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Minsuok Kim; Ciprian Ionita; Rekha Tranquebar; Kenneth R. Hoffmann; Dale B. Taulbee; Hui Meng; Stephen Rudin - Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61432G (2006) https://doi.org/10.1117/12.651773 Event: Medical Imaging, 2006, San Diego, California, United States

Stenting may provide a new, less invasive therapeutic option for cerebral aneurysms. However, a conventional porous stent may be insufficient in modifying the blood flow for clinical aneurysms. We designed an asymmetric stent consisting of a low porosity patch welded onto a porous stent for an anterior cerebral artery aneurysm of a specific patient geometry to block the strong inflow jet...

… 2.5. Angiographic flow visualization The rapid prototype aneurysm model was inserted in a flow loop consisting of a waveform generator, a pump, and a flow meter; the flow was activated by a heart simulating pump (Vivitro Systems Inc., Canada) …

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A Saini - 2011 - conservancy.umn.edu

The objective of this thesis is to 1) describe the product development cycle for the
DS1000, a surgical instrument for Mitral Valve repair. A chapter is then provided for 2)
adapting the device development cycle to a development cycle for a simulator. This is
followed by 3)...

Other Products Cited:  Ex ViVo Simulation  Pulse Duplicator

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TE Claiborne III - dspace.sunyconnect.suny.edu

Valvular heart disease remains a significant public health issue with Calcific Aortic Valve Disease (CAVD) its most life threatening form. Current treatment for CAVD involves open-heart surgical replacement of the diseased aortic valve (AV) with either a tissue (THV) or mechanical (MHV) prosthesis, with THVs being mostly nonthrombogenic but vulnerable to structural valve deterioration (SVD) and MHVs being highly durable but thrombogenic, thus requiring lifelong anticoagulant therapy.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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 V Millette, N Baddour - Biomedical engineering online, 2011 - biomedcentral.com

Heart signals represent an important way to evaluate cardiovascular function and often what is desired is to quantify the level of some signal of interest against the louder backdrop of the beating of the heart itself. An example of this type of application is the quantification of cavitation in mechanical heart valve patients.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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 A Beaulieu, E Foucault, P Braud… - … (MeMeA), 2011 IEEE …, 2011 - ieeexplore.ieee.org

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O Bazan, JP Ortiz - Revista Brasileira de Cirurgia Cardiovascular, 2011 - SciELO Brasil

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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AN Azadani, N Jaussaud, L Ge, … - The Annals of thoracic …, 2011 - Elsevier

Transcatheter aortic valve (TAV) implantation is a treatment for selected patients with failing bioprostheses. We previously showed that currently available SAPIEN (Edwards Lifesciences, Irvine, CA) TAV sizes did not yield acceptable valve-in-valve (VIV) hemodynamics in small degenerated bioprostheses because optimal TAV function requires full stent expansion to its nominal size.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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 F Robicsek, RF Padera Jr… - HSR proceedings in …, 2012 - ncbi.nlm.nih.gov

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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LN Scotten**, R Siegel - The Journal of heart valve disease, 2011 - icr-heart.com  **ViVitro Labs Founder

The results of recent hematological studies have suggested that, under non-physiological flow conditions, circulating procoagulant proteins activate the coagulation cascade. In the present study, in-vitro estimates of flow transients at or near the time of valve closure, including regional backflow velocity (RBV, m/s), flow acceleration (m/s2), and rate of acceleration (jerk, m/s3), have shed new light on the blood-damage potential of prosthetic valves.

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A Ducci, S Tzamtzis, M Mullen, G Burriesci - 2012 - ltces.dem.ist.utl.pt

Two sets of phase resolved PIV measurements were
performed in the Valsalva sinuses of a glass mock aortic root
including three polymeric valve leaflets, before and after the
implant of a Medtronic CoreValve TAVI device. The
experiments were carried out in a hydro-mechanical
cardiovascular pulse duplicator system (Vivitro Superpump
System SP3891) r...

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Matthias F. Menne; Devesh Amatya; Rob Fraser; Maximilian Kuetting; Ulrich Steinseifer; Gerry Wight - Journal of the American College of Cardiology; Volume 64, Issue 11_S, September 2014

Commercially available in-vitro cardiac simulators offer testing opportunities for transcatheter valve therapies (TVT) as they are able to replicate the physiological flow and pressure accurately.

Other Products Cited:  Ex ViVo Simulation  SuperPump

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A Falahatpisheh, A Kheradvar - European Journal of Mechanics-B/Fluids, 2012 - Elsevier

Abnormality in cardiac fluid dynamics is highly correlated with several heart conditions. This is particularly true in valvular heart diseases and congenital heart defects where changes in flow-field accompany significant variations in chambers’ pressure gradients. Particle Image Velocimetry (PIV) is a convenient technique in assessing cardiac fluid dynamics in vitro...

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B Rahmani, S Tzamtzis, H Ghanbari, G Burriesci… - Journal of …, 2012 - Elsevier

Synthetic leaflet heart valves have been widely studied as possible alternatives to the current mechanical and bioprosthetic valves. Assessing the in vitro hydrodynamic function of these prostheses is of great importance to predict their hemodynamic behaviour prior to implantation. This study introduces an innovative concept of a low-profile semi-stented surgical aortic valve (SSAV) made of a novel nanocomposite polyurethane with a polycarbonate soft segment (PCU) and polyhedral oligomeric silsesquioxane (POSS) nanoparticles covalently bonded as a pendant cage to the hard segment.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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 S Ramaswamy, M Salinas, R Carrol… - Journal of visualized …, 2012 - europepmc.org

Limitations of currently available prosthetic valves, xenografts, and homografts have prompted a recent resurgence of developments in the area of tri-leaflet polymer valve prostheses. However, identification of a protocol for initial assessment of polymer valve hydrodynamic functionality is paramount during the early stages of the design process.

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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 S Tzamtzis, J Yap, M Mullen, G Burriesci - 2011 - discovery.ucl.ac.uk

Other Products Cited:  Heart Valve Testing  Pulse Duplicator

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B Chaffin, L Mirabella… QScience Proceedings: Vol. 2012, Heart Valve Biology and Tissue Engineering, 64. DOI: 10.5339/qproc.2012.heartvalve.4.64 Published online: 10 Jul 2012

We aim to validate the performance of our fluid structure interaction (FSI) simulations of a bi-leaflet mechanical heart valve in the aortic position., whose motion is driven by the beating left ventricle. We compare in vitro experiments and computations performed on an idealized model of the left ventricle (LV) with a St. Jude Medical Regent heart valve in the aortic position.

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F Kabinejadian, HL Leo, A Danpinid, - World Congress on …, 2013 - Springer

Stenosed carotid artery is responsible for 60% of strokes in the United States and is the third major cause of death. Recently, there is an increasing interest in carotid artery stenting for treatment of cervical carotid artery bifurcation atherosclerotic disease. The ultimate goal of this study is to develop, prototype, test, and optimize a novel design of a covered carotid stent, in order to achieve emboli prevention and...

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M Vermeulen, T Claessens… - Rapid Prototyping …, 2013 - emeraldinsight.com

The purpose of this paper is to use rapid prototyping technology, in this case fused deposition modeling (FDM), to manufacture 2D and 3D particle image velocimetry (PIV) compatible patient‐specific airway models.

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Niema M. Pahlevana, Morteza Ghariba, - Journal of Biomechanics Volume 46, Issue 13, 3 September 2013, Pages 2122–2129

An impedance pump – also known as Liebau pump – is a simple valveless pump that operates based on the principles of wave propagation and reflection. It has been shown in embryonic zebrafish that a similar mechanism is responsible for the pumping action in the embryonic heart during the early stages before valve formation...

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Trung B. Le, Daniel R. Troolin, Devesh Amatya*, Ellen K. Longmire, Fotis Sotiropoulos - Annals of biomedical …, 2013 - Springer    *ViVitro Labs employee

We carry out high-resolution laboratory experiments and numerical simulations to investigate the dynamics of unsteady vortex formation across the neck of an anatomic in vitro model of an intracranial aneurysm. A transparent acrylic replica of the aneurysm is manufactured and attached to a pulse duplicator system in the laboratory.

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