Articles Related to Pulse Duplicator

Fergal B. Coulter, Manuel Schaffner, Jakob A. Faber, Ahmad Rafsanjani, Robin Smith, Harish Appa, Peter Zilla, Deon Bezuidenhout, and Andre´ R. Studart - Matter, 2019

Synthetic implants made by traditional fabrication routes are not patient specific and rarely match the performance of their biological counterparts. We present an additive manufacturing approach for the digital fabrication of tissue-like aortic heart valves featuring customizable geometry and leaflet architectures that resemble those of native valve tissue... ...Flow was driven by a forward pressure of 100 mmHg imposed across the valve using a pulsatile testing machine (PD2010; ViVitro, Victoria, BC, Canada)... ...The ability to fabricate synthetic implants with tailored designs at multiple length scales is a key contribution toward the digital fabrication of functional implants that perform on par with native body parts...

Other Products Cited:  Heart Valve Testing  Pulsatile Flow Simulation

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Changfu Wu, Neelakantan Saikrishnan, Aaron J. Chalekian, Rob Fraser, Ornella Ieropoli, Stephen M. Retta, Russell Joseph, Shouyan Lee, Salvador Marquez, David Mester, Ning Pan, Sepehr Vatanpour, Craig Weinberg, Ulrich Steinseifer - Cardiovascular Engineering and Technology 2019

...A round-robin study carried out in 2005 in accordance with ISO 5840:2005 revealed significant variabilities in prosthetic heart valve hydrodynamic performance measurements among the participating laboratories. In order to re-examine the inter-laboratory variability based on the “state-of-the-art” under ISO 5840-1 and 5840-2:2015, the ISO Cardiac Valve Working Groups decided in 2016 to repeat the round-robin study.... … took part in the round-robin study, including one academic laboratory (Helmholtz Institute of the RWTH University, Aachen, Germany), three testing service providers (BDC Laboratories, Wheat Ridge, CO; Medical Implant …

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Utku Gülan Harish Appa Pascal Corso Christian Templin Deon Bezuidenhout Peter Zilla Firat Duru Markus Holzner - Artificial organs, 2019

...In this study, we aimed at investigating the impact of transcatheter aortic valve implantation (TAVI) devices on blood flow patterns that develop in the ascending aorta under physiological flow conditions in vitro... … Graphics, Heidelberg, Germany). Valve hydrodynamics A Pulse Duplicator System (ViVitro Labs Inc) was used for the assessment of heart valve performance and function under simulated cardiac conditions. The system is a … ...We conclude that the characteristics and material designs of TAVI devices have strong influences on the hemodynamics in the ascending aorta...

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Han HungYeh, Oleksandr Barannyk, Dana Grecov, Peter Oshkaid - Computers in Biology and Medicine Volume 110, July 2019, Pages 79-92

...the objective of this study is to analyze the hemodynamics and valve mechanics of a bileaflet mechanical heart valve and investigate the hemorheological characteristics under the change of hematocrit.... … Fig. 2. Schematic illustrating DPIV test set-up used in the current experiment (Image courtesy of ViVitro Labs Inc.). To simulate the physiological flow conditions, an acrylic test chamber, that represented a simplified model of … ...The current numerical analysis revealed the hematocrit influenced the shear stress distributions over a cardiac cycle...

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Paolo Peruzzo, Francesca Maria Susin, Andrea Colli and Gaetano Burriesc - Open Heart 2019, official journal of the British Cardiovascular Society.

Clinical evaluation of pacing therapy in mitigating the aortic insufficiency after transchateter aortic valve implantation often gives contradictory outcomes... ...A series of in vitro tests reproducing the heart operating changes clinically obtained by pacing was carried out in a 26 mm Edwards Sapien XT prosthesis with mild paravalvular leakage. The effect of pacing on the regurgitant volumes per cycle and per minute was quantified, and the energy and power consumed by the left ventricle were calculated... … Following well-developed methodologies for evaluation of cardiovascular devices and in vitro haemodynamics features,14 15 physiological pulsatile flow conditions were replicated in a hydromechanical pulse duplicator …

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M. Kondruweit, N. Ebel, S. Kniesburges, M. Döllinger, M. Weyand - Thorac cardiovasc Surg 2019

...the debate about the clinical evidence of the so-called patient-prosthesis mismatch (PPM) arose again. In this context it was discussed which valve specific parameter has the biggest evidence for the PPM and therefore the geometric orifice area (GOA) was pointed out as an important factor... …Methods: Commercially available surgical aortic bioprosthetic heart valves from different manufacturers were tested in a FDA / DIN conform Pulse Duplicator System (ViVitro Labs Inc., Victoria, Canada). The system … ...it was clearly demonstrated, that this GOA is a dynamic process over the whole ejection period, which significantly differed from the maximum reached GOA...

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Janarthanan Sathananthan, Stephanie Sellers, Aaron M. Barlow, Viktória Stanová, Rob Fraser, Stefan Toggweiler, Keith B. Allen, Adnan Chhatriwalla, Dale J. Murdoch, Mark Hensey, Karen Lau, Abdullah Alkhodair, Danny Dvir, Anita W. Asgar, Anson Cheung, Philipp Blanke, Jian Ye, Régis Rieu, Phillippe Pibarot, David Wood, Jonathan Leipsic and John G. Webb - JACC: Cardiovascular Interventions Volume 12, Issue 1, January 2019

The authors assessed the effect of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) followed by bioprosthetic valve fracture (BVF), testing different transcatheter heart valve (THV) designs in an ex vivo bench study... ...The authors assessed the effect of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) followed by bioprosthetic valve fracture (BVF), testing different transcatheter heart valve (THV) designs in an ex vivo bench study....

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Andreas Agathos E, SM Journal of Cardiology and Cardiovascular Diseases Published: Sep 14, 2015

Continuous improvement in the mechanics, preservation and anticalcification treatment made bioprostheses the standard mode of valve replacement in the aging population. A novel Support System with large openings at the Commissural posts has been developed and the performance and durability of bioprostheses constructed went under evaluation. … Heart valve pulse duplicator. A heart valve pulse duplicator Vivitro SPS3891 (Vivitro Systems Inc., Victoria, BC Canada) was used to measure hemodynamic parameters. All tests were performed with the standard FDA waveform …

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Sean Guo-Dong Tan, Sangho Kim Hwa, Liang Leo - European Journal of Mechanics - B/Fluids Available online 2 November 2018

Studies have suggested that the anterior leaflet of the native mitral valve aid in the formation of an asymmetric vortex ring similar to that seen in healthy left ventricles... ...we seek to investigate if this physiological left ventricular vortex can be replicated solely by the inclusion of an “anterior leaflet-like” feature within a mechanical valve design and its subsequent effects on downstream turbulence.... ...Situated within the working chamber was the left ventricular silicon phantom actuated by a pulsatile pump (ViVitro Labs Inc., Victoria, BC), the resulting ventricular pumping motion circulated a mixture of glycerin and water (40 …

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Brandon J. Tefft, Joshua A. Choe, Melissa D. Young, Ryan S. Hennessy, David W. Morse, Jeffery A. Bouchard, Herbert J. Hedberg, Joseph F. Consiglio, Dan Dragomir-Daescu, Robert D. Simari, Amir Lerman

Tissue engineered heart valves (TEHV) are being investigated to address the limitations of currently available valve prostheses... ...A bioreactor system was designed based on the Windkessel approach. Novel features including a purpose-built valve chamber and pressure feedback control were incorporated to maintain asepsis while achieving a range of hydrodynamic conditions.... … The bioreactor was used to assess the hydrodynamic performance of a bioprosthesis and the results were compared to those obtained with a ViVitro Pulse Duplicator system (ViVitro Labs, Victoria, BC, Canada)... ...The bioreactor system was able to produce a range of pressure and flow conditions from static to resting adult left ventricular outflow tract to pathological including hypertension...

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F Guo, K Jiao, Y Bai, J Guo, Q Chen, R Yang, X Zhang - Journal of Materials Science Available online 20 September 2018

Transcatheter aortic heart valves (TAHVs) have been widely used for aortic valve replacements, with less trauma and lower clinical risk compared with traditional surgical heart valve replacements. In the present study, composites of poly(ethylene glycol) diacrylate (PEGDA) hydrogels and anisotropic high-shrinkage polyethylene terephthalate/polyamide6 (PET-PA6) fabric (PEGDA/PET-PA6) were fabricated as artificial heart valve leaflets... … 2.6. Pulse duplicator test. Hemodynamic performance of the TAHVs was assessed using a pulse duplicator system (ViVitro Labs, British Columbia, Canada) under physiological conditions according to ISO 5840-3 standards [21] …

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Oren M. RotmanBrandon KovarovicWei-Che ChiuMatteo BianchiGil MaromMarvin J. SlepianDanny Bluestei -Annals of Biomedical Engineering 07 September 2018

Transcatheter aortic valve replacement (TAVR) is a minimally-invasive approach for treating severe aortic stenosis. All clinically-used TAVR valves to date utilize chemically-fixed xenograft as the leaflet material... ... this study, we experimentally evaluated the hemodynamic performance of the valve and compared its performance to clinically-used valves: a gold standard surgical tissue valve, and a TAVR valve.... … Testing was performed in a Vivitro Pulse Duplicator (Vivitro Labs, Victoria, BC) at average Cardiac Out- puts (CO) of 4, 5, 6, and 7 L/min, Heart Rate (HR) of 70bpm, systole-diastole ratio of 0.35–0.65, aortic pressure of …

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Janarthanan Sathananthan, Stephanie Sellers, Aaron Barlow, Rob Fraser, Viktória Stanová, Anson Cheung, Jian Ye, Abdullah Alenezi, Dale J. Murdoch, Mark Hensey, Danny Dvir, Philipp Blanke, Régis Rieu, David Wood, Phillippe Pibarot, Jonathan Leipsic and John Webb - JACC: Cardiovascular Interventions Volume 11, Issue 17, September 2018

Objectives This study assessed the effect of overexpansion beyond labeled size (diameter) of transcatheter heart valves through an ex vivo bench study... Background Transcatheter heart valves function optimally when expanded to specific dimensions. However, clinicians may sometimes wish to overexpand balloon-expandable valves to address specific clinical challenges. The implications of overexpansion have assumed considerable importance, and objective information to guide practice is limited...

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Deepa SritharanParinaz FathiJason D. WeaverStephen M. RettaChangfu WuNandini Duraiswamy - Cardiovascular Engineering and Technology pp 1–14

After implantation of a transcatheter bioprosthetic heart valve its original circular circumference may become distorted, which can lead to changes in leaflet coaptation and leaflets that are stretched or sagging.... … Valve hydrodynamic performance data were collected using a commercially available left heart Pulse Duplicator (Vivitro Systems) at 0, 41, 80, and 123 M cycles; at these intervals, the valves mounted in the metallic adapter …

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K Davis, JH Muller, CJ Meyer, FE Smit - (SAIBMEC), 2018 3rd Biennial South African, 2018

...The air volume shifts the pressure and flow rate waveforms in time and impact the physical operating conditions of the valves with constant input settings in the ViVitest software... … Results obtained from current pulse duplicators are subject to the setup and physical testing settings. The ViVitro Pulse Duplicator from ViVitroLabs Inc … Three different valves were tested in a ViVitro pulse duplicator where...

Other Products Cited:  Ex ViVo Simulation  Heart Valve Testing

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J Sathananthan, JG Webb - Catheterization and Cardiovascular Interventions, 2018

Transcatheter aortic valve implantation can be successful in selected patients with annuli beyond the current recommended limits for available transcatheter heart valves.… Hopefully in future we will have both a broader understanding and a broader range of options. Conflict of interest. Dr. Webb is a consultant to Edwards Lifesciences and ViVitro Labs. Publication cover image. Volume 91, Issue 6. May 1, 2018. Pages 1157-1158

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H Saaid, P Segers, M Novara, T Claessens, P Verdonck - Experiments in Fluids, 2018

...The effects of the orientation of a prosthetic mitral valve in anatomical and anti-anatomical configurations have been investigated during the diastolic filling time... … A commercially available cardiovascular simulator (Vivitro Systems, Inc., Victoria, BC, Canada) that can impose and monitor different physiological pressure and flow conditions was adopted. The hydraulic piston pump was connected to the inner tank …

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Ram Ghosh, Gil Marom, Oren Rotman, Marvin J. Slepian, Saurabh Prabhakar, Marc Horner and Danny Bluestein -- Journal of Biomechanical Engineering doi:10.1115/1.4040600 History: Received November 06, 2017; Revised May 30, 2018

...All currently FDA-approved TAVR devices use tissue valves that were adapted to but not specifically designed for TAVR use. Emerging clinical evidence indicates that these valves may get damaged during crimping and deployment- leading to valvular calcification, thrombotic complications, and limited durability... ...Our research group has developed a novel polymeric prosthetic valve, which was optimized to reduce stresses on the leaflets, improve hemodynamics and has thrombogenic performance similar to that of a tissue valve... … The valves are then sutured to a nitinol stent for completion of the process. The valves' durability is now being assessed using a Vivitro Hi-Cycle System (Vivitro Labs, Inc … Hydrodynamic performance is being evaluated using the Vivitro left heart simulator (Vivitro Labs, Inc …

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M Jeyhani, S Shahriari, M Labrosse - Artificial Organs, 2017 First published: 23 November 2017

This in vitro study aims to evaluate the hemodynamic modifications following a simulated PEtER. A custom-made mitral valve was developed, and two configurations were tested: (i) a single-orifice valve with mitral regurgitation and (ii) a double-orifice mitral valve configuration following PEtER. … MATERIALS AND METHODS In vitro model For the purpose of this study, a ViVitro pulse duplicator (ViVitro Labs, Victoria, BC, Canada) was used (Fig. 1). This system is capable of reproducing physiological flow and pressure waveforms in left heart cavity models …

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Chung-Dann Kan, MD, PhD, Jieh-Neng Wang, PhD, Wei-Ling Chen, PhD, Pong-Jeu Lu, PhD, Ming-Yao Chan, PhD, Chia-Hung Lin, PhD, Wan Chin Hsieh, MD The Journal of Thoracic and Cardiovascular Surgery, September 2017

...The current study investigated: (i) the function of the ePTFE trileaflet-valved conduits in an ex vivo experimental system and (ii) the short-term performance of the conduit in a porcine model to verify their clinical applicability.... ... valves. 168 Right ventricular function was simulated by using a digitally controlled hydraulic piston 169 SuperPump (ViViTro Labs, Victor, British Columbia, Canada), which generated a pulsating 170 flow to drive the chamber and send it into a compliant pulmonary artery. ...

Other Products Cited:  Heart Valve Testing

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