Articles Related to Customized circulatory systems

Merhi, Y., Montero, K.L., Johansen, P. et al. npj Flex Electron 10, 31 (2026).

This work highlights how ViVitro systems enable realistic cardiovascular bench testing for next-generation bioelectronic devices, helping advance translational implant development. Using a ViVitro SuperPump to recreate physiologically relevant pulsatile left-heart conditions, this study evaluates a biodegradable PLLA piezoelectric sensor for real-time monitoring during aortic annuloplasty. The authors enhanced PLLA film performance through uniaxial stretching and thermal annealing, significantly increasing voltage output and enabling stable, pressure-correlated sensing in a ring-like prototype. Within the in-vitro setup, the sensor produced repeatable signals across clinically relevant pressure ranges, supporting its potential as a temporary smart implant.

Other Products Cited:  Customized Circulatory Loop  Peripheral devices testing  Pulsatile Flow Simulation  SuperPump

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Michael A. Bielecki, Julianne H. Spencer, Paul A. Iaizzo

Pumping New Life into Heart Research: How ViVitro's Superpump is Changing TAVR Studies In this study, researchers took a unique approach by reanimating swine and human hearts with a ViVitro Superpump to investigate how TAVR implantation affects coronary pressure. Using the Superpump and detailed CT scans, they measured what they call the Estimated Leaflet to Ostium Distance, or ELOD, and found a clear correlation: the shorter that distance, the more coronary pressure could drop. In other words, by getting these hearts beating again in a lab setting, they demonstrated that ELOD might be a better predictor of coronary obstruction risk than some traditional measurements. It’s a solid example of how ViVitro’s technology is helping refine our understanding of heart valve procedures, all without the need for animal or patient trials.

Other Products Cited:  Customized Circulatory Loop  Ex ViVo Simulation  Pressure Measurement System  SuperPump

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Sibut-Pinote, Vincent; Reymon, Philippe; Cikirikcioglu, Mustafa; Bendjelid, Karim; Huber, Christoph. ASAIO Journal ():10.1097/MAT.0000000000002454, May 13, 2025.

Use of the ViVitro Labs Super Pump to build a complex mock circulatory loop to study the effect of VA-ECMO/IABP combination on the with systemic, coronary, cerebral, and renal circulation. In this study the ViVitro Labs system is used to improve the outcome of clinical procedures. "We used the same silicone circuit as in our previous publication (model ref T-S-N-009+; Elastrat, Geneva, Switzerland). To prevent the formation of air bubbles when testing at a heart rate of 100 bpm, and to improve the quality of aortic flow measurements, a rigid plastic grid was placed in the compliance reservoir tank. We used a pulsatile pump (Superpump; ViVitro Labs, Inc., Victoria, BC, Canada) to simulate cardiac function at the circuit inlet. Positioning the pump in line with the aortic root was the configuration with the fewest disturbances flow and pressure measurements (Figure 1)"

Other Products Cited:  Customized Circulatory Loop  Peripheral devices testing  Pulsatile Flow Simulation  SuperPump

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Luca Bontempi, Marta Zattoni, Anna Ramella, Francesco Migliavacca, Steffen Ringgaard, Won Yong Kim, Peter Johansen, Monika Colombo bioRxiv 2025.03.05.641637

This publication demonstrates the modularity of the ViVitro Labs Pulsatile flow pump and how it can be used to construct an advanced mock circulatory flow-loop (MCL) and obtain boundary flow conditions for an FSI model. "A pulsatile in-vitro MCL was employed to replicate a left heart flow cycle, as previously described [9,10]. . An electromechanical piston pump (VSI Superpump, ViVitro Labs, Victoria, Canada) was connected to the ventricular chamber to generate pulsatile flow and pressure waveforms. The atrial reservoir and ventricular chamber were linked via a mechanical heart valve mimicking the mitral valve, while the ventricular chamber and the compliance chamber were connected through the AR model with the integrated AV"

Other Products Cited:  Flow Visualization  Heart Valve Repair  Pulsatile Flow Simulation  SuperPump

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Smid CC, Haselmann C, Irani SK, Cesnjevar R, Schweiger M, Pappas GA

This study demonstrates how the ViVitro Labs Pulsatile flow pump was used to design a customized pulse duplicator system to assess the hydrodynamic performance of a pediatric “biological valve model (BVM)”. The flow loop integrates a unique system to simulate aortic annulus expansion. The performance of the patient-tailored valve was benchmarked against a commercially available pulmonary conduit along with an in-house built polyurethane valve. This research provides valuable insight on valve design potential improvements and demonstrates how ViVitro systems can play a critical role in valve performance assessment.

Other Products Cited:  Customized Circulatory Loop  Heart Valve Testing  SuperPump

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Kedwai, Baqir et al. JVS-Vascular Science, Volume 6, 100287

AAA sac management with persistent growth or endoleak in patient continue to be a challenge. This publication demonstrates the modularity of the ViVitro Labs Pulsatile Flow Pump in building advanced mock circulatory loops, and how the ViVitro Labs systems can be used to assess the impact of an embolization technique on the reduction of AAA sac volume and improve a procedure clinical outcome. "A Vivitro SuperPump (Victoria, BC, Canada) cardiac simulator was connected to both ends of a 30-gallon plastic basin using plastic tubing. The graft model construct was placed into the basin and securely attached proximally and distally to the plastic tubing with circumferential clamps. The basin was filled with water and gel beads for optimal acoustic conditions. Once the model was connected to the flow circuit, water was pumped through the system at 70 beats per minute with an average flow rate of 3.5 L/min."

Other Products Cited:  Customized Circulatory Loop  Endovascular Simulator  Peripheral devices testing  Stent and Stent/Graft  SuperPump

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Mao, P.; Jin, M.; Li, W.; Zhang, H.; Li, H.; Li, S.; Yang, Y.; Zhu, M.; Shi, Y.; Zhang, X.; et al. Biomedicines 2025, 13, 1135.

This research the left ventricular chamber of a ViVitro Labs Pulse was customized to create an ex-vivo Mitral Valve Regurgitation (MR) model with isolated annular dilation. The advanced ex-vivo model in used to study the performance of various mitral annuloplasty rings in simulated used physiological conditions. The ViVitro Labs Pulse chamber design and structure provides maximum modularity to create unique support without compromising system performance. "The TaurusOne was tested in vitro in a pulse duplicator system (ViVitro Labs Inc., Victoria, BC, Canada) (Figure 1b), operating at a rate of 70 beats per minute (bpm). The test chamber was filled with 37 °C distilled water to simulate the testing environment recommended by ISO 5840-3 [20]. A linear motor-driven plunger pump was used to precisely control the pressure values on both sides of the fluid according to the aortic valve pressure gradient curve of the clinical patient"

Other Products Cited:  Customized Circulatory Loop  Heart Valve Repair  Pulse Duplicator

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Levent Beker, Alp Toymus, Süleyman Peker, Abdülkadir Atik, Umut Yener, Maide Albay, Emel Yılgör, İskender Yılgör. Research Square. 08 January 2025.

Despite the rapid emergence of wearable ultrasound technologies in the research community, the common practice still requires wired connections to benchtop instruments. For the in vitro characterization of the heart rate and blood pressure monitoring US tag, a pulsatile pump (SuperPump, ViVitro Labs) with a silicone rubber vessel was used. Thanks to the advances in soft materials, fabrication techniques and sensing strategies, wearable medical devices are revolutionizing the healthcare system by enabling continuous and quantitative assessment of various biomarkers.

Other Products Cited:  Customized Circulatory Loop  Pulsatile Flow Simulation  SuperPump  Ultrasound Measurements

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Ghanbarzadeh-Dagheyan A, van Helvert M, van de Velde L, Reijnen MMPJ, Versluis M, Groot Jebbink E. Journal of Endovascular Therapy. 2024;0(0).

Helical stents have been developed to treat peripheral arterial disease (PAD) in the superficial femoral artery (SFA), with the premise that their particular geometry could promote swirling flow in the blood. The aim of this work is to provide evidence on the existence of this swirling flow by quantifying its signatures. The flow setup consisted of a programmable piston pump (Super Pump, Vivitro, Victoria, Canada), to create pulsating flow. The in vitro results show that skewedness is increased due to the helical geometry of the stents.

Other Products Cited:  Customized Circulatory Loop  Flow Visualization  Stent and Stent/Graft  SuperPump

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Sébastien Hecht MSc, Mohamed-Salah Annabi MD, MSc, Viktória Stanová PhD, Abdellaziz Dahou MD, PhD, Ian G. Burwash MD, Matthias Koschutnik MD, Philipp E. Bartko MD, Jutta Bergler-Klein MD, Julia Mascherbauer MD, Carolina Donà MD, Stefan Orwat MD, Helmut Baumgartner MD, Joao L. Cavalcante MD, Henrique B. Ribeiro MD, PhD, Alexis Théron MD, PhD, Josep Rodes-Cabau MD, Marie-Annick Clavel DVM, PhD, Philippe Pibarot DVM, PhD, JACC: Advances, Volume 3, Issue 10, 2024

The purpose of this study was to evaluate the diagnostic and prognostic value of MG/EOA ratio. Contraction of the left ventricle is achieved by a piston pump (Vivitro Inc). MG/EOA ratio can be useful in low-flow, LG-AS to confirm AS severity and may complement DSE or aortic valve calcium scoring.

Other Products Cited:  Customized Circulatory Loop  Pulsatile Flow Simulation  SuperPump

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Michele Mastrogiacomo. Rel. Stefania Scarsoglio, Vrishank Raghav. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Aerospaziale, 2024

Given the prevalence and impact of Paravalvular Leakage, there is a critical need to study and mitigate this issue to improve patient outcomes. The experimental setup replicates the human left heart, featuring a Pulsatile Pump ViVitro, an em-tec flow meter, pressure taps, and a transparent acrylic test chamber housing a heart valve. The results of the experiments indicate that a wall jet forms during diastole, flowing back from the aortic side into the ventricular side.

Other Products Cited:  Customized Circulatory Loop  Flow Visualization  Heart Valve Testing

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Hoving, A.M., Mikhal, J., Kuipers, H. et al. Med Biol Eng Comput 62, 1165–1176 (2024).

To investigate flow conditions in a double-layered carotid artery stent, a bench-top in vitro flow setup including a bifurcation phantom was designed and fabricated. For the introduction of pulsatile flow, a linear piston pump (Superpump AR, ViVitro Labs, Victoria, BC, Canada) and two compliances were added to the stationary circuit. We illustrated, with 3D printing and molding, how it is possible to transfer geometry from literature to a model and thereafter to a flexible phantom.

Other Products Cited:  Customized Circulatory Loop  Flow Visualization  Pulsatile Flow Simulation

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Laengle S, Suria A, Poschner T, Tasdelen S, Pitsis A, Kocher A, Andreas M. Bioengineering. 2024; 11(7):666.

Clover repair offers a surgical solution that can be applied for the treatment of primary and secondary Tricuspid regurgitation (TR). Flow was provided by a pulsatile pump system (ViVitro Labs Inc., Victoria, BC, Canada), which was coupled to the right ventricle through a third connector. This new clover technique was demonstrated to successfully reduce TR in an ex vivo porcine heart model.

Other Products Cited:  Customized Circulatory Loop  Heart Valve Repair  Pulsatile Flow Simulation  SuperPump

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