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Amna Amri - Thèse en cotutelle Doctorat en génie des matériaux et de la métallurgie

...the aim of this work is to investigate strategies to improve the biocompatibility of the polyethylene terephthalate (PET) textile valve... The first strategy consists on investigating the potential of PET textiles covalently conjugated with PEG to modulate the fibrosis formation both in vitro and in vivo... ...The second strategy consists on investigating the design of a composite hybrid fibrous construction combining a woven PET layer and a non-woven PET mat,... ...The durability of the hybrid heart valves (obtained from sample A and sample B non-woven materials) was assessed using an accelerated fatigue tester (ViVitro Labs HiCycle System) a...

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Maryam Alizadeh, Melissa Cote, Alexandra Branzan Albu -J. of Medical Imaging, 8(1) (12 February 2021)

Prosthetic heart valve designs must be rigorously tested using cardiovascular equipment... ...Using video frames recorded with a high-speed digital camera during in vitro simulations, an initial estimation of the orifice area is first obtained via active contouring and thresholding and then refined to capture the leaflet free edges via a curve transformation mechanism. Results: Experiments on video data from pulsatile flow testing demonstrate the effectiveness of our approach...

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Paulo Yu, Vibhav Durgesh, Tao Xing, Ralph Budwig -J Biomech Eng. Published Online: February 4, 2021

Aneurysms are localized expansions of weakened blood vessels that can be debilitating or fatal upon rupture... ...the objective of this study was to demonstrate the application of Proper Orthogonal Decomposition (POD) to study the impact of different inflow conditions on energetic flow structures and their temporal behavior in an aneurysm. To achieve this objective, experiments were performed on an idealized rigid sidewall aneurysm model. A piston pump system was used for precise inflow control, i.e., peak Reynolds number ($Re_p$) and Womersley number ($\alpha$) were varied from 50-270 and 2-5, respectively.... … These settings provided approximately 9000 vectors in the pipe region, 6000 vectors in the neck region, and 6800 vectors in the sac region. 3.3 Pump system To generate controlled inflow conditions for this study, a piston pump (ViVitro Labs Inc …

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Daniele Dipresa, Panagiotis Kalozoumis, Michael Pflaum, Ariana Peredo, Bettina Wiegmann, Axel Haverich, Sotirios Korossis - J Biomech Eng. Paper No: BIO-20-1042 Published Online: January 19, 2021

Extracorporeal membrane oxygenation (ECMO) has been used clinically for more than 40 years as a bridge to transplantation, with hollow-fiber membrane (HFM) oxygenators gaining in popularity due to their high gas transfer and low flow resistance.... ...In this study, the blood flow through two HFM oxygenators, including the commercially-available iLA® MiniLung Petite Novalung (Xenios AG, Germany) and an experimental one for the rat animal model, was modelled using computational fluid dynamics (CFD), with a view to assessing the magnitude and distribution of the shear stress on the wall of the hollow fibers and flow fields in the oxygenators... … developed, which comprised a flow meter (Model 501, Carolina Medical Electronics, NC, US), heat exchanger and temperature controller (HE9991, Vivitro Labs, Victoria, CA), centrifugal pump (Medtronic Bio-Medicus 520C Bio …

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Annabel M. Imbrie-Moore, Matthew H. Park, Michael J. Paulsen, Mark Sellke, Rohun Kulkami, Hanjay Wang, Yuanjia Zhu, Justin M. Farry, Alexandra T. Bourdillon, Christine Callinan, Haley J. Lucian, Camille E. Hironaka, Daniela Deschamps and Y. Joseph Woo - Journal of the Royal Society Interface, December 2020

Papillary muscles serve as attachment points for chordae tendineae which anchor and position mitral valve leaflets for proper coaptation. As the ventricle contracts, the papillary muscles translate and rotate, impacting chordae and leaflet kinematics; this motion can be significantly affected in a diseased heart... ...We developed and implemented image-guided papillary muscle (IPM) robots to mimic the precise motion of papillary muscles. The IPM robotic system was designed with six degrees of freedom to fully capture the native motion... … The simulator features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) programmed to produce a physiologic waveform in compliance with ISO 5840 standards for in vitro valve testing …

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Sanjiv Gunasekera, Olivia Ng, Shannon Thomas, Ramon Varcoe, Charitha de Silva & Tracie Barber - Experiments in Fluids, 2020

The arteriovenous fistula (AVF), which is a vasculature created for end-stage renal disease patients who require haemodialysis, is susceptible to many vascular diseases. ...The current study is an investigation of the complex three-dimensional flow within a physiological AVF geometry, using tomographic particle image velocimetry... … The ViVitro Superpump (ViVitro Labs Inc., BC, Canada) was used as the flow source and a network of rigid Tygon tubing inclusive of valves, to simulate vascular resistance, and air-filled syringes, to simulate vascular compliance, connected the model to the pump …

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Sophie C. Hofferberth, Mossab Y. Saeed, Lara Tomholt, Matheus C. Fernandes, Christopher Payne, Karl Price, Gerald R. Marx , Jesse J. Esch, David W. Brown, Jonathan Brown, Peter E. Hammer, James C. Weaver , Elazer R. Edelman, Pedro J. del Nido

While congenital heart valve disease has life-threatening consequences that warrant early valve replacement, the development of a growth-accommodating prosthetic valve has remained elusive, and as such, thousands of children continue to face multiple high-risk open-heart operations to replace outgrown valves.... ...We demonstrate a biomimetic prosthetic heart valve that is sizeadaptable to accommodate somatic growth and structural asymmetries within the heart... … (Resonetics Israel Ltd, Or Akiva, Israel). In vitro testing In vitro hydrodynamic performance testing Valve prototypes were tested in an in vitro pulsatile flow loop apparatus (ViVitro Labs Inc, Victoria, BC Canada). The in vitro …

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Michael J. Paulsen, Annabel M. Imbrie-Moore, Michael Baiocchi, Hanjay Wang, Camille E. Hironaka, Haley J. Lucian, Justin M. Farry, Akshara D. Thakore, Yuanjia Zhu, Michael Ma, John W. MacArthur Jr, Y. Joseph Woo - Circulation, 2020

...The specific impact of such neosinuses on valvular and root biomechanics and the potential influence on long-term durability are unknown... ...Using a custom 3-dimenstional–printed heart simulator with porcine aortic roots (n=5), the anticommissural plication, Stanford modification, straight graft (SG), Uni-Graft, and Valsalva graft configurations were tested in series using an incomplete counterbalanced measures design, with the native root as a control, to mitigate ordering effects... ... the system is comprised of a modular 3-dimensional–printed (Carbon M2, Carbon 3D Inc., Redwood City, CA) and machined enclosure mounted to a pulsatile linear actuator (Superpump, Vivitro Labs, Vancouver, Canada).

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Janarthanan Sathananthan MBChB, MPH Mark Hensey MB BCh BAO Rob Fraser MSc Uri Landes MD Philipp Blanke MD Hoda Hatoum PhD Lakshmi Prasad Dasi PhD Alexander Sedaghat MD Vinayak N Bapat MD Jonathon Leipsic MD Lars Søndergaard MD, DMSc David A. Wood MD John G. Webb MD - October 2019 - VALVULAR AND STRUCTURAL HEART DISEASES

The commonly used valve‐in‐valve (VIV) app recommends sizing based on dimensions of both the transcatheter heart valve (THV) and bioprosthetic surgical valve.... ...This bench study assessed the hydrodynamic performance of different sizes of self‐expanding supra‐annular THVs in three different surgical aortic bioprostheses at different implantation depths.... ...Testing was performed at the Centre for Heart Valve Innovation bench testing laboratory, and ViVitro Laboratories....

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Jana Fuchsberger Philipp Aigner Gundolf Haase Steven Niederer Heinrich Schima Gernot Plank Elias Karabela - September 2020 preprint rxiv.org

Simulating the interaction of fluids with immersed moving solids is playing an important role for gaining a better quantitative understanding of how fluid dynamics is altered by the presence of obstacles and, vice versa, which forces are exerted on the solids by the moving fluid... ...application problems with focus on understanding the effect of solids on altering fluid dynamics. In this study we report on the development of a novel method for such applications. In our method rigid moving obstacles are incorporated in a fluid dynamics context using concepts from porous media theory. Based on the Navier-Stokes-Brinkman equations... ...and a piston pump (SuperPump, ViVitro Labs Inc., Victoria, BC, Canada) were used to generate stationary and pulsating inflows....

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Yuanjia Zhu, Annabel M. Imbrie-Moore, Michael J. Paulsen, Bryant Priromprintr, Matthew H. Park, Hanjay Wang, Haley J. Lucian, Justin M. Farry & Y. Joseph Woo - Journal of Cardiovascular Translational Research (2020)

To simulate Aortic Regurgitation (AR), four porcine aortic valves were explanted, and the commissure between the two largest leaflets was detached and re-implanted 5 mm lower to induce cusp prolapse. … 1c), which has been previously described in detail [17, 18]. In brief, the simulator encompasses a programmable pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) that is attached to a custom left ventricular chamber …

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Sean Guo‐Dong Tan, Jimmy Kim Fatt Hon, Yen Ngoc Nguyen, Sangho Kim, Hwa Liang Leo - Artificial Organs 22 July 2020

This study aims to investigate the effect of orifice shape and its position with respect to the posterior wall of the ventricle on vortical formation and turbulence intensity in the LV, by utilizing four separate orifice configurations within an in vitro left heart simulator. … in a native healthy heart as described in a prior study by GDS Tan et al.[25] was utilized in this study. A pulsatile pump (ViVitro Labs Inc., Victoria, BC, Canada) was employed to propel the blood analog with properties that are described in table 2 through the loop …

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Bhullar, Arpin Singh - UBC Theses and Dissertations 2020

...research topic of designing a radical mechanical heart valve prosthesis that leveraged novel design elements to mitigate anticoagulant therapy and improve patient quality of life... ....problems have plagued the most common form of MHVs, bileaflet mechanical heart valves (BMHVs), for decades as their designs have stagnated.... ... This research was conducted to design and validate a BMHV that would have similar hemodynamic properties to native heart valves, enabling implantation without reliance on post-operative anti-coagulants.... ... modern, digital ViVitro SuperPump and its power and control system which combined, produce the user-selected waveform for testing...

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Annabel M. Imbrie-Moore, Cole C. Paullin, Michael J. Paulsen, Frederick Grady, Hanjay Wang, Camille E. Hironaka, Justin M. Farry, Haley J. Lucian. Y. Joseph Woo - Medical Engineering & Physics Available online 31 January 2020

...This work shows the design and implementation of a 3D-printed valve dilation device to preferentially dilate the posterior mitral valve annulus... ...In brief, a custom 3D-printed left heart chamber (Fig. 2A) was mounted to a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) with the ability to generate physiologic conditions … ...this annular dilation device provides the means to investigate the design and optimization of novel annuloplasty rings....

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Jason Voorneveld, Hicham Saaid, Christiaan Schinkel, Nikola Radeljic, Boris Lippe, Frank J.H. Gijsen, Antonius F.W.van der Steen, Nico de Jong, Tom Claessens, Hendrik J. Vos, Sasa Kenjeres, Johan G. Bosch - Elsevier Ultrasound in Medicine & Biology - Available online 8 January 2020

Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for testing the accuracy of echo-PIV in the presence of complex flow patterns.... … 1a). The mitral and aortic tracts of the LV were connected to atrial and compliance chambers (transparent acrylic, built in-house), which were connected via a tube with an adjustable resistance valve (ViVitro Labs … ... We demonstrate that 4-D echo-PIV could be performed in just four heart cycles, which would require only a short breath-hold, providing promising results. However, methods for resolving high velocity gradients in regions of poor spatial resolution are required before clinical translation....

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Jae H. Lee, Alex D. Rygg, Ebrahim M. Kolahdouz, Simone Rossi, Stephen M. Retta, Nandini Duraiswamy, Lawrence N. Scotten, Brent A. Craven, and Boyce E. Grith -

Computer modeling and simulation (CM&S) is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) and promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance... ...This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.... … In vitro experiments are performed using two different experimental platforms, including a ViVitro Pulse Duplicator (ViVitro Labs, Inc., Victoria, BC, Canada) available through the FDA Cardiac Device Flow Lab and a customized …

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Feng Guo (郭峰)Chang Liu (刘唱)Rizheng Han (韩日峥)Qiang Lu (吕强)Yun Bai (白芸)Rui Yang (杨锐)Dun Niu (牛盾)Email authorXing Zhang (张兴) -Science China Materials

Herein, two types of silk fibroin (SF) fiber membranes with anisotropic (ASF) and isotropic (ISF) properties were prepared by electrospinning, and were further combined with poly(ethylene glycol) diacrylate (PEGDA) hydrogels to serve as polymeric heart valve (PHV) substitutes (PEGDA-ASF and PEGDA-ISF)... ...The PHVs from both PEGDA-ASF and PEGDA-ISF presented appropriate hydrodynamic properties from pulse duplicator tests according to the ISO 5840-3 standard.... ...The Gauss curvature analysis also indicated that the anisotropic PEGDA-ASF valve can produce appropriate surface morphology by dynamically adjusting the movement of bending area during the opening process... … 1c, d). Pulse duplicator tests In vitro hemodynamic properties of PHVs were tested in a 0.9% saline solution using a pulse duplicator system (Vivitro Labs, Inc., British Columbia, Canada) according to the ISO 5840-3 standard [21] …

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Miss Brittany A. Gonzalez, Miss Elnaz Pour Issa, Mr. Omkar V. Mankame, Miss Jenniffer Bustillos, Mr. Antonio Cuellar, Mr. Andres J. Rodriguez, Dr. Frank Scholl, Dr. Steven Bibevski, Dr. Lazaro Hernandez, Mr. Vincent Brehier, Mr. Mike Casares, Dr. Krishna Rivas, Dr. Pablo Morales, Mr. Jesus Lopez, Dr. Joseph Wagner, Dr. Jennifer Bibevski, Dr. Arvind Agarwal, Dr. Florence George, and Dr. Sharan Ramaswamy - Tissue Engineering Part A. December 5, 2019

Conceptually, a tissue engineered heart valve (TEHV) would be especially appealing in the pediatric setting since small size and somatic growth constraints would be alleviated. Here, we utilized porcine small intestinal submucosa (PSIS) for valve replacement... … the Dacron tubes housing the PSIS valves were measured in order to secure the valve‐in‐ conduit (Figure 1) in the mitral position within a pulse duplicator system (ViVitro Labs, Victoria, BC) … A pulse duplicator system… ... Our findings suggest that the altered structural responses of PSIS, post-fatigue, rather than de novo tissue formation, are primarily responsible for the valve’s ability to accommodate somatic growth during the acute phase (90 days) following mitral valve replacement...

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Michael J Paulsen, Annabel M Imbrie-Moore, Hanjay Wang, Jung Hwa Bae, Camille E Hironaka, Justin M Farry, Haley J Lucian, Akshara D Thakore, John W MacArthur, Jr, Mark R Cutkosky, Y Joseph Woo - European Journal of Cardio-Thoracic Surgery, ezz258

Posterior ventricular anchoring neochordal (PVAN) repair is a non-resectional technique for correcting mitral regurgitation (MR) due to posterior leaflet prolapse, utilizing a single suture anchored in the myocardium behind the leaflet... ...Porcine mitral valves were mounted in a 3-dimensional-printed heart simulator and chordal forces, haemodynamics and echocardiography were collected at baseline, after inducing MR by severing chordae, and after PVAN repair.... ...PVAN repair eliminates MR by positioning the posterior leaflet for coaptation, distributing forces throughout the valve....

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Janarthanan Sathananthan MBChB, MPH Mark Hensey MB BCh BAO Rob Fraser MSc Uri Landes MD Philipp Blanke MD Hoda Hatoum PhD Lakshmi Prasad Dasi PhD Alexander Sedaghat MD Vinayak N Bapat MD Jonathon Leipsic MD Lars Søndergaard MD, DMSc David A. Wood MD John G. Webb MD - Catheterization and Cardiovascular Interventions October 2019

...Bench study assessed the hydrodynamic performance of different sizes of self‐expanding supra‐annular THVs in three different surgical aortic bioprostheses at different implantation depths.... ...A small versus medium ACURATE neo (ACn), and a 26 mm versus 29 mm Evolut R were assessed after VIV implantation in 25 mm Mitroflow, Mosaic, and Magna Ease aortic surgical bioprostheses, at three implantation depths (+2 mm, ‐2 mm, and ‐6 mm).... ...Use of a larger self‐expanding THV was associated with superior hydrodynamic performance if the THV was implanted high....

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