Michel R. Labrosse, Keegan Lobo, Carsten J. Beller, Journal of Biomechanics 43, 1916–1922; 2010.

A novel finite element model of the natural aortic valve was developed implementing anisotropic hyperelastic material properties for the leaflets and aortic tissues, and starting from the unpressurized geometry. Static pressurization of the aortic root, silicone rubber moulds and published data helped to establish the model parameters, while high-speed video recording of the leaflet motion in a left-heart simulator allowed for comparisons with simulations.

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Andrew D. Michaels MD, David Mester, Catheterization and Cardiovascular Interventions Vol. 77, issue 5, pages 726-732, April 2011.

Abstract OBJECTIVES: Accurate assessment of prosthetic mechanical valve malfunction is challenging for non-invasive and invasive techniques. We evaluated a 0.014-inch pressure-sensing coronary guidewire to assess mechanical valve dysfunction.

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TE Claiborne III - dspace.sunyconnect.suny.edu

Valvular heart disease remains a significant public health issue with Calcific Aortic Valve Disease (CAVD) its most life threatening form. Current treatment for CAVD involves open-heart surgical replacement of the diseased aortic valve (AV) with either a tissue (THV) or mechanical (MHV) prosthesis, with THVs being mostly nonthrombogenic but vulnerable to structural valve deterioration (SVD) and MHVs being highly durable but thrombogenic, thus requiring lifelong anticoagulant therapy.

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 V Millette, N Baddour - Biomedical engineering online, 2011 - biomedcentral.com

Heart signals represent an important way to evaluate cardiovascular function and often what is desired is to quantify the level of some signal of interest against the louder backdrop of the beating of the heart itself. An example of this type of application is the quantification of cavitation in mechanical heart valve patients.

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O Bazan, JP Ortiz - Revista Brasileira de Cirurgia Cardiovascular, 2011 - SciELO Brasil

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AN Azadani, N Jaussaud, L Ge, … - The Annals of thoracic …, 2011 - Elsevier

Transcatheter aortic valve (TAV) implantation is a treatment for selected patients with failing bioprostheses. We previously showed that currently available SAPIEN (Edwards Lifesciences, Irvine, CA) TAV sizes did not yield acceptable valve-in-valve (VIV) hemodynamics in small degenerated bioprostheses because optimal TAV function requires full stent expansion to its nominal size.

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 F Robicsek, RF Padera Jr… - HSR proceedings in …, 2012 - ncbi.nlm.nih.gov

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LN Scotten**, R Siegel - The Journal of heart valve disease, 2011 - icr-heart.com  **ViVitro Labs Founder

The results of recent hematological studies have suggested that, under non-physiological flow conditions, circulating procoagulant proteins activate the coagulation cascade. In the present study, in-vitro estimates of flow transients at or near the time of valve closure, including regional backflow velocity (RBV, m/s), flow acceleration (m/s2), and rate of acceleration (jerk, m/s3), have shed new light on the blood-damage potential of prosthetic valves.

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B Rahmani, S Tzamtzis, H Ghanbari, G Burriesci… - Journal of …, 2012 - Elsevier

Synthetic leaflet heart valves have been widely studied as possible alternatives to the current mechanical and bioprosthetic valves. Assessing the in vitro hydrodynamic function of these prostheses is of great importance to predict their hemodynamic behaviour prior to implantation. This study introduces an innovative concept of a low-profile semi-stented surgical aortic valve (SSAV) made of a novel nanocomposite polyurethane with a polycarbonate soft segment (PCU) and polyhedral oligomeric silsesquioxane (POSS) nanoparticles covalently bonded as a pendant cage to the hard segment.

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 S Ramaswamy, M Salinas, R Carrol… - Journal of visualized …, 2012 - europepmc.org

Limitations of currently available prosthetic valves, xenografts, and homografts have prompted a recent resurgence of developments in the area of tri-leaflet polymer valve prostheses. However, identification of a protocol for initial assessment of polymer valve hydrodynamic functionality is paramount during the early stages of the design process.

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 S Tzamtzis, J Yap, M Mullen, G Burriesci - 2011 - discovery.ucl.ac.uk

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G Pisani, R Scaffa, O Ieropoli, EM Dell’Amico… – The Journal of Thoracic …, 2013 – Elsevier

The present in vitro study was designed to ascertain whether the presence of sinuses of Valsalva in the aortic root were able to regulate the valve effective orifice area and modulate the gradient across the valve independently from root compliance.

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Journal of Biomechanical Engineering, doi:10.1115/1.4026576. H. Maleki, S. Shahriari, M. Labrosse, P. Pibarot and L. Kadem

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Medical & Biological Engineering & Computing, January 2014, Volume 52, Issue 1, pp 1-8. H. Maleki, S. Shahriari, L. G. Durand, M. R. Labrosse, L. Kadem

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