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Sébastien Hecht MSc, Mohamed-Salah Annabi MD, MSc, Viktória Stanová PhD, Abdellaziz Dahou MD, PhD, Ian G. Burwash MD, Matthias Koschutnik MD, Philipp E. Bartko MD, Jutta Bergler-Klein MD, Julia Mascherbauer MD, Carolina Donà MD, Stefan Orwat MD, Helmut Baumgartner MD, Joao L. Cavalcante MD, Henrique B. Ribeiro MD, PhD, Alexis Théron MD, PhD, Josep Rodes-Cabau MD, Marie-Annick Clavel DVM, PhD, Philippe Pibarot DVM, PhD, JACC: Advances, Volume 3, Issue 10, 2024
The purpose of this study was to evaluate the diagnostic and prognostic value of MG/EOA ratio. Contraction of the left ventricle is achieved by a piston pump (Vivitro Inc). MG/EOA ratio can be useful in low-flow, LG-AS to confirm AS severity and may complement DSE or aortic valve calcium scoring.
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Visit SourceHoving, A.M., Mikhal, J., Kuipers, H. et al. Med Biol Eng Comput 62, 1165–1176 (2024).
To investigate flow conditions in a double-layered carotid artery stent, a bench-top in vitro flow setup including a bifurcation phantom was designed and fabricated. For the introduction of pulsatile flow, a linear piston pump (Superpump AR, ViVitro Labs, Victoria, BC, Canada) and two compliances were added to the stationary circuit. We illustrated, with 3D printing and molding, how it is possible to transfer geometry from literature to a model and thereafter to a flexible phantom.
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Visit SourceLaengle S, Suria A, Poschner T, Tasdelen S, Pitsis A, Kocher A, Andreas M. Bioengineering. 2024; 11(7):666.
Clover repair offers a surgical solution that can be applied for the treatment of primary and secondary Tricuspid regurgitation (TR). Flow was provided by a pulsatile pump system (ViVitro Labs Inc., Victoria, BC, Canada), which was coupled to the right ventricle through a third connector. This new clover technique was demonstrated to successfully reduce TR in an ex vivo porcine heart model.
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Visit SourceMohl, L., Karl, R., Hagedorn, M.N. et al. Int J CARS (2024)
Complicated type B Aortic dissection is a severe aortic pathology that requires treatment through thoracic endovascular aortic repair (TEVAR). A realistic pulsatile flow through the aortic phantom is provided by a cardiac piston pump (Superpump, Vivitro Labs Inc., Victoria, Canada). The flexible aortic dissection phantom was successfully incorporated in the hemodynamic flow loop, a systolic pressure of 112 mmHg and physiological flow of 4.05 L per minute was reached.
Other Products Cited: Customized Circulatory Loop Flow Visualization Stent and Stent/Graft SuperPump Ultrasound Measurements
Visit SourceLennart van de Velde, Majorie van Helvert, Stefan Engelhard, Ashkan Ghanbarzadeh-Dagheyan, Hadi Mirgolbabaee, Jason Voorneveld, Guillaume Lajoinie, Michel Versluis, Michel M. P. J. Reijnen, Erik Groot Jebbink, Journal of Medical Imaging, Vol. 11, Issue 3, 037001 (May 2024)
To investigate the accuracy of high-framerate echo particle image velocimetry (ePIV) and computational fluid dynamics (CFD) for determining velocity vectors in femoral bifurcation models through comparison with optical particle image velocimetry (oPIV). A hydraulic piston pump (SuperPump, ViVitro labs, Victoria, Canada) was used to enforce time-varying forward flow. The accuracy of blood flow assessment was investigated in models of the femoral bifurcation by clinically applicable ePIV measurements and CFD simulations.
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Visit SourceD. W. Gonring, Z. R. Zottola, A. A. Hirad, R. Lakony, M. S. Richards, G. Pitcher, M. C. Stoner, D. S. Mix, JVS-Vascular Science, 2024
We 3D-printed axisymmetric tissue-mimicking phantom hydrogel vessels from polyvinyl alcohol cryogel (PVA-c), a material that has previously been biologically validated against vascular tissue. Water was pumped through the phantom using a ViVitro SuperPump (Victoria, British Columbia, CA) cardiac simulator. We found that the percent reduction in average pressure normalized strain increased as the degree of graft oversizing increased.
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Visit SourceMeskin, M., Starkey, P.A., Kaspersen, A.E. et al. Sci Rep 14, 1864 (2024).
To understand the mechanisms and to assess the performance of cardiac devices and interventions, in vitro models can be used to replicate the complex physiological interplay between the pulmonary veins, left atrium, and left ventricle. It includes a pulsatile electromechanical pump (SuperPump AR Series, ViVitro Labs, Victoria, British Columbia, Canada) that provides the volume changes in the rigid LV chamber during the cardiac cycle. This study presents a new versatile left heart MCL that accurately captures the complex and interrelated sequences of left heart events and provides supplementary understanding of left heart fluid dynamics.
Other Products Cited: Ex ViVo Simulation Heart Valve Testing Pulse Duplicator SuperPump
Visit SourceZhang, X., Kizilski, S.B., Recco, D.P. et al. Cardiovasc Eng Tech 14, 827–839 (2023).
Pulmonary valve (PV) monocusp reconstruction in transannular patch (TAP) right ventricular outflow tract (RVOT) repair for Tetralogy of Fallot has variable clinical outcomes across different surgical approaches. The ViVitro Pulse Duplicator System (ViVitro Labs Inc., Victoria, BC) was used to simulate infant RVOT physiological pulsatile flow. Balancing pressure gradient, regurgitation, and oversizing for growth, a set of leaflet design parameters have been selected for pre-clinical evaluation.
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Visit SourceMirgolbabaee H, van de Velde L, Geelkerken RH, Versluis M, Groot Jebbink E, Reijnen MMPJ. Journal of Endovascular Therapy. 2023;0(0).
To identify potential hemodynamic predictors for limb thrombosis (LT) following endovascular aneurysm repair with the Anaconda endograft in a patient-specific phantom. A hydraulic piston-driven pump (SuperPump, ViVitro labs, Victoria) was used to set a suprarenal flow profile as inlet boundary condition. In conclusion, these in vitro data show that unfavorable hemodynamics are present in the limb that presented with LT, compared to the non-thrombosed side, with higher VC and longer RT.
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Visit SourceGavin A. D'Souza, Jean E. Rinaldi, Moustafa Meki, Annabelle Crusan, Eric Richardson, Meir Shinnar, Luke H. Herbertson, J Biomech Eng. Jan 2024, 146(1): 011004 (11 pages)
Mechanical circulatory support (MCS) device therapy is one of the primary treatment options for end-stage heart failure (HF), whereby a mechanical pump is integrated with the failing heart to maintain adequate tissue perfusion. In this study, the BAF solution is circulated through the MCL using a piston pump (SuperPump (AR Series), ViVitro Labs, Inc., Victoria, BC, Canada), which is fluid-coupled to a suspended silicone mock LV sac. An MCL can be an effective regulatory tool for simulating different patient disease states and evaluating the flow performance of MCS devices over their entire operating ranges in a well-controlled environment.
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Visit SourceWu, X., Saaid, H., Voorneveld, J., et al. Cardiovasc Eng Tech (2023).
The development of reliable techniques and analysis tools is essential for the application of hemodynamic biomarkers in clinical practice. A commercial piston pump (Vivitro Labs Inc., BC, Canada) was used to impose a sinusoidal-like volume change of the external pressure chamber with a cardiac cycle period of 857 ms (70 bpm, systolic duration of 300 ms, stroke volume 50 ml). The results show that the pressure distribution along the (longitudinal) base-apex axis reverses at the onset and the termination of the LV filling and ejecting, respectively.
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Visit SourceMariam Abdi Noor, Leila Louise Benhassen, Alexander Emil Kaspersen, Marc Gjern Weiss, John Michael Hasenkam, Peter Johansen, J. of Cardiovasc. Trans. Res.
The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. The ventricular chamber was coupled to a digitally controlled piston pump (SuperPump AR Series, ViVitro Labs, Victoria, Canada), delivering a pulsatile flow to simulate left ventricular ejection into the aortic root. Overall, the echographic data revealed that both interventions had a downsizing effect on the aortic root, while still maintaining the distensibility comparable to the native condition.
Other Products Cited: Heart Valve Repair Pulse Duplicator SuperPump
Visit SourceArian Aghilinejad, Heng Wei, Coskun Bilgi, Alberto Paredes, Alexander DiBartolomeo, Gregory Magee, Niema Pahlevan, J Biomech Eng. 1-31
Type B aortic dissection is a life-threatening medical emergency that can result in rupture of the aorta. The aortic simulator is a hydraulic model that has physical and dynamical properties similar to the human circulatory system. This hydraulic model consists of a piston-in-cylinder pump (ViVitro Labs Inc.) that generates a physiologically accurate pulsatile flow (using a programmable waveform generator ViVigen) and a pump head, including a silicone ventricle membrane, mitral valve, and aortic valve. Results demonstrate that the deep-learning model can accurately capture the dissection geometry from patients’ medical images.
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Visit SourceShin Yajima, Yuanjia Zhu, Charles J. Stark, Robert J. Wilkerson, Matthew H. Park, Elde Stefan, Y. Joseph Woo, The American Association for Thoracic Surgery
This study aimed to biomechanically evaluate the force profiles on the anterior primary and secondary chordae after neochord repair for anterior valve prolapse with varied degrees of residual mitral regurgitation using an ex vivo heart simulator. Briefly, a 3D printer was used to rapidly develop a prototype of a modular left heart coupled to a pulsatile linear actuator (ViVitro Superpump; ViVitro Labs). In our ex vivo AVP model, moderate residual MR following neochord repair was significantly associated with increased forces for both anterior primary and secondary chordae compared with those of less-than-moderate residual MR.
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Visit SourceLeila Louise Benhassen, Jacob Hesselby Hedensted, Mona Sharghbin, Tommy Bechsgaard, Sten Lyager Nielsen, John Michael Hasenkam, Peter Johansen, European Journal of Cardio-Thoracic Surgery, Volume 63, Issue 5, May 2023
For patients with isolated aortic regurgitation, a double sub- and supravalvular annuloplasty has been shown to reduce recurrent aortic regurgitation after aortic valve repair compared with a single subvalvular annuloplasty. The ventricular chamber was connected to an electromechanical piston pump system (Superpump AR series, ViVitro labs, Victoria, Canada). These two findings support the concept of a functional aortic annulus, where the two levels interact and affect the function and competence of the aortic valve.
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Visit SourceMaria Rocchi, Marcus Ingram, Piet Claus, Jan D'hooge, Bart Meyns, Libera Fresiello, Artif Organs. 2022; 00: 1– 13
The aim of this review is to provide an overview on Mock Circulatory Loops and to discuss the recent developments of 3D anatomical models for cardiovascular Medical Device testing. One example is the ViVitro Pulse Duplicator system. The simulator is provided with a flexible ventricular sac activated by a piston pump. The addition of 3D anatomical models enables more realistic connections of the Medical Device with the implantation site and enhances the testing capabilities of the Mock Circulatory Loop.
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Visit SourceShannen B. Kizilski, Xiaoya Zhang, Nicholas E. Kneier, Martha D. Chaillo Lizarraga, Noah E. Schulz, Peter E. Hammer & David M. Hoganson, Cardiovascular Engineering and Technology (2022)
The aim of this study was to develop a robust in vitro system for quantifying flow conditions after various RVOT interventions. The MCL was developed around the ViVitro Pulse Duplicator System with the viscoelastic impedance adapter and ventricle chamber attachments. The 3D-printed RVOT anatomical model and in vitro pulmonary circulatory loop developed in this work provide platform for planning and evaluating surgical interventions in the pediatric population.
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Visit SourceDiya Wang, Boris Chayer, François Destrempes, Jonathan Porée, Marie-Hélène Roy Cardinal, François Tournoux, Guy Cloutier, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (Volume: 69, Issue: 12, December 2022) Page(s): 3284 - 3296
Assessment of myocardial contractility during a stress test is of high clinical value for the diagnosis and evaluation of cardiovascular diseases, especially coronary disease and heart failure. Both ends of this left-ventricular mimicking phantom (wall thickness of 15 mm) was then connected to polyvinyl chloride tubing by a pair of loosely attached steel clamps to a pulse duplicator (model #SD2001-1, ViVitro systems Inc., Victoria, BC, Canada). The complex, large, and rapid myocardial deformation during stress tests were also accurately imaged by the proposed strain estimator with close agreement with sonomicrometry.
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Visit SourceLuca Rosalia, Caglar Ozturk, Jaume Coll-Font, Yiling Fan, Yasufumi Nagata, Manisha Singh, Debkalpa Goswami, Adam Mauskapf, Shi Chen, Robert A. Eder, Efrat M. Goffer, Jo H. Kim, Salva Yurista, Benjamin P. Bonner, Anna N. Foster, Robert A. Levine, Elazer R. Edelman, Marcello Panagia, Jose L. Guerrero, Ellen T. Roche & Christopher T. Nguyen, Nature Biomedical Engineering volume 6, pages 1134–1147 (2022)
Advances in soft robotics have led to the development of high-fidelity simulators of pathophysiology for biomedical applications. An MCL was built using a pulsatile pump (SuperPump, ViVitro Labs), an anatomically accurate compliant silicone aortic vessel (E ≈ 1 MPa, United Biologics) connected to two adjustable compliance chambers (that is, ventricular, systemic), and a resistive valve. The models leverage haemodynamic mimicry and may facilitate the development of patient-specific applications. The models could also facilitate the clinical translation of treatments; in particular, a cohort of AS patients could be recapitulated in an in vivo porcine model, and new treatments could be evaluated preclinically.
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Visit SourceLisa Carlson Hanse, Marcell J Tjørnild, Simon G Sørensen, Peter Johansen, Ignacio Lugones, Vibeke E Hjortdal, Interactive CardioVascular and Thoracic Surgery, Volume 35, Issue 4, October 2022, ivac227
We investigated a new surgical technique of trileaflet semilunar valve reconstruction possessing the potential of remaining sufficient and allowing for some growth with the child. Pulsatile flow was produced by a Series piston pump (SuperPump AR; ViVitro Labs, Victoria, Canada), connected to the ventricular chamber. TSVR was achievable in vitro. Hydrodynamic pressure and echocardiographic evaluations demonstrated a sufficient and non-stenotic neo-valve.
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