Amna Amri - Thèse en cotutelle Doctorat en génie des matériaux et de la métallurgie
...the aim of this work is to investigate strategies to improve the biocompatibility of the polyethylene terephthalate (PET) textile valve... The first strategy consists on investigating the potential of PET textiles covalently conjugated with PEG to modulate the fibrosis formation both in vitro and in vivo... ...The second strategy consists on investigating the design of a composite hybrid fibrous construction combining a woven PET layer and a non-woven PET mat,... ...The durability of the hybrid heart valves (obtained from sample A and sample B non-woven materials) was assessed using an accelerated fatigue tester (ViVitro Labs HiCycle System) a...
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Ramin Zareian Jen-Chieh Tseng Robert Fraser Jeffrey Meganck Marshall Kilduff Mohammad Sarraf Danny Dvir Arash Kheradvar - Interactive CardioVascular and Thoracic Surgery, ivz024, Published: 21 February 2019
...The goal of this study was to test whether stent crimping increases the risk for early calcification.... … MA, USA). The durability experiment was performed using a standard accelerated wear test (AWT) system (HiCycle Durability Tester, ViVitro Inc., Victoria, BC, Canada) that can ac- commodate up to 6 heart valves. Among the …
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Ram Ghosh, Gil Marom, Oren Rotman, Marvin J. Slepian, Saurabh Prabhakar, Marc Horner and Danny Bluestein -- Journal of Biomechanical Engineering doi:10.1115/1.4040600 History: Received November 06, 2017; Revised May 30, 2018
...All currently FDA-approved TAVR devices use tissue valves that were adapted to but not specifically designed for TAVR use. Emerging clinical evidence indicates that these valves may get damaged during crimping and deployment- leading to valvular calcification, thrombotic complications, and limited durability... ...Our research group has developed a novel polymeric prosthetic valve, which was optimized to reduce stresses on the leaflets, improve hemodynamics and has thrombogenic performance similar to that of a tissue valve... … The valves are then sutured to a nitinol stent for completion of the process. The valves' durability is now being assessed using a Vivitro Hi-Cycle System (Vivitro Labs, Inc … Hydrodynamic performance is being evaluated using the Vivitro left heart simulator (Vivitro Labs, Inc …Visit Source
O Barannyk, R Fraser, P Oshkai - Journal of Biological Physics, 2017
In this paper, a long-term in vitro dynamic calcification of three porcine aortic heart valves was investigated using a combined approach that involved accelerated wear testing of the valves in the rapid calcification solution, hydrodynamic assessment of the progressive change of effective orifice area (EOA) along with the transaortic pressure gradient, and quantitative visualization of the flow. ...ViVitro Labs Inc. for providing access to their facility and equipment for this study. Compliance with ethical standards Conflict of interest Oleksandr Barannyk has been a postdoctoral fellow at ViVitro Labs Inc. under MITACS...
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Antoine Vaesken, Christian Pidancier, Nabil Chakfe, Frederic Heim Biomedical Engineering / Biomedizinische Technik. ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: 10.1515/bmt-2016-0083, September 2016
Transcatheter aortic valve implantation (TAVI) is nowadays a popular alternative technique to surgical valve replacement for critical patients. Biological valve tissue has been used in these devices for over a decade now with over 100,000 implantations... ...The purpose of the present work is to study in vitro the mechanical as well as the hydrodynamic behavior of a hybrid elastic textile valve device combining non-deformable PET yarn and elastic polyurethane (PU) yarn... ... times for each valve. Durability testing of the devices. The prototypes were tested on a commercial fatigue apparatus (Vivitro Labs Inc., Victoria, Canada) equipped with an electromagnetic drive mechanism. Six valve prototypes ...
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