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VAD Testing
Simon Heide-Jørgensen, Sellaswasmy Kumaran Krishna, Jonas Taborsky, Tommy Bechsgaard, Rachid Zegdi and Peter Johansen J Biomech Eng 138(3), 034504 (Jan 29, 2016) (7 pages)
The aim of this study was to develop a platform for noncontact TAVI valve deformation analysis with both high temporal and spatial resolutions based on stereophotogrammetry and digital image correlation (DIC). A left-heart pulsatile in vitro flow loop system for mounting of TAVI valves was designed. ... Based on a piston pump (ViVitro SuperDup'r pump, ViVitro systems, Victoria, BC, Canada) a left-heart in vitro flow loop with peripheral units comprising a ventricular chamber, an atrial reservoir, an aortic root in which test valves can be installed, an arterial compliance section ...
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Visit SourceMorgane Evin, Carine Guivier-Curien, Philippe Pibarot, Lyes Kadem and Régis Rieu
... Jude Medical size 23 mm, a resistance and a compliance). The BMHV to be tested is placed directly between the left atrium and the left ventricle molds. The activation of the left ventricle is performed by a Vivitro superpump (VivitroLabs, Victoria, BC, Canada). ...
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Visit SourceNandini Duraiswamy , Jason D. Weaver, Yasamin Ekrami, Stephen M. Retta, Changfu Wu Cardiovascular Engineering and Technology pp 1-13 First online: 10 February 2016
... The hydrodynamic testing was per- formed using 0.9% saline solution in the commercially available Left Heart Simulator (Vivitro Systems), which simulates function of the heart by generating pulsatile flow through prosthetic heart valves. ...In the EllipMinor and EllipMajor configurations, the maximum principal stress occurred near the center of the free edge of the “stretched” leaflets. These results further affirm recommendations by the International Standards Organization (ISO) that pre-clinical testing should consider non-circular configurations for transcatheter valve durability testing.
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Visit SourceJoseph Calderan, Wenbin Mao, Eric Sirois and Wei Sun-- Artificial Organs article first published online: 29 OCT 2015 DOI: 10.1111/aor.12589
Impairment of coronary artery flow, in either acute or chronic conditions, is a severe complication of transcatheter aortic valve (TAV) implantation, which can arise due to improper TAV positioning. ... LHS. An LHS was designed with the intention of providing physiological flow and pressure waveforms in the left atrium, left ventricle (LV), and ascending aorta, similar to commercially available devices such as the ViVitro LHS (ViVitro Labs, Victoria, Canada) but with additional ...
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Visit SourceBurriesci G, Marincola FC, Zervides C. J Med Eng Technol. 2010 Jan;34(1):7-22. doi: 10.3109/03091900903261241
Polymeric heart valves could offer an optimum alternative to current prostheses, by joining the advantages of mechanical and bioprosthetic valves. Though a number of materials suitable for this application have recently become available, significant improvements in the valve design are still needed. In this paper, a novel polymeric heart valve design is proposed and its optimization procedure, based on the use of finite elements, is described...
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Visit SourceFilippo Piatti1 , Francesco Sturla 1,2 , Thomas E. Claiborne3 , Danny Bluestein3 , Alberto Redaelli 1
Experimental procedures are commonly used to obtain an overall quantification of the fluid dynamic and thrombogenic performances of cardiovascular devices [1]... (B) ViVitro gold standard testing benchmark (ViVitro Labs, BC, Canada) Boundary conditions ... obtaining comparable working conditions between the computational model and the ViVitro benchmark. Figure 2 – Schematic visualization of the ideal ...
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Visit SourceHadi Daood Toeg, Ovais Abessi , Talal Al-Atassi, Laurent de Kerchove, Gebrine El-Khoury, Michel Labrosse, Munir Boodhwani, - Cardiovasc Surg, 2014
ABSTRACT Aortic valve (AV) repair (AVr) has become an attractive alternative to AV replacement for the correction of aortic insufficiency; however, little clinical evidence exists in determining which biomaterial at AVr would be optimal. Cusp replacement in AVr has... All aortic roots were connected to the ViVitro Left Heart Simulator (LHS; ViVitro Systems, Inc, Victoria, British Columbia, Canada) for baseline valve measurements acting as paired controls...
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Visit SourceAzadani AN1, Jaussaud N, Matthews PB, Ge L, Chuter TA, Tseng EE., Interact Cardiovasc Thorac Surg. 2010 Jul;11(1):70-7. doi: 10.1510/icvts.2009.225144. Epub 2010 Apr 15.
Transcatheter aortic valves (TAVs) are a promising treatment for high risk surgical patients suffering from degeneration of previously implanted bioprostheses (valve-in-valve therapy).
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Visit SourceFrancis Robicsek, MD, PhD, Mano J Thubrikar, PhD, American Journal of Cardiology Volume 84, Issue 8, Pages 944–946, October 15, 1999
Functional morphology of the normal aortic root was studied in vitro using 500 frames/s cinematography. Stiffening of the aortic wall by spraying its exterior with plastic adhesive led to compromised function of the leaflets...
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Visit SourceFrancis Robicsek MD, PhD, Mano J. Thubrikar PhDb, Joseph W. Cook MDa and Brett Fowler RTb; The Annals of Thoracic Surgery: 77, Issue 1; 177-185.
The study was intended to investigate the reason why congenitally bicuspid valves (CBAVs), which may function hemodynamically and clinically well, have a high early failure rate.
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Visit SourceW.Lim; Journal of Biomechanics: 34, Issue 11; 1417-1427.
A two-dimensional particle image tracking velocimetry (PIV) system has been used to map the velocity vector fields and Reynolds stresses in the immediate downstream vicinity of a porcine bioprosthetic heart valve at the aortic root region in vitro under pulsatile flow conditions. Measurements were performed at five different time steps...
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Visit SourceM. Nobili, U. Morbiducci, R. Ponzini, C. Del Gaudio, A. Balducci, M. Grigioni, F. Maria Montevecchi, A. Redaelli; Journal of Biomechanics: 41, Issue 11; 2539-2550.
The main purpose of this study is to reproduce in silico the dynamics of a bileaflet mechanical heart valve (MHV; St Jude Hemodynamic Plus, 27mm characteristic size) by means of a fully implicit fluid-structure interaction (FSI) method, and experimentally validate the results using an ultrafast cinematographic technique.
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Visit SourceScotten LN**, Walker DK**, Dutton JW; Journal of Heart Valve Disease: 11, Issue 3; 368 **ViVitro Labs Founder
The accuracy of the Gorlin equation when applied to mixed valve pathology has not been investigated. An in-vitro study was performed to determine how a range of valve regurgitations and stenoses affects the Gorlin aortic valve area...
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Visit SourceBrant H. Maines, Christopher E. Brennen; Journal of Biomechanical Engineering: 127, Issue 4; 648.
The cavitation inception threshold of mechanical heart valves has been shown to be highly variable. This is in part due to the random distribution of the initial and final conditions that characterize leaflet closure.
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Visit SourceM. Labrosse, C. Beller, F. Robicsek, M. Thubrikar; Journal of Biomechanics: 39, Issue 14; 2665-2672.
The dimensions of the aortic valve components condition its ability to prevent blood from flowing back into the heart. While the theoretical parameters for best trileaflet valve performance have already been established, an effective approach to describe other less optimal, but functional models has been lacking...
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Visit SourceJ. Timothy Baldwin*, Andy Campbell, Christopher Luck, William Ogilvie and Joe Sauter; European Journal of Cardio-Thoracic Surgery: 11, Issue 2; 287-292.
To compare hydrodynamic characteristics of a new bileaflet heart valve, the CarboMedics kinetic cardiac valve prosthesis, with those of a St. Jude Medical (SJM) heart valve...
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Visit SourceG. Tansley, S. Vidakovic, and J. Reizes; Artificial Organs: 24, Issue 6; 483 – 487.
The VentrAssist pump has no shaft or seal, and the device is unique in design because the rotor is suspended passively by hydrodynamic forces, and urging is accomplished by an integrated direct current motor rotor that also acts as the pump impeller. This device has led to many challenges in its fluidic design...
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Visit SourceDaniel Zimpfer MDa, Heinz Schima PhDb, Martin Czerny MDa, Marie-Theres Kasimir MDa, Sigrid Sandner MDa, Gernot Seebacher MDa, Udo Losert PhDc, Paul Simon MDa, Michael Grimm MDa, Ernst Wolner MD, PhDa and Marek Ehrlich MD; The Annals of Thoracic Surgery: 85, Issue 2; 470-473.
BACKGROUND: This study assessed the feasibility of stent graft treatment of ascending aortic dissections in a porcine in vitro model. METHODS: The entire thoracic aortic aorta including the supraaortic branches was harvested from 12 adult pigs and an intimal tear was artificially created. ...
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Visit SourceWalker**, D.K. Scotten**, L.N.; Engineering in Medicine and Biology Society: 13; 2107-2108. **ViVitro Labs Founder
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Visit SourceD. K. Walker** and L. N. Scotten**; Medical and Biological Engineering and Computing: 29, Issue 5; 457-464; 1991. **ViVitro Labs Founder
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