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Experimental study of flow structure impact on the fluid parameters in saccular aneurysm models

Paulo Yu, Vibhav Durgesh, Experimental Thermal and Fluid Science, Vol 138, October 1 2022

Aneurysms are abnormal expansion of weakened blood vessels which can be debilitating or fatal upon rupture. Previous studies have shown that hemodynamics play a role in aneurysm formation, growth and rupture. Therefore, the objective of this work is to investigate the impact of flow structures on vortex strength, impinging location, and wall shear stress for two aneurysm models. ...The inflow parameters used in this study, and , were controlled using a ViVitro Labs Inc. SuperPump system... ...The flow evolution results showed that impacted the vortex formation, growth, and dissipation processes for the studied aneurysm model...

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The Supera Interwoven Nitinol Stent as a Flow Diverting Device in Popliteal Aneurysms

L. van de Velde, E. Groot Jebbink, B. A. Zambrano, M. Versluis, J. Tessarek & M. M. P. J. Reijnen: CardioVascular and Interventional Radiology (2022)

...To assess this flow diverting strategy for popliteal aneurysms, flow profiles and thrombus formation likelihood were investigated in popliteal aneurysm models... ...The model was placed in a circulating flow set-up with a blood-mimicking fluid (Fig. 3). At the inlet, a hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to enforce time-varying forward flow...

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Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis.

Ong, C. W.; Kabinejadian, F.; Xiong, F.; Wong, Y. R.; Toma, M.; Nguyen, Y. N.; Chua, K. J.; Cui, F. S.; Ho, P.; Leo, H. - Journal of Applied Fluid Mechanics . Nov2019, Vol. 12 Issue 6, p1855-1872. 18p.

Thoracic aortic aneurysm (TAA) is a severe cardiovascular disease with a high mortality rate, if left untreated... ...In order to gain more insight on TAA formation, we developed a computational framework in vitro to investigate and compare the flow patterns between pre-aneurismal and post-aneurismal aorta using a deformable wall model... ...The pulsatile flow was created using a piston pump (SuperPump AR series, ViVitro Labs Inc., Victoria, BC, Canada) generating the inlet velocity profile with the How rate of 4 L/min at the frequency of 1 Hz, extracted from the literature …

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Effect of stent crimping on calcification of transcatheter aortic valves

Ramin Zareian Jen-Chieh Tseng Robert Fraser Jeffrey Meganck Marshall Kilduff Mohammad Sarraf Danny Dvir Arash Kheradvar - Interactive CardioVascular and Thoracic Surgery, ivz024, Published: 21 February 2019

...The goal of this study was to test whether stent crimping increases the risk for early calcification.... … MA, USA). The durability experiment was performed using a standard accelerated wear test (AWT) system (HiCycle Durability Tester, ViVitro Inc., Victoria, BC, Canada) that can ac- commodate up to 6 heart valves. Among the …

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Hemodynamic Analysis of a Novel Stent Graft Design with Slit Perforations in Thoracic Aortic Aneurysm

Chi Wei Ong, Fei Xiong, Foad Kabinejadian, Gideon Praveen Kumar, Fang Sen Cui. Gongfa Chen, Pei Hoe, HwaLiang Leo - Journal of Biomechanics Available online 19 January 2019

Thoracic endovascular aortic repair (TEVAR) has been introduced as a less invasive approach to the treatment of thoracic aortic aneurysm (TAA). However, the effectiveness of TEVAR in the treatment of TAA is often limited due to the complex anatomy of aortic arch... ...This study proposes a novel stent graft design with slit perforations that can positively alter the hemodynamics at the aortic arch while maintaining blood flow to supra-aortic branches... … flow preservation at side branches. The system was driven by a pulse generator (SuperPump AR series, ViVitro Labs Inc., Victoria, BC, Canada) at a flow rate of 5 L/min and a pulse rate of 1 Hz. The reservoir level and mechanical …

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Flow instabilities induced by coronary artery stents: Assessment with an in vitro pulse duplicator

Peacock J, Hankins S, Jones T, Lutz R. Journal of Biomechanics: 28, Issue 1; 17-26.

An in vitro pulse duplicator system was used to investigate whether coronary artery stents induce downstream flow instabilities. Hot film or electrochemical probes were used to measure wall shear stress before and after deployment of both single and multiple (overlapping) stents in normal and diseased coronary geometries...

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Angiographic Quantification of Contrast Medium Washout from Cerebral Aneurysms after Stent Placement

Chander Sadasivana, Baruch B. Lieberc, Matthew J. Gounisc, Demetrius K. Lopese and L. N. Hopkinsb; American Journal of Neuroradiology: 23; 1214-1221.

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Evaluation of an asymmetric stent patch design for a patient specific intracranial aneurysm using Computational Fluid Dynamic (CFD) calculations in the Computed Tomography (CT) derived lumen

Minsuok Kim; Ciprian Ionita; Rekha Tranquebar; Kenneth R. Hoffmann; Dale B. Taulbee; Hui Meng; Stephen Rudin - Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61432G (2006) https://doi.org/10.1117/12.651773 Event: Medical Imaging, 2006, San Diego, California, United States

Stenting may provide a new, less invasive therapeutic option for cerebral aneurysms. However, a conventional porous stent may be insufficient in modifying the blood flow for clinical aneurysms. We designed an asymmetric stent consisting of a low porosity patch welded onto a porous stent for an anterior cerebral artery aneurysm of a specific patient geometry to block the strong inflow jet... … 2.5. Angiographic flow visualization The rapid prototype aneurysm model was inserted in a flow loop consisting of a waveform generator, a pump, and a flow meter; the flow was activated by a heart simulating pump (Vivitro Systems Inc., Canada) …

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Analysis of the flow field downstream a bileaflet valve inside an aortic arch laboratory model

S Fortini, S Espa, R Toninato, L Pacetti, G Querzoli… - assessment, 2012 - ltces.dem.ist.utl.pt

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Particle Image Velocimetry (PIV) Flow Measurements of Carotid Artery Bifurcation with Application to a Novel Covered Carotid Stent Design

F Kabinejadian, HL Leo, A Danpinid, - World Congress on …, 2013 - Springer

Stenosed carotid artery is responsible for 60% of strokes in the United States and is the third major cause of death. Recently, there is an increasing interest in carotid artery stenting for treatment of cervical carotid artery bifurcation atherosclerotic disease. The ultimate goal of this study is to develop, prototype, test, and optimize a novel design of a covered carotid stent, in order to achieve emboli prevention and...

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