraulic model consists of a piston-in-cylinder pump (ViVitro Labs Inc.) that generates a physiologically accurate pulsatile flow (using a programmable waveform generator ViVigen) and a pump head, including a silicone ventricle membrane, mitral valve, and aortic valve. Results demonstrate that the deep-learning model can accurately capture the dissection geometry from patients’ medical images.
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Visit SourceStephanie Sincomb, Francisco Moral-Pulido, Obed Campos, Carlos Martínez-Bazán, Victor Haughton, and Antonio L. Sánchez
The cerebrospinal fluid filling the ventricles of the brain moves with a cyclic velocity driven by the transmantle pressure, or instantaneous pressure difference between the lateral ventricles and the cerebral subarachnoid space. The periodic flow was generated with a programmable piston pump (SuperPump AR, ViVitro Labs, Victoria, Canada) connected through semi-rigid tubing to a ball valve located near the bottom of one of the reservoirs. MRI-informed in-vitro experiments have been used to evaluate the pressure difference between the third to fourth ventricles in the brain Δp, yielding results in good agreement with those of a previously derived mathematical model.
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Visit SourceDiya Wang, Boris Chayer, François Destrempes, Jonathan Porée, Marie-Hélène Roy Cardinal, François Tournoux, Guy Cloutier, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (Volume: 69, Issue: 12, December 2022) Page(s): 3284 - 3296
Assessment of myocardial contractility during a stress test is of high clinical value for the diagnosis and evaluation of cardiovascular diseases, especially coronary disease and heart failure. Both ends of this left-ventricular mimicking phantom (wall thickness of 15 mm) was then connected to polyvinyl chloride tubing by a pair of loosely attached steel clamps to a pulse duplicator (model #SD2001-1, ViVitro systems Inc., Victoria, BC, Canada). The complex, large, and rapid myocardial deformation during stress tests were also accurately imaged by the proposed strain estimator with close agreement with sonomicrometry.
Other Products Cited: Endovascular Simulator Pulsatile Flow Simulation Ultrasound Measurements
Visit SourceLuca Rosalia, Caglar Ozturk, Jaume Coll-Font, Yiling Fan, Yasufumi Nagata, Manisha Singh, Debkalpa Goswami, Adam Mauskapf, Shi Chen, Robert A. Eder, Efrat M. Goffer, Jo H. Kim, Salva Yurista, Benjamin P. Bonner, Anna N. Foster, Robert A. Levine, Elazer R. Edelman, Marcello Panagia, Jose L. Guerrero, Ellen T. Roche & Christopher T. Nguyen, Nature Biomedical Engineering volume 6, pages 1134–1147 (2022)
Advances in soft robotics have led to the development of high-fidelity simulators of pathophysiology for biomedical applications. An MCL was built using a pulsatile pump (SuperPump, ViVitro Labs), an anatomically accurate compliant silicone aortic vessel (E ≈ 1 MPa, United Biologics) connected to two adjustable compliance chambers (that is, ventricular, systemic), and a resistive valve. The models leverage haemodynamic mimicry and may facilitate the development of patient-specific applications. The models could also facilitate the clinical translation of treatments; in particular, a cohort of AS patients could be recapitulated in an in vivo porcine model, and new treatments could be evaluated preclinically.
Other Products Cited: Endovascular Simulator Ex ViVo Simulation Flow Visualization Pulsatile Flow Simulation Tissue Engineering
Visit SourceLisa Carlson Hanse, Marcell J Tjørnild, Simon G Sørensen, Peter Johansen, Ignacio Lugones, Vibeke E Hjortdal, Interactive CardioVascular and Thoracic Surgery, Volume 35, Issue 4, October 2022, ivac227
We investigated a new surgical technique of trileaflet semilunar valve reconstruction possessing the potential of remaining sufficient and allowing for some growth with the child. Pulsatile flow was produced by a Series piston pump (SuperPump AR; ViVitro Labs, Victoria, Canada), connected to the ventricular chamber. TSVR was achievable in vitro. Hydrodynamic pressure and echocardiographic evaluations demonstrated a sufficient and non-stenotic neo-valve.
Other Products Cited: Heart Valve Testing Pulsatile Flow Simulation
Visit SourcePaulo Yu, Vibhav Durgesh, Experimental Thermal and Fluid Science, Vol 138, October 1 2022
Aneurysms are abnormal expansion of weakened blood vessels which can be debilitating or fatal upon rupture. Previous studies have shown that hemodynamics play a role in aneurysm formation, growth and rupture. Therefore, the objective of this work is to investigate the impact of flow structures on vortex strength, impinging location, and wall shear stress for two aneurysm models. ...The inflow parameters used in this study, and , were controlled using a ViVitro Labs Inc. SuperPump system... ...The flow evolution results showed that impacted the vortex formation, growth, and dissipation processes for the studied aneurysm model...
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Visit SourcePaulo Yu, Vibhav Durgesh, Fluids, 2022, 7, 165.
Aneurysms are localized expansions of blood vessels which can be fatal upon rupture. Studies have shown that aneurysm flows exhibit complex flow phenomena which consist of single or multiple vortical structures that move within the flow cycle. ...Rep and α were the inflow parameters used to match and simulate the conditions in the human circulatory system. These inflow parameters were precisely controlled with a ViVitro Labs Inc. SuperPump system... ...Both POD and DMD are capable analysis tools to investigate the spatial and temporal behavior of large-scale structures of a given flow field. POD and DMD can be used to create mathematical models to look into the flow evolution in sufficiently high detail and at any time step...
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Visit SourceL. van de Velde, E. Groot Jebbink, B. A. Zambrano, M. Versluis, J. Tessarek & M. M. P. J. Reijnen: CardioVascular and Interventional Radiology (2022)
...To assess this flow diverting strategy for popliteal aneurysms, flow profiles and thrombus formation likelihood were investigated in popliteal aneurysm models... ...The model was placed in a circulating flow set-up with a blood-mimicking fluid (Fig. 3). At the inlet, a hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to enforce time-varying forward flow...
Other Products Cited: Pulsatile Flow Simulation Stent and Stent/Graft
Visit SourcePaulo Yu, Vibhav Durgesh, Fluids, 2022
...Rep and α were two inflow parameters used in this study, and these were controlled using a ViVitro Labs Inc. (Victoria, BC, Canada) SuperPump system...POD provides a method for analyzing complex flow phenomena in great detail. It can be used to study a variety of unsteady, physiological flows to understand the behavior of energetic flow structures..
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Visit SourceN Norris, K Lewis, C Settanni, T Becker, A Ducruet, Journal of NeuroInterventional Surgery 2021, 13 (Suppl 1)
...Physiologically-relevant patient flow parameters were tuned within the system using a Super Pump AR (ViVitro Labs)...This in-vitro aneurysm flow model utilized the latest in UV-cured 3D-printing techniques to provide a realistic simulation of neurovascular tortuosity and aneurysm device delivery...
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Visit SourceM. Marin-Cuartas, Y. Zhu, A. M. Imbrie-Moore, M. H. Park, R. J. Wilkerson, M. Leipzig, P. K. Pandya, M. J. Paulsen, M. A. Borger, Y. J. Woo, Interactive CardioVascular and Thoracic Surgery (2021) 1–9
...The severity of acute papillary muscle (PM) rupture varies according to the extent and site of the rupture. However, the haemodynamic effects of different rupture variations are still poorly understood...A 3D printer (Carbon 3D, Redwood City, CA, USA) was used to prototype a modular left heart (left atrium and ventricle) and was mounted to a pulsatile linear piston pump (ViVitro Superpump; ViVitro Labs, Victoria, BC, Canada)...
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Visit SourceA. Imbrie-Moore, Y. Zhu, T. Bandy-Vizcaino, M. Park, R. Wilkerson, Y. Woo, Annals of Biomedical Engineering, 49
Driven by a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) which generates physiologic hemodynamics in accordance with ISO 5840 in vitro cardiac valve testing standards.
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Visit SourceB. Ncho, A. Siefert, V. Sadri, J. Ortner, A. Yoganathan. Journal or Med. Devices
The physiologic pressures and flows were achieved by adjustment of systemic resistance and compliance elements, and flow driven from a piston pump (Vivitro Labs Inc. Victoria, Canada).
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Visit SourceP. Yu, V. Durgesh, Journal of Biomechanical Engineering, 5
The inflow conditions are precisely controlled using a ViVitro SuperPump system where nondimensional fluid parameters such as peak Reynolds number (Rep) and Womersely number (α) are varied from 50–270 and 2–5, respectively.
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Visit SourceJ. Westenberg, H. van Assen, P. van den Boogaard, J. Goeman, H. Saaid, J. Voorneveld, J. Bosch, S. Kenjeres, T. Claessens, P. Garg, M. Kouwenhoven, H. Lamb, Magnetic Resonance in Medicine
A pulsatile hydraulic piston pump (Vivitro Labs, Victoria, Canada) was connected to the tank with semirigid tubing. This pump, positioned outside the scanner room, generated a sinusoidal-like pulsatile waveform with 70-bpm frequency without net flow, resulting in a pressure waveform inside the tank that created contraction of the filled LV phantom with a 300-ms systolic period and 50-mL stroke volume.
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Visit SourceS. Zhan-Moodie, D. Xu, K. S. Suresh, Q. He, D. Onohara, K. Kalra, R. A. Guyton, E. L. Sarin, M. Padala. JTCVS Open.
...actuating pump with a viscoelastic impedance (Superpump, Vivitro Labs, London, ON) was connected to the LV, and programmed to generate physiological left ventricular pressures. 0.9% saline was used as the working medium in this flow loop...
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Visit SourceP. Yu, V. Durgesh, T. Xing, R. Budwig. Journal of Biomedical Engineering. Vol. 143.
… vectors in the sac region. 3.3 Pump System. To generate controlled inflow conditions for this study, a piston pump (ViVitro Labs Inc. SuperPump Sys- tem AR Series, Victoria, BC, Canada) was used. The piston pump system …
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