Articles Related to Pulsatile Flow Simulation

Maria Rocchi, Marcus Ingram, Piet Claus, Jan D'hooge, Bart Meyns, Libera Fresiello, Artif Organs. 2022; 00: 1– 13

The aim of this review is to provide an overview on Mock Circulatory Loops and to discuss the recent developments of 3D anatomical models for cardiovascular Medical Device testing. One example is the ViVitro Pulse Duplicator system. The simulator is provided with a flexible ventricular sac activated by a piston pump. The addition of 3D anatomical models enables more realistic connections of the Medical Device with the implantation site and enhances the testing capabilities of the Mock Circulatory Loop.

Other Products Cited:  Pulse Duplicator

Visit Source 
Shannen B. Kizilski, Xiaoya Zhang, Nicholas E. Kneier, Martha D. Chaillo Lizarraga, Noah E. Schulz, Peter E. Hammer & David M. Hoganson, Cardiovascular Engineering and Technology (2022)

The aim of this study was to develop a robust in vitro system for quantifying flow conditions after various RVOT interventions. The MCL was developed around the ViVitro Pulse Duplicator System with the viscoelastic impedance adapter and ventricle chamber attachments. The 3D-printed RVOT anatomical model and in vitro pulmonary circulatory loop developed in this work provide platform for planning and evaluating surgical interventions in the pediatric population.

Other Products Cited:  Pulse Duplicator

Visit Source 
Diya Wang, Boris Chayer, François Destrempes, Jonathan Porée, Marie-Hélène Roy Cardinal, François Tournoux, Guy Cloutier, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (Volume: 69, Issue: 12, December 2022) Page(s): 3284 - 3296

Assessment of myocardial contractility during a stress test is of high clinical value for the diagnosis and evaluation of cardiovascular diseases, especially coronary disease and heart failure. Both ends of this left-ventricular mimicking phantom (wall thickness of 15 mm) was then connected to polyvinyl chloride tubing by a pair of loosely attached steel clamps to a pulse duplicator (model #SD2001-1, ViVitro systems Inc., Victoria, BC, Canada). The complex, large, and rapid myocardial deformation during stress tests were also accurately imaged by the proposed strain estimator with close agreement with sonomicrometry.

Other Products Cited:  Endovascular Simulator  SuperPump  Ultrasound Measurements

Visit Source 
Luca Rosalia, Caglar Ozturk, Jaume Coll-Font, Yiling Fan, Yasufumi Nagata, Manisha Singh, Debkalpa Goswami, Adam Mauskapf, Shi Chen, Robert A. Eder, Efrat M. Goffer, Jo H. Kim, Salva Yurista, Benjamin P. Bonner, Anna N. Foster, Robert A. Levine, Elazer R. Edelman, Marcello Panagia, Jose L. Guerrero, Ellen T. Roche & Christopher T. Nguyen, Nature Biomedical Engineering volume 6, pages 1134–1147 (2022)

Advances in soft robotics have led to the development of high-fidelity simulators of pathophysiology for biomedical applications. An MCL was built using a pulsatile pump (SuperPump, ViVitro Labs), an anatomically accurate compliant silicone aortic vessel (E ≈ 1 MPa, United Biologics) connected to two adjustable compliance chambers (that is, ventricular, systemic), and a resistive valve. The models leverage haemodynamic mimicry and may facilitate the development of patient-specific applications. The models could also facilitate the clinical translation of treatments; in particular, a cohort of AS patients could be recapitulated in an in vivo porcine model, and new treatments could be evaluated preclinically.

Other Products Cited:  Endovascular Simulator  Ex ViVo Simulation  Flow Visualization  SuperPump  Tissue Engineering

Visit Source 
Lisa Carlson Hanse, Marcell J Tjørnild, Simon G Sørensen, Peter Johansen, Ignacio Lugones, Vibeke E Hjortdal, Interactive CardioVascular and Thoracic Surgery, Volume 35, Issue 4, October 2022, ivac227

We investigated a new surgical technique of trileaflet semilunar valve reconstruction possessing the potential of remaining sufficient and allowing for some growth with the child. Pulsatile flow was produced by a Series piston pump (SuperPump AR; ViVitro Labs, Victoria, Canada), connected to the ventricular chamber. TSVR was achievable in vitro. Hydrodynamic pressure and echocardiographic evaluations demonstrated a sufficient and non-stenotic neo-valve.

Other Products Cited:  Heart Valve Testing  SuperPump

Visit Source 
Emily N. Boice, David Berard, Jose M. Gonzalez, Sofia I. Hernandez Torres, Zechariah J. Knowlton, Guy Avital, Eric J. Snider, Bioengineering 2022, 9(7), 319

Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics available in these resource-limited scenarios, but they must be properly designed. Unfortunately, currently available tissue phantoms are inadequate for this use, resulting in delayed product development. ...A SuperPump (ViVitro Labs, Victoria, BC, Canada) was used for generating pulsatile, cardiac mimicking arterial flow within the flow loop test platform (Figure 1D)... ...In conclusion, the tissue phantom model presented addresses a current testing gap for developing central vascular access medical devices. Troubleshooting is essential and having to rely on live, or even ex vivo, animal testing for evaluating a medical device with physiological mimicking fluid flow or pressure levels will slow device development...

Other Products Cited:  Endovascular Simulator

Visit Source 
Paulo Yu, Vibhav Durgesh, Experimental Thermal and Fluid Science, Vol 138, October 1 2022

Aneurysms are abnormal expansion of weakened blood vessels which can be debilitating or fatal upon rupture. Previous studies have shown that hemodynamics play a role in aneurysm formation, growth and rupture. Therefore, the objective of this work is to investigate the impact of flow structures on vortex strength, impinging location, and wall shear stress for two aneurysm models. ...The inflow parameters used in this study, and , were controlled using a ViVitro Labs Inc. SuperPump system... ...The flow evolution results showed that impacted the vortex formation, growth, and dissipation processes for the studied aneurysm model...

Other Products Cited:  Analysis and Computational Modeling  Flow Visualization  Stent Testing  SuperPump

Visit Source 
Salwa B. Anam, Brandon J. Kovarovic, Ram P. Ghosh, Matteo Bianchi, Ashraf Hamdan, Rami Haj-Ali & Danny Bluestein - Cardiovascular Engineering and Technology (2022)

Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which had been treated off-label by transcatheter aortic valve replacement (TAVR) procedure for several years, until its recent approval by the Food and Drug Administration (FDA) and Conformité Européenne (CE) to treat BAVs. ...Materials and Methods Patient-specific in silico models and 3D printed replicas of 3 BAV patients with different degrees of post-TAVR paravalvular leakage (PVL) were created. Patient-specific TAVR device deployment was modeled in silico and in vitro—following … ...PVL degree and locations were consistent with the clinical data. Cross-validation comparing the stent deformation and the flow parameters between the in silico and the in vitro models demonstrated good agreement....

Other Products Cited:  Pulse Duplicator

Visit Source 
L. van de Velde, E. Groot Jebbink, B. A. Zambrano, M. Versluis, J. Tessarek & M. M. P. J. Reijnen: CardioVascular and Interventional Radiology (2022)

...To assess this flow diverting strategy for popliteal aneurysms, flow profiles and thrombus formation likelihood were investigated in popliteal aneurysm models... ...The model was placed in a circulating flow set-up with a blood-mimicking fluid (Fig. 3). At the inlet, a hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to enforce time-varying forward flow...

Other Products Cited:  Stent Testing  SuperPump

Visit Source 
N Norris, K Lewis, C Settanni, T Becker, A Ducruet, Journal of NeuroInterventional Surgery 2021, 13 (Suppl 1)

...Physiologically-relevant patient flow parameters were tuned within the system using a Super Pump AR (ViVitro Labs)...This in-vitro aneurysm flow model utilized the latest in UV-cured 3D-printing techniques to provide a realistic simulation of neurovascular tortuosity and aneurysm device delivery...

Other Products Cited:  SuperPump

Visit Source 
R. Whiting, E. Sander, C. Conway, T. J. Vaughan. 2021.

...To evaluate the hydrodynamic performance of each valve, in vitro bench testing was performed using a Vivitro Pulse Duplicator (Figure 2a) (Vivitro Labs, Inc. Victoria, B.C.) according to ISO 5840...

Other Products Cited:  Pulse Duplicator

Visit Source 
A. Packy, G. A. D'Souza, M. Farahmand, L. Herbertson, C. G. Scully. Cardiovascular Engineering and Technology.

… Pressure measurement location. ºFlow measurement location. Full size image. Deionized water is circulated through the MCL using a piston pump [ViVitro Labs, Victoria, BC, Canada] that is fluid-coupled to a suspended silicone-based mock ventricular sac …

Other Products Cited:  SuperPump

Visit Source 
N Norris, K Lewis, C Settanni, T Becker, A Ducruet. Journal of Neurointerventional Surgery. Volume 13 Issue Suppl 1.

...physiologically-relevant patient flow parameters were tuned within the system using a Super Pump AR (ViVitro Labs). A data acquisition system (DAQ) with LabVIEW® software recorded real time pressure and flow waveforms, mean arterial pressures (MAP) and flows through each inlet and outlet branch of the 3D-printed CW model. The flow model included an introducer for microcatheter and device delivery access...

Other Products Cited:  SuperPump

Visit Source 
Jae H. Lee, Alex D. Rygg, Ebrahim M. Kolahdouz, Simone Rossi, Stephen M. Retta, Nandini Duraiswamy, Lawrence N. Scotten, Brent A. Craven, and Boyce E. Grith -

Computer modeling and simulation (CM&S) is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) and promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance... ...This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.... … In vitro experiments are performed using two different experimental platforms, including a ViVitro Pulse Duplicator (ViVitro Labs, Inc., Victoria, BC, Canada) available through the FDA Cardiac Device Flow Lab and a customized …

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

Visit Source 
C Settanni, T Becker, A Ducruet, W Merritt, A Huckleberry - Journal of NeuroInterventional Surgery (JNIS) Volume 11, Issue Suppl 1

Although current microcatheter technologies have advanced in recent years, corresponding endovascular devices still lag behind... ...This research project includes development of innovative in vitro aneurysm vessel model with complex side branching.... … communicating (ACA) bifurcation. Flow is regulated through the use of a Super Pump AR (ViVitro Labs). This 3D printed model will be implemented in an in vitro flow model that enables systemic data collection. A data acquisition … ...The in vitro model is used to simulate and quantify short-and long-term viability of new biomaterials for brain aneurysm embolization...

Other Products Cited:  SuperPump

Visit Source 
Fergal B. Coulter, Manuel Schaffner, Jakob A. Faber, Ahmad Rafsanjani, Robin Smith, Harish Appa, Peter Zilla, Deon Bezuidenhout, and Andre´ R. Studart - Matter, 2019

Synthetic implants made by traditional fabrication routes are not patient specific and rarely match the performance of their biological counterparts. We present an additive manufacturing approach for the digital fabrication of tissue-like aortic heart valves featuring customizable geometry and leaflet architectures that resemble those of native valve tissue... ...Flow was driven by a forward pressure of 100 mmHg imposed across the valve using a pulsatile testing machine (PD2010; ViVitro, Victoria, BC, Canada)... ...The ability to fabricate synthetic implants with tailored designs at multiple length scales is a key contribution toward the digital fabrication of functional implants that perform on par with native body parts...

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

Visit Source 
Diya Wang; Boris Chayer ; François Destrempes ; François Toumoux ; Guy Cloutier - 2018 IEEE International Ultrasonics Symposium (IUS) 20 December 2018

Aortic stiffness is altered by cardiovascular diseases and exacerbated in innate or pathological conditions, which might be detected by noninvasive vascular elastography.... ...results suggest that the proposed model could detect and evaluate aortic aneurysm stiffness and may be useful clinically for the early and timely detection of degraded mechanical properties to impact patient outcomes.... … Hz. Normal and aneurysm aortic deformations were compared by pulsing mimicing vessels at 60 bpm, using a hydraulic pulse duplicator within a left ventricular model (Superpump system, Vivitro Inc., Victoria, BC, Canada) …

Other Products Cited:  SuperPump

Visit Source 
Brandon J. Tefft, Joshua A. Choe, Melissa D. Young, Ryan S. Hennessy, David W. Morse, Jeffery A. Bouchard, Herbert J. Hedberg, Joseph F. Consiglio, Dan Dragomir-Daescu, Robert D. Simari, Amir Lerman

Tissue engineered heart valves (TEHV) are being investigated to address the limitations of currently available valve prostheses... ...A bioreactor system was designed based on the Windkessel approach. Novel features including a purpose-built valve chamber and pressure feedback control were incorporated to maintain asepsis while achieving a range of hydrodynamic conditions.... … The bioreactor was used to assess the hydrodynamic performance of a bioprosthesis and the results were compared to those obtained with a ViVitro Pulse Duplicator system (ViVitro Labs, Victoria, BC, Canada)... ...The bioreactor system was able to produce a range of pressure and flow conditions from static to resting adult left ventricular outflow tract to pathological including hypertension...

Other Products Cited:  Pulse Duplicator

Visit Source 
Hongliang Li, Jonathan Porée, Marie-Hélène, Roy Cardinal, Guy Cloutier - Ultrasonics Available online 21 July 2018, In Press

Polar strain (radial and circumferential) estimations can suffer from artifacts because the center of a nonsymmetrical carotid atherosclerotic artery, defining the coordinate system in cross-sectional view, can be misregistered... ...Two-affine model-based estimators for vascular ultrasound elastography in cross-sectional view of the artery are evaluated in a common framework of high-frame-rate imaging... ...This paper presents two affine model-based estimators, the affine phase-based estimator (APBE) developed in the framework of transverse oscillation (TO) beamforming, and the Lagrangian speckle model estimator (LSME)...

Other Products Cited:  SuperPump

Visit Source 
Marije E. Kamphuis; Gert Jan Pelgrim; Marcel J. W. Greuter; Riemer H. J. A. Slart; Cornelis H. Slump Proceedings Volume 10577, Medical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment; 1057714 (2018); doi: 10.1117/12.2286337 Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

...Myocardial perfusion imaging (MPI) is a commonly used diagnostic method in coronary artery disease (CAD)... ... In line with proper clinical decision-making, it is essential to assess institutional MPI test validity by confronting MBF assessment to a ground truth. Our research focuses on developing such validation instrument/method for MPI by means of simulating controlled myocardial perfusion in a phantom flow setup.... … All the data presented in this paper were obtained with the open circuit setup to prevent contrast recirculation. The used piston pump (Vivitro Superpump, Vivitro Labs, Victoria, Canada) generates programmable pulsatile flow

Other Products Cited:  SuperPump

Visit Source 

Join over 5000 cardiovascular device professionals who receive our testing and engineering insights and tips every month.