Articles Related to Pulsatile Flow Simulation

A. Desai, T. Vafaee, P. Rooney, J.N. Kearney, H.E. Berry, E. Ingham, J. Fisher, L.M. Jennings Journal of the Mechanical Behavior of Biomedical Materials 14 September 2017

The use of decellularised biological heart valves in the replacement of damaged heart valves ... ...The purpose of this study was to assess the effect of low concentration sodium dodecyl sulphate decellularisation on the in vitro biomechanical and hydrodynamic properties of cryopreserved human aortic and pulmonary roots.... ... performance of the valve roots. A viscoelastic impedance adapter (VIA; Vivitro System Inc., Victoria BC, Canada) was used to deliver a more physiological ventricle pressure and flow waveform in the simulator. This system allowed for ...

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Guangyu Zhu; Masakazu Nakao; Qi Yuan and Joon Hock Yeo Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, 186-189, 2017, Porto, Portugal

Truly stentless polymeric valve prosthesis can be a viable alternative for aortic valve replacement (AVR). In the present paper, the dynamic and hemodynamic performance of a novel designed expanded-polytetrafluoroethylene (ePTFE) stentless tri-leaflet valve was assessed experimentally.... ... The in-vitro tests were performed under time-varying physiological pressure by using the Vivitro pulse duplicator. ... The Vivitro pulse duplicator (Vivitro Systems Inc., Victoria, BC, Canada) was used to generate the physiological pressure and flow in the left ventricle and aorta. ...

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Lim, Brian. Muhammad Mujahid. Tan, Rong Wang. Arunkumar, U. Singapore Polytechnic School of Mechanical and Aeronautical Engineering

Coronary heart disease (CHD) is a common cardiac disorder in which a portion of the coronary artery is blocked, leading to a potential heart attack. Timely and accurate evaluation of suspected CHD patients is critical. Computer Tomography Angiography (CTA)... In order to streamline the evaluation of suspected CHD patients, we propose to create a more accurate and consistent diagnostic method of interpreting CTA results.

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Ahmad Falahatpisheha, Daisuke Morisawaa, Taraz T. Tooskyb, Arash Kheradvara Journal of Biomechanics Available online 16 November 2016

...developed a novel polymeric valve whose leaflets possess calcium hydroxyapatite inclusions immersed in them. This study reports the characteristics and feasibility of these valves. ... The system is connected and actuated by a pulsatile pump system (Superpump system, VSI, SPS3891, Vivitro systems Inc., Victoria, BC, Canada), which operates based on a VSI Wave Generator VG2001 (Vivitro Systems Inc., Victoria, BC, Canada) and controlled by a ...

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Onur Dur, Keif Fitzgerald, Paul Muller, Chris Parker Thoratec Corporation, Sunnyvale, CA company slide

The HeartMate PHP is a 13F catheter-based trans-aortic heart pump with a collapsible distal portion that expands to 24F to provide minimally invasive acute hemodynamic stabilization and left ventricular unloading in both prophylactic and emergent clinical settings... Objective: To evaluate the interaction of the HeartMate PHP with native cardiovascular system via in vitro pulsatile mock flow loop testing. A custom-built pulsatile heart simulator adapted from Vivitro Pulse Duplicator (Vivitro Labs Inc., Canada) was tuned to generate physiological flow pressure waveforms while mimicking the preload sensitivity of the native heart.

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Cole Feagler, Zeeshan Syedain and Robert Tranquillo University of Minnesota College of Science and Engineering Poster Report

While most commercial valves today use chemically-fixed porcine tissue in the construction of the replacement valves, the Tranquillo group has been exploring the use of decellularized, engineered tissue as leaflet material... ...The goal of this project was to engineer a commissure design to mitigate valve failure through tissue tearing, and to improve overall valve hemodynamics. (I.e. reduction of PVL)... ...Prototype TEHVs were tested to failure using a ViVitro Labs pulse duplicator, running custom LabView data acquisition software...

Other Products Cited:  Pulse Duplicator  Tissue Engineering

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Sean Guo-Dong Tan, Sangho Kim, Hwa Liang Leo Experiments in Fluids June 2016, 57:110

Mechanical heart valve prostheses are often implanted in young patients due to their durability and long-term reliability. However, existing designs are known to induce elevated levels of blood damage and blood platelet activation... ...This study proposes a bi-leaflet mechanical heart valve design (Bio-MHV) that mimics the geometry of a human mitral valve, with the aim of reducing turbulence levels in the left ventricle by replicating physiological flow patterns... ... A pulsatile pump (ViVitro Labs Inc., Victoria, BC) attached to the working chamber drove the blood analog around the flow loop, via the pumping action of the silicon left ventricle, as shown in Fig. 1c. Fig. 2 a A mitral flow waveform sample observed in the experiments. ...

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Koohyar Vahidkhah, Dan Cordasco, Mostafa Abbasi, Liang Ge, Elaine Tseng, Prosenjit Bagchi, Ali N. Azadani Annals of Biomedical Engineering pp 1-13 First online: 05 April 2016

Valvular hemolysis and thrombosis are common complications associated with stenotic heart valves. This study aims to determine the extent to which hemodynamics induce such traumatic events. The viscous shear stress downstream of a severely calcified bioprosthetic valve was evaluated via in vitro 2D particle image velocimetry measurements. ... Calcification was present on all the leaflets with a very small tear, less than 0.5 mm, on one of the leaflets (Figs. 1a, 1b). The bioprosthesis was tested at room temperature in a custom-built pulse duplicator system (ViVitro Systems, Inc., Victoria, Canada). ...

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Nandini Duraiswamy , Jason D. Weaver, Yasamin Ekrami, Stephen M. Retta, Changfu Wu Cardiovascular Engineering and Technology pp 1-13 First online: 10 February 2016

... The hydrodynamic testing was per- formed using 0.9% saline solution in the commercially available Left Heart Simulator (Vivitro Systems), which simulates function of the heart by generating pulsatile flow through prosthetic heart valves. ...In the EllipMinor and EllipMajor configurations, the maximum principal stress occurred near the center of the free edge of the “stretched” leaflets. These results further affirm recommendations by the International Standards Organization (ISO) that pre-clinical testing should consider non-circular configurations for transcatheter valve durability testing.

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Ikechukwu Okafor, Arvind Santhanakrishnan, Vrishank Raghav, Ajit Yoganathan- Journal of Biomechanical Engineering 10/2015;

...The results support the hypothesis that a D-shaped mitral annulus reduces dissipative energy losses in ventricular filling during diastole, and in turn suggests that a symmetric stent design does not provide lower filling efficiency than an equivalent asymmetric design. ...fluctuations were imposed in a fluid-filled chamber housing the LV physical model using a programmable piston pump (Superpump, Vivitro Systems; British Columbia, Canada). The pressure fluctuations resulted in the deformation of the LV model, driving flow through ...

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