Articles Related to Applications

Experiments in Fluids: 33, Issue 3; 458-463; 2002.

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Julia Mascherbauera, Heinrich Schimab, Raphael Rosenheka, Martin Czernyc, Gerald Maurera and Helmut Baumgartnera; European Heart Journal: 25, Issue 9; 787-793; 2004.

The calculation of valve resistance (R) rather than aortic valve area (AVA) has been proposed for the assessment of aortic stenosis (AS), based on the claim that it is less flow-dependent. Even more importantly, valve resistance has been reported to distinguish between truly severe and "pseudosevere" AS in patients with low cardiac output. However, the diagnostic value of valve resistance remains controversial.

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Haosen Zhang, Sandra S. Halliburton, Richard D. White and George P. Chatzimavroudis; Annals of Biomedical Engineering: 32, Issue 12; 1618-1627; 2004.

Magnetic-resonance (MR) phase velocity mapping (PVM) shows promise in measuring the mitral regurgitant volume. However, in its conventional nonsegmented form, MR-PVM is slow and impractical for clinical use. The aim of this study was to evaluate the accuracy of rapid, segmented k-space MR-PVM in quantifying the mitral regurgitant flow through a control volume (CV) method.

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Vedi, Manmeet Singh; Texas A&M University; 2004.

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Toshihiro Ogawa, Lawrence N Scotten,** David K Walker**, Ajit P Yoganathan, Renee L Bess, Cheryl K Nordstrom, and Julius M Gardin; Cardiovasc Ultrasound; 2005.  **ViVitro Labs Founder

Insufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography.

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Grigioni, Mauro; Daniele, Carla; Del Gaudio, Costantino; Morbiducci, Umberto; Balducci, Antonio; D’Avenio, Giuseppe; Barbaro, Vincenzo; ASAIO Journal: 51, Issue 3; 176-183; 2005.

A three-dimensional, realistic model of an aortic mechanical heart valve and Valsalva sinuses was developed to predict, by means of a numerical time dependent simulation, the flow field during a fraction of the systolic period. The numeric simulation was performed upon a model of valve similar to a Carbomedics 27 mm placed in a physiologic aortic root shaped model,...

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George P. Chatzimavroudis, Peter G. Walker, John N. Oshinski, Robert H. Franch, Roderic I. Pettigrew, Ajit P. Yoganathan, Ph.D.; Magnetic Resonance in Medicine: 37, Issue 4; 545 – 551; 2005

Although several methods have been used clinically to assess aortic regurgitation (AR), there is no "gold standard" for regurgitant volume measurement. Magnetic resonance phase velocity mapping (PVM) can be used for noninvasive blood flow measurements.

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Suchitra Konduri, Yun Xing, James N. Warnock, Zhaoming He and Ajit P. Yoganathan; Annals of Biomedical Engineering: 33, Issue 9; 1158-1166; 2005.

Quantifying mitral regurgitation is difficult because of the complexity of the flow, geometry and motion of the mitral valve. In this paper a MRI compatible phantom was built incorporating a left ventricle and mitral valve motion. Valve motion was obtained using a pneumatic piston. The mitral valve was made regurgitant and the regurgitant volume quantified using a modified control volume method. The modification to the method was the addition of mitral motion correction. T

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David Paniagua, MD, José A. Condado, MD, José Besso, MD, Manuel Vélez, MD, Bruno Burger, MD, Salvatore Bibbo, MD, Douglas Cedeno, MD, Harry Acquatella, MD, Carlos Mejia, BA, Eduardo Induni, MD, and R. David Fish, MD; Texas Heart Institute Journal: 32, Issue 3; 393–398; 2005.

The transcatheter route is an emerging approach to treating valvular disease in high-risk patients. The 1st clinical antegrade transcatheter placement of an aortic valve prosthesis was reported in 2002. We describe the first retrograde transcatheter implantation of a new aortic valve prosthesis, in a 62-year-old man with inoperable calcific aortic stenosis and multiple severe comorbidities.

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Carsten J. Bellera, Michel R. Labrosseb, Francis Robicsek and Mano J. Thubrikar; Interactive Cardiovascular and Thoracic Surgery: 5; 526-530; 2006.

Our goal was to understand why it is difficult to achieve reliable valve competence after aortic valve-sparing surgery, and to propose quantitative data aimed at improving the outcome of the procedure. Valve-sparing procedures were performed in patients with dilated aortic roots and aortic regurgitation, and reproduced in physical models to explore what should be the restored dimensions of the aortic root and leaflets for valve sparing to be successful.

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Kaminsky, Radoslav; Kallweit, Stephan; Weber, Hans J.; Simons, Antoine P.; Verdonck, Pascal; ASAIO Journal: 52, Issue 2; 4A; 2006.

Worldwide are performed approximately 225,000 heart valve operation procedures. Various heart valve types have different efficiency, beside others, mostly given by the quality of the flow in all regions across the valve. For the visualization of the flow we employed Stereo High Speed Particle Image Velocimetry (SHSPIV)...

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Ashwin Prakash, MD, Ruchira Garg, MD, Edward N. Marcus, MSc, Glenn Reynolds, PhD, Tal Geva, MD, Andrew J. Powell, MD; Journal of Magnetic Resonance Imaging: 24, Issue 3; 676 – 682; 2006.

To test the agreement between conventional and sensitivity-encoded (SENSE) velocity encoded cine (VEC) MRI in a flow phantom and in subjects with congenital and acquired heart disease...

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Kheradvar, Arash; Kasalko, Jeff; Johnson, Derrick; Gharib, Morteza; ASAIO Journal: 52, Issue 1; 34-38; 2006.

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Arash Kheradvar and Morteza Gharib; Annals of Biomedical Engineering: 35, Issue 12; 2050-2064; 2007.

Several studies have suggested that the mitral annulus displacement and velocity in early diastole can be used as indicators of diastolic performance.

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Radoslav Kaminsky, Stephan Kallweit, Hans-Joachim Weber, Tom Claessens, Krzysztof Jozwik, and Pascal Verdonck; Artificial Organs: 31, Issue 12; 869 – 879; 2007.

The number of candidates waiting for a heart valve replacement rises yearly. Even though there is a trend toward implantation of biological valves or reconstruction, the prosthetic heart valves (PHVs) are still commonly used for implantation or as a part of cardiac assist devices in many countries worldwide...

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Kheradvar, Arash; Milano, Michele; Gharib, Morteza; ASAIO Journal: 53, Issue 1; 8-16; 2007.

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Paulo C Santos, Luís R Gerola, Ivan Casagrande, Ênio Buffolo and David T Cheung; Asian Cardiovasc Thorac Ann ;15:413-417; 2007.

Calcification of glutaraldehyde-treated bioprosthetic heart valves is a major cause of long-term failure. We studied porcine aortic valves treated by the L-Hydro process and implanted into 14 juvenile sheep (group 1). Another 10 sheep were implanted with glutaraldehyde-treated porcine bioprostheses (group 2).

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Julia Mascherbauer, Christina Fuchs, Martin Stoiber, Heinrich Schima, Elisabeth Pernicka, Gerald Maurer and Helmut Baumgartner; European Heart Journal: 29, Issue 16; 2049-2057; 2008.

Hypertension is a frequent finding in patients with aortic stenosis (AS). However, controversial data about the influence of systemic blood pressure on the quantification of AS have been published.

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A. A. Sakhaeimanesh; Journal of Medical Engineering & Technology: 32, Issue 6; 434 – 439; 2008.

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Mazur, Daniel E.; Osterholzer, Kathryn R.; Toomasian, John M.; Merz, Scott I.; ASAIO Journal: 54, Issue 5; 523-528; 2008.

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