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H.Sodawalla, M.Alnajrani, J.Wells, et al., Journal of Biomedical Materials Research Part B: Applied Biomaterials114, no. 2 (2026): e70030
The ViVitro SuperPump enabled a physiologically relevant benchtop platform for evaluating treatment strategies for giant intracranial aneurysms using a rupture-prone 3D-printed model. In this study, researchers implemented a custom flow loop to compare flow diverter-only treatment, flow diverter combined with synthetic thrombus, and flow diverter with liquid embolic, while continuously monitoring intra-aneurysmal pressure and time to rupture. The results demonstrate that benchtop aneurysm testing provides a practical and repeatable approach for assessing treatment performance and mechanical stability under controlled physiological conditions, while underscoring the value of realistic in-vitro models for preclinical device evaluation
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Visit SourceAmico et al. Physics of Fluids 38, 021916 (2026)
The ViVitro Pulse Duplicator enabled a physiologically relevant, ISO 5840-aligned test environment for direct comparison of event-based imaging velocimetry (EBIV) and conventional PIV in a left-heart simulator with a transcatheter mitral valve. The study examined whether EBIV could quantify intraventricular flow with accuracy comparable to PIV under two cardiac-output conditions. Using synchronized, phase-locked acquisitions, the authors showed that EBIV reproduced the main hemodynamic features measured by PIV, including velocity fields, diastolic vortex structures, circulation, Lagrangian trajectories, pulsatile kinetic energy, and dominant POD modes. The work positions EBIV as a data-efficient, high-dynamic-range alternative for cardiac flow analysis, while underscoring the value of the ViVitro platform in delivering realistic, reproducible bench testing for device assessment and translational cardiovascular research.
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Visit SourceTymoshenko V, Suria AJ, Dimonte G, et al. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 2026;0(0).
This study demonstrates how the ViVitro Labs SuperPump enables precise control of flow and stroke, providing the stable and clinically relevant hemodynamic conditions required to accurately quantify leakage. Automated versus manual suturing techniques in Bentall procedures were evaluated using an ex vivo passive beating heart model integrated into an advanced mock circulatory loop (MCL) platform. Twenty porcine hearts underwent Bentall surgery with either automated or manual suturing and were tested under progressively increasing aortic pressures using the ViVitro Labs SuperPump. The results revealed no significant difference in anastomotic leakage between the two techniques, even under hypertensive conditions. These findings indicate that automated suturing achieves comparable holding strength and hemostatic performance to manual methods, supporting its use in complex aortic root procedures.
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Visit SourceMerhi, Y., Montero, K.L., Johansen, P. et al. npj Flex Electron 10, 31 (2026).
This work highlights how ViVitro systems enable realistic cardiovascular bench testing for next-generation bioelectronic devices, helping advance translational implant development. Using a ViVitro SuperPump to recreate physiologically relevant pulsatile left-heart conditions, this study evaluates a biodegradable PLLA piezoelectric sensor for real-time monitoring during aortic annuloplasty. The authors enhanced PLLA film performance through uniaxial stretching and thermal annealing, significantly increasing voltage output and enabling stable, pressure-correlated sensing in a ring-like prototype. Within the in-vitro setup, the sensor produced repeatable signals across clinically relevant pressure ranges, supporting its potential as a temporary smart implant.
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Visit SourceZeping Zhang, Rizheng Han, Yueen Liu, Xinqi Yu, Guixue Wang, Yun Bai, Rui Yang, Tao Jin, Xing Zhang,Chemical Engineering Journal,Volume 518, 2025,
In this study the ViVitro Labs Pulse Duplicator system played an essential role in simulating physiological aortic and pulmonary flow conditions to assess the hydrodynamic performance of a bioinspired trilayer poly(ε-caprolactone) (PCL) scaffolds designed for tissue-engineered heart valves (TEHVs). By replicating the fibrosa-spongiosa-ventricularis architecture using electrospinning on custom collectors, the authors developed a scaffold (BTS) that successfully mimics the anisotropic and nonlinear ('J-curve') mechanical behavior of native valve leaflets. The BTS exhibited favorable biomechanical performance, excellent biocompatibility, and compliance with ISO 5840-2 criteria. These results highlight the scaffold’s translational promise in pediatric and young adult valve replacements. The successful demonstration of effective orifice area and regurgitation rate compliance underscores the Pulse Duplicator’s value in de-risking translation to clinical applications.
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Visit SourceDi Leonardo S, Vella D, Pisano C, Argano V, Burriesci G IRBM, Volume 46, Issue 4, 2025, 100897
Utilizing the ViVitro Pulse Duplicator, this study simulated a wide range of clinically relevant subaortic membrane (SAM) scenarios to quantify their impact on aortic valve hydrodynamics. By varying membrane stiffness, size, and alignment, the research team demonstrated that hemodynamic compromise becomes significant below a membrane orifice area (MOA) of 75%, with stiff membranes triggering higher pressure gradients and leaflet fluttering. Concentric flexible membranes yielded better outcomes under increasing cardiac output. Notably, the ViVitro platform enabled precise measurement of dynamic variables like regurgitation and fluttering amplitude, underscoring its value in preclinical modeling of disease states and guiding surgical thresholds for intervention
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceDelanoë, K., Erwan, S., Rieu, R., Côté, N., Pibarot, P., & Stanová, V. Bioengineering, 2025, 12, 397.
The goal of this study is to enhance the understanding of both healthy and pathological mitral valves by reproducing precisely their anatomical properties and testing them under controlled conditions. Both cavities are surrounded by liquid and are activated by piston-pumps (Vivitro Inc., Victoria, Canada) controlled using LabVIEW8.2. The main finding of this study is that silicon combination EF50DS10 (=V7) was able to replicate the anatomical features of a healthy mitral valve while inducing a normal physiological hemodynamic behavior.
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Visit SourceJosien Snoeijink, T., Lucas van der Hoek, J., Mirgolbabaee, H., Gerard Vlogman, T., Roosen, J., Frank Wilhelmus Nijsen, J., & Groot Jebbink, E. Journal of Endovascular Therapy. 2025.
A symmetrical phantom with circular successively bifurcating vessels was developed to study the behavior of the clinical catheter during microsphere injection. The outlets led to an open fluid collection reservoir, which was connected to a continuous pump and a pulsatile pump (SuperPump, ViVitro labs, Victoria, Canada). The most interesting finding from this study was the observed motion of the clinical catheter and its influence on the microsphere distribution.
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Visit SourceOdemis, E., Başar Aka, I., & Han Kızılkaya, M. Pediatric Cardiology. 2025.
This study assesses the Pulsta THV® valve’s in vitro hemodynamic performance across these RVOT morphologies using 3D-printed models. For this study, valves were tested using the ViVitro Pulse Duplicator System (ViVitro Labs Inc., Victoria, BC), a system designed to simulate physiological conditions as used in previous studies. Our experiments demonstrated that the larger valve size consistently had lower regurgitation rates across all cardiac outputs.
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Visit SourceAmponsah, J., Archibong-Eso, A., Aliyu, A. M., & Wilberforce Awotwe, T.
This work models and numerically simulate the influence of blood viscosity on cavitation within tMHVs, using FSI principles. The experiments used a hydro-mechanical pulse duplicator system (ViVitro Superpump System SP3891, ViVitro Labs Inc., Canada) designed to replicate physiological conditions. Our simulations reveal that cavitation is primarily driven by sharp pressure drops during valve closure, with cavitation inception occurring at pressures as low as 4.5 Pa, a level significantly lower than previously reported ranges of 15–20 Pa.
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Visit SourceSibut-Pinote, Vincent; Reymon, Philippe; Cikirikcioglu, Mustafa; Bendjelid, Karim; Huber, Christoph. ASAIO Journal ():10.1097/MAT.0000000000002454, May 13, 2025.
Use of the ViVitro Labs Super Pump to build a complex mock circulatory loop to study the effect of VA-ECMO/IABP combination on the with systemic, coronary, cerebral, and renal circulation. In this study the ViVitro Labs system is used to improve the outcome of clinical procedures. "We used the same silicone circuit as in our previous publication (model ref T-S-N-009+; Elastrat, Geneva, Switzerland). To prevent the formation of air bubbles when testing at a heart rate of 100 bpm, and to improve the quality of aortic flow measurements, a rigid plastic grid was placed in the compliance reservoir tank. We used a pulsatile pump (Superpump; ViVitro Labs, Inc., Victoria, BC, Canada) to simulate cardiac function at the circuit inlet. Positioning the pump in line with the aortic root was the configuration with the fewest disturbances flow and pressure measurements (Figure 1)"
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Visit SourceJelle Plomp, Ashkan Ghanbarzadeh-Dagheyan, Michel Versluis, Guillaume Lajoinie, Erik Groot Jebbink, Imaging Behind the Plaque: Improved Blood Flow Quantification Using an Iterative Scheme for Active Attenuation Correction, Ultrasound in Medicine & Biology, Volume 51, Issue 6, 2025, Pages 984-998
This publication demonstrates how the ViVitro Labs Pulsatile Flow Pump can be used to create a mock circulatory flow loop (MCL) in the context of particle image velocimetry (PIV) "To confirm ISAAC's applicability, measurements were also performed using a pulsatile flow with a frequency of 70 beats per minute, produced using the ViVitro SuperPump (ViVitro Labs Inc, Victoria, CA, USA). The setup in Figure 1a was adjusted such that the pulsatile flow would be added to the constant output of the other pump. Approximately two cycles were imaged at 1667 fps, resulting in 3000 frames. Singular value decomposition filtering was performed over all 3000 frames"
Other Products Cited: Flow Visualization SuperPump
Visit SourceLuca Bontempi, Marta Zattoni, Anna Ramella, Francesco Migliavacca, Steffen Ringgaard, Won Yong Kim, Peter Johansen, Monika Colombo bioRxiv 2025.03.05.641637
This publication demonstrates the modularity of the ViVitro Labs Pulsatile flow pump and how it can be used to construct an advanced mock circulatory flow-loop (MCL) and obtain boundary flow conditions for an FSI model. "A pulsatile in-vitro MCL was employed to replicate a left heart flow cycle, as previously described [9,10]. . An electromechanical piston pump (VSI Superpump, ViVitro Labs, Victoria, Canada) was connected to the ventricular chamber to generate pulsatile flow and pressure waveforms. The atrial reservoir and ventricular chamber were linked via a mechanical heart valve mimicking the mitral valve, while the ventricular chamber and the compliance chamber were connected through the AR model with the integrated AV"
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Visit SourceHong Fang, Shi Su, Liang Zhang, Shuchun Li, Kun Zhang, Kejing Yi, Mengxiao Shi, Nan Wang, Qing Zhou, Min Jin, Computers in Biology and Medicine, Volume 191, 2025, 110106
Elegant demonstration on how the ViVitro Labs Pulse Duplicator with a standard chamber configuration can be used to study the hemodynamic impact of transcatheter heart valve (THV) positioning during valve-in-valve (ViV) procedures. "implantation depth of the interventional valve can affect its hemodynamic performance and valve opening-closing morphology" 'SHV is mounted on the pulse duplicator system (Vivitro-08957, ViVitro Labs, Canada). Powered by the SuperPump and incorporating the Left Heart Flow Measuring and ViVitest Data Acquisition systems, the setup is tailored for resistance and compliance adjustments, allowing real-time data capture from aortic or mitral valves under various simulated cardiac pathologies. In collaboration with ViVitest software, it ensures efficient data collection and analysis of flow and pressure, strictly adhering to ISO 5840 standards for comprehensive cardiac state physiological assessments"
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Visit SourceDylan Goode, Lawrence Scotten, Rolland Siegel, David Blundon, James Dutton, Hadi Mohammadi Journal of Biomechanics, Volume 184, 2025, 112647
The in vitro evaluation was performed using a pulse duplicator system (ViVitro Laboratories Inc., Victoria, BC, Canada), which was enhanced with an optoelectronic subsystem called the Leonardo LNS apparatus. This apparatus allows the pulse duplicator to provide critical performance metrics for analyzing valve functionality. This system allows for the projected open area (POA), measured in cm2, of the prosthetic valves to be measured. With a light source illuminating the transparent flexible left
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Visit SourceLeister, R., Karl, R., Stroh, L., Mereles, D., Eden, M., Neff, L., de Simone, R., Romano, G., Kriegseis, J., Karck, M., Lichtenstern, C., Frey, N., Frohnapfel, B., Stroh, A., & Engelhardt, S. Cardiovasc Eng Tech (2025).
In this study the accuracy of the flow convergence method was assessed in a hemodynamic reproducible in-vitro environment. The frequency of the pump (ViVitro SuperPump, ViVitro Labs, Inc., Victoria, Canada) is adjusted to 80 bpm and the stroke volume of the pump is set to reach a left ventricular pressure of approximately 120 mmHg. The most obvious finding is that the RVol determined by physicians with the flow convergence methods underestimates the RVol for eight out of nine MROPs.
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Visit SourceLevent Beker, Alp Toymus, Süleyman Peker, Abdülkadir Atik, Umut Yener, Maide Albay, Emel Yılgör, İskender Yılgör. Research Square. 08 January 2025.
Despite the rapid emergence of wearable ultrasound technologies in the research community, the common practice still requires wired connections to benchtop instruments. For the in vitro characterization of the heart rate and blood pressure monitoring US tag, a pulsatile pump (SuperPump, ViVitro Labs) with a silicone rubber vessel was used. Thanks to the advances in soft materials, fabrication techniques and sensing strategies, wearable medical devices are revolutionizing the healthcare system by enabling continuous and quantitative assessment of various biomarkers.
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Visit SourceMerhi Y, Montero KL, Johansen P, Mäntysalo M, Agarwala S, ChemRxiv, 2025
We assessed the piezoelectric performance of poly-L-lactic acid (PLLA) films, fabricated using solvent casting and processed using uniaxial stretching and thermal annealing, through tapping, straining, and force- and vibration-sweep tests. The ventricular chamber was connected to a digitally controlled piston pump (Super Pump, ViVitro, Victoria, BC, Canada), which provided pulsatile flow to simulate left ventricular ejection into the aortic root. These results establish the feasibility of PLLA-based sensors for real-time biomechanical feedback during and after cardiovascular surgeries, paving the way for next-generation monitoring technologies that enhance patient outcomes.
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Visit SourceRafiei D, Pahlevan NM, PLoS ONE 19(12): e0310793
Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. To create a systolic contraction, the compliant LV sac is squeezed inside a fluid-filled plexiglass container using a programmable piston pump (ViVitro Labs Inc, SuperPump, AR SERIES). Our principal finding is that CoA increases cerebral blood flow and harmful pulsatile energy transmission to the brain.
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Visit SourceCaroline C. Smid, Georgios A. Pappas, Nikola Cesarovic, Volkmar Falk & Paolo Ermanni
This study discussed novel flexible leaflet designs, focusing on polymeric materials with proven hemocompatibility, such as polyether ether ketone, of much higher stiffness than native tissue, aiming at optimal valve implants
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