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Mariam Abdi Noor, Leila Louise Benhassen, Alexander Emil Kaspersen, Marc Gjern Weiss, John Michael Hasenkam, Peter Johansen, J. of Cardiovasc. Trans. Res.
The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. The ventricular chamber was coupled to a digitally controlled piston pump (SuperPump AR Series, ViVitro Labs, Victoria, Canada), delivering a pulsatile flow to simulate left ventricular ejection into the aortic root. Overall, the echographic data revealed that both interventions had a downsizing effect on the aortic root, while still maintaining the distensibility comparable to the native condition.
Other Products Cited: Heart Valve Repair Pulse Duplicator SuperPump
Visit SourceArian Aghilinejad, Heng Wei, Coskun Bilgi, Alberto Paredes, Alexander DiBartolomeo, Gregory Magee, Niema Pahlevan, J Biomech Eng. 1-31
Type B aortic dissection is a life-threatening medical emergency that can result in rupture of the aorta. The aortic simulator is a hydraulic model that has physical and dynamical properties similar to the human circulatory system. This hydraulic model consists of a piston-in-cylinder pump (ViVitro Labs Inc.) that generates a physiologically accurate pulsatile flow (using a programmable waveform generator ViVigen) and a pump head, including a silicone ventricle membrane, mitral valve, and aortic valve. Results demonstrate that the deep-learning model can accurately capture the dissection geometry from patients’ medical images.
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Visit SourceShin Yajima, Yuanjia Zhu, Charles J. Stark, Robert J. Wilkerson, Matthew H. Park, Elde Stefan, Y. Joseph Woo, The American Association for Thoracic Surgery
This study aimed to biomechanically evaluate the force profiles on the anterior primary and secondary chordae after neochord repair for anterior valve prolapse with varied degrees of residual mitral regurgitation using an ex vivo heart simulator. Briefly, a 3D printer was used to rapidly develop a prototype of a modular left heart coupled to a pulsatile linear actuator (ViVitro Superpump; ViVitro Labs). In our ex vivo AVP model, moderate residual MR following neochord repair was significantly associated with increased forces for both anterior primary and secondary chordae compared with those of less-than-moderate residual MR.
Other Products Cited: Ex ViVo Simulation Heart Valve Testing Pulse Duplicator
Visit SourceLeila Louise Benhassen, Jacob Hesselby Hedensted, Mona Sharghbin, Tommy Bechsgaard, Sten Lyager Nielsen, John Michael Hasenkam, Peter Johansen, European Journal of Cardio-Thoracic Surgery, Volume 63, Issue 5, May 2023
For patients with isolated aortic regurgitation, a double sub- and supravalvular annuloplasty has been shown to reduce recurrent aortic regurgitation after aortic valve repair compared with a single subvalvular annuloplasty. The ventricular chamber was connected to an electromechanical piston pump system (Superpump AR series, ViVitro labs, Victoria, Canada). These two findings support the concept of a functional aortic annulus, where the two levels interact and affect the function and competence of the aortic valve.
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Visit SourceMaria Rocchi, Marcus Ingram, Piet Claus, Jan D'hooge, Bart Meyns, Libera Fresiello, Artif Organs. 2022; 00: 1– 13
The aim of this review is to provide an overview on Mock Circulatory Loops and to discuss the recent developments of 3D anatomical models for cardiovascular Medical Device testing. One example is the ViVitro Pulse Duplicator system. The simulator is provided with a flexible ventricular sac activated by a piston pump. The addition of 3D anatomical models enables more realistic connections of the Medical Device with the implantation site and enhances the testing capabilities of the Mock Circulatory Loop.
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Visit SourceShannen B. Kizilski, Xiaoya Zhang, Nicholas E. Kneier, Martha D. Chaillo Lizarraga, Noah E. Schulz, Peter E. Hammer & David M. Hoganson, Cardiovascular Engineering and Technology (2022)
The aim of this study was to develop a robust in vitro system for quantifying flow conditions after various RVOT interventions. The MCL was developed around the ViVitro Pulse Duplicator System with the viscoelastic impedance adapter and ventricle chamber attachments. The 3D-printed RVOT anatomical model and in vitro pulmonary circulatory loop developed in this work provide platform for planning and evaluating surgical interventions in the pediatric population.
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Visit SourceDiya Wang, Boris Chayer, François Destrempes, Jonathan Porée, Marie-Hélène Roy Cardinal, François Tournoux, Guy Cloutier, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (Volume: 69, Issue: 12, December 2022) Page(s): 3284 - 3296
Assessment of myocardial contractility during a stress test is of high clinical value for the diagnosis and evaluation of cardiovascular diseases, especially coronary disease and heart failure. Both ends of this left-ventricular mimicking phantom (wall thickness of 15 mm) was then connected to polyvinyl chloride tubing by a pair of loosely attached steel clamps to a pulse duplicator (model #SD2001-1, ViVitro systems Inc., Victoria, BC, Canada). The complex, large, and rapid myocardial deformation during stress tests were also accurately imaged by the proposed strain estimator with close agreement with sonomicrometry.
Other Products Cited: Endovascular Simulator SuperPump Ultrasound Measurements
Visit SourceLuca Rosalia, Caglar Ozturk, Jaume Coll-Font, Yiling Fan, Yasufumi Nagata, Manisha Singh, Debkalpa Goswami, Adam Mauskapf, Shi Chen, Robert A. Eder, Efrat M. Goffer, Jo H. Kim, Salva Yurista, Benjamin P. Bonner, Anna N. Foster, Robert A. Levine, Elazer R. Edelman, Marcello Panagia, Jose L. Guerrero, Ellen T. Roche & Christopher T. Nguyen, Nature Biomedical Engineering volume 6, pages 1134–1147 (2022)
Advances in soft robotics have led to the development of high-fidelity simulators of pathophysiology for biomedical applications. An MCL was built using a pulsatile pump (SuperPump, ViVitro Labs), an anatomically accurate compliant silicone aortic vessel (E ≈ 1 MPa, United Biologics) connected to two adjustable compliance chambers (that is, ventricular, systemic), and a resistive valve. The models leverage haemodynamic mimicry and may facilitate the development of patient-specific applications. The models could also facilitate the clinical translation of treatments; in particular, a cohort of AS patients could be recapitulated in an in vivo porcine model, and new treatments could be evaluated preclinically.
Other Products Cited: Endovascular Simulator Ex ViVo Simulation Flow Visualization SuperPump Tissue Engineering
Visit SourceLisa Carlson Hanse, Marcell J Tjørnild, Simon G Sørensen, Peter Johansen, Ignacio Lugones, Vibeke E Hjortdal, Interactive CardioVascular and Thoracic Surgery, Volume 35, Issue 4, October 2022, ivac227
We investigated a new surgical technique of trileaflet semilunar valve reconstruction possessing the potential of remaining sufficient and allowing for some growth with the child. Pulsatile flow was produced by a Series piston pump (SuperPump AR; ViVitro Labs, Victoria, Canada), connected to the ventricular chamber. TSVR was achievable in vitro. Hydrodynamic pressure and echocardiographic evaluations demonstrated a sufficient and non-stenotic neo-valve.
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Visit SourceEmily N. Boice, David Berard, Jose M. Gonzalez, Sofia I. Hernandez Torres, Zechariah J. Knowlton, Guy Avital, Eric J. Snider, Bioengineering 2022, 9(7), 319
Central vascular access (CVA) may be critical for trauma care and stabilizing the casualty. However, it requires skilled personnel, often unavailable during remote medical situations and combat casualty care scenarios. Automated CVA medical devices have the potential to make life-saving therapeutics available in these resource-limited scenarios, but they must be properly designed. Unfortunately, currently available tissue phantoms are inadequate for this use, resulting in delayed product development. ...A SuperPump (ViVitro Labs, Victoria, BC, Canada) was used for generating pulsatile, cardiac mimicking arterial flow within the flow loop test platform (Figure 1D)... ...In conclusion, the tissue phantom model presented addresses a current testing gap for developing central vascular access medical devices. Troubleshooting is essential and having to rely on live, or even ex vivo, animal testing for evaluating a medical device with physiological mimicking fluid flow or pressure levels will slow device development...
Other Products Cited: Endovascular Simulator
Visit SourcePaulo Yu, Vibhav Durgesh, Experimental Thermal and Fluid Science, Vol 138, October 1 2022
Aneurysms are abnormal expansion of weakened blood vessels which can be debilitating or fatal upon rupture. Previous studies have shown that hemodynamics play a role in aneurysm formation, growth and rupture. Therefore, the objective of this work is to investigate the impact of flow structures on vortex strength, impinging location, and wall shear stress for two aneurysm models. ...The inflow parameters used in this study, and , were controlled using a ViVitro Labs Inc. SuperPump system... ...The flow evolution results showed that impacted the vortex formation, growth, and dissipation processes for the studied aneurysm model...
Other Products Cited: Analysis and Computational Modeling Flow Visualization Stent and Stent/Graft SuperPump
Visit SourceSalwa B. Anam, Brandon J. Kovarovic, Ram P. Ghosh, Matteo Bianchi, Ashraf Hamdan, Rami Haj-Ali & Danny Bluestein - Cardiovascular Engineering and Technology (2022)
Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which had been treated off-label by transcatheter aortic valve replacement (TAVR) procedure for several years, until its recent approval by the Food and Drug Administration (FDA) and Conformité Européenne (CE) to treat BAVs. ...Materials and Methods Patient-specific in silico models and 3D printed replicas of 3 BAV patients with different degrees of post-TAVR paravalvular leakage (PVL) were created. Patient-specific TAVR device deployment was modeled in silico and in vitro—following … ...PVL degree and locations were consistent with the clinical data. Cross-validation comparing the stent deformation and the flow parameters between the in silico and the in vitro models demonstrated good agreement....
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Visit SourceL. van de Velde, E. Groot Jebbink, B. A. Zambrano, M. Versluis, J. Tessarek & M. M. P. J. Reijnen: CardioVascular and Interventional Radiology (2022)
...To assess this flow diverting strategy for popliteal aneurysms, flow profiles and thrombus formation likelihood were investigated in popliteal aneurysm models... ...The model was placed in a circulating flow set-up with a blood-mimicking fluid (Fig. 3). At the inlet, a hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to enforce time-varying forward flow...
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Visit SourceN Norris, K Lewis, C Settanni, T Becker, A Ducruet, Journal of NeuroInterventional Surgery 2021, 13 (Suppl 1)
...Physiologically-relevant patient flow parameters were tuned within the system using a Super Pump AR (ViVitro Labs)...This in-vitro aneurysm flow model utilized the latest in UV-cured 3D-printing techniques to provide a realistic simulation of neurovascular tortuosity and aneurysm device delivery...
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Visit SourceR. Whiting, E. Sander, C. Conway, T. J. Vaughan. 2021.
...To evaluate the hydrodynamic performance of each valve, in vitro bench testing was performed using a Vivitro Pulse Duplicator (Figure 2a) (Vivitro Labs, Inc. Victoria, B.C.) according to ISO 5840...
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Visit SourceA. Packy, G. A. D'Souza, M. Farahmand, L. Herbertson, C. G. Scully. Cardiovascular Engineering and Technology.
… Pressure measurement location. ºFlow measurement location. Full size image. Deionized water is circulated through the MCL using a piston pump [ViVitro Labs, Victoria, BC, Canada] that is fluid-coupled to a suspended silicone-based mock ventricular sac …
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Visit SourceN Norris, K Lewis, C Settanni, T Becker, A Ducruet. Journal of Neurointerventional Surgery. Volume 13 Issue Suppl 1.
...physiologically-relevant patient flow parameters were tuned within the system using a Super Pump AR (ViVitro Labs). A data acquisition system (DAQ) with LabVIEW® software recorded real time pressure and flow waveforms, mean arterial pressures (MAP) and flows through each inlet and outlet branch of the 3D-printed CW model. The flow model included an introducer for microcatheter and device delivery access...
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Visit SourceJae H. Lee, Alex D. Rygg, Ebrahim M. Kolahdouz, Simone Rossi, Stephen M. Retta, Nandini Duraiswamy, Lawrence N. Scotten, Brent A. Craven, and Boyce E. Grith -
Computer modeling and simulation (CM&S) is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) and promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance... ...This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.... … In vitro experiments are performed using two different experimental platforms, including a ViVitro Pulse Duplicator (ViVitro Labs, Inc., Victoria, BC, Canada) available through the FDA Cardiac Device Flow Lab and a customized …
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceC Settanni, T Becker, A Ducruet, W Merritt, A Huckleberry - Journal of NeuroInterventional Surgery (JNIS) Volume 11, Issue Suppl 1
Although current microcatheter technologies have advanced in recent years, corresponding endovascular devices still lag behind... ...This research project includes development of innovative in vitro aneurysm vessel model with complex side branching.... … communicating (ACA) bifurcation. Flow is regulated through the use of a Super Pump AR (ViVitro Labs). This 3D printed model will be implemented in an in vitro flow model that enables systemic data collection. A data acquisition … ...The in vitro model is used to simulate and quantify short-and long-term viability of new biomaterials for brain aneurysm embolization...
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Visit SourceFergal B. Coulter, Manuel Schaffner, Jakob A. Faber, Ahmad Rafsanjani, Robin Smith, Harish Appa, Peter Zilla, Deon Bezuidenhout, and Andre´ R. Studart - Matter, 2019
Synthetic implants made by traditional fabrication routes are not patient specific and rarely match the performance of their biological counterparts. We present an additive manufacturing approach for the digital fabrication of tissue-like aortic heart valves featuring customizable geometry and leaflet architectures that resemble those of native valve tissue... ...Flow was driven by a forward pressure of 100 mmHg imposed across the valve using a pulsatile testing machine (PD2010; ViVitro, Victoria, BC, Canada)... ...The ability to fabricate synthetic implants with tailored designs at multiple length scales is a key contribution toward the digital fabrication of functional implants that perform on par with native body parts...
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