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Hong Fang, Shi Su, Liang Zhang, Shuchun Li, Kun Zhang, Kejing Yi, Mengxiao Shi, Nan Wang, Qing Zhou, Min Jin, Computers in Biology and Medicine, Volume 191, 2025, 110106
Elegant demonstration on how the ViVitro Labs Pulse Duplicator with a standard chamber configuration can be used to study the hemodynamic impact of transcatheter heart valve (THV) positioning during valve-in-valve (ViV) procedures. "implantation depth of the interventional valve can affect its hemodynamic performance and valve opening-closing morphology" 'SHV is mounted on the pulse duplicator system (Vivitro-08957, ViVitro Labs, Canada). Powered by the SuperPump and incorporating the Left Heart Flow Measuring and ViVitest Data Acquisition systems, the setup is tailored for resistance and compliance adjustments, allowing real-time data capture from aortic or mitral valves under various simulated cardiac pathologies. In collaboration with ViVitest software, it ensures efficient data collection and analysis of flow and pressure, strictly adhering to ISO 5840 standards for comprehensive cardiac state physiological assessments"
Other Products Cited: Heart Valve Testing Pulsatile Flow Simulation Pulse Duplicator
Visit SourceKedwai, Baqir et al. JVS-Vascular Science, Volume 6, 100287
AAA sac management with persistent growth or endoleak in patient continue to be a challenge. This publication demonstrates the modularity of the ViVitro Labs Pulsatile Flow Pump in building advanced mock circulatory loops, and how the ViVitro Labs systems can be used to assess the impact of an embolization technique on the reduction of AAA sac volume and improve a procedure clinical outcome. "A Vivitro SuperPump (Victoria, BC, Canada) cardiac simulator was connected to both ends of a 30-gallon plastic basin using plastic tubing. The graft model construct was placed into the basin and securely attached proximally and distally to the plastic tubing with circumferential clamps. The basin was filled with water and gel beads for optimal acoustic conditions. Once the model was connected to the flow circuit, water was pumped through the system at 70 beats per minute with an average flow rate of 3.5 L/min."
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Endovascular Simulator Peripheral devices testing Stent and Stent/Graft SuperPump
Visit SourceDylan Goode, Lawrence Scotten, Rolland Siegel, David Blundon, James Dutton, Hadi Mohammadi Journal of Biomechanics, Volume 184, 2025, 112647
The in vitro evaluation was performed using a pulse duplicator system (ViVitro Laboratories Inc., Victoria, BC, Canada), which was enhanced with an optoelectronic subsystem called the Leonardo LNS apparatus. This apparatus allows the pulse duplicator to provide critical performance metrics for analyzing valve functionality. This system allows for the projected open area (POA), measured in cm2, of the prosthetic valves to be measured. With a light source illuminating the transparent flexible left
Other Products Cited: Heart Valve Testing Pulsatile Flow Simulation Pulse Duplicator
Visit SourceMao, P.; Jin, M.; Li, W.; Zhang, H.; Li, H.; Li, S.; Yang, Y.; Zhu, M.; Shi, Y.; Zhang, X.; et al. Biomedicines 2025, 13, 1135.
This research the left ventricular chamber of a ViVitro Labs Pulse was customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. The ViVitro Labs Pulse chamber design and structure provides maximum modularity to create unique support without compromising system performance. "The TaurusOne was tested in vitro in a pulse duplicator system (ViVitro Labs Inc., Victoria, BC, Canada) (Figure 1b), operating at a rate of 70 beats per minute (bpm). The test chamber was filled with 37 °C distilled water to simulate the testing environment recommended by ISO 5840-3 [20]. A linear motor-driven plunger pump was used to precisely control the pressure values on both sides of the fluid according to the aortic valve pressure gradient curve of the clinical patient"
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Heart Valve Repair Pulse Duplicator
Visit SourceJunke Yao, Xinyi Pi, Giorgia Maria Bosi, Gaetano Burriesci, & Helge Wurdemann. IEEE Robotics and Automation Letters, vol. 10, no. 2, pp. 1114-1121, Feb 2025.
The main goal of this study is to analyze the phase synchrony of balloon inflation with cardiac frequency using a robotic device and assess its dilatation performance compared to the standard. A pressure sensor was hydraulically connected to the ventricular chamber of a ViVitro Pulse Duplicator (ViVitro Labs, Inc. Victoria, BC, Canada). The ViVitest software enables the analysis of the flow rate and pressures of the aortic and ventricular chambers and the estimation of the effective orifice area. Our method shows better dilatation performance, as evidenced by notable improvements in pressure gradient and aortic valve opening area.
Other Products Cited: Pulse Duplicator TAVI
Visit SourceHernandez Torres, S. I., Caldwell, N. W., & Snider, E. J. Bioengineering, 11(12), 1271.
Here, we conduct independent evaluation testing of the Vu-Path™ Ultrasound Guidance system, or Vu-Path™. The device was evaluated using a custom, modular tissue-mimicking phantom that can easily be adjusted to multiple different vessel diameters. The phantom was connected to a flow loop with a pulsatile, heart-mimicking pump (ViVitro Labs, Victoria, BC, Canada) circulating water, and pressure was quantified by sensors connected to a patient monitor. Overall, the Vu-Path™ device performed well for this vascular access task across the standardized test pipeline we presented.
Other Products Cited: Customized Circulatory Loop SuperPump Ultrasound Measurements
Visit SourceZhu, Y., Imbrie-Moore, A.M., Park, M.H. et al. Commun Med 5, 40 (2025). https://doi.org/10.1038/s43856-025-00753-6
This research demonstrates how the left ventricular chamber of a ViVitro Labs Pulse can be customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. "The ex vivo left heart simulator, which has been previously described17,18,19,20,21, features a pulsatile linear piston pump (ViVitro Superpump, ViVitro Labs, Victoria, BC, Canada) which generates physiologic hemodynamics in accordance with ISO 5840 in vitro cardiac valve testing standards using the pump controller and software (ViVitest Software, ViVitro Labs, Fig. 3d)."
Other Products Cited: Customized Circulatory Loop Heart Valve Repair Pulse Duplicator
Visit SourceLeister, R., Karl, R., Stroh, L., Mereles, D., Eden, M., Neff, L., de Simone, R., Romano, G., Kriegseis, J., Karck, M., Lichtenstern, C., Frey, N., Frohnapfel, B., Stroh, A., & Engelhardt, S. Cardiovasc Eng Tech (2025).
In this study the accuracy of the flow convergence method was assessed in a hemodynamic reproducible in-vitro environment. The frequency of the pump (ViVitro SuperPump, ViVitro Labs, Inc., Victoria, Canada) is adjusted to 80 bpm and the stroke volume of the pump is set to reach a left ventricular pressure of approximately 120 mmHg. The most obvious finding is that the RVol determined by physicians with the flow convergence methods underestimates the RVol for eight out of nine MROPs.
Other Products Cited: Analysis and Computational Modeling Flow Visualization Heart Valve Testing Pulsatile Flow Simulation Pulse Duplicator Ultrasound Measurements
Visit SourceLevent Beker, Alp Toymus, Süleyman Peker, Abdülkadir Atik, Umut Yener, Maide Albay, Emel Yılgör, İskender Yılgör. Research Square. 08 January 2025.
Despite the rapid emergence of wearable ultrasound technologies in the research community, the common practice still requires wired connections to benchtop instruments. For the in vitro characterization of the heart rate and blood pressure monitoring US tag, a pulsatile pump (SuperPump, ViVitro Labs) with a silicone rubber vessel was used. Thanks to the advances in soft materials, fabrication techniques and sensing strategies, wearable medical devices are revolutionizing the healthcare system by enabling continuous and quantitative assessment of various biomarkers.
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Pulsatile Flow Simulation SuperPump Ultrasound Measurements
Visit SourceGhanbarzadeh-Dagheyan A, van Helvert M, van de Velde L, Reijnen MMPJ, Versluis M, Groot Jebbink E. Journal of Endovascular Therapy. 2024;0(0).
Helical stents have been developed to treat peripheral arterial disease (PAD) in the superficial femoral artery (SFA), with the premise that their particular geometry could promote swirling flow in the blood. The aim of this work is to provide evidence on the existence of this swirling flow by quantifying its signatures. The flow setup consisted of a programmable piston pump (Super Pump, Vivitro, Victoria, Canada), to create pulsating flow. The in vitro results show that skewedness is increased due to the helical geometry of the stents.
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Flow Visualization Stent and Stent/Graft SuperPump
Visit SourceSebastian Kaule*, Michael Stiehm, Stefan Siewert, Alper Öner, and Klaus-Peter Schmitz
The ViVitro Labs Pulse Duplicator is used in its standard configuration to assess the hydrodynamic performance of Transcatheter aortic valve prosthesis (TAVI) according to ISO 5840-3:2021 requirements (TAVR). "For the pulsatile flow testing a commercial pulse duplicator system (ViVitro Labs, Inc., Victoria, BC, Canada) was used. Testing was conducted at a heart rate of 70 bpm and a systolic duration of 35% ± 3%. The test fluid was 0.9% saline at a temperature of 37 °C ± 2°C. The cardiac output (CO) was varied between 2.0 l/min, 3.5 l/min, 5 l/min, and 7 l/min. And the mean aortic pressure (MAP) was adjusted to 100 mmHg ±5 mmHg in every measurement"
Other Products Cited: Heart Valve Testing Pulse Duplicator
Visit SourceMerhi Y, Montero KL, Johansen P, Mäntysalo M, Agarwala S, ChemRxiv, 2025
We assessed the piezoelectric performance of poly-L-lactic acid (PLLA) films, fabricated using solvent casting and processed using uniaxial stretching and thermal annealing, through tapping, straining, and force- and vibration-sweep tests. The ventricular chamber was connected to a digitally controlled piston pump (Super Pump, ViVitro, Victoria, BC, Canada), which provided pulsatile flow to simulate left ventricular ejection into the aortic root. These results establish the feasibility of PLLA-based sensors for real-time biomechanical feedback during and after cardiovascular surgeries, paving the way for next-generation monitoring technologies that enhance patient outcomes.
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Visit SourceRafiei D, Pahlevan NM, PLoS ONE 19(12): e0310793
Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. To create a systolic contraction, the compliant LV sac is squeezed inside a fluid-filled plexiglass container using a programmable piston pump (ViVitro Labs Inc, SuperPump, AR SERIES). Our principal finding is that CoA increases cerebral blood flow and harmful pulsatile energy transmission to the brain.
Other Products Cited: Customized Circulatory Loop Pulsatile Flow Simulation SuperPump
Visit SourceCaroline C. Smid, Georgios A. Pappas, Nikola Cesarovic, Volkmar Falk & Paolo Ermanni
This study discussed novel flexible leaflet designs, focusing on polymeric materials with proven hemocompatibility, such as polyether ether ketone, of much higher stiffness than native tissue, aiming at optimal valve implants
Other Products Cited: Analysis and Computational Modeling Customized Circulatory Loop Heart Valve Testing Pulsatile Flow Simulation SuperPump
Visit SourceMirza, A.; Hsu, C.-P.D.; Rodriguez, A.; Alvarez, P.; Lou, L.; Sey, M.; Agarwal, A.; Ramaswamy, S.; Hutcheson. Bioengineering 2024, 11, 955.
In this study, we used a PSIS scaffold as a testing environment to investigate whether there are any hydrodynamic or mechanical differences between an uncalcified and very mildly calcified valve. PSIS valve functionality was tested using the ViVitro Pulse Duplicator system (ViVitro Labs, Inc., Victoria, BC, Canada), which has the capability for recording flow and pressure data around any valve being tested. Clinically, there is no difference in hydrodynamics between a healthy aortic valve and one that is in the very early stages of CAVD.
Other Products Cited: Analysis and Computational Modeling Heart Valve Testing Pulse Duplicator
Visit SourceSébastien Hecht MSc, Mohamed-Salah Annabi MD, MSc, Viktória Stanová PhD, Abdellaziz Dahou MD, PhD, Ian G. Burwash MD, Matthias Koschutnik MD, Philipp E. Bartko MD, Jutta Bergler-Klein MD, Julia Mascherbauer MD, Carolina Donà MD, Stefan Orwat MD, Helmut Baumgartner MD, Joao L. Cavalcante MD, Henrique B. Ribeiro MD, PhD, Alexis Théron MD, PhD, Josep Rodes-Cabau MD, Marie-Annick Clavel DVM, PhD, Philippe Pibarot DVM, PhD, JACC: Advances, Volume 3, Issue 10, 2024
The purpose of this study was to evaluate the diagnostic and prognostic value of MG/EOA ratio. Contraction of the left ventricle is achieved by a piston pump (Vivitro Inc). MG/EOA ratio can be useful in low-flow, LG-AS to confirm AS severity and may complement DSE or aortic valve calcium scoring.
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Pulsatile Flow Simulation SuperPump
Visit SourcePangelina, Chaztyn; Vu, Vi; May-Newman, Karen. ASAIO Journal. August 22, 2024.
The vortex that forms in the aortic sinus plays a vital role in optimizing blood flow. A mock circulatory loop consisting of a programmable pulse duplicator (Vivitro, Canada) attached to a customized tank for the left ventricle and LVAD, and aortic viewing chamber were integrated into a modified Windkessel circuit suitable for heart failure. The hemodynamics produced by the study conditions reflect a range of bypass conditions of the native heart and the LVAD.
Other Products Cited: Flow Visualization Pulse Duplicator VAD Testing
Visit SourceDylan Goode, Lawrence Scotten, Rolland Siegel, Hadi Mohammadi. Journal of Biomechanics, Volume 174, September 2024.
Current surgical aortic valve (AV) replacement options include bioprosthetic and mechanical heart valves (MHVs), each with inherent limitations. In-vitro testing was conducted utilizing a pulse duplicator system (ViVitro Labs Inc., Victoria, BC, Canada), enhanced by integrating an optoelectronic subsystem dubbed the Leonardo apparatus. The iValve brings forth a novel approach to MHV design that aims to bring the robust longevity of an MHV while providing hemodynamics that is more akin to the native valve.
Other Products Cited: Flow Visualization Heart Valve Testing Pulse Duplicator
Visit SourceMichele Mastrogiacomo. Rel. Stefania Scarsoglio, Vrishank Raghav. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Aerospaziale, 2024
Given the prevalence and impact of Paravalvular Leakage, there is a critical need to study and mitigate this issue to improve patient outcomes. The experimental setup replicates the human left heart, featuring a Pulsatile Pump ViVitro, an em-tec flow meter, pressure taps, and a transparent acrylic test chamber housing a heart valve. The results of the experiments indicate that a wall jet forms during diastole, flowing back from the aortic side into the ventricular side.
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Flow Visualization Heart Valve Testing
Visit SourceHoving, A.M., Mikhal, J., Kuipers, H. et al. Med Biol Eng Comput 62, 1165–1176 (2024).
To investigate flow conditions in a double-layered carotid artery stent, a bench-top in vitro flow setup including a bifurcation phantom was designed and fabricated. For the introduction of pulsatile flow, a linear piston pump (Superpump AR, ViVitro Labs, Victoria, BC, Canada) and two compliances were added to the stationary circuit. We illustrated, with 3D printing and molding, how it is possible to transfer geometry from literature to a model and thereafter to a flexible phantom.
Other Products Cited: Customized Circulatory Loop Customized circulatory systems Flow Visualization Pulsatile Flow Simulation
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