Articles Related to Heart Valve Testing

Miss Brittany A. Gonzalez, Miss Elnaz Pour Issa, Mr. Omkar V. Mankame, Miss Jenniffer Bustillos, Mr. Antonio Cuellar, Mr. Andres J. Rodriguez, Dr. Frank Scholl, Dr. Steven Bibevski, Dr. Lazaro Hernandez, Mr. Vincent Brehier, Mr. Mike Casares, Dr. Krishna Rivas, Dr. Pablo Morales, Mr. Jesus Lopez, Dr. Joseph Wagner, Dr. Jennifer Bibevski, Dr. Arvind Agarwal, Dr. Florence George, and Dr. Sharan Ramaswamy - Tissue Engineering Part A. December 5, 2019

Conceptually, a tissue engineered heart valve (TEHV) would be especially appealing in the pediatric setting since small size and somatic growth constraints would be alleviated. Here, we utilized porcine small intestinal submucosa (PSIS) for valve replacement... … the Dacron tubes housing the PSIS valves were measured in order to secure the valve‐in‐ conduit (Figure 1) in the mitral position within a pulse duplicator system (ViVitro Labs, Victoria, BC) … A pulse duplicator system… ... Our findings suggest that the altered structural responses of PSIS, post-fatigue, rather than de novo tissue formation, are primarily responsible for the valve’s ability to accommodate somatic growth during the acute phase (90 days) following mitral valve replacement...

Other Products Cited:  Pulse Duplicator  Tissue Engineering

Visit Source 
Jae H. Lee, Alex D. Rygg, Ebrahim M. Kolahdouz, Simone Rossi, Stephen M. Retta, Nandini Duraiswamy, Lawrence N. Scotten, Brent A. Craven, and Boyce E. Grith - ResearchGate 2019

This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform... ...We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator.... ...This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs....

Other Products Cited:  Pulse Duplicator

Visit Source 
Amanda Barreto,Asad M. Mirza, Daniel Chaparro, Ahmed Z. Ali, Rachel Montlavan, Joshua D. Hutcheson, Sharan Ramaswamy - FIU Digital Commons

... Aortic valve calcification (AVC) is caused by defects in the valves and it is a health condition which usually requires surgical valve replacement... ...The proposed project aims to capture images of the aortic leaflet curvature while cyclic flexure is conducted... The curvature of the leaflets will be captured using two high-frame rate video systems. The aortic valve leaflet flexure experiments will be produced using a Vivitro Pulse Duplicator (Vivitro Labs Inc. Victoria, BC, Canada) …

Other Products Cited:  Pulse Duplicator

Visit Source 
Immanuel David Madukauwa-DavidVahid SadriPrem A MidhaVasilis BabaliarosCyrus AidunAjit P. Yoganathan - Annals of Biomedical Engineering First Online: 16 July 2019

Transcatheter heart valve (THV) leaflet thrombosis in the neo-sinus and associated reduced leaflet motion is of clinical concern due to risks of embolism and worsened valve hemodynamics... ...We tested two replicas of FDA approved commercial THVs—intra-annular and supra-annular (similar to the SAPIEN 3 and CoreValve families)—in a left heart simulator with coronary flow... … The Georgia Tech left heart simulator is shown in Fig. 2a. The main flow rate was driven by the primary piston pump (Vivitro Labs Inc. Victoria, Canada); wall-tapped pressure transducers (Deltran DPT-200, Utah Medical Products Inc

Other Products Cited:  SuperPump

Visit Source 
Fergal B. Coulter, Manuel Schaffner, Jakob A. Faber, Ahmad Rafsanjani, Robin Smith, Harish Appa, Peter Zilla, Deon Bezuidenhout, and Andre´ R. Studart - Matter, 2019

Synthetic implants made by traditional fabrication routes are not patient specific and rarely match the performance of their biological counterparts. We present an additive manufacturing approach for the digital fabrication of tissue-like aortic heart valves featuring customizable geometry and leaflet architectures that resemble those of native valve tissue... ...Flow was driven by a forward pressure of 100 mmHg imposed across the valve using a pulsatile testing machine (PD2010; ViVitro, Victoria, BC, Canada)... ...The ability to fabricate synthetic implants with tailored designs at multiple length scales is a key contribution toward the digital fabrication of functional implants that perform on par with native body parts...

Other Products Cited:  Pulsatile Flow Simulation  Pulse Duplicator

Visit Source 
Changfu Wu, Neelakantan Saikrishnan, Aaron J. Chalekian, Rob Fraser, Ornella Ieropoli, Stephen M. Retta, Russell Joseph, Shouyan Lee, Salvador Marquez, David Mester, Ning Pan, Sepehr Vatanpour, Craig Weinberg, Ulrich Steinseifer - Cardiovascular Engineering and Technology 2019

...A round-robin study carried out in 2005 in accordance with ISO 5840:2005 revealed significant variabilities in prosthetic heart valve hydrodynamic performance measurements among the participating laboratories. In order to re-examine the inter-laboratory variability based on the “state-of-the-art” under ISO 5840-1 and 5840-2:2015, the ISO Cardiac Valve Working Groups decided in 2016 to repeat the round-robin study.... … took part in the round-robin study, including one academic laboratory (Helmholtz Institute of the RWTH University, Aachen, Germany), three testing service providers (BDC Laboratories, Wheat Ridge, CO; Medical Implant …

Other Products Cited:  Pulse Duplicator

Visit Source 
Utku Gülan Harish Appa Pascal Corso Christian Templin Deon Bezuidenhout Peter Zilla Firat Duru Markus Holzner - Artificial organs, 2019

...In this study, we aimed at investigating the impact of transcatheter aortic valve implantation (TAVI) devices on blood flow patterns that develop in the ascending aorta under physiological flow conditions in vitro... … Graphics, Heidelberg, Germany). Valve hydrodynamics A Pulse Duplicator System (ViVitro Labs Inc) was used for the assessment of heart valve performance and function under simulated cardiac conditions. The system is a … ...We conclude that the characteristics and material designs of TAVI devices have strong influences on the hemodynamics in the ascending aorta...

Other Products Cited:  Pulse Duplicator

Visit Source 
Paolo Peruzzo, Francesca Maria Susin, Andrea Colli and Gaetano Burriesc - Open Heart 2019, official journal of the British Cardiovascular Society.

Clinical evaluation of pacing therapy in mitigating the aortic insufficiency after transchateter aortic valve implantation often gives contradictory outcomes... ...A series of in vitro tests reproducing the heart operating changes clinically obtained by pacing was carried out in a 26 mm Edwards Sapien XT prosthesis with mild paravalvular leakage. The effect of pacing on the regurgitant volumes per cycle and per minute was quantified, and the energy and power consumed by the left ventricle were calculated... … Following well-developed methodologies for evaluation of cardiovascular devices and in vitro haemodynamics features,14 15 physiological pulsatile flow conditions were replicated in a hydromechanical pulse duplicator …

Other Products Cited:  Pulse Duplicator

Visit Source 
M. Kondruweit, N. Ebel, S. Kniesburges, M. Döllinger, M. Weyand - Thorac cardiovasc Surg 2019

...the debate about the clinical evidence of the so-called patient-prosthesis mismatch (PPM) arose again. In this context it was discussed which valve specific parameter has the biggest evidence for the PPM and therefore the geometric orifice area (GOA) was pointed out as an important factor... …Methods: Commercially available surgical aortic bioprosthetic heart valves from different manufacturers were tested in a FDA / DIN conform Pulse Duplicator System (ViVitro Labs Inc., Victoria, Canada). The system … ...it was clearly demonstrated, that this GOA is a dynamic process over the whole ejection period, which significantly differed from the maximum reached GOA...

Other Products Cited:  Pulse Duplicator

Visit Source 
Jonas Rasmussen, Søren Nielsen Skov, Ditte Bruus Nielsen, Ida Lindhardt Jensen, Marcell Juan Tjørnild, Peter Johansen, Vibeke E. Hjortdal - Journal of Cardiothoracic Surgery December 2019, 14:6

Management of congenital malformations of the pulmonary artery and valve can be challenging. The severity often demands early intervention, which is rarely definitive due to the natural growth and multiple surgeries may be required... ...In this study, a simple valve design supported by an absorbable proximal stabilization ring is evaluated both in-vitro and in-vivo... … In-vitro model and testing. All in-vitro testing was carried out in a pulsatile flow model using water as the test fluid (Fig. 2). Pulsatile flow and pressure were generated with an electromechanical piston pump (VSI Superpump, Vivitro Labs, Victoria, Canada) …

Other Products Cited:  SuperPump

Visit Source 
Janarthanan Sathananthan, Stephanie Sellers, Aaron M. Barlow, Viktória Stanová, Rob Fraser, Stefan Toggweiler, Keith B. Allen, Adnan Chhatriwalla, Dale J. Murdoch, Mark Hensey, Karen Lau, Abdullah Alkhodair, Danny Dvir, Anita W. Asgar, Anson Cheung, Philipp Blanke, Jian Ye, Régis Rieu, Phillippe Pibarot, David Wood, Jonathan Leipsic and John G. Webb - JACC: Cardiovascular Interventions Volume 12, Issue 1, January 2019

The authors assessed the effect of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) followed by bioprosthetic valve fracture (BVF), testing different transcatheter heart valve (THV) designs in an ex vivo bench study... ...The authors assessed the effect of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) followed by bioprosthetic valve fracture (BVF), testing different transcatheter heart valve (THV) designs in an ex vivo bench study....

Other Products Cited:  Pulse Duplicator

Visit Source 
Sean Guo-Dong Tan, Sangho Kim Hwa, Liang Leo - European Journal of Mechanics - B/Fluids Available online 2 November 2018

Studies have suggested that the anterior leaflet of the native mitral valve aid in the formation of an asymmetric vortex ring similar to that seen in healthy left ventricles... ...we seek to investigate if this physiological left ventricular vortex can be replicated solely by the inclusion of an “anterior leaflet-like” feature within a mechanical valve design and its subsequent effects on downstream turbulence.... ...Situated within the working chamber was the left ventricular silicon phantom actuated by a pulsatile pump (ViVitro Labs Inc., Victoria, BC), the resulting ventricular pumping motion circulated a mixture of glycerin and water (40 …

Other Products Cited:  Pulse Duplicator

Visit Source 
F Guo, K Jiao, Y Bai, J Guo, Q Chen, R Yang, X Zhang - Journal of Materials Science Available online 20 September 2018

Transcatheter aortic heart valves (TAHVs) have been widely used for aortic valve replacements, with less trauma and lower clinical risk compared with traditional surgical heart valve replacements. In the present study, composites of poly(ethylene glycol) diacrylate (PEGDA) hydrogels and anisotropic high-shrinkage polyethylene terephthalate/polyamide6 (PET-PA6) fabric (PEGDA/PET-PA6) were fabricated as artificial heart valve leaflets... … 2.6. Pulse duplicator test. Hemodynamic performance of the TAHVs was assessed using a pulse duplicator system (ViVitro Labs, British Columbia, Canada) under physiological conditions according to ISO 5840-3 standards [21] …

Other Products Cited:  Pulse Duplicator

Visit Source 
Oren M. RotmanBrandon KovarovicWei-Che ChiuMatteo BianchiGil MaromMarvin J. SlepianDanny Bluestei -Annals of Biomedical Engineering 07 September 2018

Transcatheter aortic valve replacement (TAVR) is a minimally-invasive approach for treating severe aortic stenosis. All clinically-used TAVR valves to date utilize chemically-fixed xenograft as the leaflet material... ... this study, we experimentally evaluated the hemodynamic performance of the valve and compared its performance to clinically-used valves: a gold standard surgical tissue valve, and a TAVR valve.... … Testing was performed in a Vivitro Pulse Duplicator (Vivitro Labs, Victoria, BC) at average Cardiac Out- puts (CO) of 4, 5, 6, and 7 L/min, Heart Rate (HR) of 70bpm, systole-diastole ratio of 0.35–0.65, aortic pressure of …

Other Products Cited:  Pulse Duplicator

Visit Source 
R Kotzé, L Deorsola - 2018 Design of Medical Devices Conference, 2018

Mitral subvalvular apparatus plays an important role in mitral and ventricular dynamics by preserving annuloventricular continuity, known to be fundamental for ventricular function... ...We address these issues through the design of a novel semistented and chorded mitral valve that better mimics the native mitral annulus, leaflets and chordae function and can be made from off-the-shelf biomaterials with the potential to be implanted percutaneously... … Pulse duplicator setup We performed hydrodynamic testing in the mitral position on a hydro-mechanical pulse duplicator system (Vivitro Superpump System SP3891, Vivitro, Victoria, BC, Canada), described elsewhere [4]. We used a 25mm Sorin Bicarbon bileaflet …

Other Products Cited:  SuperPump

Visit Source 
Deepa SritharanParinaz FathiJason D. WeaverStephen M. RettaChangfu WuNandini Duraiswamy - Cardiovascular Engineering and Technology pp 1–14

After implantation of a transcatheter bioprosthetic heart valve its original circular circumference may become distorted, which can lead to changes in leaflet coaptation and leaflets that are stretched or sagging.... … Valve hydrodynamic performance data were collected using a commercially available left heart Pulse Duplicator (Vivitro Systems) at 0, 41, 80, and 123 M cycles; at these intervals, the valves mounted in the metallic adapter …

Other Products Cited:  Pulse Duplicator

Visit Source 
K Davis, JH Muller, CJ Meyer, FE Smit - (SAIBMEC), 2018 3rd Biennial South African, 2018

...The air volume shifts the pressure and flow rate waveforms in time and impact the physical operating conditions of the valves with constant input settings in the ViVitest software... … Results obtained from current pulse duplicators are subject to the setup and physical testing settings. The ViVitro Pulse Duplicator from ViVitroLabs Inc … Three different valves were tested in a ViVitro pulse duplicator where...

Other Products Cited:  Ex ViVo Simulation  Pulse Duplicator

Visit Source 
Wei-Ling ChenChiu-Chin WuChung-Dann Kan - World Congress on Medical Physics and Biomedical Engineering 2018 pp 519-524

...Percutaneous pulmonary valve implantation (PPVI) has evolved as most exciting development surgical strategy with dysfunctional right ventricle-pulmonary artery conduits. ... ...The purpose of this study is to investigate the hemodynamic and functional consequences of the new design using a mock circulation system... … vasculature. Blood pressures and flows are driven by a digitally controlled hydraulic piston pump (ViViTro Labs Inc., Super Pump System, Victor, BC) to produce pulsatile waves with heart rates of 60 and 80 beats/min from ARV to ARA …

Other Products Cited:  Heart Valve Repair  SuperPump

Visit Source 
Wei-Ling Chena, Chia-Hung Linb, Jieh-Neng Wangc, Pong-Jeu Lud, Ming-Yao Chand, Jui-Te Wue, Chung-Dann Kanf

...This study proposes an assistive technology to quantify regurgitation using the regurgitation fraction (RF) and heart pump efficiency (HPE). … pulmonary valves. The blood pressure and flow were driven by a digitally controlled hydraulic piston pump (ViViTro Labs Inc., Super Pump System, Victor, BC) to produce pulsatile waves with heart rates of 60 and 80 beats/min. The …

Other Products Cited:  Heart Valve Repair  SuperPump

Visit Source 
J Sathananthan, JG Webb - Catheterization and Cardiovascular Interventions, 2018

Transcatheter aortic valve implantation can be successful in selected patients with annuli beyond the current recommended limits for available transcatheter heart valves.… Hopefully in future we will have both a broader understanding and a broader range of options. Conflict of interest. Dr. Webb is a consultant to Edwards Lifesciences and ViVitro Labs. Publication cover image. Volume 91, Issue 6. May 1, 2018. Pages 1157-1158

Other Products Cited:  Pulse Duplicator

Visit Source 

Join over 5000 cardiovascular device professionals who receive our testing and engineering insights and tips every month.