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Zeping Zhang, Rizheng Han, Yueen Liu, Xinqi Yu, Guixue Wang, Yun Bai, Rui Yang, Tao Jin, Xing Zhang,Chemical Engineering Journal,Volume 518, 2025,
In this study the ViVitro Labs Pulse Duplicator system played an essential role in simulating physiological aortic and pulmonary flow conditions to assess the hydrodynamic performance of a bioinspired trilayer poly(ε-caprolactone) (PCL) scaffolds designed for tissue-engineered heart valves (TEHVs). By replicating the fibrosa-spongiosa-ventricularis architecture using electrospinning on custom collectors, the authors developed a scaffold (BTS) that successfully mimics the anisotropic and nonlinear ('J-curve') mechanical behavior of native valve leaflets. The BTS exhibited favorable biomechanical performance, excellent biocompatibility, and compliance with ISO 5840-2 criteria. These results highlight the scaffold’s translational promise in pediatric and young adult valve replacements. The successful demonstration of effective orifice area and regurgitation rate compliance underscores the Pulse Duplicator’s value in de-risking translation to clinical applications.
Other Products Cited: Flow Visualization Heart Valve Testing Pulsatile Flow Simulation Pulse Duplicator
Visit SourceJ. Kiekenap MD, X. Sun MD, Y. Hao MD, M. Steitz M.Sc., A. Breitenstein-Attach M.Sc., J. Emeis B.A.Sc., F. Berger MD, PhD, B. Schmitt MD, PhD, Catheterization and Cardiovascular Interventions, Volume 103, Issue 4
Current heart valve implants entail major disadvantages in the treatment for younger patients or those with congenital heart defects. In vitro testing was performed in a Pulse Duplicator by the Canadian company ViVitro Labs Inc. equipped with flow and pressure sensors that is certified according to ISO-standard 5840 simulating conditions in the human heart. In vitro tests in a pulse duplicator showed compliance with regulatory requirements in terms of valve opening and insufficiency.
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceLuca Rosalia, Caglar Ozturk, Jaume Coll-Font, Yiling Fan, Yasufumi Nagata, Manisha Singh, Debkalpa Goswami, Adam Mauskapf, Shi Chen, Robert A. Eder, Efrat M. Goffer, Jo H. Kim, Salva Yurista, Benjamin P. Bonner, Anna N. Foster, Robert A. Levine, Elazer R. Edelman, Marcello Panagia, Jose L. Guerrero, Ellen T. Roche & Christopher T. Nguyen, Nature Biomedical Engineering volume 6, pages 1134–1147 (2022)
Advances in soft robotics have led to the development of high-fidelity simulators of pathophysiology for biomedical applications. An MCL was built using a pulsatile pump (SuperPump, ViVitro Labs), an anatomically accurate compliant silicone aortic vessel (E ≈ 1 MPa, United Biologics) connected to two adjustable compliance chambers (that is, ventricular, systemic), and a resistive valve. The models leverage haemodynamic mimicry and may facilitate the development of patient-specific applications. The models could also facilitate the clinical translation of treatments; in particular, a cohort of AS patients could be recapitulated in an in vivo porcine model, and new treatments could be evaluated preclinically.
Other Products Cited: Endovascular Simulator Ex ViVo Simulation Flow Visualization Pulsatile Flow Simulation SuperPump
Visit SourceF. Stieglmeier, M. Grab, F. König, J. Büch, C. Hagl, N. Thierfelder. Journal of the Mechanical Behavior of Biomedical Materials. Vol. 118.
… was applied, was documented. 2.9. Durability testing. To investigate the long-term durability, patches were tested in a modified high-cycle (HC) system (HiCycle Durability Tester; ViVitro Labs Inc., Victoria, CAN). A 3D printed …
Other Products Cited: HiCycle Durability Tester
Visit SourceMiss Brittany A. Gonzalez, Miss Elnaz Pour Issa, Mr. Omkar V. Mankame, Miss Jenniffer Bustillos, Mr. Antonio Cuellar, Mr. Andres J. Rodriguez, Dr. Frank Scholl, Dr. Steven Bibevski, Dr. Lazaro Hernandez, Mr. Vincent Brehier, Mr. Mike Casares, Dr. Krishna Rivas, Dr. Pablo Morales, Mr. Jesus Lopez, Dr. Joseph Wagner, Dr. Jennifer Bibevski, Dr. Arvind Agarwal, Dr. Florence George, and Dr. Sharan Ramaswamy - Tissue Engineering Part A. December 5, 2019
Conceptually, a tissue engineered heart valve (TEHV) would be especially appealing in the pediatric setting since small size and somatic growth constraints would be alleviated. Here, we utilized porcine small intestinal submucosa (PSIS) for valve replacement... … the Dacron tubes housing the PSIS valves were measured in order to secure the valve‐in‐ conduit (Figure 1) in the mitral position within a pulse duplicator system (ViVitro Labs, Victoria, BC) … A pulse duplicator system… ... Our findings suggest that the altered structural responses of PSIS, post-fatigue, rather than de novo tissue formation, are primarily responsible for the valve’s ability to accommodate somatic growth during the acute phase (90 days) following mitral valve replacement...
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceAndrew K. Capullia, Maximillian Y. Emmerta, b, c, Francesco S. Pasqualinia, b, Debora Kehlb, Etem Caliskanb, c, Johan U. Linda, Sean P. Sheehya, Sung Jin Parka, Seungkuk Ahna, Benedikt Webera, b, Josue A. Gossa, Simon P. Hoerstrupa, b, Kevin Kit Parkera; Biomaterials Volume 133, July 2017, Pages 229–241
Tissue engineered scaffolds have emerged as a promising solution for heart valve replacement because of their potential for regeneration. However, traditional heart valve tissue engineering has relied on resource-intensive, cell-based manufacturing, which increases cost and hinders clinical translation. ...We demonstrated controlled modulation of these scaffold parameters and show initial biocompatibility and functionality in vitro...
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Visit SourceCole Feagler, Zeeshan Syedain and Robert Tranquillo University of Minnesota College of Science and Engineering Poster Report
While most commercial valves today use chemically-fixed porcine tissue in the construction of the replacement valves, the Tranquillo group has been exploring the use of decellularized, engineered tissue as leaflet material... ...The goal of this project was to engineer a commissure design to mitigate valve failure through tissue tearing, and to improve overall valve hemodynamics. (I.e. reduction of PVL)... ...Prototype TEHVs were tested to failure using a ViVitro Labs pulse duplicator, running custom LabView data acquisition software...
Other Products Cited: Pulsatile Flow Simulation Pulse Duplicator
Visit SourceClara Seaman, Andrew McNally, Stephen Biddle, Lauren Jankowski, Philippe Sucosky Presented in part at the 2013 Biomedical Engineering Society Conference, September 2013, Seattle, WA, and at the 2013 ASME Summer Bioengineering Conference, June 2013, Sunriver, OR, USA
The study aim was to develop a laboratory protocol for the fabrication of tissue valve models mimicking mild and moderate calcific stenosis, for future use in flow studies. ... near-physiologic hemodynamics. The flow loop was driven by a programmable piston pump (Vivitro), and included resistance and compliance units to mimic the characteristics of the systemic vascular tree (Fig. 3A). The system ...
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Visit SourceJames N. Warnock, Suchitra Konduri; Journal of Biomechanical Engineering: 127, Issue 5; 857.
Other Products Cited: Ex ViVo Simulation
Visit SourceSteven Goldstein, PhDa, David R. Clarke, MDb, Steven P. Walsh, PhDa, Kirby S. Black, PhDa, Mark F. O’Brien, MDc; The Annals of Thoracic Surgery: 70; 1962-1969; 2000.
Tissue engineering approaches utilizing biomechanically suitable cell-conductive matrixes should extend xenograft heart valve performance, durability, and growth potential to an extent presently attained only by the pulmonary autograft. To test this hypothesis, we developed an acellular, unfixed porcine aortic valve-based construct. The performance of this valve has been evaluated in vitro under simulated aortic conditions, as a pulmonary valve replacement in sheep, and in aortic and pulmonary valve replacement in humans.
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Visit SourceRonald C. Elkins, MDa, Patti E. Dawson, BSb, Steven Goldstein, PhDb, Steven P. Walsh, PhDb, Kirby S. Black, PhDb; The Annals of Thoracic Surgery: 71; S428-S432; 2001.
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Visit SourceZH Syedain, LA Meier, JM Reimer… – Annals of biomedical …, 2013 – Springer
A novel tissue-engineered heart valve (TEHV) was fabricated from a decellularized tissue tube mounted on a frame with three struts, which upon back-pressure cause the tube to collapse into three coapting "leaflets." The tissue was completely biological, fabricated from ovine fibroblasts dispersed within a fibrin gel,...
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Visit SourceJ Luo, SA Korossis, SPP Wilshaw, LM Jennings… – Tissue Engineering, 2014
… testing. The flow simulator has been described previously. 27 It mimicked the right heart and was controlled and monitored by the ViviTest software (Vivitro Systems Inc). The simulator was set up as described by Korossis et al. …
Other Products Cited: Pulse Duplicator Software
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