Articles Related to Products

Laengle S, Suria A, Poschner T, Tasdelen S, Pitsis A, Kocher A, Andreas M. Bioengineering. 2024; 11(7):666.

Clover repair offers a surgical solution that can be applied for the treatment of primary and secondary Tricuspid regurgitation (TR). Flow was provided by a pulsatile pump system (ViVitro Labs Inc., Victoria, BC, Canada), which was coupled to the right ventricle through a third connector. This new clover technique was demonstrated to successfully reduce TR in an ex vivo porcine heart model.

Other Products Cited:  Customized Circulatory Loop  Customized circulatory systems  Heart Valve Repair  Pulsatile Flow Simulation  SuperPump

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Baylous K, Kovarovic B, Anam S, Helbock R, Slepian M, Bluestein D. ArXiv [Preprint].

Prosthetic heart valve interventions such as TAVR have surged over the past decade, but the associated complication of long-term, life-threatening thrombotic events continues to undermine patient outcomes. The hydrodynamic testing of a 29-mm CoreValve was conducted using a pulse duplicator system (Left Heart Simulator, ViVitro Labs, Victoria, BC). Post-TAVR deployment hemodynamics in patient-specific bicuspid aortic valve anatomies revealed varying degrees of thrombogenic risk for these patients, despite being clinically defined as “mild” paravalvular leak.

Other Products Cited:  Analysis and Computational Modeling  Flow Visualization  Heart Valve Testing  Pulse Duplicator

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Mohl, L., Karl, R., Hagedorn, M.N. et al. Int J CARS (2024)

Complicated type B Aortic dissection is a severe aortic pathology that requires treatment through thoracic endovascular aortic repair (TEVAR). A realistic pulsatile flow through the aortic phantom is provided by a cardiac piston pump (Superpump, Vivitro Labs Inc., Victoria, Canada). The flexible aortic dissection phantom was successfully incorporated in the hemodynamic flow loop, a systolic pressure of 112 mmHg and physiological flow of 4.05 L per minute was reached.

Other Products Cited:  Customized Circulatory Loop  Flow Visualization  Pulsatile Flow Simulation  Stent and Stent/Graft  SuperPump  Ultrasound Measurements

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Lennart van de Velde, Majorie van Helvert, Stefan Engelhard, Ashkan Ghanbarzadeh-Dagheyan, Hadi Mirgolbabaee, Jason Voorneveld, Guillaume Lajoinie, Michel Versluis, Michel M. P. J. Reijnen, Erik Groot Jebbink, Journal of Medical Imaging, Vol. 11, Issue 3, 037001 (May 2024)

To investigate the accuracy of high-framerate echo particle image velocimetry (ePIV) and computational fluid dynamics (CFD) for determining velocity vectors in femoral bifurcation models through comparison with optical particle image velocimetry (oPIV). A hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to enforce time-varying forward flow. The accuracy of blood flow assessment was investigated in models of the femoral bifurcation by clinically applicable ePIV measurements and CFD simulations.

Other Products Cited:  Analysis and Computational Modeling  Customized Circulatory Loop  Flow Visualization  Pulsatile Flow Simulation  SuperPump

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Breitenstein-Attach, A., Steitz, M., Sun, X. et al. Ann Biomed Eng (2024).

With about 100,000 children in need of a new pulmonary valve each year worldwide, this study evaluates geometrical approaches in adult as well as pediatric size and condition. A commercially available pulse duplicator (ViVitro Labs Inc., Victoria/Canada) was used for in vitro assessment. For both the adult and the pediatric prostheses, valves with the closed geometry had significantly reduced tightness with more inhomogeneity and pinwheeling compared to the semi-closed valves.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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D. W. Gonring, Z. R. Zottola, A. A. Hirad, R. Lakony, M. S. Richards, G. Pitcher, M. C. Stoner, D. S. Mix, JVS-Vascular Science, 2024

We 3D-printed axisymmetric tissue-mimicking phantom hydrogel vessels from polyvinyl alcohol cryogel (PVA-c), a material that has previously been biologically validated against vascular tissue. Water was pumped through the phantom using a ViVitro SuperPump (Victoria, British Columbia, CA) cardiac simulator. We found that the percent reduction in average pressure normalized strain increased as the degree of graft oversizing increased.

Other Products Cited:  Pulsatile Flow Simulation  Stent and Stent/Graft  SuperPump

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J. Kiekenap MD, X. Sun MD, Y. Hao MD, M. Steitz M.Sc., A. Breitenstein-Attach M.Sc., J. Emeis B.A.Sc., F. Berger MD, PhD, B. Schmitt MD, PhD, Catheterization and Cardiovascular Interventions, Volume 103, Issue 4

Current heart valve implants entail major disadvantages in the treatment for younger patients or those with congenital heart defects. In vitro testing was performed in a Pulse Duplicator by the Canadian company ViVitro Labs Inc. equipped with flow and pressure sensors that is certified according to ISO-standard 5840 simulating conditions in the human heart. In vitro tests in a pulse duplicator showed compliance with regulatory requirements in terms of valve opening and insufficiency.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator  Tissue Engineering

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S. F. Melo, A. Nondonfaz, A. Aqil, A. Pierrard, A. Hulin, C. Delierneux, B. Ditkowski, M. Gustin, M. Legrand, B. M. E. Tullemans, S. L. N. Brouns, A. Nchimi, R. Carrus, A. Dejosé, J. W. M. Heemskerk, M. J. E. Kuijpers, J. Ritter, U. Steinseifer, J. C. Clauser, C. Jérôme, P. Lancellotti, and C. Oury, Biomater. Sci., 2024

Valve replacement with prosthetic heart valves has shown to substantially improve survival in patients, and is currently considered the effective treatment for aortic valve disease. Manufactured tri-leaflet NIPU valves with an internal diameter of 19 mm were placed in the aortic valve position of a left heart model (pulse duplicator equipment, from ViVitro labs). Testing of the NIPU valves in a pulse duplicator showed good hydrodynamic performance.

Other Products Cited:  Analysis and Computational Modeling  Heart Valve Testing  HiCycle Durability Tester  Pulse Duplicator

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Karl, R., Leister, R., Stroh, L., Mereles, D., Eden, M., Neff, L., Simone, R.D., Romano, G., Kriegseis, J., Karck, M., Lichtenstern, C., Frey, N., Frohnapfel, B., Stroh, A., & Engelhardt, S.

Mitral regurgitation (MR) is one of the most common valvular heart conditions and caused by the retrograde flow of blood from the left ventricle (LV) into the left atrium (LA) through the mitral valve (MV). The frequency of the pump (ViVitro SuperPump, ViVitro Labs, Inc., Victoria, Canada) is adjusted to 80 bpm and the stroke volume of the pump is set to reach a left ventricular pressure of approximately 120 mmHg. The present work compares the measurement of regurgitation jet by ultrasound accomplished by three different physicians with three different systems.

Other Products Cited:  Analysis and Computational Modeling  Flow Visualization  Heart Valve Testing  SuperPump

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Meskin, M., Starkey, P.A., Kaspersen, A.E. et al. Sci Rep 14, 1864 (2024).

To understand the mechanisms and to assess the performance of cardiac devices and interventions, in vitro models can be used to replicate the complex physiological interplay between the pulmonary veins, left atrium, and left ventricle. It includes a pulsatile electromechanical pump (SuperPump AR Series, ViVitro Labs, Victoria, British Columbia, Canada) that provides the volume changes in the rigid LV chamber during the cardiac cycle. This study presents a new versatile left heart MCL that accurately captures the complex and interrelated sequences of left heart events and provides supplementary understanding of left heart fluid dynamics.

Other Products Cited:  Ex ViVo Simulation  Heart Valve Testing  Pulsatile Flow Simulation  Pulse Duplicator  SuperPump

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Spanjaards, M., Borowski, F., Supp, L. et al. Biomech Model Mechanobiol (2024).

A workflow to perform fast preoperative risk assessment of paravalvular leakage (PVL) after transcatheter aortic valve replacement (TAVR) is presented in this paper. Physiological pressure and flow conditions in the aortic root are generated using a commercial pulse duplicator system from ViVitro Labs Inc. (Victoria, Canada). This model can be used to calculate the regurgitant volume after TAVR at reduced cost.

Other Products Cited:  Analysis and Computational Modeling  Heart Valve Testing  Pulse Duplicator

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Karl, R., Romano, G., Marx, J. et al. Int J CARS (2023)

Minimally invasive mitral valve surgery (MIMVS) and transcatheter edge-to-edge repair (TEER) are complex procedures used to treat mitral valve (MV) pathologies, but with limited training opportunities available. The SuperPump, a pulsatile cardiac piston pump in combination with a viscoelastic impedance adapter (both ViVitro Labs, Inc., BC, Canada), is attached to the LV and produces preselected and customizable waveforms at various frequencies and amplitudes. Ex-vivo modelling of MV pathologies and repair procedures using the described simulator realistically replicated physiological in-vivo conditions.

Other Products Cited:  Heart Valve Repair  Pulse Duplicator

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Masheane, L., du Preez, W., & Combrinck, J. The South African Journal of Industrial Engineering, 34(4), 104–115

To design cost-effective polyurethane heart valves, comprehend haemodynamic behaviour, expedite prototype development, and reduce the need for clinical testing for functional evaluation, the implementation of an experimental test digital twinning is essential. A ViVitro CPD (ViVitro Labs Inc., British Columbia, Canada) system, combined with the ViVitest data acquisition system, was used for pulse duplication at the Robert WM Frater Cardiovascular Research Centre at the University of the Free State in Bloemfontein, South Africa. The application of pulse duplicator digital twinning enabled a rapid evaluation of the valve’s functionality and a determination of the degree of its efficacy in specified environments at a minimal cost.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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Zhang, X., Kizilski, S.B., Recco, D.P. et al. Cardiovasc Eng Tech 14, 827–839 (2023).

Pulmonary valve (PV) monocusp reconstruction in transannular patch (TAP) right ventricular outflow tract (RVOT) repair for Tetralogy of Fallot has variable clinical outcomes across different surgical approaches. The ViVitro Pulse Duplicator System (ViVitro Labs Inc., Victoria, BC) was used to simulate infant RVOT physiological pulsatile flow. Balancing pressure gradient, regurgitation, and oversizing for growth, a set of leaflet design parameters have been selected for pre-clinical evaluation.

Other Products Cited:  Pulsatile Flow Simulation  Pulse Duplicator

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Mirgolbabaee H, van de Velde L, Geelkerken RH, Versluis M, Groot Jebbink E, Reijnen MMPJ. Journal of Endovascular Therapy. 2023;0(0).

To identify potential hemodynamic predictors for limb thrombosis (LT) following endovascular aneurysm repair with the Anaconda endograft in a patient-specific phantom. A hydraulic piston-driven pump (SuperPump, ViVitro labs, Victoria) was used to set a suprarenal flow profile as inlet boundary condition. In conclusion, these in vitro data show that unfavorable hemodynamics are present in the limb that presented with LT, compared to the non-thrombosed side, with higher VC and longer RT.

Other Products Cited:  Customized Circulatory Loop  Endovascular Simulator  Flow Visualization  Pulsatile Flow Simulation  Stent and Stent/Graft  SuperPump

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Viktória Stanová, Régis Rieu, Lionel Thollon, Erwan Salaun, Josep Rodés-Cabau, Nancy Côté, Diego Mantovani, Philippe Pibarot

Aortic valve stenosis is the third most frequent cardiovascular disease in high-income countries after hypertension and coronary artery disease and is associated with increased risk of heart failure and mortality. Contraction of the left ventricle and left atrium were obtained using two ViVitro piston pumps (ViVitro Inc, Victoria, Canada). The results of this in vitro/in silico study suggest that newer generations of THVs have ∼30% lower leaflet mechanical stress than the early generations.

Other Products Cited:  Analysis and Computational Modeling  Heart Valve Testing  Pulse Duplicator

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Gavin A. D'Souza, Jean E. Rinaldi, Moustafa Meki, Annabelle Crusan, Eric Richardson, Meir Shinnar, Luke H. Herbertson, J Biomech Eng. Jan 2024, 146(1): 011004 (11 pages)

Mechanical circulatory support (MCS) device therapy is one of the primary treatment options for end-stage heart failure (HF), whereby a mechanical pump is integrated with the failing heart to maintain adequate tissue perfusion. In this study, the BAF solution is circulated through the MCL using a piston pump (SuperPump (AR Series), ViVitro Labs, Inc., Victoria, BC, Canada), which is fluid-coupled to a suspended silicone mock LV sac. An MCL can be an effective regulatory tool for simulating different patient disease states and evaluating the flow performance of MCS devices over their entire operating ranges in a well-controlled environment.

Other Products Cited:  Pulsatile Flow Simulation  Pulse Duplicator  VAD Testing

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Wu, X., Saaid, H., Voorneveld, J., et al. Cardiovasc Eng Tech (2023).

The development of reliable techniques and analysis tools is essential for the application of hemodynamic biomarkers in clinical practice. A commercial piston pump (Vivitro Labs Inc., BC, Canada) was used to impose a sinusoidal-like volume change of the external pressure chamber with a cardiac cycle period of 857 ms (70 bpm, systolic duration of 300 ms, stroke volume 50 ml). The results show that the pressure distribution along the (longitudinal) base-apex axis reverses at the onset and the termination of the LV filling and ejecting, respectively.

Other Products Cited:  Flow Visualization  Pulsatile Flow Simulation  SuperPump

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S Kaule, M Stiehm, S Siewert, A Öner, KP Schmitz, and F Borowksi. Current Directions in Biomedical Engineering, vol. 9, no. 1, 2023, pp. 503-506.

We investigated the comparability between steady-state and transient PVL measurements as an input parameter for simulations in virtual cohorts. For the pulsatile flow testing we used a commercial pulse duplicator system (ViVitro Labs, Inc., Victoria, BC, Canada). An increasing pressure on the closed Evolut PRO TAVR in different annuls models during the steady flow measurements resulted in an increased flow.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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Wang A, Wang Y, Liu W, Liu L, Zhou J. The International Journal of Artificial Organs. 2023;0(0)

We aimed to elucidate the effects of the micro-structure of the pyrolytic carbon for artificial heart valves on its hydrodynamic performance. A Vivitro PD 2010 pulse duplicator system was used. The parallel-groove pattern on leaflet surface affected the hemodynamic performance of the valve prostheses.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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