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LN Scotten**, R Siegel - The Journal of heart valve disease, 2011 - icr-heart.com **ViVitro Labs Founder
The results of recent hematological studies have suggested that, under non-physiological flow conditions, circulating procoagulant proteins activate the coagulation cascade. In the present study, in-vitro estimates of flow transients at or near the time of valve closure, including regional backflow velocity (RBV, m/s), flow acceleration (m/s2), and rate of acceleration (jerk, m/s3), have shed new light on the blood-damage potential of prosthetic valves.
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceA Ducci, S Tzamtzis, M Mullen, G Burriesci - 2012 - ltces.dem.ist.utl.pt
Two sets of phase resolved PIV measurements were performed in the Valsalva sinuses of a glass mock aortic root including three polymeric valve leaflets, before and after the implant of a Medtronic CoreValve TAVI device. The experiments were carried out in a hydro-mechanical cardiovascular pulse duplicator system (Vivitro Superpump System SP3891) r...
Other Products Cited: Flow Visualization SuperPump
Visit SourceMatthias F. Menne; Devesh Amatya; Rob Fraser; Maximilian Kuetting; Ulrich Steinseifer; Gerry Wight - Journal of the American College of Cardiology; Volume 64, Issue 11_S, September 2014
Commercially available in-vitro cardiac simulators offer testing opportunities for transcatheter valve therapies (TVT) as they are able to replicate the physiological flow and pressure accurately.
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Visit SourceA Falahatpisheh, A Kheradvar - European Journal of Mechanics-B/Fluids, 2012 - Elsevier
Abnormality in cardiac fluid dynamics is highly correlated with several heart conditions. This is particularly true in valvular heart diseases and congenital heart defects where changes in flow-field accompany significant variations in chambers’ pressure gradients. Particle Image Velocimetry (PIV) is a convenient technique in assessing cardiac fluid dynamics in vitro...
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Visit SourceB Rahmani, S Tzamtzis, H Ghanbari, G Burriesci… - Journal of …, 2012 - Elsevier
Synthetic leaflet heart valves have been widely studied as possible alternatives to the current mechanical and bioprosthetic valves. Assessing the in vitro hydrodynamic function of these prostheses is of great importance to predict their hemodynamic behaviour prior to implantation. This study introduces an innovative concept of a low-profile semi-stented surgical aortic valve (SSAV) made of a novel nanocomposite polyurethane with a polycarbonate soft segment (PCU) and polyhedral oligomeric silsesquioxane (POSS) nanoparticles covalently bonded as a pendant cage to the hard segment.
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceS Ramaswamy, M Salinas, R Carrol… - Journal of visualized …, 2012 - europepmc.org
Limitations of currently available prosthetic valves, xenografts, and homografts have prompted a recent resurgence of developments in the area of tri-leaflet polymer valve prostheses. However, identification of a protocol for initial assessment of polymer valve hydrodynamic functionality is paramount during the early stages of the design process.
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceS Tzamtzis, J Yap, M Mullen, G Burriesci - 2011 - discovery.ucl.ac.uk
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceJ Calderan, E Sirois, W Sun - … Conference (NEBEC), 2012 38th …, 2012 - ieeexplore.ieee.org
Other Products Cited: Heart Valve Testing Pulsatile Flow Simulation
Visit SourceB Chaffin, L Mirabella… QScience Proceedings: Vol. 2012, Heart Valve Biology and Tissue Engineering, 64. DOI: 10.5339/qproc.2012.heartvalve.4.64 Published online: 10 Jul 2012
We aim to validate the performance of our fluid structure interaction (FSI) simulations of a bi-leaflet mechanical heart valve in the aortic position., whose motion is driven by the beating left ventricle. We compare in vitro experiments and computations performed on an idealized model of the left ventricle (LV) with a St. Jude Medical Regent heart valve in the aortic position.
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Visit SourceF Kabinejadian, HL Leo, A Danpinid, - World Congress on …, 2013 - Springer
Stenosed carotid artery is responsible for 60% of strokes in the United States and is the third major cause of death. Recently, there is an increasing interest in carotid artery stenting for treatment of cervical carotid artery bifurcation atherosclerotic disease. The ultimate goal of this study is to develop, prototype, test, and optimize a novel design of a covered carotid stent, in order to achieve emboli prevention and...
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Visit SourceM Vermeulen, T Claessens… - Rapid Prototyping …, 2013 - emeraldinsight.com
The purpose of this paper is to use rapid prototyping technology, in this case fused deposition modeling (FDM), to manufacture 2D and 3D particle image velocimetry (PIV) compatible patient‐specific airway models.
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Visit SourceNiema M. Pahlevana, Morteza Ghariba, - Journal of Biomechanics Volume 46, Issue 13, 3 September 2013, Pages 2122–2129
An impedance pump – also known as Liebau pump – is a simple valveless pump that operates based on the principles of wave propagation and reflection. It has been shown in embryonic zebrafish that a similar mechanism is responsible for the pumping action in the embryonic heart during the early stages before valve formation...
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Visit SourceTrung B. Le, Daniel R. Troolin, Devesh Amatya*, Ellen K. Longmire, Fotis Sotiropoulos - Annals of biomedical …, 2013 - Springer *ViVitro Labs employee
We carry out high-resolution laboratory experiments and numerical simulations to investigate the dynamics of unsteady vortex formation across the neck of an anatomic in vitro model of an intracranial aneurysm. A transparent acrylic replica of the aneurysm is manufactured and attached to a pulse duplicator system in the laboratory.
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Visit SourceChoon-Sik Jhun and Joshua P. Cysyk* – Artificial Organs Volume 38, Issue 4, pages 309–315, April 2014
End-systolic elastance and end-diastolic compliance have been used to quantify systolic and diastolic function of the left ventricle (LV). In this study, the effective end-systolic elastance, (EES)eff, end-systolic volume intercept, (V0)eff, and end-diastolic compliance of the LV were assessed at various levels of left ventricular assist device (LVAD) support.
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Visit SourceA Siewnicka, K Janiszowski, M Gawlikowski – Mechatronics 2013, 2014 – Springer
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Visit SourceIn Vitro Evaluation of a Novel Hemodynamically Optimized Trileaflet Polymeric Prosthetic Heart Valve
M Kuetting, U Steinseifer, MJ Slepian, D Bluestein – researchgate.net, Journal of Biomechanical Engineering Copyright VC 2013 by ASME
Calcific aortic valve disease is the most common and life threatening form of valvular heart disease, characterized by stenosis and regurgitation, which is currently treated at the symptomatic end-stages via open-heart surgical replacement of the diseased valve with, typically, either a xenograft tissue valve or a pyrolytic carbon mechanical heart valve.
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Visit SourceZH Syedain, LA Meier, JM Reimer… – Annals of biomedical …, 2013 – Springer
A novel tissue-engineered heart valve (TEHV) was fabricated from a decellularized tissue tube mounted on a frame with three struts, which upon back-pressure cause the tube to collapse into three coapting "leaflets." The tissue was completely biological, fabricated from ovine fibroblasts dispersed within a fibrin gel,...
Other Products Cited: SuperPump Tissue Engineering
Visit SourceA Ducci, S Tzamtzis, MJ Mullen… – J Heart Valve Dis. 2013 Sep;22(5):688-96.
BACKGROUND AND AIM OF THE STUDY: The study aim was to assess, in vitro, the hemodynamic modifications produced by transcatheter valves in the Valsalva sinuses, by mean of phase-resolved particle image velocimetry (PIV) measurements...
Other Products Cited: Heart Valve Testing
Visit SourceG Pisani, R Scaffa, O Ieropoli, EM Dell’Amico… – The Journal of Thoracic …, 2013 – Elsevier
The present in vitro study was designed to ascertain whether the presence of sinuses of Valsalva in the aortic root were able to regulate the valve effective orifice area and modulate the gradient across the valve independently from root compliance.
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Visit SourceP Boloori_Zadeh, SC Corbett, H Nayeb-Hashemi – Materials Science and …, 2013 Science Direct
Tri-leaflet polyurethane heart valves have been considered as a potential candidate in heart valve replacement surgeries. In this study, polyurethane (Angioflex(®)) heart valve prostheses were fabricated using a solvent-casting method to evaluate their calcification resistance. These valves were subjected to accelerated life testing (continuous opening and closing of the leaflets) in a synthetic calcification solution. Results showed that Angioflex(®) could be ...
Other Products Cited: Heart Valve Testing
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