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S Kaule, M Stiehm, S Siewert, A Öner, KP Schmitz, and F Borowksi. Current Directions in Biomedical Engineering, vol. 9, no. 1, 2023, pp. 503-506.
We investigated the comparability between steady-state and transient PVL measurements as an input parameter for simulations in virtual cohorts. For the pulsatile flow testing we used a commercial pulse duplicator system (ViVitro Labs, Inc., Victoria, BC, Canada). An increasing pressure on the closed Evolut PRO TAVR in different annuls models during the steady flow measurements resulted in an increased flow.
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Visit SourceWang A, Wang Y, Liu W, Liu L, Zhou J. The International Journal of Artificial Organs. 2023;0(0)
We aimed to elucidate the effects of the micro-structure of the pyrolytic carbon for artificial heart valves on its hydrodynamic performance. A Vivitro PD 2010 pulse duplicator system was used. The parallel-groove pattern on leaflet surface affected the hemodynamic performance of the valve prostheses.
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Visit SourceDylan Armfield, Shane Conway, Scott Cook, Mert Celikin, Philip Cardiff, University College Dublin, Boston Scientific Galway
Towards developing a simulation methodology for the design of next-generation Transcatheter Aortic Valve Replacement (TAVR) devices, this numerical study investigates the impact of bioprosthetic valve stiffness and anisotropic behaviour on the fatigue of the nitinol stent frame during a single cardiac cycle. The simulation results were compared to in vitro testing of the device in a ViVitro pulse duplicator. The leaflet anisotropy can have a significant impact on how well the valve closes during the diastole phase, as well as whether the stent frame is symmetrically loaded, which may impact the overall fatigue life of the nitinol stent.
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Visit SourceArianna Callera, Politecnico Milano Scuola di Ingegneria Industriale e Dell'Informazione
This work focuses on introducing more physiological conditions for testing of aortic valve prosthesis and comparing the changes in behavior of different valve substitutes in these conditions. The most used commercial test bench is the ViVitro Pulse Duplicator, composed by a pump, a model left heart, a flow measuring system and a data acquisition system. In this work we have shown that it is possible to exploit 3D printing to obtain an aortic phantom with physiological mechanical and geometrical characteristics and use it to perform pulsatile tests on aortic valve prosthesis.
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Visit SourceSarah E. Motta, Michael M. Peters, Christophe O. Chantre, Huibin Chang, Luca Cera, Qihan Liu, Elizabeth M. Cordoves, Emanuela S. Fioretta, Polina Zaytseva, Nikola Cesarovic, Maximilian Y. Emmert, Simon P. Hoerstrup, Kevin Kit Parker, Matter 6, 1860–1879
Current valve manufacturing technologies struggle to create valves that facilitate native tissue remodeling for permanent replacements. FibraValve samples were sutured onto 28 mm nitinol stents and positioned into custom made holders for mounting in a pulse duplicator (ViVitro Labs, Victoria, BC, Canada). Here, we show that FRJS can serve as a biofabrication method for implantable heart valves.
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Visit SourceShin Yajima, Yuanjia Zhu, Charles J. Stark, Robert J. Wilkerson, Matthew H. Park, Elde Stefan, Y. Joseph Woo, The American Association for Thoracic Surgery
This study aimed to biomechanically evaluate the force profiles on the anterior primary and secondary chordae after neochord repair for anterior valve prolapse with varied degrees of residual mitral regurgitation using an ex vivo heart simulator. Briefly, a 3D printer was used to rapidly develop a prototype of a modular left heart coupled to a pulsatile linear actuator (ViVitro Superpump; ViVitro Labs). In our ex vivo AVP model, moderate residual MR following neochord repair was significantly associated with increased forces for both anterior primary and secondary chordae compared with those of less-than-moderate residual MR.
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Visit SourceSofia Di Leonardo, Danila Vella, Carmelo Savio Grillo, Carla Martorana, Salvatore Torre, Vincenzo Argano, Gaetano Burriesci, European Journal of Cardio-Thoracic Surgery, ezad040
This work investigates the impact of the valve-sparing technique on the aortic valve function. The hydrodynamic performance assessment of each implant was conducted in-vitro on a hydro-mechanical pulse duplicator. This shows that, despite providing generally good performance, current valve sparing techniques are still suboptimal and far from matching the physiological leaflets dynamics.
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Visit SourceRobert J Melder, Filippo Naso, Francesco Nicotra, Laura Russo, Ivan Vesely, Sugat R Tuladhar, Antonio M Calafiore, Peter Zilla, Alessandro Gandaglia, Sotiris Korossis, European Journal of Cardio-Thoracic Surgery, ezac583
This study was to evaluate the impact of a polyphenols-based treatment on the extrinsic mechanisms responsible for early BHV degeneration. The hydrodynamic performance of the polyphenolic-treated and untreated T-GT commercial BHVs was assessed under simulated pulsatile flow in a Vivitro Pulse Duplicator System. The treatment is chemically stable, improves tissue extensibility, and effectively stabilizes glutaraldehyde.
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Visit SourceYuanjia Zhu, Matthew H. Park, Annabel Imbrie-Moore, Robert Wilkerson, Sarah Madira & Y. Joseph Woo, Journal of Cardiothoracic Surgery volume 17, Article number: 303 (2022)
Aortic regurgitation (AR) is one of the most common cardiac valvular diseases, and it is frequently caused by cusp prolapse. The simulator contains a programmable pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs) and a viscoelastic impedance adapter (ViVitro) that is comprised of two compliance chambers and a fixed resistance element and generates a physiologic ventricular waveform. In this study, we successfully designed a commissure geometric alignment device that can manipulate aortic commissure positions to induce aortic cusp prolapse.
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Visit SourceFeng Guo, Rizheng Han, Jishan Ying, Zeping Zhang, Rui Yang, Xing Zhang, Journal of Materials Science & Technology, Volume 144, 1 May 2023, Pages 178-187
In this work, bioinspired anisotropic polymeric heart valves were fabricated using composite materials from polyurethane (PU) and natural cellulose fiber bundles. The hydrodynamic performance of the polymeric valve was evaluated by the ViVitro Pulse Duplicator system. Our results demonstrate the potential application of bioinspired anisotropic CPU composites as polymeric heart valves.
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Visit SourceLawrence N. Scotten, Rolland Siegel, David J. Blundon, Marcus-André Deutsch, Terence R. P. Martin, James W. Dutton, Ebrahim M. Kolahdouz, Boyce E. Griffith
To demonstrate a clear link between predicted blood shear forces during valve closure and thrombogenicity that explains the thrombogenic difference between tissue and mechanical valves and provides a practical metric to develop and refine prosthetic valve designs for reduced thrombogenicity. Incorporated as Vivitro Systems Inc (VSI), our primary focus was research, design and development of cardiac valve implant devices and on the laboratory test systems required. In 2009, work transitioned into a separate independent research and development enterprise, ViVitro Laboratories Inc. (VLI). The application of unique technology, rapid prototyping and ranking of flow velocity patterns near valve closure optimized experimental valve geometry for reduced thrombus potential compared with control valves.
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Visit SourceDavid Meier, MD; Geoffrey W. Payne, MSc, PhD; Leila B. Mostaço-Guidolin, PhD; Rihab Bouchareb, MSc, PhD; Courtney Rich, BASc; Althea Lai, BSc; Andrew G. Chatfield, MB ChB; Mariama Akodad; Hannah Salcudean, MSc; Georg Lutter, MD; Thomas Puehler, MD; Philippe Pibarot, DVM, PhD; Keith B. Allen, MD; Adnan K. Chhatriwalla, MD; Lars Sondergaard, MD; David A. Wood, MD; John G. Webb, MD; Jonathon A. Leipsic, MD; Janarthanan Sathananthan, MPH, MBChB; Stephanie L. Sellers, MSc, PhD, EuroIntervention 2022;17:1-1
To assess the impact of bioprosthetic valve fracture (BVF) timing on long-term transcatheter heart valve (THV) durability. Valve testing was performed in the ViVitro Labs testing facilities (ViVitro Labs Inc, Victoria, Canada). Hydrodynamic testing was performed using a commercially available pulse duplicator (ViVitro Labs Inc, Victoria, Canada), meeting the equipment requirements defined in ISO 5840-3 for pulsatile flow testing (16) (Figure 1A). In this bench study, the ACn and the S3 showed acceptable hydrodynamic performances after AWT to 200M cycles, equivalent to 5 years, irrespective of BVF timing compared to no fracture.
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Visit SourceLisa Carlson Hanse, Marcell J Tjørnild, Simon G Sørensen, Peter Johansen, Ignacio Lugones, Vibeke E Hjortdal, Interactive CardioVascular and Thoracic Surgery, Volume 35, Issue 4, October 2022, ivac227
We investigated a new surgical technique of trileaflet semilunar valve reconstruction possessing the potential of remaining sufficient and allowing for some growth with the child. Pulsatile flow was produced by a Series piston pump (SuperPump AR; ViVitro Labs, Victoria, Canada), connected to the ventricular chamber. TSVR was achievable in vitro. Hydrodynamic pressure and echocardiographic evaluations demonstrated a sufficient and non-stenotic neo-valve.
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Visit SourceDavid Meier, Mariama Akodad, Andrew G. Chatfield, Georg Lutter, Thomas Puehler, Lars Søndergaard, David A. Wood, John G. Webb, Stephanie L. Sellers, and Janarthanan Sathananthan, J Am Coll Cardiol Intv. 2022 Aug, 15 (15) 1532–1539
The aim of this study was to assess the impact of commissural misalignment (CMA) on hydrodynamic function following VIV intervention with the ACURATE neo THV using a bench model. In VIV using the ACURATE neo THV at deep implantation, increasing degree of CMA was associated with THV leaflet interaction with those of the surgical valve and worsening regurgitant fraction. THV leaflet interaction was prevented when there was CA.
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Visit SourceK.Yu. Klyshnikov, E.A. Ovcharenko, Yu.A. Kudryavtseva, L.S. Barbarash, RUSSIAN JOURNAL OF TRANSPLANTOLOGY AND ARTIFICIAL ORGANS, Vol. XXII, No 2–2020
The aim of the study was an in vitro hydrodynamic study of the developed prosthetic heart valve of the second generation, designed to carry out an implantation using “valve-in-valve” method. ...Prototypes of the developed prosthesis were studied under simulated physiological conditions of the heart using a Vivitro Labs pulse duplicator (Canada) in a comparative aspect with “UniLine” clinical commercial aortic valve bioprosthesis (Russia)... ...The design of the prosthesis under development has shown its consistency in terms of functional characteristics, both in comparison with the original UniLine prosthesis and with literature data....
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Visit SourceLibby H. Welborn, Anna K. Himes, Ida E. Greenlee, Nyna J. DeWitt, Ava T. Burgess, Brandon K. Eberl, Olga Pierrakos, 2022 Systems and Information Engineering Design Symposium (SIEDS)
The aim of this paper is to: 1) showcase the design process of a quadleaflet ePTFE valved conduit with a diameter of 16mm or less and 2) offer a hemodynamic performance comparison. ...The proposed valve was tested using the ViVitro Pulse Duplicator under physiologic cardiac conditions... ...A comparison between the two ePTFE handmade valves (trileaflet and quadleaflet) demonstrated hemodynamic differences in regurgitation due to leaflet number. The handmade valves both showed increased regurgitation compared to a Carbomedics valve (commercially available design). Regurgitation had varying effects on pressure gradients and cardiac output...
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Visit SourceH. Appa, K. Park, D. Bezuidenhout, B. van Breda, B. de Jongh, J. de Villiers, R. Chacko, J. Scherman, C. Ofoegbu, J. Swanevelder, M. Cousins, P. Human, R. Smith, F. Vogt, B, K. Podesser, C. Schmitz, L. Conradi, H. Treede, H. Schröfel, T. Fischlein, M. Grabenwöger, X. Luo, H. Coombes, S. Matskeplishvili, D. F. Williams, P. Zilla, Front. Cardiovasc. Med., 03 March 2022
...Hydrodynamic testing to determine gradients (ΔP), effective orifice areas (EOA) and regurgitant fractions was performed in a pulse duplicator (Cardiac Output: 5 L/min; 37°C; 70 bpm; Stroke Volume: 32 ± 5 ml; Systolic Phase Duration of 35 ± 5%) (ViVitro Labs Inc; Victoria, BC, Canada)...The BE TAVR system met all requirements for which it was developed...
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Visit SourceM. Alizadeh, M. Cote, A. Branzan Albu, Proceedings of the IEEE/CVF Winter Conference on Applications of Computer Vision 2022
...Our experimental setup to collect high-quality videos and pressure and velocity data involves tricupsid BHVs mounted in the Pulse Duplicator device from ViVitro Labs...Experiments on four cases that include three different tricuspid BHVs yielded promising results, with the DTW scores showing a good coherence with respect to the simulations...
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Visit SourceB. Ncho, A. Siefert, V. Sadri, J. Ortner, A. Yoganathan. Journal or Med. Devices
The physiologic pressures and flows were achieved by adjustment of systemic resistance and compliance elements, and flow driven from a piston pump (Vivitro Labs Inc. Victoria, Canada).
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Visit SourceC. D. Hsu, A. Mirza, R. Matheny, S. Ramaswamy. Structural Heart. Vol. 5.
...hydrodynamic testing of the valves mounted in mitral and tricuspid positions were performed using a pulse duplicator system (ViVitro Labs) using 0.9% saline solution...
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