Articles Related to Pulse Duplicator

Miss Brittany A. Gonzalez, Miss Elnaz Pour Issa, Mr. Omkar V. Mankame, Miss Jenniffer Bustillos, Mr. Antonio Cuellar, Mr. Andres J. Rodriguez, Dr. Frank Scholl, Dr. Steven Bibevski, Dr. Lazaro Hernandez, Mr. Vincent Brehier, Mr. Mike Casares, Dr. Krishna Rivas, Dr. Pablo Morales, Mr. Jesus Lopez, Dr. Joseph Wagner, Dr. Jennifer Bibevski, Dr. Arvind Agarwal, Dr. Florence George, and Dr. Sharan Ramaswamy - Tissue Engineering Part A. December 5, 2019

Conceptually, a tissue engineered heart valve (TEHV) would be especially appealing in the pediatric setting since small size and somatic growth constraints would be alleviated. Here, we utilized porcine small intestinal submucosa (PSIS) for valve replacement... … the Dacron tubes housing the PSIS valves were measured in order to secure the valve‐in‐ conduit (Figure 1) in the mitral position within a pulse duplicator system (ViVitro Labs, Victoria, BC) … A pulse duplicator system… ... Our findings suggest that the altered structural responses of PSIS, post-fatigue, rather than de novo tissue formation, are primarily responsible for the valve’s ability to accommodate somatic growth during the acute phase (90 days) following mitral valve replacement...

Other Products Cited:  Heart Valve Testing  Tissue Engineering

Visit Source 
Janarthanan Sathananthan MBChB, MPH Mark Hensey MB BCh BAO Rob Fraser MSc Uri Landes MD Philipp Blanke MD Hoda Hatoum PhD Lakshmi Prasad Dasi PhD Alexander Sedaghat MD Vinayak N Bapat MD Jonathon Leipsic MD Lars Søndergaard MD, DMSc David A. Wood MD John G. Webb MD - Catheterization and Cardiovascular Interventions October 2019

...Bench study assessed the hydrodynamic performance of different sizes of self‐expanding supra‐annular THVs in three different surgical aortic bioprostheses at different implantation depths.... ...A small versus medium ACURATE neo (ACn), and a 26 mm versus 29 mm Evolut R were assessed after VIV implantation in 25 mm Mitroflow, Mosaic, and Magna Ease aortic surgical bioprostheses, at three implantation depths (+2 mm, ‐2 mm, and ‐6 mm).... ...Use of a larger self‐expanding THV was associated with superior hydrodynamic performance if the THV was implanted high....

Other Products Cited:  TAVI

Visit Source 
Jae H. Lee, Alex D. Rygg, Ebrahim M. Kolahdouz, Simone Rossi, Stephen M. Retta, Nandini Duraiswamy, Lawrence N. Scotten, Brent A. Craven, and Boyce E. Grith - ResearchGate 2019

This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform... ...We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator.... ...This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs....

Other Products Cited:  Heart Valve Testing

Visit Source 
HH Yeh - 2019 UBC Theses and Dissertations

... thesis firstly evaluated the biomechanical contributions to ATAA progression under the influence of anatomy, hypertension, and hematocrit using fully coupled fluid-structure interaction (FSI) with arterial wall anisotropy to provide additional information in patient evaluations... ...The three different ATAA models identified different aortic expansions that were not uniform under pulsatile pressure and a geometry depended on elevated wall stress under hypertension.... ... A commercially available, 23 mm BMHV with a tissue annulus diameter / internal diameter (TAD/ID) of 18.5 mm (Figure 3.2), was used as the test model. ViVitro pulse duplicator was used to assess the performance and function of prosthetic heart valves under simulated cardiac conditions. ...

Other Products Cited:  Flow Visualization

Visit Source 
Amanda Barreto,Asad M. Mirza, Daniel Chaparro, Ahmed Z. Ali, Rachel Montlavan, Joshua D. Hutcheson, Sharan Ramaswamy - FIU Digital Commons

... Aortic valve calcification (AVC) is caused by defects in the valves and it is a health condition which usually requires surgical valve replacement... ...The proposed project aims to capture images of the aortic leaflet curvature while cyclic flexure is conducted... The curvature of the leaflets will be captured using two high-frame rate video systems. The aortic valve leaflet flexure experiments will be produced using a Vivitro Pulse Duplicator (Vivitro Labs Inc. Victoria, BC, Canada) …

Other Products Cited:  Heart Valve Testing

Visit Source 
Fergal B. Coulter, Manuel Schaffner, Jakob A. Faber, Ahmad Rafsanjani, Robin Smith, Harish Appa, Peter Zilla, Deon Bezuidenhout, and Andre´ R. Studart - Matter, 2019

Synthetic implants made by traditional fabrication routes are not patient specific and rarely match the performance of their biological counterparts. We present an additive manufacturing approach for the digital fabrication of tissue-like aortic heart valves featuring customizable geometry and leaflet architectures that resemble those of native valve tissue... ...Flow was driven by a forward pressure of 100 mmHg imposed across the valve using a pulsatile testing machine (PD2010; ViVitro, Victoria, BC, Canada)... ...The ability to fabricate synthetic implants with tailored designs at multiple length scales is a key contribution toward the digital fabrication of functional implants that perform on par with native body parts...

Other Products Cited:  Heart Valve Testing  Pulsatile Flow Simulation

Visit Source 
Changfu Wu, Neelakantan Saikrishnan, Aaron J. Chalekian, Rob Fraser, Ornella Ieropoli, Stephen M. Retta, Russell Joseph, Shouyan Lee, Salvador Marquez, David Mester, Ning Pan, Sepehr Vatanpour, Craig Weinberg, Ulrich Steinseifer - Cardiovascular Engineering and Technology 2019

...A round-robin study carried out in 2005 in accordance with ISO 5840:2005 revealed significant variabilities in prosthetic heart valve hydrodynamic performance measurements among the participating laboratories. In order to re-examine the inter-laboratory variability based on the “state-of-the-art” under ISO 5840-1 and 5840-2:2015, the ISO Cardiac Valve Working Groups decided in 2016 to repeat the round-robin study.... … took part in the round-robin study, including one academic laboratory (Helmholtz Institute of the RWTH University, Aachen, Germany), three testing service providers (BDC Laboratories, Wheat Ridge, CO; Medical Implant …

Other Products Cited:  Heart Valve Testing

Visit Source 
Utku Gülan Harish Appa Pascal Corso Christian Templin Deon Bezuidenhout Peter Zilla Firat Duru Markus Holzner - Artificial organs, 2019

...In this study, we aimed at investigating the impact of transcatheter aortic valve implantation (TAVI) devices on blood flow patterns that develop in the ascending aorta under physiological flow conditions in vitro... … Graphics, Heidelberg, Germany). Valve hydrodynamics A Pulse Duplicator System (ViVitro Labs Inc) was used for the assessment of heart valve performance and function under simulated cardiac conditions. The system is a … ...We conclude that the characteristics and material designs of TAVI devices have strong influences on the hemodynamics in the ascending aorta...

Other Products Cited:  Heart Valve Testing

Visit Source 
Han HungYeh, Oleksandr Barannyk, Dana Grecov, Peter Oshkaid - Computers in Biology and Medicine Volume 110, July 2019, Pages 79-92

...the objective of this study is to analyze the hemodynamics and valve mechanics of a bileaflet mechanical heart valve and investigate the hemorheological characteristics under the change of hematocrit.... … Fig. 2. Schematic illustrating DPIV test set-up used in the current experiment (Image courtesy of ViVitro Labs Inc.). To simulate the physiological flow conditions, an acrylic test chamber, that represented a simplified model of … ...The current numerical analysis revealed the hematocrit influenced the shear stress distributions over a cardiac cycle...

Other Products Cited:  Flow Visualization

Visit Source 
Paolo Peruzzo, Francesca Maria Susin, Andrea Colli and Gaetano Burriesc - Open Heart 2019, official journal of the British Cardiovascular Society.

Clinical evaluation of pacing therapy in mitigating the aortic insufficiency after transchateter aortic valve implantation often gives contradictory outcomes... ...A series of in vitro tests reproducing the heart operating changes clinically obtained by pacing was carried out in a 26 mm Edwards Sapien XT prosthesis with mild paravalvular leakage. The effect of pacing on the regurgitant volumes per cycle and per minute was quantified, and the energy and power consumed by the left ventricle were calculated... … Following well-developed methodologies for evaluation of cardiovascular devices and in vitro haemodynamics features,14 15 physiological pulsatile flow conditions were replicated in a hydromechanical pulse duplicator …

Other Products Cited:  Heart Valve Testing

Visit Source 
M. Kondruweit, N. Ebel, S. Kniesburges, M. Döllinger, M. Weyand - Thorac cardiovasc Surg 2019

...the debate about the clinical evidence of the so-called patient-prosthesis mismatch (PPM) arose again. In this context it was discussed which valve specific parameter has the biggest evidence for the PPM and therefore the geometric orifice area (GOA) was pointed out as an important factor... …Methods: Commercially available surgical aortic bioprosthetic heart valves from different manufacturers were tested in a FDA / DIN conform Pulse Duplicator System (ViVitro Labs Inc., Victoria, Canada). The system … ...it was clearly demonstrated, that this GOA is a dynamic process over the whole ejection period, which significantly differed from the maximum reached GOA...

Other Products Cited:  Heart Valve Testing

Visit Source 
Janarthanan Sathananthan, Stephanie Sellers, Aaron M. Barlow, Viktória Stanová, Rob Fraser, Stefan Toggweiler, Keith B. Allen, Adnan Chhatriwalla, Dale J. Murdoch, Mark Hensey, Karen Lau, Abdullah Alkhodair, Danny Dvir, Anita W. Asgar, Anson Cheung, Philipp Blanke, Jian Ye, Régis Rieu, Phillippe Pibarot, David Wood, Jonathan Leipsic and John G. Webb - JACC: Cardiovascular Interventions Volume 12, Issue 1, January 2019

The authors assessed the effect of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) followed by bioprosthetic valve fracture (BVF), testing different transcatheter heart valve (THV) designs in an ex vivo bench study... ...The authors assessed the effect of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) followed by bioprosthetic valve fracture (BVF), testing different transcatheter heart valve (THV) designs in an ex vivo bench study....

Other Products Cited:  Heart Valve Testing

Visit Source 
Andreas Agathos E, SM Journal of Cardiology and Cardiovascular Diseases Published: Sep 14, 2015

Continuous improvement in the mechanics, preservation and anticalcification treatment made bioprostheses the standard mode of valve replacement in the aging population. A novel Support System with large openings at the Commissural posts has been developed and the performance and durability of bioprostheses constructed went under evaluation. … Heart valve pulse duplicator. A heart valve pulse duplicator Vivitro SPS3891 (Vivitro Systems Inc., Victoria, BC Canada) was used to measure hemodynamic parameters. All tests were performed with the standard FDA waveform …

Other Products Cited:

Visit Source 
Sean Guo-Dong Tan, Sangho Kim Hwa, Liang Leo - European Journal of Mechanics - B/Fluids Available online 2 November 2018

Studies have suggested that the anterior leaflet of the native mitral valve aid in the formation of an asymmetric vortex ring similar to that seen in healthy left ventricles... ...we seek to investigate if this physiological left ventricular vortex can be replicated solely by the inclusion of an “anterior leaflet-like” feature within a mechanical valve design and its subsequent effects on downstream turbulence.... ...Situated within the working chamber was the left ventricular silicon phantom actuated by a pulsatile pump (ViVitro Labs Inc., Victoria, BC), the resulting ventricular pumping motion circulated a mixture of glycerin and water (40 …

Other Products Cited:  Heart Valve Testing

Visit Source 
Brandon J. Tefft, Joshua A. Choe, Melissa D. Young, Ryan S. Hennessy, David W. Morse, Jeffery A. Bouchard, Herbert J. Hedberg, Joseph F. Consiglio, Dan Dragomir-Daescu, Robert D. Simari, Amir Lerman

Tissue engineered heart valves (TEHV) are being investigated to address the limitations of currently available valve prostheses... ...A bioreactor system was designed based on the Windkessel approach. Novel features including a purpose-built valve chamber and pressure feedback control were incorporated to maintain asepsis while achieving a range of hydrodynamic conditions.... … The bioreactor was used to assess the hydrodynamic performance of a bioprosthesis and the results were compared to those obtained with a ViVitro Pulse Duplicator system (ViVitro Labs, Victoria, BC, Canada)... ...The bioreactor system was able to produce a range of pressure and flow conditions from static to resting adult left ventricular outflow tract to pathological including hypertension...

Other Products Cited:  Pulsatile Flow Simulation

Visit Source 
F Guo, K Jiao, Y Bai, J Guo, Q Chen, R Yang, X Zhang - Journal of Materials Science Available online 20 September 2018

Transcatheter aortic heart valves (TAHVs) have been widely used for aortic valve replacements, with less trauma and lower clinical risk compared with traditional surgical heart valve replacements. In the present study, composites of poly(ethylene glycol) diacrylate (PEGDA) hydrogels and anisotropic high-shrinkage polyethylene terephthalate/polyamide6 (PET-PA6) fabric (PEGDA/PET-PA6) were fabricated as artificial heart valve leaflets... … 2.6. Pulse duplicator test. Hemodynamic performance of the TAHVs was assessed using a pulse duplicator system (ViVitro Labs, British Columbia, Canada) under physiological conditions according to ISO 5840-3 standards [21] …

Other Products Cited:  Heart Valve Testing

Visit Source 
Oren M. RotmanBrandon KovarovicWei-Che ChiuMatteo BianchiGil MaromMarvin J. SlepianDanny Bluestei -Annals of Biomedical Engineering 07 September 2018

Transcatheter aortic valve replacement (TAVR) is a minimally-invasive approach for treating severe aortic stenosis. All clinically-used TAVR valves to date utilize chemically-fixed xenograft as the leaflet material... ... this study, we experimentally evaluated the hemodynamic performance of the valve and compared its performance to clinically-used valves: a gold standard surgical tissue valve, and a TAVR valve.... … Testing was performed in a Vivitro Pulse Duplicator (Vivitro Labs, Victoria, BC) at average Cardiac Out- puts (CO) of 4, 5, 6, and 7 L/min, Heart Rate (HR) of 70bpm, systole-diastole ratio of 0.35–0.65, aortic pressure of …

Other Products Cited:  Heart Valve Testing

Visit Source 
Janarthanan Sathananthan, Stephanie Sellers, Aaron Barlow, Rob Fraser, Viktória Stanová, Anson Cheung, Jian Ye, Abdullah Alenezi, Dale J. Murdoch, Mark Hensey, Danny Dvir, Philipp Blanke, Régis Rieu, David Wood, Phillippe Pibarot, Jonathan Leipsic and John Webb - JACC: Cardiovascular Interventions Volume 11, Issue 17, September 2018

Objectives This study assessed the effect of overexpansion beyond labeled size (diameter) of transcatheter heart valves through an ex vivo bench study... Background Transcatheter heart valves function optimally when expanded to specific dimensions. However, clinicians may sometimes wish to overexpand balloon-expandable valves to address specific clinical challenges. The implications of overexpansion have assumed considerable importance, and objective information to guide practice is limited...

Other Products Cited:  TAVI

Visit Source 
Deepa SritharanParinaz FathiJason D. WeaverStephen M. RettaChangfu WuNandini Duraiswamy - Cardiovascular Engineering and Technology pp 1–14

After implantation of a transcatheter bioprosthetic heart valve its original circular circumference may become distorted, which can lead to changes in leaflet coaptation and leaflets that are stretched or sagging.... … Valve hydrodynamic performance data were collected using a commercially available left heart Pulse Duplicator (Vivitro Systems) at 0, 41, 80, and 123 M cycles; at these intervals, the valves mounted in the metallic adapter …

Other Products Cited:  Heart Valve Testing

Visit Source 
K Davis, JH Muller, CJ Meyer, FE Smit - (SAIBMEC), 2018 3rd Biennial South African, 2018

...The air volume shifts the pressure and flow rate waveforms in time and impact the physical operating conditions of the valves with constant input settings in the ViVitest software... … Results obtained from current pulse duplicators are subject to the setup and physical testing settings. The ViVitro Pulse Duplicator from ViVitroLabs Inc … Three different valves were tested in a ViVitro pulse duplicator where...

Other Products Cited:  Ex ViVo Simulation  Heart Valve Testing

Visit Source 

Join over 5000 cardiovascular device professionals who receive our testing and engineering insights and tips every month.