Articles Related to Applications

M L J Rose, G A Wright, T G Mackay, W Martin and D J Wheatley; Physiological Measurement: 18; 171-182; 1997.

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J. M. Guccione, W. G. O’Dell, A. D. McCulloch and W. C. Hunter; American Journal of Physiology: 272; 1997.

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Richard H. Marcus, MBBCh; Russell S. Heinrich, BSE; James Bednarz, BS; Stephen Lupovitch, MD; Joseph Abruzzo, MD; Raphael Borok, MBBCh; Byron Vandenberg, MD; Richard E. Kerber, MD; William Piccione, MD; Ajit P. Yoganathan, PhD; Roberto M. Lang, MD; American Heart Association: 98; 866-872; 1998.

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Bradley D. Bolster, Jr, MSE, Ergin Atalar, PhD, Christopher J. Hardy, PhD, and Elliot R. McVeigh, PhD; Journal of Magnetic Resonance Imaging: 8, Issue 4; 878–888; 1998.

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J. Michael Hasenkama, b, Steffen Ringgaardc, Kim Houlindb, René M. Botnard, Hans Stødkilde-Jørgensenc, Peter Boesigerd, Erik Morre Pedersena, b, c; European Journal of Cardio-Thoracic Surgery: 16; 300-305; 1999.

To evaluate the potential of magnetic resonance imaging (MRI) for evaluation of velocity fields downstream of prosthetic aortic valves. Furthermore, to provide comparative data from bileaflet aortic valve prostheses in vitro and in patients.

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Sheng-Jing Dong, Paul S. Hees, Wen-Mei Huang, Sam A. Buffer Jr., James L. Weiss, and Edward P. Shapiro; American Journal of Physiology: 277; 1999.

Shortening of oblique left ventricular (LV) fibers results in torsion. A unique relationship between volume and torsion is therefore expected, and the effects of load and contractility on torsion should be predictable. However, volume-independent behavior of torsion has been observed, and the effects of load on this deformation remain controversial....

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A. A. Sakhaeimanesh; Y. S. Morsi; Journal of Medical Engineering & Technology: 23, Issue 2; 63 – 68; 1999.

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Edmond Rambod, Masoud Beizaie, Michael Shusser, Simcha Milo and Morteza Gharib; Annals of Biomedical Engineering: 27, Issue 6; 774-792; 1999.

This study was aimed at developing a physical model, supported by experimental observations, to describe the formation and growth of microbubbles seen in patients with mitral mechanical heart valves (MHV). This phenomenon, often referred to as high intensity transient signals (HITS), appears as bright, intense, high-velocity and persistent echoes detected by Doppler ultrasonography at the instant of closure.

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Steven Goldstein, PhDa, David R. Clarke, MDb, Steven P. Walsh, PhDa, Kirby S. Black, PhDa, Mark F. O’Brien, MDc; The Annals of Thoracic Surgery: 70; 1962-1969; 2000.

Tissue engineering approaches utilizing biomechanically suitable cell-conductive matrixes should extend xenograft heart valve performance, durability, and growth potential to an extent presently attained only by the pulmonary autograft. To test this hypothesis, we developed an acellular, unfixed porcine aortic valve-based construct. The performance of this valve has been evaluated in vitro under simulated aortic conditions, as a pulmonary valve replacement in sheep, and in aortic and pulmonary valve replacement in humans.

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Peter G. Walker, K. Houlind, C. Djurhuus, W.Y. Kim, E.M. Pedersen; Magnetic Resonance in Medicine: 43, Issue 5; 726 – 733; 2000.

Quantifying mitral regurgitation is difficult because of the complexity of the flow, geometry and motion of the mitral valve. In this paper a MRI compatible phantom was built incorporating a left ventricle and mitral valve motion. Valve motion was obtained using a pneumatic piston. The mitral valve was made regurgitant and the regurgitant volume quantified using a modified control volume method. The modification to the method was the addition of mitral motion correction...

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M. J. Thubrikar; G. G. Gong; I. E. Konstantinov; G. A. Selim; B. L. Fowler; F. Robicsek; Journal of Medical Engineering & Technology: 24, Issue 4; 173 – 180; 2000.

The function and longevity of the homograft aortic valve may be influenced by valve size and subcoronary implantation technique. Dynamic function and leaflet configuration of the porcine aortic valve were analysed first in its natural root in a left heart simulator using glycerol at 120/80 mm Hg pressure and 4 l min-1 Cardiac Output (C.O.)...

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Yos S. Morsi; Journal of Artificial Organs: 3, Issue 2; 143-148; 2000.

In examining the hydrodynamic performance of artificial heart valves in vitro, experiments are carried out under either steady or pulsatile flow conditions. Steady flow experiments are simple to set up and analysis of the data is also simple; however, their validity and accuracy have been questioned...

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Yu, Yih-Choung; Boston, J. Robert; Simaan, Marwan A.; Miller, Phil J.; Antaki, James F.; ASAIO Journal: 47, Issue 3; 293-301; 2001.

A mathematical model describing the pressure-volume relationship of the Novacor left ventricular assist system (LVAS) was developed. The model consists of lumped resistance, capacitance, and inductance elements with one time varying capacitor to estimate the cyclic pressure generation of the pump using pump volume measurement.

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Makoto Arita, Kiyotaka Iwasaki, Mitsuo Umezu, Masanori Yoshida, Tetsuo Fujimoto, Hisayoshi Suma and Tadashi Isomura; Journal of Artificial Organs: 4, Issue 2; 131-137; 2001

The purpose of this study was to explore a valve selection criterion based on the impact force generated at valve closure, and to test a statistical mathematical model for comparing valve performance. The impact force generated at valve closure in the mitral position was measured continuously, using a load cell mounted in the left atrial section of a mock circulatory system...

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Yos S. Morsi and Ali A. Sakhaeimanesh; Artificial Organs: 24, Issue 7; 564 – 574; 2001.

Thrombus formation and hemolysis have been linked to the dynamic flow characteristics of heart valve prostheses. To enhance our understanding of the flow characteristics past the aortic position of a Jellyfish (JF) valve in the left ventricle, in vitro laser Doppler anemometry (LDA) measurements were carried out under physiological pulsatile flow conditions...

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George P. Chatzimavroudis; John N. Oshinski; Robert H. Franch; Peter G. Walker; Ajit P. Yoganathan; Roderic I. Pettigrew; Journal of Cardiovascular Magnetic Resonance: 3, Issue 1; 11 – 19; 2001.

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Ronald C. Elkins, MDa, Patti E. Dawson, BSb, Steven Goldstein, PhDb, Steven P. Walsh, PhDb, Kirby S. Black, PhDb; The Annals of Thoracic Surgery: 71; S428-S432; 2001.

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Mano J. Thubrikar, PhDa, Francis Robicsek, MD, PhDa, Geoffrey G. Gong, MDa, Brett L. Fowler, BSa; The Annals of Thoracic Surgery: 71; S318-S322; 2001.

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Haosen Zhang, Sandra S. Halliburton, James R. Moore, Orlando P. Simonetti, Paulo R. Schvartzman, Richard D. White and George P. Chatzimavroudis; Annals of Biomedical Engineering: 30, Issue 1; 120-128; 2002.

Magnetic resonance (MR) phase-velocity mapping (PVM) is routinely being used clinically to measure blood flow velocity. Conventional nonsegmented PVM is accurate but relatively slow (3-5 min per measurement). Ultrafast k-space segmented PVM offers much shorter acquisitions (on the order of seconds instead of minutes).

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Natascha Simon-Kupilik, MDa, Heinz Schima, PhDb, Leopold Huber, MEb, Reinhard Moidl, MDa, Gerhard Wipplingerb, Udo Losert, MDc, Ernst Wolner, MDa, Paul Simon, MD; The Annals of Thoracic Surgery: 73; 455-459; 2002.

Aortic root replacement for prosthetic aortic valve endocarditis with accompanying destruction of the aortic root is a well-established surgical intervention. However, there is still no consensus whether prosthetic material or allogeneic material should be used. Here we report on our experience with prosthetic composite and aortic allograft root replacement in such patients during a 10-year interval.

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