Articles Related to Flow Visualization

Karl, R., Leister, R., Stroh, L., Mereles, D., Eden, M., Neff, L., Simone, R.D., Romano, G., Kriegseis, J., Karck, M., Lichtenstern, C., Frey, N., Frohnapfel, B., Stroh, A., & Engelhardt, S.

Mitral regurgitation (MR) is one of the most common valvular heart conditions and caused by the retrograde flow of blood from the left ventricle (LV) into the left atrium (LA) through the mitral valve (MV). The frequency of the pump (ViVitro SuperPump, ViVitro Labs, Inc., Victoria, Canada) is adjusted to 80 bpm and the stroke volume of the pump is set to reach a left ventricular pressure of approximately 120 mmHg. The present work compares the measurement of regurgitation jet by ultrasound accomplished by three different physicians with three different systems.

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Mirgolbabaee H, van de Velde L, Geelkerken RH, Versluis M, Groot Jebbink E, Reijnen MMPJ. Journal of Endovascular Therapy. 2023;0(0).

To identify potential hemodynamic predictors for limb thrombosis (LT) following endovascular aneurysm repair with the Anaconda endograft in a patient-specific phantom. A hydraulic piston-driven pump (SuperPump, ViVitro labs, Victoria) was used to set a suprarenal flow profile as inlet boundary condition. In conclusion, these in vitro data show that unfavorable hemodynamics are present in the limb that presented with LT, compared to the non-thrombosed side, with higher VC and longer RT.

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Wu, X., Saaid, H., Voorneveld, J., et al. Cardiovasc Eng Tech (2023).

The development of reliable techniques and analysis tools is essential for the application of hemodynamic biomarkers in clinical practice. A commercial piston pump (Vivitro Labs Inc., BC, Canada) was used to impose a sinusoidal-like volume change of the external pressure chamber with a cardiac cycle period of 857 ms (70 bpm, systolic duration of 300 ms, stroke volume 50 ml). The results show that the pressure distribution along the (longitudinal) base-apex axis reverses at the onset and the termination of the LV filling and ejecting, respectively.

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Finja Borowski, Sebastian Kaule, Jan Oldenburg, Klaus-Peter Schmitz, Alper Öner, and Michael Stiehm, tm - Technisches Messen

Durability of transcatheter aortic valve replacement (TAVR) could be limited by leaflet thrombosis. A commercially available pulse duplicator system (ViVitro Inc., Victoria, BC, Canada) was used to generate physiological flow and pressure conditions of the cardiovascular circulation. Since commissural alignment in TAVR has only recently become the focus of clinical research, there is a clear gap in understanding the long-term clinical impact of commissural alignment.

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Luca Rosalia, Caglar Ozturk, Jaume Coll-Font, Yiling Fan, Yasufumi Nagata, Manisha Singh, Debkalpa Goswami, Adam Mauskapf, Shi Chen, Robert A. Eder, Efrat M. Goffer, Jo H. Kim, Salva Yurista, Benjamin P. Bonner, Anna N. Foster, Robert A. Levine, Elazer R. Edelman, Marcello Panagia, Jose L. Guerrero, Ellen T. Roche & Christopher T. Nguyen, Nature Biomedical Engineering volume 6, pages 1134–1147 (2022)

Advances in soft robotics have led to the development of high-fidelity simulators of pathophysiology for biomedical applications. An MCL was built using a pulsatile pump (SuperPump, ViVitro Labs), an anatomically accurate compliant silicone aortic vessel (E ≈ 1 MPa, United Biologics) connected to two adjustable compliance chambers (that is, ventricular, systemic), and a resistive valve. The models leverage haemodynamic mimicry and may facilitate the development of patient-specific applications. The models could also facilitate the clinical translation of treatments; in particular, a cohort of AS patients could be recapitulated in an in vivo porcine model, and new treatments could be evaluated preclinically.

Other Products Cited:  Endovascular Simulator  Ex ViVo Simulation  Pulsatile Flow Simulation  SuperPump  Tissue Engineering

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Paulo Yu, Vibhav Durgesh, Experimental Thermal and Fluid Science, Vol 138, October 1 2022

Aneurysms are abnormal expansion of weakened blood vessels which can be debilitating or fatal upon rupture. Previous studies have shown that hemodynamics play a role in aneurysm formation, growth and rupture. Therefore, the objective of this work is to investigate the impact of flow structures on vortex strength, impinging location, and wall shear stress for two aneurysm models. ...The inflow parameters used in this study, and , were controlled using a ViVitro Labs Inc. SuperPump system... ...The flow evolution results showed that impacted the vortex formation, growth, and dissipation processes for the studied aneurysm model...

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Paulo Yu, Vibhav Durgesh, Fluids, 2022, 7, 165.

Aneurysms are localized expansions of blood vessels which can be fatal upon rupture. Studies have shown that aneurysm flows exhibit complex flow phenomena which consist of single or multiple vortical structures that move within the flow cycle. ...Rep and α were the inflow parameters used to match and simulate the conditions in the human circulatory system. These inflow parameters were precisely controlled with a ViVitro Labs Inc. SuperPump system... ...Both POD and DMD are capable analysis tools to investigate the spatial and temporal behavior of large-scale structures of a given flow field. POD and DMD can be used to create mathematical models to look into the flow evolution in sufficiently high detail and at any time step...

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Paulo Yu, Vibhav Durgesh, Fluids, 2022

...Rep and α were two inflow parameters used in this study, and these were controlled using a ViVitro Labs Inc. (Victoria, BC, Canada) SuperPump system...POD provides a method for analyzing complex flow phenomena in great detail. It can be used to study a variety of unsteady, physiological flows to understand the behavior of energetic flow structures..

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B. Ncho, A. Siefert, V. Sadri, J. Ortner, A. Yoganathan. Journal or Med. Devices

The physiologic pressures and flows were achieved by adjustment of systemic resistance and compliance elements, and flow driven from a piston pump (Vivitro Labs Inc. Victoria, Canada).

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P. Yu, V. Durgesh, Journal of Biomechanical Engineering, 5

The inflow conditions are precisely controlled using a ViVitro SuperPump system where nondimensional fluid parameters such as peak Reynolds number (Rep) and Womersely number (α) are varied from 50–270 and 2–5, respectively.

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J. Westenberg, H. van Assen, P. van den Boogaard, J. Goeman, H. Saaid, J. Voorneveld, J. Bosch, S. Kenjeres, T. Claessens, P. Garg, M. Kouwenhoven, H. Lamb, Magnetic Resonance in Medicine

A pulsatile hydraulic piston pump (Vivitro Labs, Victoria, Canada) was connected to the tank with semirigid tubing. This pump, positioned outside the scanner room, generated a sinusoidal-like pulsatile waveform with 70-bpm frequency without net flow, resulting in a pressure waveform inside the tank that created contraction of the filled LV phantom with a 300-ms systolic period and 50-mL stroke volume.

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P. Yu, V. Durgesh, T. Xing, R. Budwig. Journal of Biomedical Engineering. Vol. 143.

… vectors in the sac region. 3.3 Pump System. To generate controlled inflow conditions for this study, a piston pump (ViVitro Labs Inc. SuperPump Sys- tem AR Series, Victoria, BC, Canada) was used. The piston pump system …

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K. Busink

...the Vivitro pump, labeled F, (SuperPump, ViVitro labs,Victoria, Canada) was used to create the oscillatory waveform...

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J. Van der Hoek

...a hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to generate the pulsatile flow and...

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Omid Bafkar, Gary Rosengarten, Milan.J. Patel, Daniel Lester, Hadrien Calmet, Vu Nguyen, Stefan Gulizia, Ivan.S. Cole, Effect of inhalation on oropharynx collapse via flow visualisation, Journal of Biomechanics, Volume 118, 2021, 110200, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2020.110200.

… Fluorescent spherical particles (500-600 µm diameter, Cospheric LLC, Santa Barbara, USA) were injected into the head of a piston-driven SuperPump (Vivitro Labs, Victoria, Canada) that was connected to an …

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Jason Voorneveld, Hicham Saaid, Christiaan Schinkel, Nikola Radeljic, Boris Lippe, Frank J.H. Gijsen, Antonius F.W.van der Steen, Nico de Jong, Tom Claessens, Hendrik J. Vos, Sasa Kenjeres, Johan G. Bosch - Elsevier Ultrasound in Medicine & Biology - Available online 8 January 2020

Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for testing the accuracy of echo-PIV in the presence of complex flow patterns.... … 1a). The mitral and aortic tracts of the LV were connected to atrial and compliance chambers (transparent acrylic, built in-house), which were connected via a tube with an adjustable resistance valve (ViVitro Labs … ... We demonstrate that 4-D echo-PIV could be performed in just four heart cycles, which would require only a short breath-hold, providing promising results. However, methods for resolving high velocity gradients in regions of poor spatial resolution are required before clinical translation....

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HH Yeh - 2019 UBC Theses and Dissertations

... thesis firstly evaluated the biomechanical contributions to ATAA progression under the influence of anatomy, hypertension, and hematocrit using fully coupled fluid-structure interaction (FSI) with arterial wall anisotropy to provide additional information in patient evaluations... ...The three different ATAA models identified different aortic expansions that were not uniform under pulsatile pressure and a geometry depended on elevated wall stress under hypertension.... ... A commercially available, 23 mm BMHV with a tissue annulus diameter / internal diameter (TAD/ID) of 18.5 mm (Figure 3.2), was used as the test model. ViVitro pulse duplicator was used to assess the performance and function of prosthetic heart valves under simulated cardiac conditions. ...

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Yen Ngoc Nguyen, Edgar Lik Wui Tay, Foad Kabinejadian, Chi Wei Ong, Munirah Ismail, and Hwa Liang Leo -American Journal of Physiology-Heart and Circulatory Physiology 11 OCT 2019

The deteriorating nature of severe functional tricuspid regurgitation (FTR) has led to the heightened interest in this pathology... ...In this study, the hemodynamics of the right ventricle (RV) after (i) clover edge-to-edge tricuspid repair and (ii) double orifice tricuspid repair was evaluated in three right heart models using an ex vivo pulsatile platform emulating severe FTR with the aid of stereoscopic particle image velocimetry... … circulation (35). A closed ventricular chamber housing the silicon RV model was directly 184 connected to the pulsatile wave-generating piston pump (SuperPump AR series, ViVitro Labs 185 Inc., Victoria, BC, Canada) to …

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Han HungYeh, Oleksandr Barannyk, Dana Grecov, Peter Oshkaid - Computers in Biology and Medicine Volume 110, July 2019, Pages 79-92

...the objective of this study is to analyze the hemodynamics and valve mechanics of a bileaflet mechanical heart valve and investigate the hemorheological characteristics under the change of hematocrit.... … Fig. 2. Schematic illustrating DPIV test set-up used in the current experiment (Image courtesy of ViVitro Labs Inc.). To simulate the physiological flow conditions, an acrylic test chamber, that represented a simplified model of … ...The current numerical analysis revealed the hematocrit influenced the shear stress distributions over a cardiac cycle...

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P Yu Electronic Theses & Dissertations (ETDs) (2011-) [3339] 2018

...This study focuses on investigating the hemodynamics inside an aneurysm for different inflow conditions and varying geometrical shapes. ... … precisely controlled. Re and α were varied between 50-250 and 2-5, respectively. A ViVitro Labs pump system was used to pump the fluid and Particle Image Velocimetry (PIV) was used to perform velocity measurements. The flow …

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