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Luca Bontempi, Marta Zattoni, Anna Ramella, Francesco Migliavacca, Steffen Ringgaard, Won Yong Kim, Peter Johansen, Monika Colombo bioRxiv 2025.03.05.641637
This publication demonstrates the modularity of the ViVitro Labs Pulsatile flow pump and how it can be used to construct an advanced mock circulatory flow-loop (MCL) and obtain boundary flow conditions for an FSI model. "A pulsatile in-vitro MCL was employed to replicate a left heart flow cycle, as previously described [9,10]. . An electromechanical piston pump (VSI Superpump, ViVitro Labs, Victoria, Canada) was connected to the ventricular chamber to generate pulsatile flow and pressure waveforms. The atrial reservoir and ventricular chamber were linked via a mechanical heart valve mimicking the mitral valve, while the ventricular chamber and the compliance chamber were connected through the AR model with the integrated AV"
Other Products Cited: Customized circulatory systems Flow Visualization Pulsatile Flow Simulation SuperPump
Visit SourceMao, P.; Jin, M.; Li, W.; Zhang, H.; Li, H.; Li, S.; Yang, Y.; Zhu, M.; Shi, Y.; Zhang, X.; et al. Biomedicines 2025, 13, 1135.
This research the left ventricular chamber of a ViVitro Labs Pulse was customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. The ViVitro Labs Pulse chamber design and structure provides maximum modularity to create unique support without compromising system performance. "The TaurusOne was tested in vitro in a pulse duplicator system (ViVitro Labs Inc., Victoria, BC, Canada) (Figure 1b), operating at a rate of 70 beats per minute (bpm). The test chamber was filled with 37 °C distilled water to simulate the testing environment recommended by ISO 5840-3 [20]. A linear motor-driven plunger pump was used to precisely control the pressure values on both sides of the fluid according to the aortic valve pressure gradient curve of the clinical patient"
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Visit SourceZhu, Y., Imbrie-Moore, A.M., Park, M.H. et al. Commun Med 5, 40 (2025). https://doi.org/10.1038/s43856-025-00753-6
This research demonstrates how the left ventricular chamber of a ViVitro Labs Pulse can be customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. "The ex vivo left heart simulator, which has been previously described17,18,19,20,21, features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) which generates physiologic hemodynamics in accordance with ISO 5840 in vitro cardiac valve testing standards using the pump controller and software (ViVitest Software, ViVitro Labs, Fig. 3d)."
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Visit SourceLaengle S, Suria A, Poschner T, Tasdelen S, Pitsis A, Kocher A, Andreas M. Bioengineering. 2024; 11(7):666.
Clover repair offers a surgical solution that can be applied for the treatment of primary and secondary Tricuspid regurgitation (TR). Flow was provided by a pulsatile pump system (ViVitro Labs Inc., Victoria, BC, Canada), which was coupled to the right ventricle through a third connector. This new clover technique was demonstrated to successfully reduce TR in an ex vivo porcine heart model.
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Visit SourceKarl, R., Romano, G., Marx, J. et al. Int J CARS (2023)
Minimally invasive mitral valve surgery (MIMVS) and transcatheter edge-to-edge repair (TEER) are complex procedures used to treat mitral valve (MV) pathologies, but with limited training opportunities available. The SuperPump, a pulsatile cardiac piston pump in combination with a viscoelastic impedance adapter (both ViVitro Labs, Inc., BC, Canada), is attached to the LV and produces preselected and customizable waveforms at various frequencies and amplitudes. Ex-vivo modelling of MV pathologies and repair procedures using the described simulator realistically replicated physiological in-vivo conditions.
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Visit SourceMariam Abdi Noor, Leila Louise Benhassen, Alexander Emil Kaspersen, Marc Gjern Weiss, John Michael Hasenkam, Peter Johansen, J. of Cardiovasc. Trans. Res.
The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. The ventricular chamber was coupled to a digitally controlled piston pump (SuperPump AR Series, ViVitro Labs, Victoria, Canada), delivering a pulsatile flow to simulate left ventricular ejection into the aortic root. Overall, the echographic data revealed that both interventions had a downsizing effect on the aortic root, while still maintaining the distensibility comparable to the native condition.
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Visit SourceY. Zhu, A. M. Imbrie-Moore, R. J. Wilkerson, M. J. Paulsen, M. H. Park & Y. Joseph Woo, BMC Cardiovascular Disorders volume 22, Article number: 73 (2022)
...The left heart simulator, which has been previously described, features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, British Columbia, Canada) to generate physiologic parameters using the pump controller and software (ViVitest Software, ViVitro Labs) programmed in accordance with ISO 5840 standards for in vitro valve testing...The mitral annular dilation system successfully generated an ex vivo mitral annular dilation model with MR...
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Visit SourceM. Marin-Cuartas, Y. Zhu, A. M. Imbrie-Moore, M. H. Park, R. J. Wilkerson, M. Leipzig, P. K. Pandya, M. J. Paulsen, M. A. Borger, Y. J. Woo, Interactive CardioVascular and Thoracic Surgery (2021) 1–9
...The severity of acute papillary muscle (PM) rupture varies according to the extent and site of the rupture. However, the haemodynamic effects of different rupture variations are still poorly understood...A 3D printer (Carbon 3D, Redwood City, CA, USA) was used to prototype a modular left heart (left atrium and ventricle) and was mounted to a pulsatile linear piston pump (ViVitro Superpump; ViVitro Labs, Victoria, BC, Canada)...
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Visit SourceA. Imbrie-Moore, Y. Zhu, T. Bandy-Vizcaino, M. Park, R. Wilkerson, Y. Woo, Annals of Biomedical Engineering, 49
Driven by a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) which generates physiologic hemodynamics in accordance with ISO 5840 in vitro cardiac valve testing standards.
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Visit SourceCharles H. Bloodworth MS IV Eric L. Pierce PhD Keshav Kohli MS Nancy J. Deaton BS Kaitlin J. Jones BS Radhika Duvvuri BS Norihiko Kamioka MD Vasilis - C. Babaliaros MD Ajit P. Yoganathan PhD - Catheterization and Cardiovascular Interventions 09 August 2018
...Leaflet tethering commonly seen in functional mitral regurgitation may be a significant factor affecting the severity of MS after MitraClip implantation... … conditions. A piston pump (Vivitro Labs Inc. Victoria, Canada) drove physiological left heart flow within the simulator, while an electromagnetic flow probe (Carolina Medical Electronics, East Bend, NC) measured cardiac output (CO) …
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Visit SourceWei-Ling ChenChiu-Chin WuChung-Dann Kan - World Congress on Medical Physics and Biomedical Engineering 2018 pp 519-524
...Percutaneous pulmonary valve implantation (PPVI) has evolved as most exciting development surgical strategy with dysfunctional right ventricle-pulmonary artery conduits. ... ...The purpose of this study is to investigate the hemodynamic and functional consequences of the new design using a mock circulation system... … vasculature. Blood pressures and flows are driven by a digitally controlled hydraulic piston pump (ViViTro Labs Inc., Super Pump System, Victor, BC) to produce pulsatile waves with heart rates of 60 and 80 beats/min from ARV to ARA …
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Visit SourceWei-Ling Chena, Chia-Hung Linb, Jieh-Neng Wangc, Pong-Jeu Lud, Ming-Yao Chand, Jui-Te Wue, Chung-Dann Kanf
...This study proposes an assistive technology to quantify regurgitation using the regurgitation fraction (RF) and heart pump efficiency (HPE). … pulmonary valves. The blood pressure and flow were driven by a digitally controlled hydraulic piston pump (ViViTro Labs Inc., Super Pump System, Victor, BC) to produce pulsatile waves with heart rates of 60 and 80 beats/min. The …
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Visit SourceM Jeyhani, S Shahriari, M Labrosse - Artificial Organs, 2017 First published: 23 November 2017
This in vitro study aims to evaluate the hemodynamic modifications following a simulated PEtER. A custom-made mitral valve was developed, and two configurations were tested: (i) a single-orifice valve with mitral regurgitation and (ii) a double-orifice mitral valve configuration following PEtER. … MATERIALS AND METHODS In vitro model For the purpose of this study, a ViVitro pulse duplicator (ViVitro Labs, Victoria, BC, Canada) was used (Fig. 1). This system is capable of reproducing physiological flow and pressure waveforms in left heart cavity models …
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