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Gavin A. D'Souza, Jean E. Rinaldi, Moustafa Meki, Annabelle Crusan, Eric Richardson, Meir Shinnar, Luke H. Herbertson, J Biomech Eng. Jan 2024, 146(1): 011004 (11 pages)
Mechanical circulatory support (MCS) device therapy is one of the primary treatment options for end-stage heart failure (HF), whereby a mechanical pump is integrated with the failing heart to maintain adequate tissue perfusion. In this study, the BAF solution is circulated through the MCL using a piston pump (SuperPump (AR Series), ViVitro Labs, Inc., Victoria, BC, Canada), which is fluid-coupled to a suspended silicone mock LV sac. An MCL can be an effective regulatory tool for simulating different patient disease states and evaluating the flow performance of MCS devices over their entire operating ranges in a well-controlled environment.
Other Products Cited: Pulsatile Flow Simulation VAD Testing
Visit SourceS Kaule, M Stiehm, S Siewert, A Öner, KP Schmitz, and F Borowksi. Current Directions in Biomedical Engineering, vol. 9, no. 1, 2023, pp. 503-506.
We investigated the comparability between steady-state and transient PVL measurements as an input parameter for simulations in virtual cohorts. For the pulsatile flow testing we used a commercial pulse duplicator system (ViVitro Labs, Inc., Victoria, BC, Canada). An increasing pressure on the closed Evolut PRO TAVR in different annuls models during the steady flow measurements resulted in an increased flow.
Other Products Cited: Heart Valve Testing
Visit SourceWang A, Wang Y, Liu W, Liu L, Zhou J. The International Journal of Artificial Organs. 2023;0(0)
We aimed to elucidate the effects of the micro-structure of the pyrolytic carbon for artificial heart valves on its hydrodynamic performance. A Vivitro PD 2010 pulse duplicator system was used. The parallel-groove pattern on leaflet surface affected the hemodynamic performance of the valve prostheses.
Other Products Cited: Heart Valve Testing
Visit SourceDylan Armfield, Shane Conway, Scott Cook, Mert Celikin, Philip Cardiff, University College Dublin, Boston Scientific Galway
Towards developing a simulation methodology for the design of next-generation Transcatheter Aortic Valve Replacement (TAVR) devices, this numerical study investigates the impact of bioprosthetic valve stiffness and anisotropic behaviour on the fatigue of the nitinol stent frame during a single cardiac cycle. The simulation results were compared to in vitro testing of the device in a ViVitro pulse duplicator. The leaflet anisotropy can have a significant impact on how well the valve closes during the diastole phase, as well as whether the stent frame is symmetrically loaded, which may impact the overall fatigue life of the nitinol stent.
Other Products Cited: Heart Valve Testing
Visit SourceArianna Callera, Politecnico Milano Scuola di Ingegneria Industriale e Dell'Informazione
This work focuses on introducing more physiological conditions for testing of aortic valve prosthesis and comparing the changes in behavior of different valve substitutes in these conditions. The most used commercial test bench is the ViVitro Pulse Duplicator, composed by a pump, a model left heart, a flow measuring system and a data acquisition system. In this work we have shown that it is possible to exploit 3D printing to obtain an aortic phantom with physiological mechanical and geometrical characteristics and use it to perform pulsatile tests on aortic valve prosthesis.
Other Products Cited: Heart Valve Testing
Visit SourceSarah E. Motta, Michael M. Peters, Christophe O. Chantre, Huibin Chang, Luca Cera, Qihan Liu, Elizabeth M. Cordoves, Emanuela S. Fioretta, Polina Zaytseva, Nikola Cesarovic, Maximilian Y. Emmert, Simon P. Hoerstrup, Kevin Kit Parker, Matter 6, 1860–1879
Current valve manufacturing technologies struggle to create valves that facilitate native tissue remodeling for permanent replacements. FibraValve samples were sutured onto 28 mm nitinol stents and positioned into custom made holders for mounting in a pulse duplicator (ViVitro Labs, Victoria, BC, Canada). Here, we show that FRJS can serve as a biofabrication method for implantable heart valves.
Other Products Cited: Heart Valve Testing
Visit SourceMariam Abdi Noor, Leila Louise Benhassen, Alexander Emil Kaspersen, Marc Gjern Weiss, John Michael Hasenkam, Peter Johansen, J. of Cardiovasc. Trans. Res.
The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. The ventricular chamber was coupled to a digitally controlled piston pump (SuperPump AR Series, ViVitro Labs, Victoria, Canada), delivering a pulsatile flow to simulate left ventricular ejection into the aortic root. Overall, the echographic data revealed that both interventions had a downsizing effect on the aortic root, while still maintaining the distensibility comparable to the native condition.
Other Products Cited: Heart Valve Repair Pulsatile Flow Simulation SuperPump
Visit SourceShin Yajima, Yuanjia Zhu, Charles J. Stark, Robert J. Wilkerson, Matthew H. Park, Elde Stefan, Y. Joseph Woo, The American Association for Thoracic Surgery
This study aimed to biomechanically evaluate the force profiles on the anterior primary and secondary chordae after neochord repair for anterior valve prolapse with varied degrees of residual mitral regurgitation using an ex vivo heart simulator. Briefly, a 3D printer was used to rapidly develop a prototype of a modular left heart coupled to a pulsatile linear actuator (ViVitro Superpump; ViVitro Labs). In our ex vivo AVP model, moderate residual MR following neochord repair was significantly associated with increased forces for both anterior primary and secondary chordae compared with those of less-than-moderate residual MR.
Other Products Cited: Ex ViVo Simulation Heart Valve Testing Pulsatile Flow Simulation
Visit SourceFinja Borowski, Sebastian Kaule, Jan Oldenburg, Klaus-Peter Schmitz, Alper Öner, and Michael Stiehm, tm - Technisches Messen
Durability of transcatheter aortic valve replacement (TAVR) could be limited by leaflet thrombosis. A commercially available pulse duplicator system (ViVitro Inc., Victoria, BC, Canada) was used to generate physiological flow and pressure conditions of the cardiovascular circulation. Since commissural alignment in TAVR has only recently become the focus of clinical research, there is a clear gap in understanding the long-term clinical impact of commissural alignment.
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Visit SourceSofia Di Leonardo, Danila Vella, Carmelo Savio Grillo, Carla Martorana, Salvatore Torre, Vincenzo Argano, Gaetano Burriesci, European Journal of Cardio-Thoracic Surgery, ezad040
This work investigates the impact of the valve-sparing technique on the aortic valve function. The hydrodynamic performance assessment of each implant was conducted in-vitro on a hydro-mechanical pulse duplicator. This shows that, despite providing generally good performance, current valve sparing techniques are still suboptimal and far from matching the physiological leaflets dynamics.
Other Products Cited: Heart Valve Testing
Visit SourceRobert J Melder, Filippo Naso, Francesco Nicotra, Laura Russo, Ivan Vesely, Sugat R Tuladhar, Antonio M Calafiore, Peter Zilla, Alessandro Gandaglia, Sotiris Korossis, European Journal of Cardio-Thoracic Surgery, ezac583
This study was to evaluate the impact of a polyphenols-based treatment on the extrinsic mechanisms responsible for early BHV degeneration. The hydrodynamic performance of the polyphenolic-treated and untreated T-GT commercial BHVs was assessed under simulated pulsatile flow in a Vivitro Pulse Duplicator System. The treatment is chemically stable, improves tissue extensibility, and effectively stabilizes glutaraldehyde.
Other Products Cited: Heart Valve Testing
Visit SourceYuanjia Zhu, Matthew H. Park, Annabel Imbrie-Moore, Robert Wilkerson, Sarah Madira & Y. Joseph Woo, Journal of Cardiothoracic Surgery volume 17, Article number: 303 (2022)
Aortic regurgitation (AR) is one of the most common cardiac valvular diseases, and it is frequently caused by cusp prolapse. The simulator contains a programmable pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs) and a viscoelastic impedance adapter (ViVitro) that is comprised of two compliance chambers and a fixed resistance element and generates a physiologic ventricular waveform. In this study, we successfully designed a commissure geometric alignment device that can manipulate aortic commissure positions to induce aortic cusp prolapse.
Other Products Cited: Heart Valve Testing
Visit SourceFeng Guo, Rizheng Han, Jishan Ying, Zeping Zhang, Rui Yang, Xing Zhang, Journal of Materials Science & Technology, Volume 144, 1 May 2023, Pages 178-187
In this work, bioinspired anisotropic polymeric heart valves were fabricated using composite materials from polyurethane (PU) and natural cellulose fiber bundles. The hydrodynamic performance of the polymeric valve was evaluated by the ViVitro Pulse Duplicator system. Our results demonstrate the potential application of bioinspired anisotropic CPU composites as polymeric heart valves.
Other Products Cited: Heart Valve Testing
Visit SourceMaria Rocchi, Marcus Ingram, Piet Claus, Jan D'hooge, Bart Meyns, Libera Fresiello, Artif Organs. 2022; 00: 1– 13
The aim of this review is to provide an overview on Mock Circulatory Loops and to discuss the recent developments of 3D anatomical models for cardiovascular Medical Device testing. One example is the ViVitro Pulse Duplicator system. The simulator is provided with a flexible ventricular sac activated by a piston pump. The addition of 3D anatomical models enables more realistic connections of the Medical Device with the implantation site and enhances the testing capabilities of the Mock Circulatory Loop.
Other Products Cited: Pulsatile Flow Simulation
Visit SourceShannen B. Kizilski, Xiaoya Zhang, Nicholas E. Kneier, Martha D. Chaillo Lizarraga, Noah E. Schulz, Peter E. Hammer & David M. Hoganson, Cardiovascular Engineering and Technology (2022)
The aim of this study was to develop a robust in vitro system for quantifying flow conditions after various RVOT interventions. The MCL was developed around the ViVitro Pulse Duplicator System with the viscoelastic impedance adapter and ventricle chamber attachments. The 3D-printed RVOT anatomical model and in vitro pulmonary circulatory loop developed in this work provide platform for planning and evaluating surgical interventions in the pediatric population.
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Visit SourceLawrence N. Scotten, Rolland Siegel, David J. Blundon, Marcus-André Deutsch, Terence R. P. Martin, James W. Dutton, Ebrahim M. Kolahdouz, Boyce E. Griffith
To demonstrate a clear link between predicted blood shear forces during valve closure and thrombogenicity that explains the thrombogenic difference between tissue and mechanical valves and provides a practical metric to develop and refine prosthetic valve designs for reduced thrombogenicity. Incorporated as Vivitro Systems Inc (VSI), our primary focus was research, design and development of cardiac valve implant devices and on the laboratory test systems required. In 2009, work transitioned into a separate independent research and development enterprise, ViVitro Laboratories Inc. (VLI). The application of unique technology, rapid prototyping and ranking of flow velocity patterns near valve closure optimized experimental valve geometry for reduced thrombus potential compared with control valves.
Other Products Cited: Heart Valve Testing
Visit SourceDavid Meier, Mariama Akodad, Andrew G. Chatfield, Georg Lutter, Thomas Puehler, Lars Søndergaard, David A. Wood, John G. Webb, Stephanie L. Sellers, and Janarthanan Sathananthan, J Am Coll Cardiol Intv. 2022 Aug, 15 (15) 1532–1539
The aim of this study was to assess the impact of commissural misalignment (CMA) on hydrodynamic function following VIV intervention with the ACURATE neo THV using a bench model. In VIV using the ACURATE neo THV at deep implantation, increasing degree of CMA was associated with THV leaflet interaction with those of the surgical valve and worsening regurgitant fraction. THV leaflet interaction was prevented when there was CA.
Other Products Cited: Heart Valve Testing
Visit SourceK.Yu. Klyshnikov, E.A. Ovcharenko, Yu.A. Kudryavtseva, L.S. Barbarash, RUSSIAN JOURNAL OF TRANSPLANTOLOGY AND ARTIFICIAL ORGANS, Vol. XXII, No 2–2020
The aim of the study was an in vitro hydrodynamic study of the developed prosthetic heart valve of the second generation, designed to carry out an implantation using “valve-in-valve” method. ...Prototypes of the developed prosthesis were studied under simulated physiological conditions of the heart using a Vivitro Labs pulse duplicator (Canada) in a comparative aspect with “UniLine” clinical commercial aortic valve bioprosthesis (Russia)... ...The design of the prosthesis under development has shown its consistency in terms of functional characteristics, both in comparison with the original UniLine prosthesis and with literature data....
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Visit SourceLibby H. Welborn, Anna K. Himes, Ida E. Greenlee, Nyna J. DeWitt, Ava T. Burgess, Brandon K. Eberl, Olga Pierrakos, 2022 Systems and Information Engineering Design Symposium (SIEDS)
The aim of this paper is to: 1) showcase the design process of a quadleaflet ePTFE valved conduit with a diameter of 16mm or less and 2) offer a hemodynamic performance comparison. ...The proposed valve was tested using the ViVitro Pulse Duplicator under physiologic cardiac conditions... ...A comparison between the two ePTFE handmade valves (trileaflet and quadleaflet) demonstrated hemodynamic differences in regurgitation due to leaflet number. The handmade valves both showed increased regurgitation compared to a Carbomedics valve (commercially available design). Regurgitation had varying effects on pressure gradients and cardiac output...
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Visit SourceK.Yu. Klyshnikov, P.S. Onischenko, Е.А. Ovcharenko, СТМ, 2022, vol. 14, No.2
The aim of the study was to study the complex biomechanics of the aortic valve prosthesis and to analyze the effect of frame mobility on the stress-strain state and geometry of the valve leaflet apparatus using a numerical simulation method, which reproduces the qualitative and quantitative results of its bench tests. ...The simulation was validated by comparing the results of numerical and bench simulation on the ViVitro Labs hydrodynamic system (ViVitro Labs Inc., Canada)... ...The results of the UniLine prosthesis biomechanics modeling have demonstrated that mobility of the frame struts of the heart valve prosthesis is a crucial aspect in assessing the effectiveness of the leaflet apparatus geometry and may be a negative factor in case of a highly elastic leaflet material...
Other Products Cited: Analysis and Computational Modeling
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