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Onur Dur, Keif Fitzgerald, Paul Muller, Chris Parker Thoratec Corporation, Sunnyvale, CA company slide
The HeartMate PHP is a 13F catheter-based trans-aortic heart pump with a collapsible distal portion that expands to 24F to provide minimally invasive acute hemodynamic stabilization and left ventricular unloading in both prophylactic and emergent clinical settings... Objective: To evaluate the interaction of the HeartMate PHP with native cardiovascular system via in vitro pulsatile mock flow loop testing. A custom-built pulsatile heart simulator adapted from Vivitro Pulse Duplicator (Vivitro Labs Inc., Canada) was tuned to generate physiological flow pressure waveforms while mimicking the preload sensitivity of the native heart.
Other Products Cited: Customized Circulatory Loop Pulse Duplicator VAD Testing
Visit SourceCole Feagler, Zeeshan Syedain and Robert Tranquillo University of Minnesota College of Science and Engineering Poster Report
While most commercial valves today use chemically-fixed porcine tissue in the construction of the replacement valves, the Tranquillo group has been exploring the use of decellularized, engineered tissue as leaflet material... ...The goal of this project was to engineer a commissure design to mitigate valve failure through tissue tearing, and to improve overall valve hemodynamics. (I.e. reduction of PVL)... ...Prototype TEHVs were tested to failure using a ViVitro Labs pulse duplicator, running custom LabView data acquisition software...
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Visit SourceSean Guo-Dong Tan, Sangho Kim, Hwa Liang Leo Experiments in Fluids June 2016, 57:110
Mechanical heart valve prostheses are often implanted in young patients due to their durability and long-term reliability. However, existing designs are known to induce elevated levels of blood damage and blood platelet activation... ...This study proposes a bi-leaflet mechanical heart valve design (Bio-MHV) that mimics the geometry of a human mitral valve, with the aim of reducing turbulence levels in the left ventricle by replicating physiological flow patterns... ... A pulsatile pump (ViVitro Labs Inc., Victoria, BC) attached to the working chamber drove the blood analog around the flow loop, via the pumping action of the silicon left ventricle, as shown in Fig. 1c. Fig. 2 a A mitral flow waveform sample observed in the experiments. ...
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Visit SourceKoohyar Vahidkhah, Dan Cordasco, Mostafa Abbasi, Liang Ge, Elaine Tseng, Prosenjit Bagchi, Ali N. Azadani Annals of Biomedical Engineering pp 1-13 First online: 05 April 2016
Valvular hemolysis and thrombosis are common complications associated with stenotic heart valves. This study aims to determine the extent to which hemodynamics induce such traumatic events. The viscous shear stress downstream of a severely calcified bioprosthetic valve was evaluated via in vitro 2D particle image velocimetry measurements. ... Calcification was present on all the leaflets with a very small tear, less than 0.5 mm, on one of the leaflets (Figs. 1a, 1b). The bioprosthesis was tested at room temperature in a custom-built pulse duplicator system (ViVitro Systems, Inc., Victoria, Canada). ...
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Visit SourceNandini Duraiswamy , Jason D. Weaver, Yasamin Ekrami, Stephen M. Retta, Changfu Wu Cardiovascular Engineering and Technology pp 1-13 First online: 10 February 2016
... The hydrodynamic testing was per- formed using 0.9% saline solution in the commercially available Left Heart Simulator (Vivitro Systems), which simulates function of the heart by generating pulsatile flow through prosthetic heart valves. ...In the EllipMinor and EllipMajor configurations, the maximum principal stress occurred near the center of the free edge of the “stretched” leaflets. These results further affirm recommendations by the International Standards Organization (ISO) that pre-clinical testing should consider non-circular configurations for transcatheter valve durability testing.
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Visit SourceIkechukwu Okafor, Arvind Santhanakrishnan, Vrishank Raghav, Ajit Yoganathan- Journal of Biomechanical Engineering 10/2015;
...The results support the hypothesis that a D-shaped mitral annulus reduces dissipative energy losses in ventricular filling during diastole, and in turn suggests that a symmetric stent design does not provide lower filling efficiency than an equivalent asymmetric design. ...fluctuations were imposed in a fluid-filled chamber housing the LV physical model using a programmable piston pump (Superpump, Vivitro Systems; British Columbia, Canada). The pressure fluctuations resulted in the deformation of the LV model, driving flow through ...
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Visit SourceZeeshan Syedaina, Jay Reimera, Jillian Schmidta, Matthew Lahtic, James Berryc, Richard Biancoc, Robert T. Tranquillo - doi:10.1016/j.biomaterials.2015.09.016
Diseased aortic valves often require replacement, with over 30% of the current aortic valve surgeries performed in patients who will outlive a bioprosthetic valve. While many promising tissue-engineered valves have been created in the lab using the cell-seeded polymeric scaffold paradigm, none have been successfully tested long-term in the aortic position of pre-clinical model. ... A customized pulse duplicator system was designed based on a commercial wave generator and pump (ViVitro Systems). ...
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Visit SourceAndrea Salicaa, Giuseppe Pisanib, Umberto Morbiduccib, Raffaele Scaffaa, Diana Massaib, Alberto Audeninob, Luca Welterta, Lorenzo Guerrieri Wolfa and Ruggero De Paulisa - - European Journal of Cardio- Thoracic Surgery (2015), First published online: September 10, 2015
Normal aortic valve opening and closing movement is a complex mechanism mainly regulated by the blood flow characteristics and the cyclic modifications of the aortic root. Our previous in vitro observations demonstrated that the presence of the Valsalva sinuses, independently from root compliance, is important in reducing systolic pressure drop across the aortic valve. ... The hydrodynamic performances under pulsatile flow regimen were investigated, using a Vivitro System, Inc. ... Direct visualization of valve operating condition was performed, using an ultrafast speed camera (Casio Exlim Ex F1), mounted on top of the Vivitro system [19, 20]. ...
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Visit SourceFilippo Piatti, Francesco Sturla, Gil Marom, Jawaad Sheriff, Thomas E. Claiborne, Marvin J. Slepian, Alberto Redaelli, Danny Bluestein - Journal of Biomechanics, 2015 Published Online: August 21, 2015
... The aim of this study was to characterize the hemodynamics and thrombogenic potential of the Polynova polymeric trileaflet valve prototype using a fluid-structure interaction (FSI) approach. The FSI model replicated experimental conditions of the valve as tested in a ViVitro Left Heart Simulator (ViVitro Labs Inc., Victoria, BC, Canada). ... FSI data, ViVitro data. Cardiac output (L/min), 5.62, 5.50. ...
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Visit SourceJahren, Silje Ekroll; Heinisch, Paul Philipp; Wirz, Jessica; Winkler, Bernhard; Carrel, Thierry; Obrist, Dominik (31 March 2015). Hemodynamic Performance of Edwards Intuity Valve in a Compliant Aortic Root Model (In Press). In: IEEE EMBC 2015. Milano. 25.08.-29.08.2015.
...It was the aim of this study to perform hemodynamic and kinematic measurements for this type of valves to serve as a baseline for following studies which investigate the effect of the aortic root on the valve performance. To this end, the Edwards Intuity aortic valve was investigated in a new in vitro flow loop mimicking the left heart...
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Visit SourceBernhard Vennemann, David Hasler, Silje E. Jahren, Thomas Rösgen, Thierry P. Carrel, Dominik Obrist - Heart Valve Society 1st Annual Meeting MAY 6-9, MONTE CARLO, MONACO, GRIMALDI FORUM
...so called hot spots, where activated platelets might aggregate and form a thrombus that can ultimately lead to leaflet blockage. It is the aim of this study to assess the hemodynamics in the pivoting area of the Triflo valve.
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Visit SourceF Shu, S Vandenberghe, J Brackett, JF Antaki - Cardiovascular Engineering and Technology July 2015
Rotodynamic blood pumps (also known as rotary or continuous flow blood pumps) are commonly evaluated in vitro under steady flow conditions. However, when these devices are used clinically as ventricular assist devices (VADs), the flow is pulsatile due to the contribution of the native heart. ... Flow Loop The pump prototype was dynamically tested using a cardiovascular simulator circuit (modified from Vivitro Systems Inc., Victoria, British Columbia) built around a silicone mock left ventricle (LV) encased in a rigid acrylic chamber ...
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Visit SourceHoda Maleki, MASc, Shahrokh Shahriari, PhD, Michel Labrosse, PhD, Josep Rodés-Cabau, MD, Philippe Pibarot, PhD, FACC, FAHA, FESC, Lyes Kadem, PhD, Eng. -Canadian Journal of Cardiology 28 March 2015
There is few data about the patient- and prosthesis- related factors influencing the hemodynamics of transcatheter heart valves (THVs). The objective of this in vitro study was to assess the effect of aortic annulus size and prosthesis oversizing on the valve hemodynamics and estimated leaflet bending stress of the SAPIEN balloon-expandable THV. ... THV). Methods. In Vitro Model. For the purpose of this study, a left heart duplicator system was used (ViVitro Labs. Inc, BC, Canada). This simulator is capable of reproducing physiological pressure and flow waveforms. Briefly ...
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Visit SourceZ Trawiński, J Wójcik, A Nowicki, A Balcerzak…
... Our model of the LV was driven by the computer-controlled hydraulic piston Super-Pump (Vivitro Inc., Canada) with adjustable fluid volumes. ... The data were reconstructed every 10% of the R-to-R interval of the ECG signal produced by the Vivitro SuperPump control device. ...
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Visit SourcePeacock J, Hankins S, Jones T, Lutz R. Journal of Biomechanics: 28, Issue 1; 17-26.
An in vitro pulse duplicator system was used to investigate whether coronary artery stents induce downstream flow instabilities. Hot film or electrochemical probes were used to measure wall shear stress before and after deployment of both single and multiple (overlapping) stents in normal and diseased coronary geometries...
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Visit SourceNwosuh, I.A. Roberts, D. Kosiniski, S. Ciampa, S. Thomas, G.A.; Bioengineering Conference, 2005. Proceedings of the IEEE 31st Annual Northeast; 20- 21.
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Visit SourceR. J. Okamoto, M. J. Moulton, S. J. Peterson; Journal of Biomechanical Engineering: 122, Issue 5; 479.
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Visit SourceM. Thubrikar, F. Robicsek, B. Fowler, Y. Sun, Y. Lan Zhu, J. Holleman, Jr., T. Roush; Annals of Vascular Surgery: 18, Issue 5; 578-588.
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Visit SourceEuropean Journal of Vascular and Endovascular Surgery: 18, Issue 3; 191-200.
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Visit SourceT.Nielsen, C.Djurhuus, E.Pedersen, J.Laustsen, J.Hasenkam, T.Schroeder; Journal of Vascular Surgery: 24, Issue 6; 1043-1049.
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