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Ram P. Ghosh, Gil Marom, Oren M. Rotman, Matteo Bianchi, Saurabh Prabhakar, Marc Horner, Marvin J. Slepian, Danny Bluestein -- Presentation at Summer Biomechanics, Bioengineering and Biotransport Conference June 21 – 24, Tucson, AZ, USA

...Our research group has developed a novel polymeric prosthetic valve, which was optimized to reduce stresses on the leaflets, improve hemodynamics and has thrombogenic performance similar to that of a tissue valve... … The valves are then sutured to a nitinol stent for completion of the process. The valves' durability is now being assessed using a Vivitro Hi-Cycle System (Vivitro Labs, Inc … Hydrodynamic performance is being evaluated using the Vivitro left heart simulator (Vivitro Labs, Inc …

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M Jeyhani, S Shahriari, M Labrosse - Artificial Organs, 2017 First published: 23 November 2017

This in vitro study aims to evaluate the hemodynamic modifications following a simulated PEtER. A custom-made mitral valve was developed, and two configurations were tested: (i) a single-orifice valve with mitral regurgitation and (ii) a double-orifice mitral valve configuration following PEtER. … MATERIALS AND METHODS In vitro model For the purpose of this study, a ViVitro pulse duplicator (ViVitro Labs, Victoria, BC, Canada) was used (Fig. 1). This system is capable of reproducing physiological flow and pressure waveforms in left heart cavity models …

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Munirah Ismail, Foad Kabinejadian, Yen Ngoc Nguyen, Edgar Tay Lik Wui, Sangho Kim, Hwa Liang Leo - - Medical Engineering and Physics October 25, 2017

...The study utilises both 2-D and 3-D particle image velocimetry (PIV) to interrogate the flow patterns in the vicinity of the extra-cardiac tricuspid valves in an in vitro physiological flow loop, specifically at four measurement locations in the cavo-atrial anatomy. ... ... of the hepatic vein. In contrast, the SVC valve was fully implanted in the SVC. The mock circulatory system was driven by a pulse generator (SuperPump AR series, ViVitro Labs Inc., Victoria, BC, Canada). It comprised of an ultrasonic ...

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W Conlin, P Yu, V Durgesh - Bulletin of the American Physical Society, 2017

...The objective of this study is to identify the large-scale structures in the aneurysm, study temporal behavior, and quantify their interaction with the inflow condition. ... ... For this purpose, detailed Particle Image Velocimetry (PIV) measurements were performed at the center plane of an idealized aneurysm model for a range of inflow conditions. Inflow conditions were precisely controlled using a ViVitro SuperPump system. ...

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P Yu, V Durgesh, H Johari - Bulletin of the American Physical Society, 2017

...Studies have shown that hemodynamics is integral to developing an understanding of aneurysm formation, growth, and rupture. This investigation focuses on a comprehensive study of the impact of varying inflow conditions and aneurysm shapes on spatial and temporal behavior of flow parameters and structures in an aneurysm.... ... For this purpose, detailed Particle Image Velocimetry (PIV) measurements were performed at the center plane of an idealized aneurysm model for a range of inflow conditions. Inflow conditions were precisely controlled using a ViVitro SuperPump system. ...

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Chung-Dann Kan, MD, PhD, Jieh-Neng Wang, PhD, Wei-Ling Chen, PhD, Pong-Jeu Lu, PhD, Ming-Yao Chan, PhD, Chia-Hung Lin, PhD, Wan Chin Hsieh, MD The Journal of Thoracic and Cardiovascular Surgery, September 2017

...The current study investigated: (i) the function of the ePTFE trileaflet-valved conduits in an ex vivo experimental system and (ii) the short-term performance of the conduit in a porcine model to verify their clinical applicability.... ... valves. 168 Right ventricular function was simulated by using a digitally controlled hydraulic piston 169 SuperPump (ViViTro Labs, Victor, British Columbia, Canada), which generated a pulsating 170 flow to drive the chamber and send it into a compliant pulmonary artery. ...

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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A. Desai, T. Vafaee, P. Rooney, J.N. Kearney, H.E. Berry, E. Ingham, J. Fisher, L.M. Jennings Journal of the Mechanical Behavior of Biomedical Materials 14 September 2017

The use of decellularised biological heart valves in the replacement of damaged heart valves ... ...The purpose of this study was to assess the effect of low concentration sodium dodecyl sulphate decellularisation on the in vitro biomechanical and hydrodynamic properties of cryopreserved human aortic and pulmonary roots.... ... performance of the valve roots. A viscoelastic impedance adapter (VIA; Vivitro System Inc., Victoria BC, Canada) was used to deliver a more physiological ventricle pressure and flow waveform in the simulator. This system allowed for ...

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Retta SM, Kepner J, Marquez S, Herman BA, S Shu MC, Grossman LW J Heart Valve Dis. 2017 Jan;26(1):72-80.

One of the first steps in qualifying a new prosthetic valve for eventual clinical use is preclinical flow performance testing in vitro... ...This collaborative effort between heart valve manufacturers and the Food and Drug Administration (FDA) was designed to evaluate the variability of the pulse duplicator test technology for pulsatile flow performance measurement in an interlaboratory round robin... ...A commercially available duplicator, the Vivitro system (Vivitro, Inc., Vancouver, Canada), was used at two centers. The design specifications are summarized in Table I....

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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Yen Ngoc NguyenMunirah IsmailFoad KabinejadianChi Wei OngEdgar Lik Wui TayHwa Liang Leo - Cardiovascular Engineering and Technology 2017

The increased understanding of right heart diseases has led to more aggressive interventions to manage functional tricuspid regurgitation (FTR)... ...In this study, a novel in vitro mock circulatory system that incorporated a realistic tricuspid valve apparatus in a patient-specific silicon right ventricle (RV) was designed and fabricated... ... A closed ventricular chamber housing the silicon RV model was connected to a closed atrial chamber at one end, and was directly connected to the pulsatile wave-generating piston pump (SuperPump AR series, ViVitro Labs Inc., Victoria, BC, Canada) at the other end to simu ...

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Guangyu Zhu; Masakazu Nakao; Qi Yuan and Joon Hock Yeo Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, 186-189, 2017, Porto, Portugal

Truly stentless polymeric valve prosthesis can be a viable alternative for aortic valve replacement (AVR). In the present paper, the dynamic and hemodynamic performance of a novel designed expanded-polytetrafluoroethylene (ePTFE) stentless tri-leaflet valve was assessed experimentally.... ... The in-vitro tests were performed under time-varying physiological pressure by using the Vivitro pulse duplicator. ... The Vivitro pulse duplicator (Vivitro Systems Inc., Victoria, BC, Canada) was used to generate the physiological pressure and flow in the left ventricle and aorta. ...

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O Barannyk, R Fraser, P Oshkai - Journal of Biological Physics, 2017

In this paper, a long-term in vitro dynamic calcification of three porcine aortic heart valves was investigated using a combined approach that involved accelerated wear testing of the valves in the rapid calcification solution, hydrodynamic assessment of the progressive change of effective orifice area (EOA) along with the transaortic pressure gradient, and quantitative visualization of the flow. ...ViVitro Labs Inc. for providing access to their facility and equipment for this study. Compliance with ethical standards Conflict of interest Oleksandr Barannyk has been a postdoctoral fellow at ViVitro Labs Inc. under MITACS...

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M. Alizadeh, M. Cote, and A Branzan Albu P Sharma, FM Bianchi - Image Analysis 20th Scandinavian Conference, SCIA 2017,

...The valve orifi ce area over time, which informs on the opening and closing motion patterns, constitutes a key quality metric for PHV assessment... ...In this paper, we propose a novel orifi ce segmentation approach for automatic prosthetic heart valves quantitative performance analysis, based on the detection of the leaflet free edges to accurately extract the actual orifi ce area.

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FM Cardoso, SS Furuie - Proc. of SPIE Vol, 2017

Ultrasound elastography has become an important procedure that provides information about the tissue dynamics and may help on the detection of tissue abnormalities. We propose a novel algorithm to perform speckle tracking, which consists in an implementation of 2D Block Matching with two enhancements: sub-pixel linear interpolation and displacement propagation, which are able to increase resolution, reduce computation time and prevent kernel mismatching errors. ... studies on their numerical analogs. Fig. 1 Section of the f20dX LV phantom. Dimensions in [mm]. METHODS Fig. 2 Experimental setup. 1 – GE Vivid 6 scanner; 2 – water tank; 3 – LV model; 4 – M4S-RS probe; 5 – windkessel; 6 – Vivitro Superpump; 7 – Pump Controller; 8 – PC. ...

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Lim, Brian. Muhammad Mujahid. Tan, Rong Wang. Arunkumar, U. Singapore Polytechnic School of Mechanical and Aeronautical Engineering

Coronary heart disease (CHD) is a common cardiac disorder in which a portion of the coronary artery is blocked, leading to a potential heart attack. Timely and accurate evaluation of suspected CHD patients is critical. Computer Tomography Angiography (CTA)... In order to streamline the evaluation of suspected CHD patients, we propose to create a more accurate and consistent diagnostic method of interpreting CTA results.

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Ng, Daniel Wai Hung. Neo, Si Yang. Ng, Chung Liu. Wong, Benedict Jun Shuan. Singapore Polytechnic School of Mechanical & Aeronautical Engineering

...Mechanical valves usually made from metal and fabrics are very durable but they have poor hemodynamic and are thrombogenic requiring permanent anticoagulation. Tissue heart valves constructed from biological tissues have excellent hemodynamic blood flow, but they lack durability. The project proposed a new valve design that is similar to a stentless tissue valve but made from a synthetic material, Polytetrafluoroethylene (PTFE)... The scope of this project includes designing a fixture to accommodate the valves in the ViVitro System and studying hemodynamic parameters such as pressure drop, flow rate, and dynamic leaflet behaviour of the valves. ...

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Andrew K. Capullia, Maximillian Y. Emmerta, b, c, Francesco S. Pasqualinia, b, Debora Kehlb, Etem Caliskanb, c, Johan U. Linda, Sean P. Sheehya, Sung Jin Parka, Seungkuk Ahna, Benedikt Webera, b, Josue A. Gossa, Simon P. Hoerstrupa, b, Kevin Kit Parkera; Biomaterials Volume 133, July 2017, Pages 229–241

Tissue engineered scaffolds have emerged as a promising solution for heart valve replacement because of their potential for regeneration. However, traditional heart valve tissue engineering has relied on resource-intensive, cell-based manufacturing, which increases cost and hinders clinical translation. ...We demonstrated controlled modulation of these scaffold parameters and show initial biocompatibility and functionality in vitro...

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Bozkurt, S., Preston-Maher, G.L., Torii, R. et al. Ann Biomed Eng (2017). doi:10.1007/s10439-017-1828-2 First Online: 03 April 2017

Mitral regurgitation is a common mitral valve dysfunction which may lead to heart failure. This paper presents the design, development and hydrodynamic assessment of a novel bi-leaflet mitral valve suitable for transcatheter implantation. ... animal models. Hydrodynamic Tests. The hydrodynamic performances of the three valve prototypes were assessed on a hydro-mechanical cardiovascular pulse duplicator system (ViVitro Superpump SP3891, ViVitro, BC) (Fig. 3 ...

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Wentao Feng, Xianda Yang, Yang Liu, Yubo Fan Artificial Organs, 24 February 2017

Clinically, the percutaneous transcatheter aortic valve (TAV) has been reported to be deformed in a noncircular configuration after its implant. The deformation is universal and various, and it leads to serious leakage and durability problems. ...the present study investigated the effects of the aortic annulus deformation and the leaflet tissue thickness on the hydrodynamics of the TAV. ... Hydrodynamic testing. The TAVs were tested in a quasi-physiological artery pulsatile flow duplicator system, which was custom remoulded to adapt the testing of deformed TAV from commercially available pulse duplicator (Pulse Duplicator; Vivitro Labs, Victoria, BC, Canada.). ...

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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Sharan Ramaswamy, Makensley Lordeus, Omkar V. Mankame, Lilliam Valdes-Cruz, Steven Bibevski, Sarah M. Bell, Ivan Baez, Frank Scholl: Cardiovasc Eng Tech (2016).

...Assess the functional effectiveness of tri-leaflet PSIS bioscaffolds in the aortic position compared to standard tri-leaflet porcine bioprosthetic valves... ... (b) Pulse duplicator system (Vivitro Laboratories) used for the hydrodynamic evaluation of the valves. ... System calibration, pump control, data collection and analysis are all computer-controlled via software (Vivitest, Vivitro Labs). ...

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S. Hamed Alavi, Marc Soriano Baliarda, Noemi Bonessio, Lorenzo Valdevit, Arash Kheradvar: Annals of Biomedical Engineering First Online: 22 December 2016

...The main problem with the tissue engineered heart valves is their progressive deterioration that leads to regurgitation and/or leaflet thickening a few months after implantation... ...The current work aims to study the effects of the design features on mechanical characteristics of this valve scaffold to attain proper function prior to in vivo implantation. ... The heart flow simulator system was adjusted for left ventricular pressure waveform with diastolic/systolic pressures of 80/120 mmHg produced by a hydraulic pump system (Superpump system, VSI, SPS3891, Vivitro systems Inc., Victoria, BC, Canada).10 The scaffolds were ...

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